Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
HSF1 [nucleoplasm]
Stable Identifier
R-HSA-5082385
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Heat shock transcription factor 1, HSTF 1, Heat shock factor protein 1
Icon
Locations in the PathwayBrowser for interactor UniProt:Q15029 EFTUD2
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to heat stress (Homo sapiens)
HSF1 activation (Homo sapiens)
Dissociation of HSF1:HSP90 complex in the nucleus (Homo sapiens)
HSF1 [nucleoplasm] (Homo sapiens)
Trimerization of HSF1 in the nucleus (Homo sapiens)
HSF1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q00613 HSF1
Gene Names
HSF1, HSTF1
Chain
chain:1-529
Reference Genes
BioGPS Gene:3297 HSF1
COSMIC (genes):HSF1 HSF1
CTD Gene:3297 HSF1
dbSNP Gene:3297 HSF1
ENSEMBL:ENSG00000185122 HSF1
ENSEMBL_homo_sapiens_GENE:ENSG00000185122.11 HSF1
ENSEMBL_homo_sapiens_GENE:ENSG00000284774.2 HSF1
HGNC:5224 HSF1
KEGG Gene (Homo sapiens):3297 HSF1
Monarch:3297 HSF1
NCBI Gene:3297 HSF1
OMIM:140580 HSF1
UCSC:Q00613 HSF1
Reference Transcript
RefSeq:NM_005526.3 HSF1
RefSeq:XM_017013377.1 HSF1
Other Identifiers
11723695_s_at
17073759
202344_PM_at
202344_at
213756_PM_s_at
213756_s_at
244_at
3120359
3120360
3120361
3120362
3120384
3120386
3120387
3120388
3120392
3120393
3120394
3120395
3120396
3120397
3120398
3120405
3120407
3120408
3120410
3120411
3120412
3120413
3297
40200_at
4049903
4049904
4049905
4049907
4049908
4049909
4049910
4049918
4049920
4049921
4049922
4049923
4049924
4049927
4049928
4049929
8148824
A_23_P253841
A_33_P3347932
A_33_P3347937
GO:0000122
GO:0000165
GO:0000278
GO:0000775
GO:0000776
GO:0000785
GO:0000791
GO:0000792
GO:0000922
GO:0000976
GO:0000978
GO:0000981
GO:0001162
GO:0001227
GO:0001228
GO:0002376
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0006281
GO:0006351
GO:0006355
GO:0006357
GO:0006397
GO:0006952
GO:0006974
GO:0007584
GO:0010243
GO:0010628
GO:0010629
GO:0010667
GO:0012501
GO:0014070
GO:0014823
GO:0016071
GO:0016605
GO:0019901
GO:0023052
GO:0030154
GO:0031072
GO:0031333
GO:0031490
GO:0032355
GO:0033574
GO:0034605
GO:0034620
GO:0035865
GO:0036211
GO:0042531
GO:0042802
GO:0043200
GO:0043226
GO:0043565
GO:0043621
GO:0045651
GO:0045931
GO:0045944
GO:0046982
GO:0048471
GO:0048856
GO:0051028
GO:0051091
GO:0051879
GO:0061770
GO:0065003
GO:0070301
GO:0071222
GO:0071230
GO:0071276
GO:0071280
GO:0071392
GO:0071407
GO:0071466
GO:0071478
GO:0071480
GO:0072738
GO:0090084
GO:0090261
GO:0097165
GO:0097431
GO:0097677
GO:0098847
GO:0101031
GO:0120162
GO:0140110
GO:0140296
GO:1900034
GO:1901652
GO:1902512
GO:1903936
GO:1904385
GO:1904843
GO:1904845
GO:1990837
GO:1990841
GO:1990904
GO:1990910
GO:1990911
GO:2001033
HMNXSV003007205
HMNXSV003033648
Hs.1499.1.S1_3p_a_at
ILMN_1665621
ILMN_1667060
ILMN_1679371
ILMN_1679867
M64673_at
PH_hs_0031748
TC08000849.hg
TC08002160.hg
g5031766_3p_at
g5031766_3p_x_at
Participates
as an output of
Dissociation of HSF1:HSP90 complex in the nucleus (Homo sapiens)
as a component of
HSF1:HSP90:PTGES3 [nucleoplasm] (Homo sapiens)
as an input of
Trimerization of HSF1 in the nucleus (Homo sapiens)
Other forms of this molecule
p-S121-HSF1 [cytosol]
p-S303-HSF1 [cytosol]
p-S307-HSF1 [cytosol]
p-S303,307-HSF1 [cytosol]
hC36,103-HSF1 [cytosol]
p-S230-hC36,103-HSF1 [nucleoplasm]
Ac-K80-hC36,103-HSF1 [nucleoplasm]
hC36,103-HSF1 [nucleoplasm]
p-S326-hC36,103-HSF1 [nucleoplasm]
HSF1 [cytosol]
Inferred To
Hsf1 [nucleoplasm]
(Mus musculus)
Hsf1 [nucleoplasm]
(Rattus norvegicus)
Hsf [nucleoplasm]
(Drosophila melanogaster)
hsf-1 [nucleoplasm]
(Caenorhabditis elegans)
HSF1 [nucleoplasm]
(Bos taurus)
HSF1 [nucleoplasm]
(Canis familiaris)
HSF1 [nucleoplasm]
(Dictyostelium discoideum)
HSF1 [nucleoplasm]
(Gallus gallus)
HSF1 [nucleoplasm]
(Saccharomyces cerevisiae)
HSF1 [nucleoplasm]
(Sus scrofa)
hsf1 [nucleoplasm]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_005517.1
,
XP_016868866.1
OpenTargets
ENSG00000185122
ZINC - Substances
HSF1_HUMAN
ZINC - Biogenic
HSF1_HUMAN
ZINC target
Q00613
PRO
Q00613
PDB
5D5U
,
7DCJ
,
5D5V
,
2LDU
,
5HDN
,
7DCS
,
7DCT
,
5HDG
ZINC - Metabolites
HSF1_HUMAN
GeneCards
Q00613
HPA
ENSG00000185122-HSF1
Ensembl
ENSG00000185122
,
ENSP00000493830
,
ENST00000646252
,
ENSP00000431512
,
ENST00000528838
,
ENSG00000284774
Pharos - Targets
Q00613
Orphanet
24605
ZINC - Predictions - Purchasable
HSF1_HUMAN
Interactors (30)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q03933 HSF2
0.848
11
UniProt:Q9NZL4 HPBP1
0.725
4
UniProt:O00505 KPNA3
2
KPNA3 [nucleoplasm]
(R-HSA-1176061)
KPNA3 [cytosol]
(R-HSA-1176070)
0.638
3
UniProt:O00629 KPNA4
2
KPNA4 [cytosol]
(R-HSA-1176066)
KPNA4 [nucleoplasm]
(R-HSA-1176058)
0.638
3
UniProt:O95817 BAG3
1
BAG3 [cytosol]
(R-HSA-5255451)
0.638
3
UniProt:P49137 MAPKAPK2
5
MAPKAPK2 [cytosol]
(R-HSA-187743)
p-T222,S272-MAPKAPK2 [nucleoplasm]
(R-HSA-199936)
p-S272,T222,T334-MAPKAPK2 [cytosol]
(R-HSA-187760)
p-T222,S272,T334-MAPKAPK2 [nucleoplasm]
(R-HSA-450268)
MAPKAPK2 [nucleoplasm]
(R-HSA-450235)
0.602
5
UniProt:Q5VY09 IER5
0.589
3
UniProt:Q00613 HSF1
11
p-S121-HSF1 [cytosol]
(R-HSA-4793906)
p-S303-HSF1 [cytosol]
(R-HSA-4793927)
p-S307-HSF1 [cytosol]
(R-HSA-4793929)
p-S303,307-HSF1 [cytosol]
(R-HSA-4793922)
HSF1 [nucleoplasm]
(R-HSA-5082385)
hC36,103-HSF1 [cytosol]
(R-HSA-4793916)
p-S230-hC36,103-HSF1 [nucleoplasm]
(R-HSA-5082361)
Ac-K80-hC36,103-HSF1 [nucleoplasm]
(R-HSA-5097238)
hC36,103-HSF1 [nucleoplasm]
(R-HSA-3371416)
p-S326-hC36,103-HSF1 [nucleoplasm]
(R-HSA-5082355)
HSF1 [cytosol]
(R-HSA-3371452)
0.571
2
IntAct:EBI-25856799 CCSB
0.556
3
UniProt:Q14693 LPIN1
3
p-S106-LPIN1 [nucleoplasm]
(R-HSA-4419936)
LPIN1 [nuclear envelope]
(R-HSA-4419927)
LPIN1 [endoplasmic reticulum membrane]
(R-HSA-549157)
0.556
3
UniProt:Q9UIH9 KLF15
1
KLF15 [nucleoplasm]
(R-HSA-8878735)
0.556
3
UniProt:Q96CM3 RUSD4
0.556
3
UniProt:P11684 UTER
0.556
3
UniProt:Q6ZMY6-2 Q6ZMY62
0.556
3
UniProt:Q8NFB2 T185A
0.556
3
UniProt:Q9UNY5 ZN232
0.556
3
UniProt:Q13352 ITGB3BP
2
ITGB3BP [cytosol]
(R-HSA-3006405)
ITGB3BP [nucleoplasm]
(R-HSA-606325)
0.556
3
UniProt:O14744 PRMT5
3
p-Y297,304,307-PRMT5 [nucleoplasm]
(R-HSA-5211300)
PRMT5 [nucleoplasm]
(R-HSA-5205609)
PRMT5 [cytosol]
(R-HSA-191876)
0.556
3
UniProt:Q8N4C8 MINK1
1
MINK1 [cytosol]
(R-HSA-2532788)
0.544
2
UniProt:Q04759 PRKCQ
9
PRKCQ [photoreceptor disc membrane]
(R-HSA-2648997)
p-Y90,T219,T538,S676,S695-PRKCQ [plasma membrane]
(R-HSA-2685606)
PRKCQ(1-354) [cytosol]
(R-HSA-212526)
PRKCQ(355-706) [cytosol]
(R-HSA-212514)
PRKCQ [cytosol]
(R-HSA-58216)
PRKQC closed conformation [cytosol]
(R-HSA-202185)
PRKCQ [plasma membrane]
(R-HSA-202346)
p-Y90-PRKCQ [plasma membrane]
(R-HSA-202395)
p-Y90,T538,S676,S695-PRKCQ [plasma membrane]
(R-HSA-202152)
0.544
2
UniProt:Q9ULV5 HSF4
0.527
2
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.527
2
UniProt:P34931 HSPA1L
2
HSPA1L [cytosol]
(R-HSA-3371410)
HSPA1L [nucleoplasm]
(R-HSA-5082367)
0.508
2
UniProt:Q96SB8 SMC6
1
SMC6 [nucleoplasm]
(R-HSA-2993777)
0.508
2
UniProt:Q8NEH6 MNS1
0.508
2
UniProt:Q8NET4 RTL9
0.508
2
UniProt:O43683 BUB1
1
BUB1 [cytosol]
(R-HSA-377888)
0.508
2
UniProt:P53350 PLK1
4
PLK1 [nucleoplasm]
(R-HSA-156720)
p-T210-PLK1 [cytosol]
(R-HSA-3000318)
p-T210-PLK1 [nucleoplasm]
(R-HSA-3002800)
PLK1 [cytosol]
(R-HSA-164603)
0.508
2
UniProt:Q15029 EFTUD2
1
EFTUD2 [nucleoplasm]
(R-HSA-71883)
0.508
2
UniProt:Q5VZK9 CARMIL1
1
LRRC16A [cytosol]
(R-HSA-994131)
0.508
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text