The mammalian target of rapamycin complex 1 (mTORC1) has been implicated in sensing intracellular protein misfolding (Qian SB et al. 2010; Chou SD et al. 2012). RNA interference?mediated repression of mTOR kinase activity in human HeLa cells was found to increase sensitivity to heat shock. Moreover, inhibition of HSF1 phosphorylation on Ser326 by rapamycin suggests that this site in HSF1 is a target for the mTORC1complex (Chou SD et al. 2012).
Prince, T, Chou, SD, Gong, J, Calderwood, SK
Lane, WS, Voellmy, R, Guettouche, T, Boellmann, F
protein serine/threonine kinase activity of mTORC1 dimer [nucleoplasm]
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