Reactome | BID(1-195) [cytosol]

BID(1-195) [cytosol]

Stable Identifier

R-HSA-50825

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

BID, BH3 interacting domain death agonist (BID), BH3 interacting domain death agonist

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Homo sapiens)
        
        TP53 stimulates BID gene expression (Homo sapiens)
        
        BID(1-195) [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P55957 BID

Gene Names

BID

Chain

chain:1-195, chain:61-195, chain:76-195, chain:100-195

Reference Genes

BioGPS Gene:637 BID

COSMIC (genes):BID BID

CTD Gene:637 BID

dbSNP Gene:637 BID

ENSEMBL:ENSG00000015475 BID

ENSEMBL_homo_sapiens_GENE:ENSG00000015475.19 BID

HGNC:1050 BID

KEGG Gene (Homo sapiens):637 BID

Monarch:637 BID

NCBI Gene:637 BID

OMIM:601997 BID

UCSC:P55957 BID

Reference Transcript

Other Identifiers

11724046_a_at

11732217_a_at

11732218_x_at

11745421_a_at

16932008

204493_PM_at

204493_at

211725_PM_s_at

211725_s_at

227143_PM_s_at

227143_s_at

32725_at

32726_g_at

3951928

3951929

3951930

3951931

3951932

3951935

3951936

3951937

3951938

3951939

3951942

3951944

3951945

3951951

3951952

3951953

3951954

3951955

59612_at

59614_g_at

637

8074261

A_23_P154929

A_24_P187948

A_33_P3227041

GE54366

GO:0000278

GO:0001836

GO:0002376

GO:0005123

GO:0005515

GO:0005737

GO:0005739

GO:0005741

GO:0005829

GO:0006091

GO:0006626

GO:0006886

GO:0006915

GO:0006950

GO:0007005

GO:0008625

GO:0008637

GO:0010918

GO:0012501

GO:0016020

GO:0023052

GO:0031334

GO:0031625

GO:0031966

GO:0042129

GO:0042770

GO:0042775

GO:0042981

GO:0043028

GO:0043065

GO:0043226

GO:0050678

GO:0051402

GO:0061024

GO:0065003

GO:0090150

GO:0090200

GO:0097191

GO:0097284

GO:0097345

GO:0097435

GO:0098772

GO:1902108

GO:1902230

GO:2000045

GO:2000271

GO:2001233

GO:2001235

GO:2001238

GO:2001244

HMNXSV003050536

Hs.315689.1.A1_3p_at

ILMN_1763386

ILMN_2259495

ILMN_2372413

PH_hs_0029676

TC22000476.hg

g13543452_3p_s_at

g4557360_3p_at

Participates

as an input of

as an output of

TP53 stimulates BID gene expression (Homo sapiens)

Other forms of this molecule

MYS-BID(62-195) [mitochondrial outer membrane]

MYS-BID(62-195) [cytosol]

BID(62-195) [cytosol]

Inferred To

Bid [cytosol] (Mus musculus)

Bid [cytosol] (Rattus norvegicus)

bida [cytosol] (Danio rerio)

bid [cytosol] (Xenopus tropicalis)

BID(1-195) [cytosol] (Gallus gallus)

BID [cytosol] (Bos taurus)

BID [cytosol] (Canis familiaris)

BID [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001187.1, NP_932071.1, NP_932070.1, NP_001231501.1, NP_001231496.1, NP_001231499.1, NP_001231498.1

OpenTargets

ENSG00000015475

HPA

ENSG00000015475-BID

GeneCards

P55957

Ensembl

ENSG00000015475, ENST00000622694, ENST00000399767, ENST00000342111, ENST00000317361, ENSP00000382669, ENST00000399765, ENSP00000382667, ENSP00000449236, ENSP00000477773, ENSP00000318822, ENSP00000344594, ENSP00000480414, ENST00000551952, ENST00000614949

PRO

P55957

Pharos - Targets

P55957

PDB

2M5I, 8SM5, 5C3F, 4ZEQ, 7QTW, 4ZII, 1ZY3, 4ZIG, 2KBW, 2M5B, 7M5B, 4BD2, 4QVE, 5AJJ, 7P33, 2BID, 7M5A

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10415 BCL2	1	BCL2 [mitochondrial outer membrane] (R-HSA-50757)	0.869	9
UniProt:Q07817-1 BCL2L1			0.862	7
UniProt:Q07812 BAX	3	BAX [cytosol] (R-HSA-139916) BAX activated [cytosol] (R-HSA-139907) BAX [mitochondrial outer membrane] (R-HSA-139949)	0.823	17
UniProt:Q92843 B2CL2			0.806	7
UniProt:Q16611 BAK1	2	BAK1 [mitochondrial outer membrane] (R-HSA-139896) BAK1 activated [mitochondrial outer membrane] (R-HSA-50690)	0.761	4
UniProt:Q07820 MCL1	1	MCL1 [cytosol] (R-HSA-5661490)	0.702	3
UniProt:Q07817 BCL2L1	2	BCL2L1 [cytosol] (R-HSA-50771) BCL2L1 [mitochondrial outer membrane] (R-HSA-114236)	0.675	3
UniProt:Q07440 B2LA1			0.609	3
UniProt:P17361 PG035			0.589	2
UniProt:Q04864 REL	2	REL [cytosol] (R-HSA-1168579) REL [nucleoplasm] (R-HSA-1168585)	0.556	3
UniProt:Q96D03 DDT4L			0.556	3
UniProt:O43865 AHCYL1	1	AHCYL1 [endoplasmic reticulum membrane] (R-HSA-5215973)	0.556	3
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.524	2
UniProt:P97287 MCL1			0.499	3
UniProt:Q03135 CAV1	5	CAV1 [Golgi membrane] (R-HSA-204504) CAV1 [plasma membrane] (R-HSA-534994) CAV1 [early endosome membrane] (R-HSA-5368451) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [endocytic vesicle membrane] (R-HSA-535009)	0.463	3