SYK is a substrate for JAK1

Stable Identifier
R-HSA-508282
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Studies have shown that coexpression of Syk with catalytically active Jak1 results in Syk phosphorylation whereas coexpression of Syk with catalytically active Jak3 does not, suggesting that IL-2 driven phosphorylation of Syk is driven by Jak1 (Zhou et al. 2000).

Literature References
PubMed ID Title Journal Year
10825200 Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation

Zhou, YJ, Magnuson, KS, Cheng, TP, Gadina, M, Frucht, DM, Galon, J, Candotti, F, Geahlen, RL, Changelian, PS, O'Shea, JJ

Mol Cell Biol 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane]
Physical Entity
Activity
Orthologous Events
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