alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+

Stable Identifier
R-HSA-508369
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Mitochondrial 3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10; HADH2) catalyzes the reversible reaction of alpha-methylacetoacetyl-CoA and NADH + H+ to form alpha-methyl-beta-hydroxybutyryl-CoA and NAD+ (Ofman et al. 2003). Crystallographic data indicate that the enzyme is a homotetramer (Kissinger et al. 2004).

Literature References
PubMed ID Title Journal Year
12696021 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency is caused by mutations in the HADH2 gene.

Ofman, R, Ruiter, JP, Feenstra, M, Duran, M, Poll-The, BT, Zschocke, J, Ensenauer, R, Lehnert, W, Sass, JO, Sperl, W

Am J Hum Genet 2003
15342248 Crystal structure of human ABAD/HSD10 with a bound inhibitor: implications for design of Alzheimer's disease therapeutics

Kissinger, CR, Rejto, PA, Pelletier, LA, Thomson, JA, Showalter, RE, Abreo, MA, Agree, CS, Margosiak, S, Meng, JJ, Aust, RM, Vanderpool, D, Li, B, Tempczyk-Russell, A, Villafranca, JE

J Mol Biol 2004
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
3-hydroxyacyl-CoA dehydrogenase activity of HSD17B10 tetramer [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Created