Reactome: A Curated Pathway Database

Pyk2 associates with Jak3

Stable Identifier
R-HSA-508513
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The proline-rich tyrosine kinase 2 (PYK2) is a nonreceptor protein tyrosine kinase that is structurally related to FAK and thought to be important for leukocyte activation (Ostergaard & Lysechko 2005).
Coimmunoprecipitation experiments have demonstrated a physical association of Jak3 and Pyk2. A dominant interfering mutant of Pyk2 inhibited IL-2-induced cell proliferation without affecting Stat5 activation. Collectively, these results suggest that Pyk2 is a component of the Jak-mediated IL-2 signaling pathway, but a role has not been firmly established.

Literature References
Participants
Participant Of
Orthologous Events