PTK2B binds JAK3

Stable Identifier
R-HSA-508513
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Pyk2 associates with Jak3
Locations in the PathwayBrowser
Summation

The proline-rich tyrosine kinase 2 (PYK2) is a nonreceptor protein tyrosine kinase that is structurally related to FAK and thought to be important for leukocyte activation (Ostergaard & Lysechko 2005).
Coimmunoprecipitation experiments have demonstrated a physical association of Jak3 and Pyk2. A dominant interfering mutant of Pyk2 inhibited IL-2-induced cell proliferation without affecting Stat5 activation. Collectively, these results suggest that Pyk2 is a component of the Jak-mediated IL-2 signaling pathway, but a role has not been firmly established.

Literature References
PubMed ID Title Journal Year
9512511 Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway

Miyazaki, T, Takaoka, A, Nogueira, L, Dikic, I, Fujii, H, Tsujino, S, Mitani, Y, Maeda, M, Schlessinger, J, Taniguchi, T

Genes Dev 1998
Participants
Participant Of
Orthologous Events
Authored
Reviewed