Reactome | BIRC7 [cytosol]

BIRC7 [cytosol]

Stable Identifier

R-HSA-50855

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

BIRC7(1-298), ML-IAP, Baculoviral IAP repeat-containing protein 7, Kidney inhibitor of apoptosis protein, KIAP, Melanoma inhibitor of apoptosis protein, Livin

Locations in the PathwayBrowser for interactor UniProt:Q86WC4 OSTM1

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External Reference Information

External Reference

UniProt:Q96CA5 BIRC7

Gene Names

BIRC7, KIAP, LIVIN, MLIAP, RNF50, UNQ5800/PRO19607/PRO21344

Chain

chain:1-298, chain:53-298

Reference Genes

BioGPS Gene:79444 BIRC7

COSMIC (genes):BIRC7 BIRC7

CTD Gene:79444 BIRC7

dbSNP Gene:79444 BIRC7

ENSEMBL:ENSG00000101197 BIRC7

HGNC:13702 BIRC7

KEGG:hsa:79444 BIRC7

Monarch:79444 BIRC7

NCBI Gene:79444 BIRC7

OMIM:605737 BIRC7

UCSC:Q96CA5 BIRC7

Reference Transcript

Participates

as an output of

MITF-M-dependent BIRC7 gene expression (Homo sapiens)

Cross References

RefSeq

NP_071444.1, NP_647478.1

Guide to Pharmacology - Targets

2794

ENSEMBL

ENST00000217169, ENSG00000101197, ENSP00000345213, ENSP00000217169, ENST00000342412

OpenTargets

ENSG00000101197

ZINC - Substances

BIRC7_HUMAN

ZINC target

Q96CA5

PRO

Q96CA5

GlyGen

Q96CA5

PDB

3F7G, 3F7H, 3F7I, 1TW6, 1OY7, 3GT9, 4AUQ, 1OXQ, 1OXN, 2I3H, 2I3I, 3UW5, 3GTA

ZINC - Investigational

BIRC7_HUMAN

IntEnz

2.3.2.27

GeneCards

BIRC7

HPA

ENSG00000101197-BIRC7

Pharos - Targets

Q96CA5

ZINC - Predictions - Purchasable

BIRC7_HUMAN

HMDB Protein

HMDBP14440

Interactors (36)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P55211 CASP9	5	CASP9(1-416) [cytosol] (R-HSA-57033) CASP9(?-315) [cytosol] (R-HSA-141638) CASP9(331-416) [cytosol] (R-HSA-141639) p-T412-CASP9(1-416) [cytosol] (R-HSA-9627087) p-S196-CASP9(1-416) [cytosol] (R-HSA-198636)	0.924	12
UniProt:Q13490 BIRC2	5	BIRC2 [cytosol] (R-HSA-50847) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2(373-618) [cytosol] (R-HSA-202931) BIRC2(1-372) [cytosol] (R-HSA-202913) K63polyUb-BIRC2 [cytosol] (R-HSA-5668512)	0.801	8
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.781	7
UniProt:O15160 POLR1C	2	POLR1C [cytosol] (R-HSA-1964454) POLR1C [nucleoplasm] (R-HSA-63498)	0.718	6
UniProt:Q9NR28 DIABLO	2	DIABLO [cytosol] (R-HSA-114298) DIABLO [mitochondrial intermembrane space] (R-HSA-64637)	0.688	9
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.666	4
UniProt:O43189 PHF1	1	PHF1 [nucleoplasm] (R-HSA-5084105)	0.666	4
UniProt:O43464 HTRA2	1	HTRA2 [mitochondrial intermembrane space] (R-HSA-56655)	0.641	5
UniProt:P49638 TTPA	1	TTPA [cytosol] (R-HSA-2980979)	0.556	3
UniProt:O75604 USP2	2	USP2 [cytosol] (R-HSA-5212661) USP2 [nucleoplasm] (R-HSA-5689946)	0.556	3
UniProt:P47897 QARS1	2	QARS [cytosol] (R-HSA-379615) QARS [mitochondrial matrix] (R-HSA-379592)	0.556	3
UniProt:Q96HA8 NTAQ1			0.556	3
UniProt:P61968 LMO4			0.556	3
UniProt:P35711-4 SOX5			0.556	3
UniProt:Q6GPH4 XAF1	1	XAF1 [cytosol] (R-HSA-1015680)	0.556	3
UniProt:Q08117-2 TLE5			0.556	3
UniProt:O14787-2 TNPO2			0.556	3
UniProt:Q96N21 AP4AT			0.556	3
UniProt:Q3SY00 T10IP			0.556	3
UniProt:P61086 UBE2K	2	UBE2K [cytosol] (R-HSA-934631) Ub-C92-UBE2K [cytosol] (R-HSA-8864200)	0.556	3
UniProt:Q96JN0-2 LCOR			0.556	3
UniProt:Q63ZY3 KANK2			0.556	3
UniProt:A5D8V6 VPS37C	1	VPS37C [endosome membrane] (R-HSA-184438)	0.556	3
UniProt:A0A087WZT3 A0A087WZT3			0.556	5
UniProt:P20618 PSMB1	7	PSMB1 [cytosol] (R-HSA-68738) PSMB1 [nucleoplasm] (R-HSA-174347) pro-PSMB1 [cytosol] (R-HSA-9908139) PSMB1(1-28) [cytosol] (R-HSA-9908143) PSMB1 [secretory granule lumen] (R-HSA-6803287) PSMB1 [extracellular region] (R-HSA-6806477) PSMB1 [ficolin-1-rich granule lumen] (R-HSA-6803340)	0.556	5
UniProt:P0CG20 PRR35			0.556	3
UniProt:P52655 GTF2A1	2	GTF2A1(1-274) [nucleoplasm] (R-HSA-109767) GTF2A1(275-376) [nucleoplasm] (R-HSA-109768)	0.556	3
UniProt:Q9Y3E2 BOLA1			0.556	3
UniProt:Q9UQB9 AURKC			0.556	3
UniProt:Q9H5Z6 F124B			0.556	3
UniProt:P98170 XIAP	3	XIAP [cytosol] (R-HSA-50849) K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [nucleoplasm] (R-HSA-3322366)	0.527	3
UniProt:O95613 PCNT	8	PCNT [cytosol] (R-HSA-380290) PolyUb-Misfolded PCNT [late endosome lumen] (R-HSA-9660016) PCNT [cilium] (R-HSA-9639683) Misfolded PCNT [cilium] (R-HSA-9639705) Misfolded PCNT [cytosol] (R-HSA-9640102) Ub-Misfolded PCNT [cytosol] (R-HSA-9641122) PolyUb-Misfolded PCNT [cytosol] (R-HSA-9641112) PolyUb-Misfolded PCNT [lysosomal lumen] (R-HSA-9660027)	0.527	2
UniProt:P51798 CLCN7	1	CLCN7 [lysosomal membrane] (R-HSA-2671899)	0.527	3
UniProt:Q9BTZ2 DHRS4	3	DHRS4 [cytosol] (R-HSA-9033122) DHRS4 [peroxisomal matrix] (R-HSA-9033097) DHRS4 [endoplasmic reticulum membrane] (R-HSA-2980897)	0.527	2
UniProt:Q8IWR0 Z3H7A			0.527	2
UniProt:Q86WC4 OSTM1	1	OSTM1 [lysosomal membrane] (R-HSA-2730944)	0.527	2

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