BRCA2 [nucleoplasm]

Stable Identifier
R-HSA-50951
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Breast cancer type 2 susceptibility protein
Icon
BRCA2 [nucleoplasm] icon
BRCA2 [nucleoplasm] icon
Locations in the PathwayBrowser
Expand all
External Reference Information
External Reference
UniProt:P51587 BRCA2
Gene Names
BRCA2, FACD, FANCD1
Chain
chain:1-3418
Reference Genes
BioGPS Gene:675 BRCA2
COSMIC (genes):BRCA2 BRCA2
CTD Gene:675 BRCA2
dbSNP Gene:675 BRCA2
ENSEMBL:ENSG00000139618 BRCA2
HGNC:1101 BRCA2
KEGG:hsa:675 BRCA2
Monarch:675 BRCA2
NCBI Gene:675 BRCA2
OMIM:600185 BRCA2
UCSC:P51587 BRCA2
Reference Transcript
Other Identifiers
11740416_at
1503_at
16773840
1989_at
1990_g_at
208368_3p_s_at
208368_PM_s_at
208368_s_at
211390_PM_at
211390_at
214727_PM_at
214727_at
214886_PM_s_at
214886_s_at
214887_PM_at
214887_at
3484642
3484643
3484644
3484645
3484646
3484647
3484648
3484649
3484650
3484651
3484652
3484653
3484654
3484655
3484657
3484658
3484659
3484660
3484662
3484663
3484664
3484666
3484667
3484668
3484669
3484670
3484671
3484672
3484673
3484674
3484675
3484676
3484677
3484678
3484690
3484691
3484692
3484694
3484695
3484696
3484697
3484698
3484699
3484701
3484703
3484705
3484707
3484708
3484710
3484712
3484713
3484714
3484715
675
7968484
7968514
A_14_P100214
A_14_P109686
A_14_P122735
A_14_P131744
A_23_P88067
A_23_P99452
GE60169
GO:0000152
GO:0000722
GO:0000724
GO:0000781
GO:0000800
GO:0001556
GO:0001833
GO:0002020
GO:0003677
GO:0003697
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0006281
GO:0006289
GO:0006302
GO:0006310
GO:0006325
GO:0006338
GO:0006355
GO:0006974
GO:0006978
GO:0007141
GO:0007283
GO:0007420
GO:0008092
GO:0008283
GO:0008585
GO:0008630
GO:0010165
GO:0010225
GO:0010332
GO:0010484
GO:0010485
GO:0016740
GO:0022414
GO:0030097
GO:0030141
GO:0031297
GO:0031410
GO:0032200
GO:0032465
GO:0032991
GO:0033593
GO:0033600
GO:0042771
GO:0042802
GO:0043009
GO:0043015
GO:0043226
GO:0045893
GO:0045931
GO:0048856
GO:0051276
GO:0051298
GO:0070200
GO:0071425
GO:0071479
GO:0072089
GO:0090398
GO:0140013
GO:0140096
GO:1990391
GO:1990426
GO:2000001
HMNXSV003047584
Hs.22174.2.A1_3p_at
Hs.34012.1.S1_3p_at
ILMN_1677794
PH_hs_0002816
PH_hs_0009162
TC13000111.hg
X95152_rna1_at
g4502450_3p_a_at
g6642741_3p_at
g6642741_3p_s_at
Participates
as an input of
as a component of
as an output of
This entity regulates
Negatively
Other forms of this molecule
BRCA2 D2983Ffs*34 [cytosol]
BRCA2 K2555* [cytosol]
BRCA2 N2553Tfs*95 [cytosol]
BRCA2 T2685Hfs*9 [cytosol]
BRCA2 K2674Rfs*2 [cytosol]
BRCA2 S3231* [cytosol]
BRCA2 I2675Dfs*6 [cytosol]
BRCA2 R2625* [cytosol]
BRCA2 E3071* [cytosol]
BRCA2 V2716Wfs*17 [cytosol]
BRCA2 W2586* [cytosol]
BRCA2 P2767Lfs*10 [cytosol]
BRCA2 K3032* [cytosol]
BRCA2 S2835* [cytosol]
BRCA2 Y3006* [cytosol]
BRCA2 L2926* [cytosol]
BRCA2 R3128* [cytosol]
BRCA2 E2599* [cytosol]
BRCA2 E2571* [cytosol]
BRCA2 Y2977* [cytosol]
BRCA2 E2959* [cytosol]
BRCA2 C3198Yfs*23 [cytosol]
BRCA2 Q2823* [cytosol]
BRCA2 V2969Cfs*7 [cytosol]
BRCA2 T3033Lfs*29 [cytosol]
BRCA2 Q3026* [cytosol]
BRCA2 G2837* [cytosol]
BRCA2 K3263Rfs*12 [cytosol]
BRCA2 L3172Afs*44 [cytosol]
BRCA2 K2570* [cytosol]
BRCA2 E2981Rfs*37 [cytosol]
BRCA2 E2863* [cytosol]
BRCA2 T2517Hfs*22 [cytosol]
BRCA2 R2502Lfs*24 [cytosol]
BRCA2 E3053* [cytosol]
BRCA2 R2645Nfs*3 [cytosol]
BRCA2 E2872* [cytosol]
BRCA2 R3237Gfs*12 [cytosol]
BRCA2 E2956* [cytosol]
BRCA2 S3144Ffs*6 [cytosol]
BRCA2 Y2884* [cytosol]
BRCA2 P2608Qfs*40 [cytosol]
BRCA2 E2476* [cytosol]
BRCA2 G2760Pfs*13 [cytosol]
BRCA2 K3015* [cytosol]
BRCA2 E3111* [cytosol]
BRCA2 L2696* [cytosol]
BRCA2 N3164Ifs*53 [cytosol]
BRCA2 S2994* [cytosol]
BRCA2 T3085Nfs*26 [cytosol]
BRCA2 E3256Rfs*19 [cytosol]
BRCA2 C3069Lfs*5 [cytosol]
BRCA2 E2906* [cytosol]
BRCA2 T3085Qfs*19 [cytosol]
BRCA2 S2697Kfs*31 [cytosol]
BRCA2 G2593* [cytosol]
BRCA2 E2981Kfs*7 [cytosol]
BRCA2 Q3036* [cytosol]
BRCA2 Q3066* [cytosol]
BRCA2 T3033Nfs*11 [cytosol]
BRCA2 Q2731* [cytosol]
BRCA2 L2745Qfs*31 [cytosol]
BRCA2 Y2997* [cytosol]
BRCA2 S3245* [cytosol]
BRCA2 Q2870* [cytosol]
BRCA2 E2474* [cytosol]
BRCA2 E2847* [cytosol]
BRCA2 T2766Nfs*11 [cytosol]
BRCA2 T2515Nfs*24 [cytosol]
BRCA2 F3159Ifs*9 [cytosol]
BRCA2 S2978* [cytosol]
BRCA2 Q2749* [cytosol]
BRCA2 R2520* [cytosol]
BRCA2 R2787Lfs*35 [cytosol]
BRCA2 N2556Mfs*92 [cytosol]
BRCA2 W2970* [cytosol]
BRCA2 S2695* [cytosol]
BRCA2 P3089Lfs*15 [cytosol]
BRCA2 D2723H [cytosol]
BRCA2 R2659T [cytosol]
BRCA2 T2722R [cytosol]
BRCA2 G2748D [cytosol]
BRCA2 I2627F [cytosol]
BRCA2 D2723G [cytosol]
BRCA2 E2663V [cytosol]
BRCA2 W2626C [cytosol]
BRCA2 L2362Cfs*5 [cytosol]
BRCA2 Y1762* [cytosol]
BRCA2 N1055Ifs*5 [cytosol]
BRCA2 R2318* [cytosol]
BRCA2 E294* [cytosol]
BRCA2 D1199Vfs*9 [cytosol]
BRCA2 E1493* [cytosol]
BRCA2 Q1175* [cytosol]
BRCA2 L771Ifs*2 [cytosol]
BRCA2 V464Gfs*3 [cytosol]
BRCA2 Q754* [cytosol]
BRCA2 K1082* [cytosol]
BRCA2 S744* [cytosol]
BRCA2 P190Gfs*3 [cytosol]
BRCA2 L2092Pfs*7 [cytosol]
BRCA2 Q1452* [cytosol]
BRCA2 Q1063* [cytosol]
BRCA2 Q1124* [cytosol]
BRCA2 E1276* [cytosol]
BRCA2 N1784Hfs*2 [cytosol]
BRCA2 E510* [cytosol]
BRCA2 M1890Tfs*15 [cytosol]
BRCA2 Q2159* [cytosol]
BRCA2 L1965Ffs*39 [cytosol]
BRCA2 E2198Nfs*4 [cytosol]
BRCA2 E532Rfs*3 [cytosol]
BRCA2 E654* [cytosol]
BRCA2 N812Ifs*13 [cytosol]
BRCA2 E1717* [cytosol]
BRCA2 E826* [cytosol]
BRCA2 E808* [cytosol]
BRCA2 S1442* [cytosol]
BRCA2 S611* [cytosol]
BRCA2 R67Gfs*13 [cytosol]
BRCA2 I1364Mfs*3 [cytosol]
BRCA2 T1359Yfs*2 [cytosol]
BRCA2 S2148Yfs*2 [cytosol]
BRCA2 Q1429* [cytosol]
BRCA2 E1353Vfs*5 [cytosol]
BRCA2 N460Kfs*6 [cytosol]
BRCA2 L105* [cytosol]
BRCA2 S1230Lfs*9 [cytosol]
BRCA2 K601Rfs*14 [cytosol]
BRCA2 N863Kfs*18 [cytosol]
BRCA2 A938Efs*22 [cytosol]
BRCA2 E1120* [cytosol]
BRCA2 G1006* [cytosol]
BRCA2 L2362* [cytosol]
BRCA2 E1581* [cytosol]
BRCA2 S1064* [cytosol]
BRCA2 L1908Rfs*2 [cytosol]
BRCA2 S2372* [cytosol]
BRCA2 H543Tfs*17 [cytosol]
BRCA2 E1646* [cytosol]
BRCA2 D946Rfs*13 [cytosol]
BRCA2 S353* [cytosol]
BRCA2 N255Kfs*21 [cytosol]
BRCA2 S313Lfs*11 [cytosol]
BRCA2 I2194Lfs*12 [cytosol]
BRCA2 Q373* [cytosol]
BRCA2 D1796Mfs*9 [cytosol]
BRCA2 S1720* [cytosol]
BRCA2 I1962Mfs*42 [cytosol]
BRCA2 N1833Ifs*7 [cytosol]
BRCA2 F1182* [cytosol]
BRCA2 I1258* [cytosol]
BRCA2 T582Kfs*3 [cytosol]
BRCA2 M2393* [cytosol]
BRCA2 V1862* [cytosol]
BRCA2 F2058Lfs*12 [cytosol]
BRCA2 S450* [cytosol]
BRCA2 E475* [cytosol]
BRCA2 T515Ifs*10 [cytosol]
BRCA2 P655Qfs*5 [cytosol]
BRCA2 Q499* [cytosol]
BRCA2 L2375* [cytosol]
BRCA2 E1441* [cytosol]
BRCA2 E2028* [cytosol]
BRCA2 K230* [cytosol]
BRCA2 C711* [cytosol]
BRCA2 V1214Wfs*14 [cytosol]
BRCA2 K1860* [cytosol]
BRCA2 K1453* [cytosol]
BRCA2 E1593* [cytosol]
BRCA2 D1451Ifs*12 [cytosol]
BRCA2 L1208* [cytosol]
BRCA2 S1968* [cytosol]
BRCA2 E1518* [cytosol]
BRCA2 T2722I [cytosol]
BRCA2 L2357Vfs*2 [cytosol]
BRCA2 S1882* [cytosol]
BRCA2 I594Yfs*20 [cytosol]
BRCA2 E1514* [cytosol]
BRCA2 Q407Rfs*23 [cytosol]
BRCA2 L769Hfs*21 [cytosol]
BRCA2 H1362Tfs*12 [cytosol]
BRCA2 E2663Q [cytosol]
BRCA2 E718Kfs*12 [cytosol]
BRCA2 W31* [cytosol]
BRCA2 N2452Mfs*15 [cytosol]
BRCA2 W2626L [cytosol]
BRCA2 Q73* [cytosol]
BRCA2 K1823Nfs*6 [cytosol]
BRCA2 N1066Lfs*10 [cytosol]
BRCA2 G2281* [cytosol]
BRCA2 L834Ffs*7 [cytosol]
BRCA2 E1113* [cytosol]
BRCA2 K1517Ifs*23 [cytosol]
BRCA2 L759Ffs*3 [cytosol]
BRCA2 S309Ffs*6 [cytosol]
BRCA2 N2135Kfs*3 [cytosol]
BRCA2 Q1658* [cytosol]
BRCA2 P704Qfs*26 [cytosol]
BRCA2 D420Tfs*10 [cytosol]
BRCA2 K2392* [cytosol]
BRCA2 K178* [cytosol]
BRCA2 G2078Ifs*2 [cytosol]
BRCA2 D1054Efs*9 [cytosol]
BRCA2 C1365Mfs*3 [cytosol]
BRCA2 E1812* [cytosol]
BRCA2 L1491Kfs*12 [cytosol]
BRCA2 Q2354* [cytosol]
BRCA2 M524Dfs*2 [cytosol]
BRCA2 C1853Vfs*10 [cytosol]
BRCA2 R329Gfs*20 [cytosol]
BRCA2 S871* [cytosol]
BRCA2 L2253Ffs*7 [cytosol]
BRCA2 G1122* [cytosol]
BRCA2 N1287Ifs*6 [cytosol]
BRCA2 M794Cfs*16 [cytosol]
BRCA2 E816Kfs*9 [cytosol]
BRCA2 Y1894* [cytosol]
BRCA2 V1532Sfs*2 [cytosol]
BRCA2 E2129* [cytosol]
BRCA2 T933Rfs*2 [cytosol]
BRCA2 E470Kfs*15 [cytosol]
BRCA2 K1026Ifs*10 [cytosol]
BRCA2 Q2157Ifs*18 [cytosol]
BRCA2 E897* [cytosol]
BRCA2 S871Qfs*3 [cytosol]
BRCA2 K485Sfs*24 [cytosol]
BRCA2 L638* [cytosol]
BRCA2 H1918Cfs*20 [cytosol]
BRCA2 K1515* [cytosol]
BRCA2 C419Wfs*11 [cytosol]
BRCA2 I1859Kfs*3 [cytosol]
BRCA2 S1630* [cytosol]
BRCA2 V1532Lfs*11 [cytosol]
BRCA2 S1271* [cytosol]
BRCA2 L2428* [cytosol]
BRCA2 K585Nfs*3 [cytosol]
BRCA2 E1688* [cytosol]
BRCA2 R645Efs*15 [cytosol]
BRCA2 G2044Afs*7 [cytosol]
BRCA2 K944* [cytosol]
BRCA2 G995* [cytosol]
BRCA2 E731Gfs*19 [cytosol]
BRCA2 G561* [cytosol]
BRCA2 A938Pfs*21 [cytosol]
BRCA2 L1740* [cytosol]
BRCA2 L1390Ffs*13 [cytosol]
BRCA2 T1040Lfs*3 [cytosol]
BRCA2 D1990Cfs*12 [cytosol]
BRCA2 V1804Kfs*2 [cytosol]
BRCA2 L553* [cytosol]
BRCA2 V726Sfs*25 [cytosol]
BRCA2 S2095* [cytosol]
BRCA2 E866* [cytosol]
BRCA2 V1532Efs*12 [cytosol]
BRCA2 M1300* [cytosol]
BRCA2 V323* [cytosol]
BRCA2 Y839Ifs*42 [cytosol]
BRCA2 K2075* [cytosol]
BRCA2 S1650Vfs*20 [cytosol]
BRCA2 C1200* [cytosol]
BRCA2 E305Gfs*2 [cytosol]
BRCA2 L1776* [cytosol]
BRCA2 E2236Kfs*5 [cytosol]
BRCA2 L557* [cytosol]
BRCA2 F1005Lfs*38 [cytosol]
BRCA2 S2052* [cytosol]
BRCA2 A483Gfs*31 [cytosol]
BRCA2 G934* [cytosol]
BRCA2 M965* [cytosol]
BRCA2 L659* [cytosol]
BRCA2 D885Afs*10 [cytosol]
BRCA2 E880* [cytosol]
BRCA2 N1066Ifs*11 [cytosol]
BRCA2 N1784Kfs*3 [cytosol]
BRCA2 T2125Nfs*4 [cytosol]
BRCA2 Y949Lfs*10 [cytosol]
BRCA2 Q1089Sfs*10 [cytosol]
BRCA2 F1978Lfs*26 [cytosol]
BRCA2 N986Kfs*2 [cytosol]
BRCA2 V1144Cfs*6 [cytosol]
BRCA2 I27Mfs*6 [cytosol]
BRCA2 E305* [cytosol]
BRCA2 T926Pfs*34 [cytosol]
BRCA2 Q609* [cytosol]
BRCA2 D806Mfs*4 [cytosol]
BRCA2 R2401* [cytosol]
BRCA2 Q1562* [cytosol]
BRCA2 Y1714* [cytosol]
BRCA2 Q1987* [cytosol]
BRCA2 S648* [cytosol]
BRCA2 W1692Mfs*3 [cytosol]
BRCA2 K1649* [cytosol]
BRCA2 G1122Efs*28 [cytosol]
BRCA2 E1555* [cytosol]
BRCA2 E2226Sfs*6 [cytosol]
BRCA2 Q2024* [cytosol]
BRCA2 T1154Pfs*14 [cytosol]
BRCA2 I332Ffs*17 [cytosol]
BRCA2 D1868Vfs*5 [cytosol]
BRCA2 G904* [cytosol]
BRCA2 V1283Kfs*2 [cytosol]
BRCA2 L1952* [cytosol]
BRCA2 K437Ifs*22 [cytosol]
BRCA2 S1013* [cytosol]
BRCA2 V1045Dfs*5 [cytosol]
BRCA2 Q1551* [cytosol]
BRCA2 N1784Tfs*7 [cytosol]
BRCA2 F2254Lfs*26 [cytosol]
BRCA2 K1691Nfs*15 [cytosol]
BRCA2 E865* [cytosol]
BRCA2 N986Ifs*5 [cytosol]
BRCA2 K1406Nfs*3 [cytosol]
BRCA2 Y803* [cytosol]
BRCA2 E409* [cytosol]
BRCA2 E187* [cytosol]
BRCA2 Q1998* [cytosol]
BRCA2 L1545Rfs*3 [cytosol]
BRCA2 G4* [cytosol]
BRCA2 I605Nfs*11 [cytosol]
BRCA2 S1385* [cytosol]
BRCA2 E97* [cytosol]
BRCA2 S1099* [cytosol]
BRCA2 I605Yfs*9 [cytosol]
BRCA2 S1982Rfs*22 [cytosol]
BRCA2 F1421Kfs*4 [cytosol]
BRCA2 N1544Tfs*24 [cytosol]
BRCA2 Q893* [cytosol]
BRCA2 K1872* [cytosol]
BRCA2 K467* [cytosol]
BRCA2 S1720Ffs*7 [cytosol]
BRCA2 H763Lfs*2 [cytosol]
BRCA2 C2422* [cytosol]
p-T3387-BRCA2 [nucleoplasm]
BRCA2 [cytosol]
BRCA2 G1529E [nucleoplasm]
BRCA2 S3291A [nucleoplasm]
BRCA2 G1529R [nucleoplasm]
BRCA2 G25V [nucleoplasm]
BRCA2 W31R [nucleoplasm]
BRCA2 W31C [nucleoplasm]
BRCA2 G25R [nucleoplasm]
BRCA2 G106* [cytosol]
BRCA2 E1285* [cytosol]
BRCA2 G405* [cytosol]
BRCA2 D885Mfs*9 [cytosol]
BRCA2 E1119Rfs*7 [cytosol]
BRCA2 F62Lfs*18 [cytosol]
BRCA2 K604* [cytosol]
BRCA2 L929Ffs*8 [cytosol]
BRCA2 S76* [cytosol]
BRCA2 N1287Kfs*2 [cytosol]
BRCA2 N863Ifs*11 [cytosol]
BRCA2 K2404Sfs*7 [cytosol]
BRCA2 T302Nfs*3 [cytosol]
BRCA2 D252Vfs*24 [cytosol]
Inferred To
BRCA2 [nucleoplasm] (Bos taurus)
BRCA2 [nucleoplasm] (Gallus gallus)
BRCA2 [nucleoplasm] (Sus scrofa)
Brca2 [nucleoplasm] (Mus musculus)
Brca2 [nucleoplasm] (Rattus norvegicus)
Cross References
RefSeq
OpenTargets
ENSEMBL
GeneCards
HPA
PRO
Pharos - Targets
GlyGen
Orphanet
PDB
Interactors (29)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q06609 RAD51  2 0.982 46
 UniProt:Q86YC2 PALB2  20 0.972 30
 UniProt:P60896 SEM1  2 0.83 10
 UniProt:Q14565 DMC1  1 0.765 12
 UniProt:Q06609-1 RAD51      0.743 12
 UniProt:P38398 BRCA1  20 0.727 8
 UniProt:Q9BXW9 FANCD2  3 0.688 16
 UniProt:Q9Y253 POLH  2 0.676 6
 UniProt:P04637 TP53  20 0.655 7
 UniProt:Q9UJY1 HSPB8  1 0.643 3
 UniProt:Q9NTI5 PDS5B  4 0.641 26
 UniProt:Q9P0W2 HMG20B  1 0.576 8
 UniProt:P51587 BRCA2  20 0.573 3
 UniProt:Q9GZQ8 MAP1LC3B  3 0.558 2
 UniProt:O43502 RAD51C  1 0.532 5
 UniProt:Q9H410 DSN1  3 0.527 3
 UniProt:Q86XE0 SNX32      0.527 2
 UniProt:Q8NA69 SAXO5      0.527 2
 UniProt:Q9NS26 SPNXA      0.527 2
 UniProt:Q15014 MORF4L2  1 0.527 2
 UniProt:Q9NXX6 NSMCE4A  1 0.527 2
 UniProt:Q969H4 CNKSR1  1 0.527 2
 UniProt:Q5SZD1 CF141      0.527 2
 UniProt:P58340 MLF1      0.527 2
 UniProt:O43542 XRCC3  1 0.527 2
 UniProt:O95429 BAG4  3 0.527 2
 UniProt:Q8IZU3 SYCP3  1 0.463 2
 UniProt:P15927 RPA2  2 0.462 3
 UniProt:P27694 RPA1  2 0.462 3
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