Reactome | BRCA2 [nucleoplasm]

BRCA2 [nucleoplasm]

Stable Identifier

R-HSA-50951

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Breast cancer type 2 susceptibility protein

Locations in the PathwayBrowser

Expand all

DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - Homology Directed Repair (Homo sapiens)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
      - HDR through Homologous Recombination (HRR) (Homo sapiens)
        
        Homologous DNA Pairing and Strand Exchange (Homo sapiens)
        
        Presynaptic phase of homologous DNA pairing and strand exchange (Homo sapiens)
        
        CHEK1 phosphorylates BRCA2 (Homo sapiens)
        
        BRCA2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P51587 BRCA2

Gene Names

BRCA2, FACD, FANCD1

Chain

chain:1-3418

Reference Genes

BioGPS Gene:675 BRCA2

COSMIC (genes):BRCA2 BRCA2

CTD Gene:675 BRCA2

dbSNP Gene:675 BRCA2

ENSEMBL:ENSG00000139618 BRCA2

HGNC:1101 BRCA2

KEGG Gene (Homo sapiens):675 BRCA2

Monarch:675 BRCA2

NCBI Gene:675 BRCA2

OMIM:600185 BRCA2

UCSC:P51587 BRCA2

Reference Transcript

RefSeq:NM_000059.3 BRCA2

Other Identifiers

0005670053

11740416_at

1503_at

16773840

1989_at

1990_g_at

208368_3p_s_at

208368_s_at

214727_at

3484642

3484643

3484645

3484646

3484647

3484648

3484649

3484650

3484651

3484652

3484653

3484654

3484655

3484657

3484658

3484659

3484660

3484662

3484663

3484664

3484666

3484667

3484668

3484669

3484670

3484671

3484672

3484673

3484674

3484675

3484676

3484677

3484678

3484690

3484692

3484694

3484695

3484696

3484697

3484698

3484699

3484701

3484703

675

7968484

A_14_P109686

A_23_P99452

GE60169

GO:0000003

GO:0000228

GO:0000278

GO:0000722

GO:0000724

GO:0000784

GO:0000800

GO:0001556

GO:0001833

GO:0002020

GO:0002376

GO:0003674

GO:0003677

GO:0003697

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0006259

GO:0006281

GO:0006289

GO:0006302

GO:0006310

GO:0006355

GO:0006464

GO:0006950

GO:0006974

GO:0006978

GO:0007010

GO:0007049

GO:0007141

GO:0007165

GO:0007283

GO:0007420

GO:0007568

GO:0007569

GO:0008022

GO:0008092

GO:0008150

GO:0008219

GO:0008283

GO:0008585

GO:0008630

GO:0009058

GO:0009790

GO:0010165

GO:0010225

GO:0010332

GO:0010484

GO:0010485

GO:0016746

GO:0019899

GO:0021700

GO:0030097

GO:0030141

GO:0030154

GO:0031410

GO:0032465

GO:0032991

GO:0033593

GO:0033600

GO:0034641

GO:0040007

GO:0042592

GO:0042771

GO:0042802

GO:0043009

GO:0043015

GO:0043226

GO:0043966

GO:0043967

GO:0045893

GO:0045931

GO:0048478

GO:0048856

GO:0051276

GO:0051298

GO:0051301

GO:0070200

GO:1990426

Hs.34012.1.S1_3p_at

ILMN_1677794

PH_hs_0002816

PH_hs_0009162

TC13000111.hg

X95152_rna1_at

g4502450_3p_a_at

Participant Of

input

hasComponent

output

Resolution of meiotic holliday junction

Other forms of this molecule

p-T3387-BRCA2 [nucleoplasm]

Inferred To

BRCA2 [nucleoplasm] (Bos taurus)

BRCA2 [nucleoplasm] (Canis familiaris)

BRCA2 [nucleoplasm] (Dictyostelium discoideum)

BRCA2 [nucleoplasm] (Gallus gallus)

BRCA2 [nucleoplasm] (Sus scrofa)

BRCA2 [nucleoplasm] (Xenopus tropicalis)

brca2 [nucleoplasm] (Danio rerio)

Brca2 [nucleoplasm] (Mus musculus)

Brca2 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_000050.2

OpenTargets

ENSG00000139618

HPA

ENSG00000139618-BRCA2

GeneCards

P51587

Ensembl

ENSP00000369497, ENST00000380152, ENSP00000439902, ENSG00000139618, ENST00000544455

PRO

P51587

Orphanet

15378

PDB

3EU7, 6HQU, 1N0W, 6GY2

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q06609 RAD51	2	p-T309-RAD51 [nucleoplasm] (R-HSA-5685231) RAD51 [nucleoplasm] (R-HSA-62637)	0.982	45
UniProt:Q86YC2 PALB2	1	PALB2 [nucleoplasm] (R-HSA-419548)	0.969	25
UniProt:P60896 SEM1	2	SHFM1 [nucleoplasm] (R-HSA-8866665) SHFM1 [cytosol] (R-HSA-8866674)	0.835	10
UniProt:Q14565 DMC1	1	DMC1 [nucleoplasm] (R-HSA-912490)	0.765	12
UniProt:Q06609-1 RAD51			0.743	12
UniProt:P38398 BRCA1	5	SUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) SUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-5683800) BRCA1 [nucleoplasm] (R-HSA-50949) p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-75234)	0.737	8
UniProt:Q9BXW9 FANCD2	3	p-T691,S717-FANCD2 [nucleoplasm] (R-HSA-6788481) MonoUb-K561,p-T691,S717-FANCD2 [nucleoplasm] (R-HSA-6785318) FANCD2 [nucleoplasm] (R-HSA-419522)	0.688	16
UniProt:Q9Y253 POLH	2	POLH [nucleoplasm] (R-HSA-110287) MonoUb-K682,K686,K694,K709-POLH [nucleoplasm] (R-HSA-5655163)	0.676	6
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.655	7
UniProt:Q9NTI5 PDS5B	4	PDS5B [chromosome, centromeric region] (R-HSA-2468263) PDS5B [cytosol] (R-HSA-2484800) PDS5B [chromosome] (R-HSA-2466361) PDS5B [nucleoplasm] (R-HSA-2468051)	0.641	26
UniProt:Q9P0W2 HMG20B	1	HMG20B [nucleoplasm] (R-HSA-996745)	0.576	8
UniProt:P51587 BRCA2	2	BRCA2 [nucleoplasm] (R-HSA-50951) p-T3387-BRCA2 [nucleoplasm] (R-HSA-5685241)	0.573	3
UniProt:O43502 RAD51C	1	RAD51C [nucleoplasm] (R-HSA-217039)	0.532	5
UniProt:O43542 XRCC3	1	XRCC3 [nucleoplasm] (R-HSA-5685303)	0.527	2
UniProt:Q8IZU3 SYCP3	1	SYCP3 [nucleoplasm] (R-HSA-912329)	0.463	2
UniProt:P27694 RPA1	2	RPA1 [nucleoplasm] (R-HSA-68461) SUMO2,3-K449,K577-RPA1 [nucleoplasm] (R-HSA-4551644)	0.462	3
UniProt:P15927 RPA2	2	p-S33-RPA2 [nucleoplasm] (R-HSA-5685148) RPA2 [nucleoplasm] (R-HSA-68457)	0.462	3

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