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BRCA2 [nucleoplasm]
Stable Identifier
R-HSA-50951
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Breast cancer type 2 susceptibility protein
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Meiosis (Homo sapiens)
Meiotic recombination (Homo sapiens)
Formation of meiotic heteroduplex (Homo sapiens)
Meiotic D-loop complex [nucleoplasm] (Homo sapiens)
BRCA2 [nucleoplasm] (Homo sapiens)
Meiotic single-stranded DNA complex [nucleoplasm] (Homo sapiens)
BRCA2 [nucleoplasm] (Homo sapiens)
Formation of meiotic holliday junction (Homo sapiens)
Meiotic D-loop complex [nucleoplasm] (Homo sapiens)
BRCA2 [nucleoplasm] (Homo sapiens)
Meiotic Holliday Junction [nucleoplasm] (Homo sapiens)
BRCA2 [nucleoplasm] (Homo sapiens)
Formation of meiotic single-stranded DNA invasion complex (Homo sapiens)
BRCA2 [nucleoplasm] (Homo sapiens)
Meiotic single-stranded DNA complex [nucleoplasm] (Homo sapiens)
BRCA2 [nucleoplasm] (Homo sapiens)
Resolution of meiotic holliday junction (Homo sapiens)
BRCA2 [nucleoplasm] (Homo sapiens)
Meiotic Holliday Junction [nucleoplasm] (Homo sapiens)
BRCA2 [nucleoplasm] (Homo sapiens)
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
Homology Directed Repair (Homo sapiens)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Homo sapiens)
HDR through Homologous Recombination (HRR) (Homo sapiens)
Homologous DNA Pairing and Strand Exchange (Homo sapiens)
Presynaptic phase of homologous DNA pairing and strand exchange (Homo sapiens)
CHEK1 phosphorylates BRCA2 (Homo sapiens)
BRCA2 [nucleoplasm] (Homo sapiens)
Reproduction (Homo sapiens)
Meiosis (Homo sapiens)
Meiotic recombination (Homo sapiens)
Formation of meiotic heteroduplex (Homo sapiens)
Meiotic D-loop complex [nucleoplasm] (Homo sapiens)
BRCA2 [nucleoplasm] (Homo sapiens)
Meiotic single-stranded DNA complex [nucleoplasm] (Homo sapiens)
BRCA2 [nucleoplasm] (Homo sapiens)
Formation of meiotic holliday junction (Homo sapiens)
Meiotic D-loop complex [nucleoplasm] (Homo sapiens)
BRCA2 [nucleoplasm] (Homo sapiens)
Meiotic Holliday Junction [nucleoplasm] (Homo sapiens)
BRCA2 [nucleoplasm] (Homo sapiens)
Formation of meiotic single-stranded DNA invasion complex (Homo sapiens)
BRCA2 [nucleoplasm] (Homo sapiens)
Meiotic single-stranded DNA complex [nucleoplasm] (Homo sapiens)
BRCA2 [nucleoplasm] (Homo sapiens)
Resolution of meiotic holliday junction (Homo sapiens)
BRCA2 [nucleoplasm] (Homo sapiens)
Meiotic Holliday Junction [nucleoplasm] (Homo sapiens)
BRCA2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P51587 BRCA2
Gene Names
BRCA2, FACD, FANCD1
Chain
chain:1-3418
Reference Genes
BioGPS Gene:675 BRCA2
COSMIC (genes):BRCA2 BRCA2
CTD Gene:675 BRCA2
dbSNP Gene:675 BRCA2
ENSEMBL:ENSG00000139618 BRCA2
HGNC:1101 BRCA2
KEGG Gene (Homo sapiens):675 BRCA2
Monarch:675 BRCA2
NCBI Gene:675 BRCA2
OMIM:600185 BRCA2
UCSC:P51587 BRCA2
Reference Transcript
RefSeq:NM_000059.3 BRCA2
Other Identifiers
0005670053
11740416_at
1503_at
16773840
1989_at
1990_g_at
208368_3p_s_at
208368_s_at
214727_at
3484642
3484643
3484645
3484646
3484647
3484648
3484649
3484650
3484651
3484652
3484653
3484654
3484655
3484657
3484658
3484659
3484660
3484662
3484663
3484664
3484666
3484667
3484668
3484669
3484670
3484671
3484672
3484673
3484674
3484675
3484676
3484677
3484678
3484690
3484692
3484694
3484695
3484696
3484697
3484698
3484699
3484701
3484703
675
7968484
A_14_P109686
A_23_P99452
GE60169
GO:0000003
GO:0000228
GO:0000278
GO:0000722
GO:0000724
GO:0000784
GO:0000800
GO:0001556
GO:0001833
GO:0002020
GO:0002376
GO:0003674
GO:0003677
GO:0003697
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0006259
GO:0006281
GO:0006289
GO:0006302
GO:0006310
GO:0006355
GO:0006464
GO:0006950
GO:0006974
GO:0006978
GO:0007010
GO:0007049
GO:0007141
GO:0007165
GO:0007283
GO:0007420
GO:0007568
GO:0007569
GO:0008022
GO:0008092
GO:0008150
GO:0008219
GO:0008283
GO:0008585
GO:0008630
GO:0009058
GO:0009790
GO:0010165
GO:0010225
GO:0010332
GO:0010484
GO:0010485
GO:0016746
GO:0019899
GO:0021700
GO:0030097
GO:0030141
GO:0030154
GO:0031410
GO:0032465
GO:0032991
GO:0033593
GO:0033600
GO:0034641
GO:0040007
GO:0042592
GO:0042771
GO:0042802
GO:0043009
GO:0043015
GO:0043226
GO:0043966
GO:0043967
GO:0045893
GO:0045931
GO:0048478
GO:0048856
GO:0051276
GO:0051298
GO:0051301
GO:0070200
GO:1990426
Hs.34012.1.S1_3p_at
ILMN_1677794
PH_hs_0002816
PH_hs_0009162
TC13000111.hg
X95152_rna1_at
g4502450_3p_a_at
Participant Of
input
CHEK1 phosphorylates BRCA2
Formation of meiotic single-stranded DNA invasion complex
hasComponent
Meiotic D-loop complex [nucleoplasm]
Meiotic Holliday Junction [nucleoplasm]
Meiotic single-stranded DNA complex [nucleoplasm]
output
Resolution of meiotic holliday junction
Other forms of this molecule
p-T3387-BRCA2 [nucleoplasm]
Inferred To
BRCA2 [nucleoplasm] (Canis familiaris)
BRCA2 [nucleoplasm] (Dictyostelium discoideum)
BRCA2 [nucleoplasm] (Gallus gallus)
BRCA2 [nucleoplasm] (Sus scrofa)
BRCA2 [nucleoplasm] (Xenopus tropicalis)
brca2 [nucleoplasm] (Danio rerio)
Brca2 [nucleoplasm] (Mus musculus)
Brca2 [nucleoplasm] (Rattus norvegicus)
Cross References
RefSeq
NP_000050.2
OpenTargets
ENSG00000139618
HPA
ENSG00000139618-BRCA2
GeneCards
P51587
Ensembl
ENST00000544455
,
ENSP00000439902
,
ENSG00000139618
,
ENST00000380152
,
ENSP00000369497
PRO
P51587
Orphanet
15378
PDB
6HQU
,
3EU7
,
1N0W
,
6GY2
Interactors (17)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q06609 RAD51
2
p-T309-RAD51 [nucleoplasm]
(R-HSA-5685231)
RAD51 [nucleoplasm]
(R-HSA-62637)
0.982
46
UniProt:Q86YC2 PALB2
1
PALB2 [nucleoplasm]
(R-HSA-419548)
0.969
25
UniProt:P60896 SEM1
2
SHFM1 [cytosol]
(R-HSA-8866674)
SHFM1 [nucleoplasm]
(R-HSA-8866665)
0.835
10
UniProt:Q14565 DMC1
1
DMC1 [nucleoplasm]
(R-HSA-912490)
0.765
12
UniProt:Q06609-1 RAD51
0.743
12
UniProt:P38398 BRCA1
27
SUMO1-K109-BRCA1 [nucleoplasm]
(R-HSA-2997644)
SUMO2,3-BRCA1 [nucleoplasm]
(R-HSA-2997624)
BRCA1 C64R [nucleoplasm]
(R-HSA-9700907)
BRCA1 C61G [nucleoplasm]
(R-HSA-9700890)
BRCA1 C39Y [nucleoplasm]
(R-HSA-9700938)
BRCA1 H41R [nucleoplasm]
(R-HSA-9700921)
BRCA1 C24R [nucleoplasm]
(R-HSA-9663198)
BRCA1 H41A [nucleoplasm]
(R-HSA-9700927)
BRCA1 M18T [nucleoplasm]
(R-HSA-9700911)
BRCA1 C47G [nucleoplasm]
(R-HSA-9700941)
BRCA1 C64G [nucleoplasm]
(R-HSA-9700899)
BRCA1 C44F [nucleoplasm]
(R-HSA-9700944)
BRCA1 T37R [nucleoplasm]
(R-HSA-9700934)
BRCA1 C27A [nucleoplasm]
(R-HSA-9700916)
BRCA1 H41Q [nucleoplasm]
(R-HSA-9700923)
BRCA1 Q12Tfs*5 [nucleoplasm]
(R-HSA-9700953)
BRCA1 E23Afs*18 [nucleoplasm]
(R-HSA-9700959)
BRCA1 C61Y [nucleoplasm]
(R-HSA-9700894)
BRCA1 C24F [nucleoplasm]
(R-HSA-9663206)
BRCA1 E23Rfs*18 [nucleoplasm]
(R-HSA-9700960)
BRCA1 E23Vfs*17 [nucleoplasm]
(R-HSA-9700967)
p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm]
(R-HSA-5683800)
K6PolyUb,p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm]
(R-HSA-9707298)
BRCA1 [nucleoplasm]
(R-HSA-50949)
K6PolyUb-BRCA1 [nucleoplasm]
(R-HSA-9701022)
K6PolyUb,p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm]
(R-HSA-9707290)
p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm]
(R-HSA-75234)
0.737
8
UniProt:Q9BXW9 FANCD2
3
p-T691,S717-FANCD2 [nucleoplasm]
(R-HSA-6788481)
FANCD2 [nucleoplasm]
(R-HSA-419522)
MonoUb-K561,p-T691,S717-FANCD2 [nucleoplasm]
(R-HSA-6785318)
0.688
16
UniProt:Q9Y253 POLH
2
POLH [nucleoplasm]
(R-HSA-110287)
MonoUb-K682,K686,K694,K709-POLH [nucleoplasm]
(R-HSA-5655163)
0.676
6
UniProt:P04637 TP53
27
TP53 [cytosol]
(R-HSA-8869337)
Unfolded TP53 [cytosol]
(R-HSA-6813797)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
SUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
Me2K-370,382-TP53 [nucleoplasm]
(R-HSA-3222242)
p-S15,S33,S46-TP53 [nucleoplasm]
(R-HSA-6805268)
p-S15,S392-TP53 [nucleoplasm]
(R-HSA-3222015)
p-T55-TP53 [nucleoplasm]
(R-HSA-6805400)
p-S15,S20,S392-TP53 [nucleoplasm]
(R-HSA-6805053)
p-S15,S20,S269,T284-TP53 [nucleoplasm]
(R-HSA-6805133)
p-S315-TP53 [nucleoplasm]
(R-HSA-6805106)
Ac-K120,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805656)
Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805631)
Ac-K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-5628868)
Me2-K373-TP53 [nucleoplasm]
(R-HSA-6805759)
MeK-370,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-3222226)
p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm]
(R-HSA-6804378)
Me-K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-3222124)
Me1-K372,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805719)
p-S15,S20,S46-TP53 [nucleoplasm]
(R-HSA-6798369)
p-S37-TP53 [nucleoplasm]
(R-HSA-3239022)
PolyUb,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6804446)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6793679)
PolyUb-TP53 [cytosol]
(R-HSA-6793681)
p-S15,S20-TP53 [nucleoplasm]
(R-HSA-69683)
p-S15-TP53 [nucleoplasm]
(R-HSA-69507)
TP53 [nucleoplasm]
(R-HSA-69488)
0.655
7
UniProt:Q9NTI5 PDS5B
4
PDS5B [chromosome, centromeric region]
(R-HSA-2468263)
PDS5B [cytosol]
(R-HSA-2484800)
PDS5B [chromosome]
(R-HSA-2466361)
PDS5B [nucleoplasm]
(R-HSA-2468051)
0.641
26
UniProt:Q9P0W2 HMG20B
1
HMG20B [nucleoplasm]
(R-HSA-996745)
0.576
8
UniProt:P51587 BRCA2
2
BRCA2 [nucleoplasm]
(R-HSA-50951)
p-T3387-BRCA2 [nucleoplasm]
(R-HSA-5685241)
0.573
3
UniProt:O43502 RAD51C
1
RAD51C [nucleoplasm]
(R-HSA-217039)
0.532
5
UniProt:O43542 XRCC3
1
XRCC3 [nucleoplasm]
(R-HSA-5685303)
0.527
2
UniProt:Q8IZU3 SYCP3
1
SYCP3 [nucleoplasm]
(R-HSA-912329)
0.463
2
UniProt:P27694 RPA1
2
RPA1 [nucleoplasm]
(R-HSA-68461)
SUMO2,3-K449,K577-RPA1 [nucleoplasm]
(R-HSA-4551644)
0.462
3
UniProt:P15927 RPA2
2
p-S33-RPA2 [nucleoplasm]
(R-HSA-5685148)
RPA2 [nucleoplasm]
(R-HSA-68457)
0.462
3
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