WNT5A binding to FZD promotes PRICKLE1 degradation

Stable Identifier
R-HSA-5099886
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Binding of WNT5A to FZD receptors triggers the phosphorylation of DVL2 in the constitutive DVL2:PARD6A complex and is required for the SMURF-mediated degradation of the core PCP protein PRICKLE1 (Narimatsu et al, 2009)

Literature References
PubMed ID Title Journal Year
19379695 Regulation of planar cell polarity by Smurf ubiquitin ligases

Narimatsu, M, Bose, R, Pye, M, Zhang, L, Miller, B, Ching, P, Sakuma, R, Luga, V, Roncari, L, Attisano, L, Wrana, JL

Cell 2009
Participants
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Orthologous Events
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Created