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PPP3R1 [cytosol]
Stable Identifier
R-HSA-51291
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Calcineurin B, alpha regulatory, Calcineurin B subunit isoform 1, Protein phosphatase 2B regulatory subunit 1, Protein phosphatase 3 regulatory subunit B alpha isoform 1
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Downstream signaling events of B Cell Receptor (BCR) (Homo sapiens)
Calcineurin activates NFAT (Homo sapiens)
Calcineurin binds NFATC1,2,3 (Homo sapiens)
Calcineurin (CaN) [cytosol] (Homo sapiens)
PPP3R1 [cytosol] (Homo sapiens)
Calcineurin:p-NFATC1,2,3 [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Homo sapiens)
PPP3R1 [cytosol] (Homo sapiens)
Calcineurin dephosphorylates NFATC1,2,3 (Homo sapiens)
Calcineurin:p-NFATC1,2,3 [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Homo sapiens)
PPP3R1 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
CLEC7A (Dectin-1) induces NFAT activation (Homo sapiens)
Activation of Calcineurin (Homo sapiens)
Calcineurin (CaN) [cytosol] (Homo sapiens)
PPP3R1 [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Homo sapiens)
PPP3R1 [cytosol] (Homo sapiens)
Calcineurin binds and dephosphorylates NFAT (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Homo sapiens)
PPP3R1 [cytosol] (Homo sapiens)
NFAT:CaN:CaM [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Homo sapiens)
PPP3R1 [cytosol] (Homo sapiens)
Translocation of CaN:CaM:NFAT to nucleus (Homo sapiens)
NFAT:CaN:CaM [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Homo sapiens)
PPP3R1 [cytosol] (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated Ca+2 mobilization (Homo sapiens)
Activation of Calcineurin (Homo sapiens)
Calcineurin (CaN) [cytosol] (Homo sapiens)
PPP3R1 [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Homo sapiens)
PPP3R1 [cytosol] (Homo sapiens)
Calcineurin binds and dephosphorylates NFAT (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Homo sapiens)
PPP3R1 [cytosol] (Homo sapiens)
NFAT:CaN:CaM [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Homo sapiens)
PPP3R1 [cytosol] (Homo sapiens)
Translocation of CaN:CaM:NFAT to nucleus (Homo sapiens)
NFAT:CaN:CaM [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Homo sapiens)
PPP3R1 [cytosol] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Intrinsic Pathway for Apoptosis (Homo sapiens)
Activation of BH3-only proteins (Homo sapiens)
Activation of BAD and translocation to mitochondria (Homo sapiens)
Activation of BAD by calcineurin (Homo sapiens)
Calcineurin B complex [cytosol] (Homo sapiens)
PPP3R1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
DARPP-32 events (Homo sapiens)
PPP3 complex dephosphorylates DARPP-32 on Thr34 (Homo sapiens)
PPP3 complex [cytosol] (Homo sapiens)
PPP3R1 [cytosol] (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
Ca2+ pathway (Homo sapiens)
Activation of Calcineurin (Homo sapiens)
Calcineurin (CaN) [cytosol] (Homo sapiens)
PPP3R1 [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Homo sapiens)
PPP3R1 [cytosol] (Homo sapiens)
Calcineurin binds and dephosphorylates NFAT1 in response to WNT/Ca2+ signaling (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Homo sapiens)
PPP3R1 [cytosol] (Homo sapiens)
NFATC1:CaN:CaM [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Homo sapiens)
PPP3R1 [cytosol] (Homo sapiens)
Translocation of NFATC1:CaN:CaM to nucleus (Homo sapiens)
NFATC1:CaN:CaM [cytosol] (Homo sapiens)
Calcineurin:Calmodulin (CaN:CaM) [cytosol] (Homo sapiens)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Homo sapiens)
PPP3R1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P63098 PPP3R1
Gene Names
PPP3R1, CNA2, CNB
Chain
initiator methionine:, chain:2-170
Reference Genes
BioGPS Gene:5534 PPP3R1
COSMIC (genes):PPP3R1 PPP3R1
CTD Gene:5534 PPP3R1
dbSNP Gene:5534 PPP3R1
ENSEMBL:ENSG00000221823 PPP3R1
ENSEMBL_homo_sapiens_GENE:ENSG00000221823.11 PPP3R1
HGNC:9317 PPP3R1
KEGG Gene (Homo sapiens):5534 PPP3R1
Monarch:5534 PPP3R1
NCBI Gene:5534 PPP3R1
OMIM:601302 PPP3R1
UCSC:P63098 PPP3R1
Reference Transcript
RefSeq:NM_000945.3 PPP3R1
Other Identifiers
11728879_at
11728880_s_at
11728881_at
11747093_a_at
16898518
204506_PM_at
204506_at
204507_PM_s_at
204507_s_at
2557700
2557701
2557702
2557703
2557704
2557707
2557708
2557709
2557722
2557736
40513_at
5534
8052721
A_23_P108592
A_24_P388252
A_33_P3214293
GO:0001569
GO:0001837
GO:0003824
GO:0004721
GO:0004723
GO:0005509
GO:0005515
GO:0005516
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0005955
GO:0006351
GO:0006355
GO:0006606
GO:0006886
GO:0006913
GO:0007507
GO:0008287
GO:0008597
GO:0014044
GO:0016018
GO:0016020
GO:0016192
GO:0016787
GO:0019902
GO:0019904
GO:0022011
GO:0023052
GO:0030154
GO:0033173
GO:0034504
GO:0042383
GO:0043226
GO:0045202
GO:0045944
GO:0046872
GO:0048856
GO:0055085
GO:0060487
GO:0070886
GO:0097720
GO:0098685
GO:0098686
GO:0098688
GO:0098693
GO:0098772
GO:0098794
GO:0098978
GO:0099149
GO:0099170
GO:0140096
GO:1905665
GO:1905949
HMNXSV003042740
Hs.278540.0.A2_3p_at
ILMN_1796962
M30773_at
PH_hs_0032466
TC02005028.hg
g4506024_3p_a_at
Participates
as a component of
PPP3 complex [cytosol] (Homo sapiens)
Calcineurin alpha regulatory subunit:Calcium [cytosol] (Homo sapiens)
Calcineurin (CaN) [cytosol] (Homo sapiens)
Calcineurin B complex [cytosol] (Homo sapiens)
Other forms of this molecule
PPP3R1 [nucleoplasm]
Inferred To
PPP3R1 [cytosol]
(Caenorhabditis elegans)
PPP3R1 [cytosol]
(Canis familiaris)
PPP3R1 [cytosol]
(Dictyostelium discoideum)
PPP3R1 [cytosol]
(Drosophila melanogaster)
PPP3R1 [cytosol]
(Gallus gallus)
PPP3R1 [cytosol]
(Plasmodium falciparum)
PPP3R1 [cytosol]
(Saccharomyces cerevisiae)
PPP3R1 [cytosol]
(Schizosaccharomyces pombe)
PPP3R1 [cytosol]
(Sus scrofa)
Calcineurin subunit B type 1 [cytosol]
(Bos taurus)
ppp3r1 [cytosol]
(Xenopus tropicalis)
Ppp3r1 [cytosol]
(Mus musculus)
Ppp3r1 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_000936.1
OpenTargets
ENSG00000221823
HPA
ENSG00000221823-PPP3R1
GeneCards
P63098
Ensembl
ENSP00000234310
,
ENSG00000221823
,
ENST00000234310
PRO
P63098
Pharos - Targets
P63098
HMDB Protein
HMDBP07550
PDB
6NUC
,
4OR9
,
5SVE
,
1AUI
,
6NUU
,
7U0T
,
6NUF
,
4F0Z
,
4ORA
,
1MF8
,
1M63
,
4ORC
,
2P6B
,
3LL8
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P24588 AKAP5
2
AKAP5 [plasma membrane]
(R-HSA-381669)
AKAP5 [cytosol]
(R-HSA-416331)
0.591
4
UniProt:P10415 BCL2
1
BCL2 [mitochondrial outer membrane]
(R-HSA-50757)
0.489
2
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