Reactome | PPP3R1 [cytosol]

PPP3R1 [cytosol]

Stable Identifier

R-HSA-51291

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Calcineurin B, alpha regulatory, Calcineurin B subunit isoform 1, Protein phosphatase 2B regulatory subunit 1, Protein phosphatase 3 regulatory subunit B alpha isoform 1

Locations in the PathwayBrowser

Expand all

Programmed Cell Death (Homo sapiens)

- Apoptosis (Homo sapiens)
  - Intrinsic Pathway for Apoptosis (Homo sapiens)
    - Activation of BH3-only proteins (Homo sapiens)
      - Activation of BAD and translocation to mitochondria (Homo sapiens)
        
        Activation of BAD by calcineurin (Homo sapiens)
        
        Calcineurin B complex [cytosol] (Homo sapiens)
        
        PPP3R1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P63098 PPP3R1

Gene Names

PPP3R1, CNA2, CNB

Chain

initiator methionine:1, chain:2-170

Reference Genes

BioGPS Gene:5534 PPP3R1

COSMIC (genes):PPP3R1 PPP3R1

CTD Gene:5534 PPP3R1

dbSNP Gene:5534 PPP3R1

ENSEMBL:ENSG00000221823 PPP3R1

HGNC:9317 PPP3R1

KEGG Gene (Homo sapiens):5534 PPP3R1

Monarch:5534 PPP3R1

NCBI Gene:5534 PPP3R1

OMIM:601302 PPP3R1

UCSC:P63098 PPP3R1

Reference Transcript

RefSeq:NM_000945.3 PPP3R1

Other Identifiers

0001050528

11728879_at

11728880_s_at

11728881_at

11747093_a_at

16898518

204506_at

204507_s_at

2557700

2557701

2557702

2557703

2557704

2557707

2557708

2557709

2557722

2557736

40513_at

5534

8052721

A_23_P108592

A_24_P388252

A_33_P3214293

GO:0002376

GO:0003674

GO:0004723

GO:0005509

GO:0005515

GO:0005516

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005829

GO:0005886

GO:0005955

GO:0006464

GO:0006470

GO:0006810

GO:0007005

GO:0007165

GO:0007223

GO:0007267

GO:0008150

GO:0008219

GO:0009058

GO:0016018

GO:0016020

GO:0016791

GO:0019899

GO:0019902

GO:0019904

GO:0032991

GO:0033173

GO:0034641

GO:0038095

GO:0042383

GO:0043167

GO:0043226

GO:0045944

GO:0046872

GO:0061024

GO:1900740

Hs.278540.0.A2_3p_at

ILMN_1796962

M30773_at

PH_hs_0032466

TC02005028.hg

g4506024_3p_a_at

Participant Of

hasComponent

Other forms of this molecule

PPP3R1 [nucleoplasm]

Inferred To

Ghost homologue of PPP3R1 [cytosol] (Canis familiaris)

PPP3R1 [cytosol] (Gallus gallus)

PPP3R1 [cytosol] (Plasmodium falciparum)

PPP3R1 [cytosol] (Sus scrofa)

cnbA [cytosol] (Dictyostelium discoideum)

CNB1 [cytosol] (Saccharomyces cerevisiae)

cnb1 [cytosol] (Schizosaccharomyces pombe)

ppp3r1 [cytosol] (Xenopus tropicalis)

ppp3r1b [cytosol] (Danio rerio)

CanB2 [cytosol] (Drosophila melanogaster)

Ppp3r1 [cytosol] (Mus musculus)

Ppp3r1 [cytosol] (Rattus norvegicus)

cnb-1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_000936.1

OpenTargets

ENSG00000221823

GeneCards

P63098

HPA

ENSG00000221823-PPP3R1

Ensembl

ENSP00000234310, ENST00000234310, ENSG00000221823

PRO

P63098

HMDB Protein

HMDBP07550

PDB

6NUU, 1AUI, 2P6B, 3LL8, 5SVE, 6NUF, 4ORC, 4ORA, 6NUC, 4F0Z, 1M63, 1MF8, 4OR9

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P24588 AKAP5	2	AKAP5 [cytosol] (R-HSA-416331) AKAP5 [plasma membrane] (R-HSA-381669)	0.591	4
UniProt:P10415 BCL2	1	BCL2 [mitochondrial outer membrane] (R-HSA-50757)	0.489	2

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