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CLTC [clathrin-coated endocytic vesicle membrane]
Stable Identifier
R-HSA-5138450
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
clathrin-coated endocytic vesicle membrane
Synonyms
Clathrin heavy chain 1, CLH1_HUMAN, CLH17, CLTCL2, KIAA0034
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
PCP/CE pathway (Homo sapiens)
WNT5A-dependent internalization of FZD4 (Homo sapiens)
WNT5A:FZD4 is endocytosed (Homo sapiens)
WNT5A:FZD4:p-DVL2:AP-2:clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
clathrin:AP-2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
3xCLTC:3(CLTA,B) [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
CLTC [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q00610 CLTC
Gene Names
CLTC, CLH17, CLTCL2, KIAA0034
Chain
initiator methionine:, chain:2-1675
Reference Genes
BioGPS Gene:1213 CLTC
COSMIC (genes):CLTC CLTC
CTD Gene:1213 CLTC
dbSNP Gene:1213 CLTC
ENSEMBL:ENSG00000141367 CLTC
ENSEMBL_homo_sapiens_GENE:ENSG00000141367.13 CLTC
HGNC:2092 CLTC
KEGG Gene (Homo sapiens):1213 CLTC
Monarch:1213 CLTC
NCBI Gene:1213 CLTC
OMIM:118955 CLTC
UCSC:Q00610 CLTC
Reference Transcript
RefSeq:NM_004859.3 CLTC
Other Identifiers
11739027_at
11739028_s_at
11739029_a_at
11739030_s_at
11746341_a_at
1213
16836564
200614_PM_at
200614_at
3728897
3728898
3729173
3729174
3729175
3729177
3729178
3729179
3729181
3729183
3729184
3729186
3729188
3729189
3729190
3729191
3729193
3729194
3729195
3729196
3729197
3729199
3729201
3729202
3729203
3729204
3729205
3729206
3729207
3729208
3729209
3729210
3729211
3729212
3729213
3729214
3729216
3729218
3729223
3729224
3729225
3729226
3729227
3729228
3729229
3729230
41159_at
8008834
84461_at
91168_at
A_14_P116029
A_14_P122089
A_23_P118544
A_33_P3274731
A_33_P3353170
D21260_at
GE57114
GO:0000278
GO:0001649
GO:0003723
GO:0003725
GO:0005198
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005764
GO:0005768
GO:0005773
GO:0005794
GO:0005819
GO:0005829
GO:0005856
GO:0005886
GO:0005905
GO:0005925
GO:0005975
GO:0006886
GO:0006898
GO:0006914
GO:0007010
GO:0007049
GO:0012505
GO:0016020
GO:0016192
GO:0019901
GO:0030118
GO:0030130
GO:0030132
GO:0030136
GO:0030154
GO:0030659
GO:0030669
GO:0031410
GO:0031623
GO:0032051
GO:0032588
GO:0032991
GO:0033572
GO:0036020
GO:0042147
GO:0042470
GO:0043226
GO:0045334
GO:0046907
GO:0048268
GO:0050750
GO:0051301
GO:0060236
GO:0065003
GO:0070062
GO:0071439
GO:0072318
GO:0072583
GO:0072659
GO:0072686
GO:0097718
GO:0150093
GO:1900126
GO:1901135
GO:1903077
GO:1903561
GO:1990381
GO:1990498
HMNXSV003026476
HMNXSV003043633
ILMN_1756779
PH_hs_0022888
TC17000725.hg
g4758011_3p_at
Participates
as a component of
3xCLTC:3(CLTA,B) [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Other forms of this molecule
CLTC [trans-Golgi network membrane]
CLTC [cytosol]
CLTC(2-1634)insDGVSSVTQAGVQWRDLGSLQPSRARLPGHVAADHPPA-ALK(1058-1620) fusion [cytosol]
CLTC(2-1634)insV-p-7Y-ALK(1059-1620) fusion [cytosol]
CLTC [plasma membrane]
CLTC [lysosomal membrane]
CLTC [endolysosome membrane]
CLTC(2-1634)insV-ALK(1059-1620) fusion [cytosol]
CLTC(2-1634)insDGVSSVTQAGVQWRDLGSLQPSRARLPGHVAADHPPA-p-7Y-ALK(1058-1620) fusion [cytosol]
Inferred To
Chc [clathrin-coated endocytic vesicle membrane]
(Drosophila melanogaster)
Ghost homologue of CLTC [clathrin-coated endocytic vesicle membrane]
(Xenopus tropicalis)
CLTC [clathrin-coated endocytic vesicle membrane]
(Bos taurus)
CLTC [clathrin-coated endocytic vesicle membrane]
(Canis familiaris)
CLTC [clathrin-coated endocytic vesicle membrane]
(Sus scrofa)
chc-1 [clathrin-coated endocytic vesicle membrane]
(Caenorhabditis elegans)
Cltc [clathrin-coated endocytic vesicle membrane]
(Mus musculus)
Cltc [clathrin-coated endocytic vesicle membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_004850.1
OpenTargets
ENSG00000141367
ZINC - Substances
CLH1_HUMAN
GeneCards
Q00610
HPA
ENSG00000141367-CLTC
Ensembl
ENSP00000269122
,
ENST00000700707
,
ENST00000269122
,
ENSG00000141367
,
ENSP00000376763
,
ENSP00000515147
,
ENST00000393043
ZINC target
Q00610
PRO
Q00610
Pharos - Targets
Q00610
Orphanet
21870
ZINC - Predictions - Purchasable
CLH1_HUMAN
PDB
6QNP
,
6QNN
,
2XZG
,
4G55
,
6E4L
,
7ZX4
,
7BN1
,
7BN2
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P32121 ARRB2
3
ARRB2 [cytosol]
(R-HSA-416464)
PolyUb-ARRB2 [cytosol]
(R-HSA-6783000)
ARRB2 [endocytic vesicle membrane]
(R-HSA-9910881)
0.676
6
UniProt:Q15398 DLGAP5
1
DLGAP5 [cytosol]
(R-HSA-264452)
0.645
4
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.615
21
UniProt:P03372 ESR1
10
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.597
3
UniProt:Q14164 IKBKE
5
monoSUMO1-K231-p-S172-IKBKE [nucleoplasm]
(R-HSA-4755535)
IKBKE [cytosol]
(R-HSA-450225)
p-S172-IKBKE [cytosol]
(R-HSA-450278)
K63polyUb-K30,K401-IKBKE [cytosol]
(R-HSA-9730436)
p-S172-IKBKE [nucleoplasm]
(R-HSA-4755521)
0.589
2
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.569
11
UniProt:Q9NYZ3 GTSE1
4
GTSE1 [cytosol]
(R-HSA-8852264)
p-S435-GTSE1 [cytosol]
(R-HSA-8852316)
p-S435-GTSE1 [nucleoplasm]
(R-HSA-8852332)
p-T513,T526-GTSE1 [cytosol]
(R-HSA-8852308)
0.564
3
UniProt:Q13627 DYRK1A
1
DYRK1A [nucleoplasm]
(R-HSA-1362267)
0.547
2
UniProt:O14920 IKBKB
3
IKBKB Q432Pfs*62 [cytosol]
(R-HSA-9628518)
IKBKB [cytosol]
(R-HSA-168114)
p-S177,S181-IKBKB [cytosol]
(R-HSA-202506)
0.536
2
UniProt:Q96FJ0 STAMBPL1
1
STAMBPL1 [cytosol]
(R-HSA-6783264)
0.527
2
UniProt:P10242 MYB
1
MYB [nucleoplasm]
(R-HSA-992697)
0.499
4
UniProt:P49407 ARRB1
6
ARRB1 [cytosol]
(R-HSA-264470)
PolyUb-ARRB1 [cytosol]
(R-HSA-6783186)
ARRB1 [endocytic vesicle membrane]
(R-HSA-9910882)
ARRB1 [lysosomal membrane]
(R-HSA-432701)
ARRB1 [Golgi membrane]
(R-HSA-350831)
ARRB1 [cytoplasmic vesicle membrane]
(R-HSA-351187)
0.491
3
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