WNT5A:FZD4 is endocytosed

Stable Identifier
R-HSA-5138459
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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WNT5A-dependent FZD4 uptake into clathrin-coated vesicles depends upon AP-2 and possibly ARBB2 (Chen et al, 2003; Yu et al, 2007). Evidence suggests that ARBB2 dissociates from the receptor-ligand complex before internalization (Chen et al, 2003).

Literature References
PubMed ID Title Journal Year
12958364 Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4

Chen, W, ten Berge, D, Brown, J, Ahn, S, Hu, LA, Miller, WE, Caron, MG, Barak, LS, Nusse, R, Lefkowitz, RJ

Science 2003
17199046 Association of Dishevelled with the clathrin AP-2 adaptor is required for Frizzled endocytosis and planar cell polarity signaling

Yu, A, Rual, JF, Tamai, K, Harada, Y, Vidal, M, He, X, Kirchhausen, T

Dev. Cell 2007
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