Reactome | ROR1 [clathrin-coated endocytic vesicle membrane]

ROR1 [clathrin-coated endocytic vesicle membrane]

Stable Identifier

R-HSA-5140727

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

clathrin-coated endocytic vesicle membrane

Synonyms

Tyrosine-protein kinase transmembrane receptor ROR1 precursor, ROR1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q01973 ROR1

Gene Names

ROR1, NTRKR1

Chain

signal peptide:1-29, chain:30-937

Reference Genes

BioGPS Gene:4919 ROR1

COSMIC (genes):ROR1 ROR1

CTD Gene:4919 ROR1

dbSNP Gene:4919 ROR1

ENSEMBL:ENSG00000185483 ROR1

HGNC:10256 ROR1

KEGG Gene (Homo sapiens):4919 ROR1

Monarch:4919 ROR1

NCBI Gene:4919 ROR1

OMIM:602336 ROR1

UCSC:Q01973 ROR1

Reference Transcript

Other Identifiers

0001410156

0106370402

11738115_at

11752290_s_at

16665588

205805_s_at

211057_at

213_at

232060_at

2339873

2339874

2339875

2339876

2339932

2339942

2339945

2339966

2339967

2339968

2339969

2339976

2339983

2339984

2339985

2339986

2339987

2339988

2339996

2339998

4919

74338_at

7901969

85417_r_at

A_14_P114455

A_14_P122305

A_14_P136179

A_23_P12363

A_32_P4018

GE55619

GE62401

GO:0000166

GO:0001725

GO:0003674

GO:0004672

GO:0004714

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005737

GO:0005856

GO:0005886

GO:0005887

GO:0006464

GO:0006468

GO:0007165

GO:0007169

GO:0007267

GO:0007275

GO:0007399

GO:0007605

GO:0008150

GO:0009058

GO:0009986

GO:0010976

GO:0014002

GO:0014068

GO:0016020

GO:0016021

GO:0016055

GO:0016301

GO:0016310

GO:0016740

GO:0017147

GO:0018108

GO:0030154

GO:0030424

GO:0032991

GO:0033674

GO:0034641

GO:0042813

GO:0042995

GO:0043123

GO:0043167

GO:0043226

GO:0043235

GO:0043408

GO:0043410

GO:0043679

GO:0048839

GO:0048856

GO:0050877

GO:0051092

GO:0060071

GO:1904929

Hs.128753.0.S1_3p_at

ILMN_1655904

ILMN_1899404

M97675_at

PH_hs_0007467

PH_hs_0014128

TC01000723.hg

TC01004449.hg

g13623530_3p_at

g4826867_3p_a_at

Participant Of

hasCandidate

FZD2/FZD5/ROR2 [clathrin-coated endocytic vesicle membrane]

Other forms of this molecule

ROR1 [plasma membrane]

Inferred To

Ror [clathrin-coated endocytic vesicle membrane] (Drosophila melanogaster)

ROR1 [clathrin-coated endocytic vesicle membrane] (Bos taurus)

ROR1 [clathrin-coated endocytic vesicle membrane] (Canis familiaris)

ROR1 [clathrin-coated endocytic vesicle membrane] (Gallus gallus)

ROR1 [clathrin-coated endocytic vesicle membrane] (Sus scrofa)

ror1 [clathrin-coated endocytic vesicle membrane] (Danio rerio)

Ror1 [clathrin-coated endocytic vesicle membrane] (Mus musculus)

Ror1 [clathrin-coated endocytic vesicle membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_001077061.1, NP_005003.2

OpenTargets

ENSG00000185483

GeneCards

Q01973

HPA

ENSG00000185483-ROR1

Ensembl

ENST00000371079, ENSP00000360120, ENSP00000360121, ENSG00000185483, ENST00000371080

PRO

Q01973

Orphanet

25518

HMDB Protein

HMDBP09450

PDB

6BAN, 5Z55, 6BA5, 6TU9

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P12931 SRC	6	p-Y416-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [nucleoplasm] (R-HSA-8937690) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.682	9
UniProt:P05480 Src	12	phospho-Src [cytosol] (R-MMU-377592) Src [cytosol] (R-MMU-191648) phospho-Src [plasma membrane] (R-MMU-1810408) phospho-Src [plasma membrane] (R-MMU-377598) Src [plasma membrane] (R-MMU-65043) Src [cytosol] (R-MMU-418782) phospho-Src [plasma membrane] (R-MMU-112331) Src [plasma membrane] (R-MMU-8876922) MyrG-p-Y424-Src [plasma membrane] (R-MMU-9011258) Activated Src [nucleoplasm] (R-MMU-8937700) phospho-Src [cytosol] (R-MMU-8964276) Src [cytosol] (R-MMU-9628701)	0.602	3
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.576	8

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