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ROR1 [clathrin-coated endocytic vesicle membrane]
Stable Identifier
R-HSA-5140727
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
clathrin-coated endocytic vesicle membrane
Synonyms
Tyrosine-protein kinase transmembrane receptor ROR1 precursor, ROR1_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
PCP/CE pathway (Homo sapiens)
WNT5A-dependent internalization of FZD2, FZD5 and ROR2 (Homo sapiens)
FZD2, FZD5 and ROR2 are internalized in a WNT5A and clathrin-dependent manner (Homo sapiens)
WNT5A:FZDs/ROR [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
FZD2/FZD5/ROR2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
ROR1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q01973 ROR1
Gene Names
ROR1, NTRKR1
Chain
signal peptide:1-29, chain:30-937
Reference Genes
BioGPS Gene:4919 ROR1
COSMIC (genes):ROR1 ROR1
CTD Gene:4919 ROR1
dbSNP Gene:4919 ROR1
ENSEMBL:ENSG00000185483 ROR1
HGNC:10256 ROR1
KEGG Gene (Homo sapiens):4919 ROR1
Monarch:4919 ROR1
NCBI Gene:4919 ROR1
OMIM:602336 ROR1
UCSC:Q01973 ROR1
Reference Transcript
RefSeq:NM_005012.3 ROR1
RefSeq:NM_001083592.1 ROR1
Other Identifiers
0001410156
0106370402
11738115_at
11752290_s_at
16665588
205805_s_at
211057_at
213_at
232060_at
2339873
2339874
2339875
2339876
2339932
2339942
2339945
2339966
2339967
2339968
2339969
2339976
2339983
2339984
2339985
2339986
2339987
2339988
2339996
2339998
4919
74338_at
7901969
85417_r_at
A_14_P114455
A_14_P122305
A_14_P136179
A_23_P12363
A_32_P4018
GE55619
GE62401
GO:0000166
GO:0001725
GO:0003674
GO:0004672
GO:0004714
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005737
GO:0005856
GO:0005886
GO:0005887
GO:0006464
GO:0006468
GO:0007165
GO:0007169
GO:0007267
GO:0007275
GO:0007605
GO:0008150
GO:0009058
GO:0009986
GO:0010976
GO:0014002
GO:0014068
GO:0016020
GO:0016021
GO:0016055
GO:0016301
GO:0016310
GO:0016740
GO:0017147
GO:0018108
GO:0030154
GO:0030424
GO:0032991
GO:0033674
GO:0034641
GO:0042813
GO:0042995
GO:0043123
GO:0043167
GO:0043226
GO:0043235
GO:0043410
GO:0043679
GO:0048839
GO:0048856
GO:0050877
GO:0051092
GO:0060071
GO:1904929
HMNXSV003003405
Hs.128753.0.S1_3p_at
ILMN_1655904
ILMN_1899404
M97675_at
PH_hs_0007467
PH_hs_0014128
TC01000723.hg
TC01004449.hg
g13623530_3p_at
g4826867_3p_a_at
Participates
as a candidate of
FZD2/FZD5/ROR2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Other forms of this molecule
ROR1 [plasma membrane]
Inferred To
Ror [clathrin-coated endocytic vesicle membrane]
(Drosophila melanogaster)
ROR1 [clathrin-coated endocytic vesicle membrane]
(Bos taurus)
ROR1 [clathrin-coated endocytic vesicle membrane]
(Canis familiaris)
ROR1 [clathrin-coated endocytic vesicle membrane]
(Gallus gallus)
ROR1 [clathrin-coated endocytic vesicle membrane]
(Sus scrofa)
ror1 [clathrin-coated endocytic vesicle membrane]
(Danio rerio)
cam-1 [clathrin-coated endocytic vesicle membrane]
(Caenorhabditis elegans)
Ror1 [clathrin-coated endocytic vesicle membrane]
(Mus musculus)
Ror1 [clathrin-coated endocytic vesicle membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_005003.2
,
NP_001077061.1
OpenTargets
ENSG00000185483
HPA
ENSG00000185483-ROR1
GeneCards
Q01973
Ensembl
ENST00000371079
,
ENST00000371080
,
ENSG00000185483
,
ENSP00000360121
,
ENSP00000360120
PRO
Q01973
Orphanet
25518
HMDB Protein
HMDBP09450
PDB
6BAN
,
6TU9
,
6BA5
,
5Z55
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P12931 SRC
6
p-Y416-SRC [cytosol]
(R-HSA-8964276)
SRC [cytosol]
(R-HSA-9628701)
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
0.682
9
UniProt:P05480 Src
12
phospho-Src [cytosol]
(R-MMU-377592)
Src [cytosol]
(R-MMU-191648)
phospho-Src [plasma membrane]
(R-MMU-1810408)
Src [plasma membrane]
(R-MMU-65043)
phospho-Src [plasma membrane]
(R-MMU-377598)
Src [cytosol]
(R-MMU-418782)
phospho-Src [plasma membrane]
(R-MMU-112331)
Src [plasma membrane]
(R-MMU-8876922)
MyrG-p-Y424-Src [plasma membrane]
(R-MMU-9011258)
Activated Src [nucleoplasm]
(R-MMU-8937700)
phospho-Src [cytosol]
(R-MMU-8964276)
Src [cytosol]
(R-MMU-9628701)
0.602
3
UniProt:P00533 EGFR
59
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
EGFR [endosome membrane]
(R-HSA-9611160)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.576
8
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