WNT5A binds FZD and ROR receptors

Stable Identifier
R-HSA-5140741
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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WNT5A induces the internalization of FZD2, FZD5 and ROR2 in a clathrin-mediated route, but the activation of PKC is not required (Kurayoshi et al, 2007; Sato et al, 2010; Hanaki et al, 2012).

Literature References
PubMed ID Title Journal Year
17117926 Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling

Kurayoshi, M, Yamamoto, H, Izumi, S, Kikuchi, A

Biochem. J. 2007
19910923 Wnt5a regulates distinct signalling pathways by binding to Frizzled2

Sato, A, Yamamoto, H, Sakane, H, Koyama, H, Kikuchi, A

EMBO J. 2010
22101459 An anti-Wnt5a antibody suppresses metastasis of gastric cancer cells in vivo by inhibiting receptor-mediated endocytosis

Hanaki, H, Yamamoto, H, Sakane, H, Matsumoto, S, Ohdan, H, Sato, A, Kikuchi, A

Mol. Cancer Ther. 2012
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