WNT5A-dependent internalization of FZD2, FZD5 and ROR2

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R-HSA-5140745
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Pathway
Species
Homo sapiens
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Internalization of FZD2, FZD5 and ROR2 after WNT5A binding is thought to occur in a clathrin-dependent manner and is required for the activation of RAC signaling (Kurayoshi et al, 2007; Sato et al, 2010; Hanaki et al, 2012; Yamamoto et al, 2009).

Literature References
PubMed ID Title Journal Year
17117926 Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling

Kurayoshi, M, Yamamoto, H, Izumi, S, Kikuchi, A

Biochem. J. 2007
19910923 Wnt5a regulates distinct signalling pathways by binding to Frizzled2

Sato, A, Yamamoto, H, Sakane, H, Koyama, H, Kikuchi, A

EMBO J. 2010
22101459 An anti-Wnt5a antibody suppresses metastasis of gastric cancer cells in vivo by inhibiting receptor-mediated endocytosis

Hanaki, H, Yamamoto, H, Sakane, H, Matsumoto, S, Ohdan, H, Sato, A, Kikuchi, A

Mol. Cancer Ther. 2012
19582886 Laminin gamma2 mediates Wnt5a-induced invasion of gastric cancer cells

Yamamoto, H, Yamamoto, H, Kitadai, Y, Oue, N, Ohdan, H, Yasui, W, Kikuchi, A

Gastroenterology 2009
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