GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2)

Stable Identifier
R-HSA-514604
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cytosolic GMP reductase (GMPR) catalyzes the reaction of GMP and NADPH + H+ to yield IMP and NADP+ + NH4+ (Spector et al. 1979; Deng et al. 2002). Two GMPR proteins have been identified, GMPR and GMPR2. Both proteins form homotetramers (GMPR - unpublished crstallographic data PDB 2BLE; GMPR2 - Li et al. 2006).

Literature References
PubMed ID Title Journal Year
12009299 NADPH-dependent GMP reductase isoenzyme of human (GMPR2). Expression, purification, and kinetic properties

Deng, Y, Wang, Z, Ying, K, Gu, S, Ji, C, Huang, Y, Gu, X, Wang, Y, Xu, Y, Li, Y, Xie, Y, Mao, Y

Int J Biochem Cell Biol 2002
16359702 Crystal structure of human guanosine monophosphate reductase 2 (GMPR2) in complex with GMP

Li, J, Wei, Z, Zheng, M, Gu, X, Deng, Y, Qiu, R, Chen, F, Ji, C, Gong, W, Xie, Y, Mao, Y

J Mol Biol 2006
218932 Reaction mechanism and specificity of human GMP reductase. Substrates, inhibitors, activators, and inactivators

Spector, T, Jones, TE, Miller, RL

J Biol Chem 1979
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
GMP reductase activity of GMPR tetramers [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created