Reactome | NCBP2 [nucleoplasm]

NCBP2 [nucleoplasm]

Stable Identifier

R-HSA-51463

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

CBP20, 20 kDa nuclear cap binding protein (NCBP 20 kDa subunit) (CBP20) (NCBP interacting protein 1) (NIP1), 20 kDa nuclear cap binding protein, NCBP 20 kDa subunit, NCBP interacting protein 1, NIP1

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Locations in the PathwayBrowser for interactor UniProt:P18615 NELFE

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External Reference Information

External Reference

UniProt:P52298 NCBP2

Gene Names

NCBP2, CBP20, PIG55

Chain

initiator methionine:, chain:2-156

Reference Genes

BioGPS Gene:22916 NCBP2

COSMIC (genes):NCBP2 NCBP2

CTD Gene:22916 NCBP2

dbSNP Gene:22916 NCBP2

ENSEMBL:ENSG00000114503 NCBP2

HGNC:7659 NCBP2

KEGG:hsa:22916 NCBP2

Monarch:22916 NCBP2

NCBI Gene:22916 NCBP2

OMIM:605133 NCBP2

UCSC:P52298 NCBP2

Reference Transcript

Participates

as a component of

as an output of

Docking of Mature Replication Dependent Histone mRNA with the NPC (Homo sapiens)

as an input of

Formation of cap binding complex (CBC) (Homo sapiens)

Other forms of this molecule

NCBP2 [cytosol]

Inferred To

CBC2 [nucleoplasm] (Saccharomyces cerevisiae)

ncbp-2 [nucleoplasm] (Caenorhabditis elegans)

Cbp20 [nucleoplasm] (Drosophila melanogaster)

NCBP2 [nucleoplasm] (Bos taurus)

NCBP2 [nucleoplasm] (Canis familiaris)

NCBP2 [nucleoplasm] (Gallus gallus)

NCBP2 [nucleoplasm] (Plasmodium falciparum)

NCBP2 [nucleoplasm] (Sus scrofa)

cbc2 [nucleoplasm] (Schizosaccharomyces pombe)

ncbp2 [nucleoplasm] (Danio rerio)

ncbp2 [nucleoplasm] (Dictyostelium discoideum)

ncbp2 [nucleoplasm] (Xenopus tropicalis)

Ncbp2 [nucleoplasm] (Mus musculus)

Ncbp2 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_001294965.1, NP_031388.2, NP_001036005.1

ENSEMBL

ENSG00000114503, ENSP00000326806, ENSP00000412785, ENST00000321256, ENST00000452404, ENSP00000397619, ENST00000427641

OpenTargets

ENSG00000114503

HPA

ENSG00000114503-NCBP2

GeneCards

NCBP2

PRO

P52298

Pharos - Targets

P52298

GlyGen

P52298

PDB

5OO6, 1H2T, 1N52, 1N54, 1H2V, 1H2U, 6D0Y, 8SUY, 8PNT, 5OOB, 8PMP, 7ABG, 8SRR, 3FEX, 1H6K, 3FEY, 8BY6

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.965	54
UniProt:Q9H814 PHAX	2	PHAX [cytosol] (R-HSA-191804) PHAX [nucleoplasm] (R-HSA-191803)	0.725	10
ChEBI:50210 7-METHYL-GTP			0.688	13
UniProt:P52294 KPNA1	2	KPNA1 [cytosol] (R-HSA-180612) KPNA1 [nucleoplasm] (R-HSA-188865)	0.643	3
UniProt:P52292 KPNA2	2	KPNA2 [cytosol] (R-HSA-205976) KPNA2 [nucleoplasm] (R-HSA-206045)	0.643	6
UniProt:Q9BXP5 SRRT	1	SRRT [nucleoplasm] (R-HSA-6814858)	0.643	8
UniProt:Q86VM9 ZC3H18	1	ZC3H18 [nucleoplasm] (R-HSA-9930040)	0.643	6
UniProt:O00505 KPNA3	2	KPNA3 [nucleoplasm] (R-HSA-1176061) KPNA3 [cytosol] (R-HSA-1176070)	0.643	9
UniProt:P18615 NELFE	2	NELFE [nucleoplasm] (R-HSA-62907) p-NELFE [nucleoplasm] (R-HSA-170698)	0.643	4
UniProt:Q6NZY4 ZCCHC8	1	ZCCHC8 [nucleoplasm] (R-HSA-8985573)	0.643	3
UniProt:Q9Y5S9 RBM8A	2	RBM8A [cytosol] (R-HSA-162462) RBM8A [nucleoplasm] (R-HSA-156659)	0.643	3
UniProt:Q9BRK4 LZTS2			0.556	3
UniProt:P14678 SNRPB	4	2xMe-SNRPB [cytosol] (R-HSA-192218) SNRPB [cytosol] (R-HSA-191798) SNRPB [nucleoplasm] (R-HSA-71896) Me2-R108,R112-SNRPB [nucleoplasm] (R-HSA-192213)	0.527	2
UniProt:Q8WX92 NELFB	3	NELFB [nucleoplasm] (R-HSA-112427) NELFB [cytosol] (R-HSA-9603526) NELFB [mitochondrial outer membrane] (R-HSA-9603553)	0.527	3
UniProt:Q92900 UPF1	2	UPF1 [cytosol] (R-HSA-927734) p-4S-UPF1 [cytosol] (R-HSA-927856)	0.527	3
UniProt:P38919 EIF4A3	2	EIF4A3 [cytosol] (R-HSA-927868) EIF4A3 [nucleoplasm] (R-HSA-8849149)	0.527	5
UniProt:Q9Y580 RBM7	1	RBM7 [nucleoplasm] (R-HSA-8985564)	0.527	2
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.527	2
UniProt:P42285 SKIV2L2	2	SKIV2L2 [nucleoplasm] (R-HSA-6791189) MTREX [nucleolus] (R-HSA-9935826)	0.527	4
UniProt:O60684 KPNA6	2	KPNA6 [nucleoplasm] (R-HSA-9734665) KPNA6 [cytosol] (R-HSA-9734672)	0.527	2
UniProt:Q53F19 NCBP3			0.527	4
UniProt:O00629 KPNA4	2	KPNA4 [cytosol] (R-HSA-1176066) KPNA4 [nucleoplasm] (R-HSA-1176058)	0.527	2
UniProt:P09012 SNRPA	1	SNRPA [nucleoplasm] (R-HSA-71915)	0.527	2
UniProt:P27824 CANX	3	CANX [endoplasmic reticulum lumen] (R-HSA-195906) CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum membrane] (R-HSA-9932989)	0.483	2
UniProt:Q9NWB6 ARGL1			0.483	2

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