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TGFB1 [plasma membrane]
Stable Identifier
R-HSA-5146781
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
TGF-beta-1, Transforming Growth Factor beta 1
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Influenza Infection (Homo sapiens)
Host Interactions with Influenza Factors (Homo sapiens)
Influenza Virus Induced Apoptosis (Homo sapiens)
NA activation of TGF-beta (Homo sapiens)
Large latent complex of TGFB1 [plasma membrane] (Homo sapiens)
TGFB1 [plasma membrane] (Homo sapiens)
Hemostasis (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
PSGs bind proteoglycans and TGF-beta1 (Homo sapiens)
PSGs:Proteoglycan,TGFB1 [plasma membrane] (Homo sapiens)
Proteoglycans,TGFB1 [plasma membrane] (Homo sapiens)
TGFB1 [plasma membrane] (Homo sapiens)
Proteoglycans,TGFB1 [plasma membrane] (Homo sapiens)
TGFB1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01137 TGFB1
Gene Names
TGFB1, TGFB
Chain
signal peptide:1-29, chain:30-278, chain:279-390
Reference Genes
BioGPS Gene:7040 TGFB1
COSMIC (genes):TGFB1 TGFB1
CTD Gene:7040 TGFB1
dbSNP Gene:7040 TGFB1
ENSEMBL:ENSG00000105329 TGFB1
HGNC:11766 TGFB1
KEGG Gene (Homo sapiens):7040 TGFB1
Monarch:7040 TGFB1
NCBI Gene:7040 TGFB1
OMIM:190180 TGFB1
UCSC:P01137 TGFB1
Reference Transcript
RefSeq:NM_000660.6 TGFB1
Participant Of
hasComponent
Large latent complex of TGFB1 [plasma membrane]
hasMember
Proteoglycans,TGFB1 [plasma membrane]
Other forms of this molecule
TGFB1 [extracellular region]
TGFB1 [Golgi lumen]
TGFB1(30-390) [Golgi lumen]
TGFB1(30-278) [extracellular region]
TGFB1(30-278) [platelet alpha granule lumen]
Inferred To
Homologues of TGFB1 [plasma membrane] (Caenorhabditis elegans)
Homologues of TGFB1 [plasma membrane] (Drosophila melanogaster)
TGFB1 [plasma membrane] (Bos taurus)
TGFB1 [plasma membrane] (Caenorhabditis elegans)
TGFB1 [plasma membrane] (Canis familiaris)
TGFB1 [plasma membrane] (Danio rerio)
TGFB1 [plasma membrane] (Drosophila melanogaster)
TGFB1 [plasma membrane] (Mus musculus)
TGFB1 [plasma membrane] (Rattus norvegicus)
Cross References
RefSeq
NP_000651.3
OpenTargets
ENSG00000105329
GeneCards
P01137
ZINC - Substances
TGFB1_HUMAN
ZINC target
P01137
PRO
P01137
Orphanet
15606
ZINC - Predictions - Purchasable
TGFB1_HUMAN
PDB
4KV5
,
3KFD
,
5FFO
,
1KLA
,
1KLD
,
1KLC
,
5VQP
Interactors (32)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P37173 TGFBR2
9
TGFBR2 E526Q [plasma membrane]
(R-HSA-3645770)
TGFBR2 Y470D [plasma membrane]
(R-HSA-3640905)
TGFBR2 D522N [plasma membrane]
(R-HSA-3640907)
TGFBR2 R528H [plasma membrane]
(R-HSA-3640894)
TGFBR2 R528C [plasma membrane]
(R-HSA-3640899)
TGFBR2 K128fs*3 [cytosol]
(R-HSA-3642173)
TGFBR2 K128fs*35 [cytosol]
(R-HSA-3642166)
NEDD8-K556,K567-TGFBR2 [plasma membrane]
(R-HSA-4332222)
TGFBR2 [plasma membrane]
(R-HSA-170842)
0.811
6
UniProt:P05067 APP
20
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.641
3
UniProt:Q14766-1 LTBP1
0.637
4
UniProt:Q14392 LRC32
0.564
2
UniProt:P11464 PSG1
1
PSG1 [extracellular region]
(R-HSA-8870766)
0.558
3
IntAct:EBI-10171584 80125
0.556
3
UniProt:P50222 MEOX2
0.556
3
UniProt:Q12841 FSTL1
3
p-FSTL1 [endoplasmic reticulum lumen]
(R-HSA-8957089)
FSTL1 [extracellular region]
(R-HSA-201832)
FSTL1 [endoplasmic reticulum lumen]
(R-HSA-8956749)
0.544
2
UniProt:P07996 THBS1
5
glc-fuc-THBS1 [endoplasmic reticulum lumen]
(R-HSA-5172997)
THBS1 [endoplasmic reticulum lumen]
(R-HSA-5173263)
O-fuc-THBS1 [endoplasmic reticulum lumen]
(R-HSA-5173278)
THBS1 [platelet alpha granule lumen]
(R-HSA-114701)
THBS1 [extracellular region]
(R-HSA-66518)
0.525
2
UniProt:P01137 TGFB1
6
TGFB1 [Golgi lumen]
(R-HSA-177108)
TGFB1 [extracellular region]
(R-HSA-170838)
TGFB1(30-390) [Golgi lumen]
(R-HSA-114705)
TGFB1 [plasma membrane]
(R-HSA-5146781)
TGFB1(30-278) [extracellular region]
(R-HSA-2395367)
TGFB1(30-278) [platelet alpha granule lumen]
(R-HSA-65936)
0.522
2
UniProt:O60711 LPXN
0.488
2
IntAct:EBI-12416678 RAPGEF3
0.488
2
UniProt:Q5TA81 LCE2C
1
LCE2C [cytosol]
(R-HSA-6814284)
0.488
2
UniProt:O14633 LCE2B
1
LCE2B [cytosol]
(R-HSA-6814295)
0.488
2
UniProt:Q8NEC5 CATSPER1
1
CATSPER1 [plasma membrane]
(R-HSA-2534335)
0.488
2
UniProt:P06756 ITGAV
3
ITGAV(31-1048) [specific granule membrane]
(R-HSA-6806145)
ITGAV(31-1048) [phagocytic vesicle]
(R-HSA-1236773)
ITGAV(31-1048) [plasma membrane]
(R-HSA-210013)
0.488
2
UniProt:Q9BYE3 LCE3D
1
LCE3D [cytosol]
(R-HSA-6814297)
0.488
2
UniProt:Q5T751 LCE1C
1
LCE1C [cytosol]
(R-HSA-6814267)
0.488
2
UniProt:Q5T752 LCE1D
1
LCE1D [cytosol]
(R-HSA-6814283)
0.488
2
UniProt:P60410 KRTAP10-8
1
KRTAP10-8 [cytosol]
(R-HSA-6810301)
0.488
2
UniProt:Q07627 KRTAP1-1
1
KRTAP1-1 [cytosol]
(R-HSA-6809855)
0.488
2
UniProt:Q5T7P2 LCE1A
1
LCE1A [cytosol]
(R-HSA-6814305)
0.488
2
UniProt:Q5TA76 LCE3A
1
LCE3A [cytosol]
(R-HSA-6814296)
0.488
2
UniProt:A0A0C3SFZ9 A0A0C3SFZ9
0.488
2
IntAct:EBI-11749135 KRTAP13
0.488
2
UniProt:Q6UY14-3 ADAMTSL4
0.488
2
UniProt:Q9BYQ6 KRTAP4-11
1
KRTAP4-11 [cytosol]
(R-HSA-6809960)
0.488
2
UniProt:Q5TA77 LCE3B
1
LCE3B [cytosol]
(R-HSA-6814269)
0.488
2
UniProt:P07237 P4HB
3
HC53,56-P4HB [endoplasmic reticulum lumen]
(R-HSA-3341287)
P4HB [endoplasmic reticulum lumen]
(R-HSA-174692)
p-P4HB [endoplasmic reticulum lumen]
(R-HSA-8956902)
0.488
2
UniProt:Q12837 POU4F2
1
POU4F2 [nucleoplasm]
(R-HSA-6804414)
0.488
2
UniProt:P49639 HOXA1
1
HOXA1 [nucleoplasm]
(R-HSA-5617464)
0.488
2
UniProt:A8MQ03 CRTP1
0.488
2
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