Reactome | NCBP1 [nucleoplasm]

NCBP1 [nucleoplasm]

Stable Identifier

R-HSA-51469

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

CBP80, 80 kDa nuclear cap binding protein (NCBP 80 kDa subunit) (CBP80), 80 kDa nuclear cap binding protein, NCBP 80 kDa subunit

Locations in the PathwayBrowser for interactor UniProt:O75150 RNF40

Expand all

External Reference Information

External Reference

UniProt:Q09161 NCBP1

Gene Names

NCBP1, CBP80, NCBP

Chain

chain:1-790

Reference Genes

BioGPS Gene:4686 NCBP1

COSMIC (genes):NCBP1 NCBP1

CTD Gene:4686 NCBP1

dbSNP Gene:4686 NCBP1

ENSEMBL:ENSG00000136937 NCBP1

HGNC:7658 NCBP1

KEGG:hsa:4686 NCBP1

Monarch:4686 NCBP1

NCBI Gene:4686 NCBP1

OMIM:600469 NCBP1

UCSC:Q09161 NCBP1

Reference Transcript

RefSeq:NM_002486.4 NCBP1

Other Identifiers

11725977_at

11725978_at

17087343

209519_3p_at

209519_PM_at

209519_at

209520_PM_s_at

209520_s_at

3181303

3181304

3181307

3181308

3181310

3181311

3181312

3181313

3181314

3181315

3181316

3181318

3181320

3181321

3181322

3181323

3181325

3181326

3181327

3181329

3181330

3181331

3181332

3181333

3181334

3181335

3181336

3181337

3181338

3181339

3181340

3181341

3181342

3181343

3181344

3181345

3181346

37987_at

4686

53692_at

8156718

A_14_P113175

A_14_P116217

A_23_P257104

A_33_P3261192

A_33_P3261197

A_33_P3299854

D32002_s_at

GE79811

GO:0000184

GO:0000245

GO:0000339

GO:0000340

GO:0000380

GO:0000398

GO:0002191

GO:0003723

GO:0003729

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005829

GO:0005846

GO:0006351

GO:0006355

GO:0006370

GO:0006401

GO:0006406

GO:0006408

GO:0006417

GO:0006446

GO:0006913

GO:0008334

GO:0008380

GO:0016070

GO:0016071

GO:0030307

GO:0031047

GO:0031053

GO:0031124

GO:0031442

GO:0032968

GO:0034518

GO:0035194

GO:0035195

GO:0042789

GO:0043226

GO:0048026

GO:0050684

GO:0051028

GO:0051607

GO:0060090

GO:0065003

GO:0098542

GO:1905216

GO:1990904

HMNXSV003009315

Hs.89563.0.S2_3p_at

Hs.89563.0.S2_3p_x_at

ILMN_1777528

PH_hs_0033442

TC09000492.hg

g12655186_3p_a_at

Participates

as a component of

as an output of

Docking of Mature Replication Dependent Histone mRNA with the NPC (Homo sapiens)

as an input of

Formation of cap binding complex (CBC) (Homo sapiens)

Other forms of this molecule

NCBP1 [cytosol]

Inferred To

Ncbp1 [nucleoplasm] (Mus musculus)

Ncbp1 [nucleoplasm] (Rattus norvegicus)

Ghost homologue of NCBP1 [nucleoplasm] (Danio rerio)

Ghost homologue of NCBP1 [nucleoplasm] (Plasmodium falciparum)

STO1 [nucleoplasm] (Saccharomyces cerevisiae)

ncbp-1 [nucleoplasm] (Caenorhabditis elegans)

NCBP1 [nucleoplasm] (Bos taurus)

NCBP1 [nucleoplasm] (Canis familiaris)

NCBP1 [nucleoplasm] (Gallus gallus)

NCBP1 [nucleoplasm] (Sus scrofa)

ncbp1 [nucleoplasm] (Dictyostelium discoideum)

ncbp1 [nucleoplasm] (Xenopus tropicalis)

Cbp80 [nucleoplasm] (Drosophila melanogaster)

cbc1 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_002477.1

OpenTargets

ENSG00000136937

ENSEMBL

ENSP00000364289, ENSG00000136937, ENST00000375147

GeneCards

NCBP1

HPA

ENSG00000136937-NCBP1

PRO

Q09161

Pharos - Targets

Q09161

GlyGen

Q09161

PDB

5OOB, 8PMP, 8SRR, 6D0Y, 8PNT, 5OO6, 8SUY, 7ABG, 1H2T, 1N52, 1N54, 1H2U, 1H2V, 3FEY, 3FEX, 1H6K, 8BY6

Interactors (56)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P52298 NCBP2	2	NCBP2 [nucleoplasm] (R-HSA-51463) NCBP2 [cytosol] (R-HSA-162458)	0.965	54
UniProt:P52292 KPNA2	2	KPNA2 [cytosol] (R-HSA-205976) KPNA2 [nucleoplasm] (R-HSA-206045)	0.872	14
UniProt:P52298-1 NCBP2			0.771	8
UniProt:Q9H814 PHAX	2	PHAX [cytosol] (R-HSA-191804) PHAX [nucleoplasm] (R-HSA-191803)	0.744	10
UniProt:O75150 RNF40	1	RNF40 [nucleoplasm] (R-HSA-5689015)	0.743	5
UniProt:Q53F19 NCBP3			0.716	11
UniProt:Q92900 UPF1	2	UPF1 [cytosol] (R-HSA-927734) p-4S-UPF1 [cytosol] (R-HSA-927856)	0.69	9
ChEBI:50210 7-METHYL-GTP			0.688	14
UniProt:P11940 PABPC1	1	PABPC1 [cytosol] (R-HSA-156803)	0.662	9
UniProt:Q86VM9 ZC3H18	1	ZC3H18 [nucleoplasm] (R-HSA-9930040)	0.643	10
UniProt:P52294 KPNA1	2	KPNA1 [cytosol] (R-HSA-180612) KPNA1 [nucleoplasm] (R-HSA-188865)	0.643	3
UniProt:P07910 HNRNPC	3	HNRNPC [nucleoplasm] (R-HSA-71933) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [cytosol] (R-HSA-9715136)	0.643	5
UniProt:O00629 KPNA4	2	KPNA4 [cytosol] (R-HSA-1176066) KPNA4 [nucleoplasm] (R-HSA-1176058)	0.643	4
UniProt:O00505 KPNA3	2	KPNA3 [nucleoplasm] (R-HSA-1176061) KPNA3 [cytosol] (R-HSA-1176070)	0.643	8
UniProt:P08621 SNRNP70	1	SNRNP70 [nucleoplasm] (R-HSA-71913)	0.643	6
UniProt:P09234 SNRPC	1	SNRPC [nucleoplasm] (R-HSA-8865876)	0.643	3
UniProt:P62753 RPS6	4	RPS6 [cytosol] (R-HSA-72381) p-5S-RPS6 [cytosol] (R-HSA-165727) 3OHR147-RPS6 [cytosol] (R-HSA-9629876) RPS6 [nucleoplasm] (R-HSA-6790606)	0.576	3
UniProt:Q15428 SF3A2	1	SF3A2 [nucleoplasm] (R-HSA-71964)	0.564	2
UniProt:Q9BY77 POLDIP3	2	POLDIP3 [cytosol] (R-HSA-8850627) POLDIP3 [nucleoplasm] (R-HSA-8850646)	0.558	3
UniProt:Q5VTR2 RNF20	2	RNF20 [cytosol] (R-HSA-9715141) RNF20 [nucleoplasm] (R-HSA-5689011)	0.556	3
UniProt:O43586 PSTPIP1	1	PSTPIP1 [cytosol] (R-HSA-879220)	0.556	3
UniProt:O00571 DDX3X	3	DDX3X [ficolin-1-rich granule lumen] (R-HSA-6801273) DDX3X [extracellular region] (R-HSA-6806507) DDX3X [secretory granule lumen] (R-HSA-6801275)	0.527	2
UniProt:Q9HCE1 MOV10	1	MOV10 [cytosol] (R-HSA-427772)	0.527	3
UniProt:Q8WX92 NELFB	3	NELFB [cytosol] (R-HSA-9603526) NELFB [mitochondrial outer membrane] (R-HSA-9603553) NELFB [nucleoplasm] (R-HSA-112427)	0.527	3
UniProt:P38919 EIF4A3	2	EIF4A3 [nucleoplasm] (R-HSA-8849149) EIF4A3 [cytosol] (R-HSA-927868)	0.527	6
UniProt:Q9Y5S9 RBM8A	2	RBM8A [nucleoplasm] (R-HSA-156659) RBM8A [cytosol] (R-HSA-162462)	0.527	4
UniProt:P62826 RAN	2	RAN [cytosol] (R-HSA-165540) RAN [nucleoplasm] (R-HSA-165528)	0.527	2
UniProt:Q9UHI6 DDX20	2	DDX20 [nucleoplasm] (R-HSA-191847) DDX20 [cytosol] (R-HSA-191838)	0.527	7
UniProt:P09012 SNRPA	1	SNRPA [nucleoplasm] (R-HSA-71915)	0.527	2
UniProt:P31943 HNRNPH1	1	HNRNPH1 [nucleoplasm] (R-HSA-71941)	0.527	4
UniProt:Q08211 DHX9	3	DHX9 [nucleoplasm] (R-HSA-53517) DHX9 [cytosol] (R-HSA-847700) p-DHX9 [cytosol] (R-HSA-9836168)	0.527	2
UniProt:Q15459 SF3A1	1	SF3A1 [nucleoplasm] (R-HSA-71962)	0.527	4
UniProt:Q86V81 ALYREF	2	ALYREF [cytosol] (R-HSA-158482) ALYREF [nucleoplasm] (R-HSA-156649)	0.527	3
UniProt:P67809 YBX1	5	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) p-S32,S36-YBX1 [cytosol] (R-HSA-9736837) YBX1 [cytosol] (R-HSA-9736840) YBX1 [nucleoplasm] (R-HSA-72041) YBX1 [extracellular region] (R-HSA-9017791)	0.527	4
UniProt:P42285 SKIV2L2	2	SKIV2L2 [nucleoplasm] (R-HSA-6791189) MTREX [nucleolus] (R-HSA-9935826)	0.527	6
UniProt:P18615 NELFE	2	NELFE [nucleoplasm] (R-HSA-62907) p-NELFE [nucleoplasm] (R-HSA-170698)	0.527	4
UniProt:O75533 SF3B1	1	SF3B1 [nucleoplasm] (R-HSA-71968)	0.527	3
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.527	2
UniProt:P26368 U2AF2	2	U2AF2 [nucleoplasm] (R-HSA-71987) 5OHK15,276-U2AF2 [nucleoplasm] (R-HSA-9630011)	0.527	3
UniProt:Q86U42 PABPN1	2	PABPN1 [cytosol] (R-HSA-9822424) PABPN1 [nucleoplasm] (R-HSA-72008)	0.527	6
UniProt:P09651 HNRNPA1	2	HNRNPA1 [nucleoplasm] (R-HSA-71927) HNRNPA1 [cytosol] (R-HSA-9727902)	0.527	3
UniProt:Q13838 DDX39B	2	DDX39B [nucleoplasm] (R-HSA-8849139) DDX39B [cytosol] (R-HSA-9715154)	0.527	6
UniProt:Q14974 KPNB1	5	KPNB1 [cytosol] (R-HSA-180733) KPNB1 [nucleoplasm] (R-HSA-180714) KPNB1 [ficolin-1-rich granule lumen] (R-HSA-6800978) KPNB1 [extracellular region] (R-HSA-6806306) KPNB1 [specific granule lumen] (R-HSA-6799646)	0.527	6
UniProt:P14678 SNRPB	4	2xMe-SNRPB [cytosol] (R-HSA-192218) SNRPB [cytosol] (R-HSA-191798) Me2-R108,R112-SNRPB [nucleoplasm] (R-HSA-192213) SNRPB [nucleoplasm] (R-HSA-71896)	0.527	4
UniProt:Q14498 RBM39	1	RBM39 [nucleoplasm] (R-HSA-9770254)	0.527	3
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.527	2
UniProt:Q16630 CPSF6	2	CPSF6(1-490)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1838987) CPSF6(1-490)-FGFR1(429-822) fusion [cytosol] (R-HSA-1614368)	0.527	3
UniProt:O60684 KPNA6	2	KPNA6 [nucleoplasm] (R-HSA-9734665) KPNA6 [cytosol] (R-HSA-9734672)	0.527	2
UniProt:Q8TAD8 SNIP1	1	SNIP1 [nucleoplasm] (R-HSA-3222315)	0.527	2
UniProt:P62316 SNRPD2	2	SNRPD2 [cytosol] (R-HSA-191810) SNRPD2 [nucleoplasm] (R-HSA-71901)	0.527	5
UniProt:P09661 SNRPA1	1	SNRPA1 [nucleoplasm] (R-HSA-71958)	0.527	2
UniProt:Q8IYD1 GSPT2	1	GSPT2 [cytosol] (R-HSA-143379)	0.527	3
UniProt:O95453 PARN	1	PARN [cytosol] (R-HSA-430009)	0.525	2
UniProt:P55884 EIF3B	1	EIF3B [cytosol] (R-HSA-72542)	0.462	8
UniProt:Q04637 EIF4G1	2	EIF4G1 [cytosol] (R-HSA-72584) p-S1108,S1148,S1192-EIF4G1 [cytosol] (R-HSA-165762)	0.462	2
UniProt:Q9UKV8 AGO2	2	AGO2 [cytosol] (R-HSA-209723) AGO2 [nucleoplasm] (R-HSA-5578701)	0.462	2

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