POFUT2 transfers fucose to TSR domain-containing proteins

Stable Identifier
R-HSA-5173192
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The O-fucosylation of proteins containing thrombospondin type 1 repeat (TSR1) domains is carried out by protein fucosyltransferase 2 (POFUT2). Only POFUT2 recognises the consensus sequence CSXS/TCG found in TSR1 domains and the fucosyl residue is attached to the hydroxyl group of conserved serine (S) or threonine (T) residues within the consensus sequence (Chen et al. 2012). The modification was first demonstrated on thrombospondin 1 (THBS1, TSP1), found in platelets and the ECM (Hofsteenge et al. 2001, Luo et al. 2006). In humans, there are more than 60 of these TSR1 domain-containing proteins. Only the proteins with similarity to experimentally confirmed ones are listed as candidates.

Literature References
PubMed ID Title Journal Year
16464858 Two distinct pathways for O-fucosylation of epidermal growth factor-like or thrombospondin type 1 repeats

Luo, Y, Nita-Lazar, A, Haltiwanger, RS

J. Biol. Chem. 2006
22588082 Structure of human POFUT2: insights into thrombospondin type 1 repeat fold and O-fucosylation

Chen, CI, Keusch, JJ, Klein, D, Hess, D, Hofsteenge, J, Gut, H

EMBO J. 2012
11067851 C-mannosylation and O-fucosylation of the thrombospondin type 1 module

Hofsteenge, J, Huwiler, KG, Macek, B, Hess, D, Lawler, J, Mosher, DF, Peter-Katalinic, J

J. Biol. Chem. 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
peptide-O-fucosyltransferase activity of POFUT2 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created