Reactome | FZD7 [plasma membrane]

FZD7 [plasma membrane]

Stable Identifier

R-HSA-517394

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Frizzled-7, FZD7_HUMAN

Locations in the PathwayBrowser for interactor UniProt:O14863 ZNT4

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Parasitic Infection Pathways (Homo sapiens)
    - Leishmania infection (Homo sapiens)
      - Killing mechanisms (Homo sapiens)
        
        WNT5:FZD7-mediated leishmania damping (Homo sapiens)
        
        WNT5 binds FZD7 (Homo sapiens)
        
        FZD7 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O75084 FZD7

Gene Names

FZD7

Chain

signal peptide:1-32, chain:33-574

Reference Genes

BioGPS Gene:8324 FZD7

COSMIC (genes):FZD7 FZD7

CTD Gene:8324 FZD7

dbSNP Gene:8324 FZD7

ENSEMBL:ENSG00000155760 FZD7

ENSEMBL_homo_sapiens_GENE:ENSG00000155760.3 FZD7

HGNC:4045 FZD7

KEGG Gene (Homo sapiens):8324 FZD7

Monarch:8324 FZD7

NCBI Gene:8324 FZD7

OMIM:603410 FZD7

UCSC:O75084 FZD7

Reference Transcript

RefSeq:NM_003507.1 FZD7

Other Identifiers

11721750_at

11721751_s_at

11721752_at

16889563

203705_PM_s_at

203705_s_at

203706_PM_s_at

203706_s_at

2523044

2523046

2523047

2523048

2523049

2523050

2523051

2523052

2523053

2523054

2523055

2523056

2523057

33222_at

8047487

8324

A_14_P124646

A_14_P137024

A_23_P209449

GE53426

GO:0002376

GO:0004888

GO:0004930

GO:0005109

GO:0005515

GO:0005546

GO:0005768

GO:0005886

GO:0006351

GO:0006355

GO:0007155

GO:0007165

GO:0007166

GO:0007186

GO:0008289

GO:0010008

GO:0010812

GO:0014834

GO:0016020

GO:0016055

GO:0017147

GO:0019827

GO:0023052

GO:0030154

GO:0030165

GO:0030182

GO:0031410

GO:0033077

GO:0034446

GO:0035567

GO:0042060

GO:0042327

GO:0042666

GO:0042813

GO:0043226

GO:0043231

GO:0043410

GO:0045893

GO:0046330

GO:0048103

GO:0048856

GO:0055038

GO:0060054

GO:0060070

GO:0060071

GO:0060089

GO:0060231

GO:0060828

GO:0071300

GO:2000726

HMNXSV003029596

Hs.173859.0.S2_3p_a_at

ILMN_1804351

ILMN_2108823

PH_hs_0010417

TC02001185.hg

g4503832_3p_a_at

Participates

as a member of

as an input of

as a component of

as a candidate of

WNT5A-binding FZDs [plasma membrane] (Homo sapiens)

Inferred To

FZD7 [plasma membrane] (Bos taurus)

FZD7 [plasma membrane] (Canis familiaris)

FZD7 [plasma membrane] (Gallus gallus)

FZD7 [plasma membrane] (Sus scrofa)

fzd7a [plasma membrane] (Danio rerio)

fzd7 [plasma membrane] (Xenopus tropicalis)

fz [plasma membrane] (Drosophila melanogaster)

mom-5 [plasma membrane] (Caenorhabditis elegans)

Fzd7 [plasma membrane] (Mus musculus)

Fzd7 [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_003498.1

Guide to Pharmacology - Targets

235

OpenTargets

ENSG00000155760

HPA

ENSG00000155760-FZD7

GeneCards

O75084

Ensembl

ENST00000286201, ENSP00000286201, ENSG00000155760

PRO

O75084

Pharos - Targets

O75084

HMDB Protein

HMDBP07703

PDB

4Z33, 7EVW, 5T44, 6O3A, 5WBS, 6NE4, 5URV, 6NE2, 6O3B

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.742	5
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.626	4
UniProt:P56703 WNT3	9	N4GlycoAsn-PalmS WNT3 [plasma membrane] (R-HSA-3247830) N4GlycoAsn-PalmS WNT3 [extracellular region] (R-HSA-3247786) N4GlycoAsn-PalmS WNT3 [Golgi lumen] (R-HSA-3247818) N4GlycoAsn-PalmS WNT3 [endoplasmic reticulum lumen] (R-HSA-3238342) N4GlycoAsn-WNT3 [endoplasmic reticulum lumen] (R-HSA-3238227) WNT3 [endoplasmic reticulum lumen] (R-HSA-3238288) N4GlycoAsn-PalmS WNT3 [endocytic vesicle membrane] (R-HSA-3781967) N4GlycoAsn-PalmS WNT3 [extracellular exosome] (R-HSA-3781966) WNT3 [extracellular region] (R-HSA-201676)	0.589	3
UniProt:P37235 HPCL1			0.556	3
UniProt:P62166 NCS1			0.556	5
UniProt:P61601 NCALD	1	NCALD [cytosol] (R-HSA-450887)	0.556	3
UniProt:Q9UHD9 UBQLN2	1	UBQLN2 [cytosol] (R-HSA-8866007)	0.556	3
UniProt:P10620 MGST1	3	MGST1 [azurophil granule membrane] (R-HSA-6799226) MGST1 [plasma membrane] (R-HSA-6806259) MGST1 [endoplasmic reticulum membrane] (R-HSA-158545)	0.556	3
UniProt:Q96Q45-2 TMEM237			0.556	3
UniProt:Q9H2J7 SLC6A15	1	SLC6A15 [plasma membrane] (R-HSA-352060)	0.556	3
UniProt:A8MZ59 LEUTX	1	LEUTX [nucleoplasm] (R-HSA-9817277)	0.556	3
UniProt:Q9BXK5 B2L13			0.556	3
UniProt:O14863 ZNT4			0.556	3
UniProt:O43315 AQP9	1	AQP9 [plasma membrane] (R-HSA-431761)	0.556	3
UniProt:Q96EQ0 SGTB			0.556	3
UniProt:O15552 FFAR2	1	FFAR2 [plasma membrane] (R-HSA-443944)	0.556	3
UniProt:Q9NP94 SLC39A2	1	SLC39A2 [plasma membrane] (R-HSA-442395)	0.556	3
UniProt:O43765 SGTA	1	SGTA [cytosol] (R-HSA-5423595)	0.556	3
UniProt:P04156 PRNP	2	PRNP [cytosol] (R-HSA-9617597) PRNP [plasma membrane] (R-HSA-375060)	0.553	3
UniProt:P11279 LAMP1	3	LAMP1 [azurophil granule membrane] (R-HSA-6799162) LAMP1 [plasma membrane] (R-HSA-6806268) LAMP1 [ficolin-1-rich granule membrane] (R-HSA-6800966)	0.527	3

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