Reactome | CSF2 [extracellular region]

CSF2 [extracellular region]

Stable Identifier

R-HSA-517562

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Granulocyte-macrophage colony-stimulating factor, CSF2_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:P01023 A2M

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External Reference Information

External Reference

UniProt:P04141 CSF2

Gene Names

CSF2, GMCSF

Chain

signal peptide:1-17, chain:18-144

Reference Genes

BioGPS Gene:1437 CSF2

COSMIC (genes):CSF2 CSF2

CTD Gene:1437 CSF2

dbSNP Gene:1437 CSF2

ENSEMBL:ENSG00000164400 CSF2 gene

HGNC:2434 CSF2

KEGG Gene (Homo sapiens):1437 CSF2

Monarch:1437 CSF2

NCBI Gene:1437 CSF2

OMIM:138960 CSF2

UCSC:P04141 CSF2

Reference Transcript

RefSeq:NM_000758.3 CSF2

Other Identifiers

0004230438

11728876_at

1400_at

1401_g_at

1437

16988971

210229_s_at

2828357

2828358

2828359

2828360

2828361

2828362

2828363

8107887

A_23_P133408

GE80952

GO:0000003

GO:0000165

GO:0001821

GO:0001892

GO:0002376

GO:0003674

GO:0005125

GO:0005129

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0006464

GO:0006810

GO:0006950

GO:0006955

GO:0007165

GO:0008083

GO:0008150

GO:0008219

GO:0008283

GO:0008284

GO:0009058

GO:0009790

GO:0010468

GO:0010628

GO:0010744

GO:0019221

GO:0022607

GO:0030099

GO:0030154

GO:0030223

GO:0030224

GO:0030225

GO:0032747

GO:0034021

GO:0034405

GO:0034641

GO:0042045

GO:0042116

GO:0042127

GO:0042531

GO:0043011

GO:0043226

GO:0043231

GO:0045187

GO:0045637

GO:0045892

GO:0048856

GO:0065003

GO:0071222

GO:0071803

GO:0097011

GO:0097028

GO:2001240

HMNXSV003019774

ILMN_1661861

M13207_at

TC05000629.hg

g181149_3p_at

Participates

as a member of

IL10-downregulated extracellular proteins [extracellular region] (Homo sapiens)

as an output of

CSF2 (GM-CSF) gene expression is stimulated by RUNX1 and CREBBP (Homo sapiens)

as an input of

GM-CSF receptor alpha subunit binds GM-CSF (Homo sapiens)

as a component of

GM-CSF:GM-CSF receptor alpha subunit [plasma membrane] (Homo sapiens)

Inferred To

Ghost homologue of CSF2 [extracellular region] (Danio rerio)

Ghost homologue of CSF2 [extracellular region] (Gallus gallus)

Csf2 [extracellular region] (Mus musculus)

Csf2 [extracellular region] (Rattus norvegicus)

CSF2 [extracellular region] (Bos taurus)

CSF2 [extracellular region] (Canis familiaris)

CSF2 [extracellular region] (Sus scrofa)

Cross References

RefSeq

NP_000749.2

OpenTargets

ENSG00000164400

GeneCards

P04141

HPA

ENSG00000164400-CSF2

Ensembl

ENST00000296871, ENSP00000296871, ENSG00000164400

PRO

P04141

Pharos - Targets

P04141

GlyGen

P04141

PDB

4NKQ, 4RS1, 6BFS, 5D70, 5C7X, 5D71, 1CSG, 6BFQ, 2GMF, 5D72

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P50222 MEOX2			0.718	6
UniProt:P01023 A2M	2	A2M [platelet alpha granule lumen] (R-HSA-139834) A2M [extracellular region] (R-HSA-49291)	0.556	3
UniProt:P50570-2 DNM2			0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	15
UniProt:P32927 CSF2RB	6	CSF2RB S271L [plasma membrane] (R-HSA-5688879) p-Y593,Y628-CSF2RB [plasma membrane] (R-HSA-912312) CSF2RB [plasma membrane] (R-HSA-879960) p-S585-CSF2RB [plasma membrane] (R-HSA-914170) p-Y593-CSF2RB [plasma membrane] (R-HSA-914092) CSF2RB R211Efs*54 [plasma membrane] (R-HSA-5688863)	0.524	2