p-S158,221-HuR binds mRNA

Stable Identifier
R-HSA-517674
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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HuR (ELAV1) phosphorylated on serine221 and serine158 binds COX-2 mRNA in the nucleus. The phosphorylation of serine 158 appears to affect RNA-binding while phosphorylation on serine 221 affects nucleocytoplasmic shuffling.

Literature References
PubMed ID Title Journal Year
17392515 Protein kinase C alpha-dependent phosphorylation of the mRNA-stabilizing factor HuR: implications for posttranscriptional regulation of cyclooxygenase-2

Doller, A, Huwiler, A, Müller, R, Radeke, HH, Pfeilschifter, J, Eberhardt, W

Mol Biol Cell 2007
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