Expression of IL-8

Stable Identifier
R-HSA-517731
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, extracellular region
ReviewStatus
5/5
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Expression of IL-8
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The IL-8 gene is transcribed to yield mRNA which is translated to yield protein. KSRP binds an AU-rich element in the mRNA encoding IL-8 and destabilizes the mRNA.
Literature References
PubMed ID Title Journal Year
3260265 Molecular cloning of a human monocyte-derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin 1 and tumor necrosis factor

Kobayashi, Y, Lavu, S, Yoshimura, T, Oppenheim, JJ, Kung, HF, Lew, W, Appella, E, Morishita, K, Leonard, EJ, Matsushima, K

J Exp Med 1988
2664463 Regulation of the mRNA for monocyte-derived neutrophil-activating peptide in differentiating HL60 promyelocytes

Kowalski, J, Denhardt, DT

Mol Cell Biol 1989
2663993 Genomic structure of the human monocyte-derived neutrophil chemotactic factor IL-8

Shiroo, M, Mukaida, N, Matsushima, K

J Immunol 1989
16931790 The unfolded protein response is an important regulator of inflammatory genes in endothelial cells

Gargalovic, PS, Berliner, JA, Lusis, AJ, Kirchgessner, TG, Baruch-Oren, T, Truong, A, He, A, Clark, MJ, Pagnon, J, Gharavi, NM, Yang, WP

Arterioscler Thromb Vasc Biol 2006
16912112 Identification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipids

Lusis, AJ, Kirchgessner, TG, He, A, Patel, S, Clark, MJ, Gharavi, NM, Yang, WP, Nelson, SF, Gargalovic, PS, Imura, M, Berliner, JA, Zhang, B, Truong, A, Horvath, S, Pagnon, J

Proc Natl Acad Sci U S A 2006
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
KSRP:mRNA Degradation Complex [cytosol] (Homo sapiens)
Positively by
Regulator
ATF4 [nucleoplasm] (Homo sapiens)
Authored
May, B  (2010-02-18)
Reviewed
Gillespie, ME  (2008-12-02)
D'Eustachio, P  (2008-12-02)
Matthews, L  (2008-12-02)
Urano, F  (2010-04-30)
Created
May, B  (2010-02-20)
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