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Ub-p-S-CRY2 [nucleoplasm]
Stable Identifier
R-HSA-517935
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
ub-p-CRY2, Ubiquitinated Phosphorylated Cryptochrome-2, CRY2_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Circadian Clock (Homo sapiens)
CRY proteins are ubiquitinylated (Homo sapiens)
ub-p-CRY1,ub-p-CRY2 [nucleoplasm] (Homo sapiens)
Ub-p-S-CRY2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q49AN0 CRY2
Gene Names
CRY2, KIAA0658
Chain
chain:1-593
Reference Genes
BioGPS Gene:1408 CRY2
COSMIC (genes):CRY2 CRY2
CTD Gene:1408 CRY2
dbSNP Gene:1408 CRY2
ENSEMBL:ENSG00000121671 CRY2
ENSEMBL_homo_sapiens_GENE:ENSG00000121671.12 CRY2
HGNC:2385 CRY2
KEGG Gene (Homo sapiens):1408 CRY2
Monarch:1408 CRY2
NCBI Gene:1408 CRY2
OMIM:603732 CRY2
UCSC:Q49AN0 CRY2
Reference Transcript
RefSeq:NM_001127457.2 CRY2
RefSeq:NM_021117.3 CRY2
Other Identifiers
11719310_a_at
11719311_a_at
1408
16724194
212695_PM_at
212695_at
3329037
3329038
3329039
3329041
3329049
3329052
3329054
3329058
3329060
3329061
3329063
3329064
3329065
3329066
3329067
3329068
35852_at
7939595
A_14_P133733
A_23_P127394
A_23_P388027
A_24_P158587
GE53368
GO:0000122
GO:0000166
GO:0000976
GO:0003677
GO:0003684
GO:0003697
GO:0003824
GO:0005515
GO:0005576
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005829
GO:0006351
GO:0006355
GO:0006606
GO:0006886
GO:0006913
GO:0007623
GO:0009416
GO:0009785
GO:0009881
GO:0009882
GO:0014823
GO:0016607
GO:0016829
GO:0016922
GO:0019900
GO:0019901
GO:0019902
GO:0019915
GO:0023052
GO:0032515
GO:0032868
GO:0032922
GO:0036211
GO:0042593
GO:0042752
GO:0042754
GO:0043153
GO:0043226
GO:0045892
GO:0048511
GO:0050886
GO:0050896
GO:0060089
GO:0071949
GO:2000118
GO:2000323
GO:2000850
HMNXSV003017990
Hs.7278.0.S1_3p_at
ILMN_1796180
PH_hs_0000749
TC11000388.hg
Participates
as a member of
ub-p-CRY1,ub-p-CRY2 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
p-S-CRY2 [cytosol]
p-S-CRY2 [nucleoplasm]
CRY2 [cytosol]
Modified Residues
Name
O-phospho-L-serine at unknown position
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
ubiquitinylated lysine (polyubiquitin chain [nucleoplasm]) at unknown position
Modification
polyubiquitin chain [nucleoplasm]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_001120929.1
,
NP_066940.2
OpenTargets
ENSG00000121671
GeneCards
Q49AN0
HPA
ENSG00000121671-CRY2
Ensembl
ENST00000616080
,
ENSG00000121671
,
ENSP00000484684
,
ENST00000417225
,
ENSP00000397419
PRO
Q49AN0
Pharos - Targets
Q49AN0
HMDB Protein
HMDBP08265
Interactors (39)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49674 CSNK1E
2
CSNK1E [nucleoplasm]
(R-HSA-421306)
CSNK1E [cytosol]
(R-HSA-205877)
0.643
5
UniProt:Q3LI67 KRTAP6-3
1
KRTAP6-3 [cytosol]
(R-HSA-6810281)
0.556
3
UniProt:O76083 PDE9A
1
PDE9A [cytosol]
(R-HSA-418533)
0.556
3
UniProt:Q8IUG1 KRTAP1-3
1
KRTAP1-3 [cytosol]
(R-HSA-6809866)
0.556
3
UniProt:P26371 KRTAP5-9
1
KRTAP5-9 [cytosol]
(R-HSA-6810265)
0.556
3
UniProt:Q6L8H4 KRTAP5-1
1
KRTAP5-1 [cytosol]
(R-HSA-6810297)
0.556
3
UniProt:O95544 NADK
1
NADK [cytosol]
(R-HSA-197282)
0.556
3
UniProt:O15344 MID1
1
MID1 [cytosol]
(R-HSA-976027)
0.556
3
UniProt:Q9BYR5 KRTAP4-2
1
KRTAP4-2 [cytosol]
(R-HSA-6809948)
0.556
3
UniProt:Q3LI70 KRTAP19-6
1
KRTAP19-6 [cytosol]
(R-HSA-6810286)
0.556
3
UniProt:P60409 KRTAP10-7
1
KRTAP10-7 [cytosol]
(R-HSA-6810279)
0.556
3
UniProt:Q701N4 KRTAP5-2
1
KRTAP5-2 [cytosol]
(R-HSA-6810291)
0.556
3
UniProt:Q9H190 SDCB2
0.556
3
UniProt:O76083-2 PDE9A
0.556
3
UniProt:Q5JR59-3 MTUS2
0.556
5
UniProt:P60410 KRTAP10-8
1
KRTAP10-8 [cytosol]
(R-HSA-6810301)
0.556
3
UniProt:P0DPK4 NOTCH2NLC
1
NOTCH2NLC [extracellular region]
(R-HSA-9908932)
0.556
3
UniProt:Q07627 KRTAP1-1
1
KRTAP1-1 [cytosol]
(R-HSA-6809855)
0.556
3
UniProt:Q13363-2 CTBP1
0.556
3
UniProt:Q6L8G8 KRTAP5-7
1
KRTAP5-7 [cytosol]
(R-HSA-6810273)
0.556
3
UniProt:Q8WZ60 KLHL6
0.556
5
UniProt:Q2TAL6 VWC2
0.556
3
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.556
3
UniProt:Q13077 TRAF1
3
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.556
3
UniProt:A8MQ03 CRTP1
0.556
3
UniProt:B2RXF5 ZBT42
0.556
3
UniProt:Q9BYQ0 KRTAP9-8
1
KRTAP9-8 [cytosol]
(R-HSA-6809953)
0.556
3
UniProt:Q6A162 KRT40
1
KRT40 [cytosol]
(R-HSA-6809605)
0.556
3
UniProt:P28799 GRN
2
GRN [azurophil granule lumen]
(R-HSA-6799168)
GRN [extracellular region]
(R-HSA-6806217)
0.556
3
UniProt:Q6L8H1 KRTAP5-4
1
KRTAP5-4 [cytosol]
(R-HSA-6810264)
0.556
3
UniProt:Q9H0D6 XRN2
2
XRN2 [nucleoplasm]
(R-HSA-6791205)
XRN2 [cytosol]
(R-HSA-391297)
0.556
3
UniProt:Q12933 TRAF2
5
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.556
3
UniProt:P0C264 SBK3
0.556
3
UniProt:Q5JR59 MTUS2
0.556
3
UniProt:P48730 CSNK1D
3
CSNK1D [nucleoplasm]
(R-HSA-421305)
CSNK1D [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5685717)
CSNK1D [cytosol]
(R-HSA-380315)
0.527
3
UniProt:Q16526 CRY1
4
Ub-p-S-CRY1 [nucleoplasm]
(R-HSA-517931)
CRY1 [cytosol]
(R-HSA-400247)
p-S-CRY1 [nucleoplasm]
(R-HSA-400340)
p-S-CRY1 [cytosol]
(R-HSA-400270)
0.527
3
UniProt:Q9UKT7 FBXL3
2
FBXL3 [nucleoplasm]
(R-HSA-400380)
FBXL3 [cytosol]
(R-HSA-391289)
0.527
4
UniProt:P63208 SKP1
2
SKP1 [nucleoplasm]
(R-HSA-187538)
SKP1 [cytosol]
(R-HSA-174150)
0.527
4
UniProt:P53041 PPP5C
2
PPP5C [cytosol]
(R-HSA-5675402)
PPP5C [nucleoplasm]
(R-HSA-5683410)
0.499
3
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