Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
CFD [extracellular region]
Stable Identifier
R-HSA-51919
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Complement factor D precursor , C3 convertase activator, Properdin factor D, Adipsin
Icon
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Response to elevated platelet cytosolic Ca2+ (Homo sapiens)
Platelet degranulation (Homo sapiens)
Exocytosis of platelet alpha granule contents (Homo sapiens)
Platelet alpha granule contents [extracellular region] (Homo sapiens)
CFD [extracellular region] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Complement cascade (Homo sapiens)
Initial triggering of complement (Homo sapiens)
Alternative complement activation (Homo sapiens)
Factor D cleaves C3(H2O)-bound Factor B (Homo sapiens)
Complement factor D [extracellular region] (Homo sapiens)
CFD [extracellular region] (Homo sapiens)
Factor D cleaves C3b-bound Factor B (Homo sapiens)
Complement factor D [extracellular region] (Homo sapiens)
CFD [extracellular region] (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of ficolin-rich granule lumen proteins (Homo sapiens)
Ficolin-rich granule lumen proteins [extracellular region] (Homo sapiens)
CFD [extracellular region] (Homo sapiens)
Exocytosis of secretory granule lumen proteins (Homo sapiens)
Secretory granule lumen proteins [extracellular region] (Homo sapiens)
CFD [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P00746 CFD
Gene Names
CFD, DF, PFD
Chain
signal peptide:1-20, propeptide:21-25, chain:26-253
Reference Genes
BioGPS Gene:1675 CFD
COSMIC (genes):CFD CFD
CTD Gene:1675 CFD
dbSNP Gene:1675 CFD
ENSEMBL:ENSG00000197766 CFD
HGNC:2771 CFD
KEGG:hsa:1675 CFD
Monarch:1675 CFD
NCBI Gene:1675 CFD
OMIM:134350 CFD
UCSC:P00746 CFD
Reference Transcript
RefSeq:NM_001317335.1 CFD
RefSeq:NM_001928.3 CFD
Other Identifiers
11725980_at
1675
16856299
205382_PM_s_at
205382_s_at
3815244
3815245
3815246
3815247
3815248
3815249
3815251
3815252
3815253
3815254
3815255
3815257
40282_s_at
8024062
A_14_P124724
A_23_P119562
GE81088
GO:0002376
GO:0003824
GO:0004252
GO:0005576
GO:0005615
GO:0006508
GO:0006956
GO:0006957
GO:0008236
GO:0009617
GO:0016787
GO:0031093
GO:0034774
GO:0043226
GO:0070062
GO:0098542
GO:0140096
GO:1904813
HMNXSV003001420
ILMN_1777190
M84526_at
PH_hs_0029251
TC19000020.hg
g4503308_3p_at
Participates
as a member of
Platelet alpha granule contents [extracellular region] (Homo sapiens)
Ficolin-rich granule lumen proteins [extracellular region] (Homo sapiens)
Secretory granule lumen proteins [extracellular region] (Homo sapiens)
Complement factor D [extracellular region] (Homo sapiens)
Other forms of this molecule
CFD [secretory granule lumen]
CFD [ficolin-1-rich granule lumen]
CFD [platelet alpha granule lumen]
Inferred To
CFD [extracellular region]
(Bos taurus)
CFD [extracellular region]
(Canis familiaris)
CFD [extracellular region]
(Gallus gallus)
CFD [extracellular region]
(Sus scrofa)
Cfd [extracellular region]
(Mus musculus)
Cfd [extracellular region]
(Rattus norvegicus)
ami [extracellular region]
(Xenopus tropicalis)
cfd [extracellular region]
(Danio rerio)
Cross References
RefSeq
NP_001919.2
,
NP_001304264.1
Guide to Pharmacology - Targets
2842
OpenTargets
ENSG00000197766
ENSEMBL
ENSP00000478745
,
ENST00000327726
,
ENST00000617994
,
ENSP00000332139
HPA
ENSG00000197766-CFD
ZINC - Substances
CFAD_HUMAN
ZINC target
P00746
PRO
P00746
Pharos - Targets
P00746
Orphanet
CFD
ZINC - Predictions - Purchasable
CFAD_HUMAN
PDB
4CBN
,
6FTZ
,
4CBO
,
1DIC
,
5TCA
,
1DST
,
1DSU
,
5TCC
,
5MT4
,
5FCK
,
5MT0
,
6FTY
,
8DG6
,
8D95
,
5NAR
,
8DEA
,
6FUG
,
6FUH
,
2XWA
,
2XW9
,
6VMJ
,
6FUT
,
5NB7
,
1FDP
,
6VMK
,
6QMT
,
4D9R
,
1HFD
,
2XWB
,
1BIO
,
5FBI
,
5NB6
,
1DFP
,
5NAT
,
6FUI
,
6FUJ
,
5NBA
,
5FBE
,
5NAW
,
6QMR
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text