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pT5-WDR77 [nucleoplasm]
Stable Identifier
R-HSA-5205602
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
pT5-MEP50
Locations in the PathwayBrowser
Expand all
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
RMTs methylate histone arginines (Homo sapiens)
CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Homo sapiens)
CCND1:CDK4:PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
pT5-WDR77 [nucleoplasm] (Homo sapiens)
SWI/SNF chromatin remodelling complex:PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
pT5-WDR77 [nucleoplasm] (Homo sapiens)
CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Homo sapiens)
CCND1:CDK4:PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
pT5-WDR77 [nucleoplasm] (Homo sapiens)
CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Homo sapiens)
CCND1:CDK4:PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
pT5-WDR77 [nucleoplasm] (Homo sapiens)
COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 (Homo sapiens)
CCND1:CDK4:PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
pT5-WDR77 [nucleoplasm] (Homo sapiens)
CCND1:CDK4:PRMT5:pT5-WDR77:COPRS [nucleoplasm] (Homo sapiens)
CCND1:CDK4:PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
pT5-WDR77 [nucleoplasm] (Homo sapiens)
COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Homo sapiens)
CCND1:CDK4:PRMT5:pT5-WDR77:COPRS [nucleoplasm] (Homo sapiens)
CCND1:CDK4:PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
pT5-WDR77 [nucleoplasm] (Homo sapiens)
SWI/SNF chromatin remodelling complex:PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
pT5-WDR77 [nucleoplasm] (Homo sapiens)
PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Homo sapiens)
PRMT5:pT5-WDR77, PRMT7 [nucleoplasm] (Homo sapiens)
PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
pT5-WDR77 [nucleoplasm] (Homo sapiens)
PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) (Homo sapiens)
CCND1:CDK4:PRMT5:pT5-WDR77:COPRS [nucleoplasm] (Homo sapiens)
CCND1:CDK4:PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
pT5-WDR77 [nucleoplasm] (Homo sapiens)
SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Homo sapiens)
PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
pT5-WDR77 [nucleoplasm] (Homo sapiens)
SWI/SNF chromatin remodelling complex:PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
pT5-WDR77 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BQA1 WDR77
Gene Names
WDR77, MEP50, WD45, HKMT1069, Nbla10071
Chain
chain:1-342
Reference Genes
BioGPS Gene:79084 WDR77
COSMIC (genes):WDR77 WDR77
CTD Gene:79084 WDR77
dbSNP Gene:79084 WDR77
ENSEMBL:ENSG00000116455 WDR77
HGNC:29652 WDR77
KEGG Gene (Homo sapiens):79084 WDR77
Monarch:79084 WDR77
NCBI Gene:79084 WDR77
OMIM:611734 WDR77
UCSC:Q9BQA1 WDR77
Reference Transcript
RefSeq:NM_001317063.1 WDR77
RefSeq:NM_024102.3 WDR77
RefSeq:NM_001317064.1 WDR77
RefSeq:NM_001317062.1 WDR77
Other Identifiers
0004230504
11716081_a_at
11716082_s_at
11749299_a_at
11749300_x_at
11751686_a_at
16690843
201420_s_at
201421_s_at
2427932
2427933
2427934
2427935
2427936
2427937
2427938
2427939
2427940
2427941
2427942
2427943
2427944
2427945
2427946
2427951
2427955
2427956
2427957
2427958
2427960
2427962
2427965
2427967
2427968
2967689
38987_at
64494_at
79084
7918517
A_23_P115149
GE80209
GO:0000003
GO:0000387
GO:0003674
GO:0003677
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005794
GO:0005829
GO:0006357
GO:0006397
GO:0007315
GO:0008150
GO:0008283
GO:0008284
GO:0008285
GO:0008327
GO:0009058
GO:0009790
GO:0021700
GO:0022607
GO:0022618
GO:0030154
GO:0030374
GO:0032991
GO:0034641
GO:0034709
GO:0043226
GO:0045495
GO:0045893
GO:0048856
GO:0060528
GO:0060770
GO:0065003
HMNXSV003028784
HMNXSV003050437
Hs.11039.0.S1_3p_s_at
ILMN_1655358
ILMN_1742889
PH_hs_0026108
TC01002985.hg
g13129109_3p_s_at
Participates
as a component of
PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
WDR77 [cytosol]
WDR77 [nucleoplasm]
Inferred To
phospho-WDR77 [nucleoplasm]
(Canis familiaris)
phospho-WDR77 [nucleoplasm]
(Sus scrofa)
phospho-pT5-WDR77 [nucleoplasm]
(Danio rerio)
Ghost homologue of pT5-WDR77 [nucleoplasm]
(Saccharomyces cerevisiae)
phospho-vls [nucleoplasm]
(Drosophila melanogaster)
phospho-Wdr77 [nucleoplasm]
(Mus musculus)
phospho-Wdr77 [nucleoplasm]
(Rattus norvegicus)
Modified Residues
Name
O-phospho-L-threonine at 5
Coordinate
5
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_001303993.1
,
NP_001303992.1
,
NP_001303991.1
,
NP_077007.1
OpenTargets
ENSG00000116455
GeneCards
Q9BQA1
HPA
ENSG00000116455-WDR77
Ensembl
ENSG00000116455
,
ENSP00000235090
,
ENST00000235090
PRO
Q9BQA1
PDB
4X63
,
6V0O
,
6RLL
,
6RLQ
,
5EMK
,
5EML
,
6K1S
,
5FA5
,
4X60
,
4GQB
,
6UXX
,
6UXY
,
6CKC
,
5EMM
,
5C9Z
,
5EMJ
,
4X61
,
6V0N
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O14744 PRMT5
3
p-Y297,304,307-PRMT5 [nucleoplasm]
(R-HSA-5211300)
PRMT5 [cytosol]
(R-HSA-191876)
PRMT5 [nucleoplasm]
(R-HSA-5205609)
0.96
17
UniProt:P03418 NCAP
0.576
3
UniProt:P80318
1
Cct3 [cytosol]
(R-MMU-390463)
0.564
2
UniProt:P62826 RAN
2
RAN [cytosol]
(R-HSA-165540)
RAN [nucleoplasm]
(R-HSA-165528)
0.556
3
UniProt:O60333-2 KIF1B
0.556
3
UniProt:P55212 CASP6
5
CASP6(24-179) [nucleoplasm]
(R-HSA-352247)
CASP6(194-293) [nucleoplasm]
(R-HSA-352246)
CASP6(24-179) [cytosol]
(R-HSA-350313)
CASP6(194-293) [cytosol]
(R-HSA-266128)
CASP6 (1-293) [cytosol]
(R-HSA-6798132)
0.556
3
UniProt:Q9Y3C5 RNF11
0.556
3
UniProt:P13473-2 P134732
0.556
3
UniProt:P04792 HSPB1
3
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
HSPB1 [cytosol]
(R-HSA-450563)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.556
3
UniProt:O76024 WFS1
3
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:P54105 CLNS1A
1
CLNS1A [cytosol]
(R-HSA-191796)
0.527
2
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