Reactome | pT5-WDR77 [nucleoplasm]

pT5-WDR77 [nucleoplasm]

Stable Identifier

R-HSA-5205602

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

pT5-MEP50

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9BQA1 WDR77

Gene Names

WDR77, MEP50, WD45, HKMT1069, Nbla10071

Chain

chain:1-342

Reference Genes

BioGPS Gene:79084 WDR77

COSMIC (genes):WDR77 WDR77

CTD Gene:79084 WDR77

dbSNP Gene:79084 WDR77

ENSEMBL:ENSG00000116455 WDR77

HGNC:29652 WDR77

KEGG Gene (Homo sapiens):79084 WDR77

Monarch:79084 WDR77

NCBI Gene:79084 WDR77

OMIM:611734 WDR77

UCSC:Q9BQA1 WDR77

Reference Transcript

Other Identifiers

0004230504

11716081_a_at

11716082_s_at

11749299_a_at

11749300_x_at

11751686_a_at

16690843

201420_s_at

201421_s_at

2427932

2427933

2427934

2427935

2427936

2427937

2427938

2427939

2427940

2427941

2427942

2427943

2427944

2427945

2427946

2427951

2427955

2427956

2427957

2427958

2427960

2427962

2427965

2427967

2427968

2967689

38987_at

64494_at

79084

7918517

A_23_P115149

GE80209

GO:0000003

GO:0000387

GO:0003674

GO:0003677

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005794

GO:0005829

GO:0006357

GO:0006397

GO:0007315

GO:0008150

GO:0008283

GO:0008284

GO:0008285

GO:0008327

GO:0009058

GO:0009790

GO:0021700

GO:0022607

GO:0022618

GO:0030154

GO:0030374

GO:0032991

GO:0034641

GO:0034709

GO:0043226

GO:0045495

GO:0045893

GO:0048856

GO:0060528

GO:0060770

GO:0065003

HMNXSV003028784

HMNXSV003050437

Hs.11039.0.S1_3p_s_at

ILMN_1655358

ILMN_1742889

PH_hs_0026108

TC01002985.hg

g13129109_3p_s_at

Participates

as a component of

PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

WDR77 [cytosol]

WDR77 [nucleoplasm]

Inferred To

phospho-WDR77 [nucleoplasm] (Canis familiaris)

phospho-WDR77 [nucleoplasm] (Sus scrofa)

phospho-pT5-WDR77 [nucleoplasm] (Danio rerio)

Ghost homologue of pT5-WDR77 [nucleoplasm] (Saccharomyces cerevisiae)

phospho-vls [nucleoplasm] (Drosophila melanogaster)

phospho-Wdr77 [nucleoplasm] (Mus musculus)

phospho-Wdr77 [nucleoplasm] (Rattus norvegicus)

Modified Residues

Name

O-phospho-L-threonine at 5

Coordinate

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_001303993.1, NP_001303992.1, NP_001303991.1, NP_077007.1

OpenTargets

ENSG00000116455

GeneCards

Q9BQA1

HPA

ENSG00000116455-WDR77

Ensembl

ENSG00000116455, ENSP00000235090, ENST00000235090

PRO

Q9BQA1

PDB

4X63, 6V0O, 6RLL, 6RLQ, 5EMK, 5EML, 6K1S, 5FA5, 4X60, 4GQB, 6UXX, 6UXY, 6CKC, 5EMM, 5C9Z, 5EMJ, 4X61, 6V0N

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14744 PRMT5	3	p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300) PRMT5 [cytosol] (R-HSA-191876) PRMT5 [nucleoplasm] (R-HSA-5205609)	0.96	17
UniProt:P03418 NCAP			0.576	3
UniProt:P80318	1	Cct3 [cytosol] (R-MMU-390463)	0.564	2
UniProt:P62826 RAN	2	RAN [cytosol] (R-HSA-165540) RAN [nucleoplasm] (R-HSA-165528)	0.556	3
UniProt:O60333-2 KIF1B			0.556	3
UniProt:P55212 CASP6	5	CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(194-293) [cytosol] (R-HSA-266128) CASP6 (1-293) [cytosol] (R-HSA-6798132)	0.556	3
UniProt:Q9Y3C5 RNF11			0.556	3
UniProt:P13473-2 P134732			0.556	3
UniProt:P04792 HSPB1	3	p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) HSPB1 [cytosol] (R-HSA-450563) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:O76024 WFS1	3	p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P54105 CLNS1A	1	CLNS1A [cytosol] (R-HSA-191796)	0.527	2