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PRMT5 [nucleoplasm]
Stable Identifier
R-HSA-5205609
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
JBP1
Icon
Locations in the PathwayBrowser
Expand all
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
RMTs methylate histone arginines (Homo sapiens)
CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8) (Homo sapiens)
CCND1:CDK4:PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
PRMT5 [nucleoplasm] (Homo sapiens)
PRMT5 [nucleoplasm] (Homo sapiens)
SWI/SNF chromatin remodelling complex:PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
PRMT5 [nucleoplasm] (Homo sapiens)
CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3 (Homo sapiens)
CCND1:CDK4:PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
PRMT5 [nucleoplasm] (Homo sapiens)
PRMT5 [nucleoplasm] (Homo sapiens)
CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77 (Homo sapiens)
CCND1:CDK4:PRMT5:WDR77 [nucleoplasm] (Homo sapiens)
PRMT5:WDR77 [nucleoplasm] (Homo sapiens)
PRMT5 [nucleoplasm] (Homo sapiens)
CCND1:CDK4:PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
PRMT5 [nucleoplasm] (Homo sapiens)
COPRS binds CCND1:CDK4:PRMT5:pT5-WDR77 (Homo sapiens)
CCND1:CDK4:PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
PRMT5 [nucleoplasm] (Homo sapiens)
CCND1:CDK4:PRMT5:pT5-WDR77:COPRS [nucleoplasm] (Homo sapiens)
CCND1:CDK4:PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
PRMT5 [nucleoplasm] (Homo sapiens)
COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3) (Homo sapiens)
CCND1:CDK4:PRMT5:pT5-WDR77:COPRS [nucleoplasm] (Homo sapiens)
CCND1:CDK4:PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
PRMT5 [nucleoplasm] (Homo sapiens)
PRMT5 [nucleoplasm] (Homo sapiens)
SWI/SNF chromatin remodelling complex:PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
PRMT5 [nucleoplasm] (Homo sapiens)
PRMT5 binds WDR77 (Homo sapiens)
PRMT5 [nucleoplasm] (Homo sapiens)
PRMT5:WDR77 [nucleoplasm] (Homo sapiens)
PRMT5 [nucleoplasm] (Homo sapiens)
PRMT5 is tyrosine phosphorylated by JAK2 V617F (Homo sapiens)
PRMT5 [nucleoplasm] (Homo sapiens)
PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2) (Homo sapiens)
PRMT5:pT5-WDR77, PRMT7 [nucleoplasm] (Homo sapiens)
PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
PRMT5 [nucleoplasm] (Homo sapiens)
PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3) (Homo sapiens)
CCND1:CDK4:PRMT5:pT5-WDR77:COPRS [nucleoplasm] (Homo sapiens)
CCND1:CDK4:PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
PRMT5 [nucleoplasm] (Homo sapiens)
PRMT5 [nucleoplasm] (Homo sapiens)
SWI/SNF chromatin remodelling complex enhances MEP50:PRMT5 methyltransferase activity (Homo sapiens)
PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
PRMT5 [nucleoplasm] (Homo sapiens)
SWI/SNF chromatin remodelling complex:PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
PRMT5:pT5-WDR77 [nucleoplasm] (Homo sapiens)
PRMT5 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Activity through Methylation (Homo sapiens)
PRMT5 binds TTC5 (Homo sapiens)
PRMT5 [nucleoplasm] (Homo sapiens)
p-S15,S20-TP53 Tetramer:p-S203,S221-TTC5:EP300:JMY:PRMT5 [nucleoplasm] (Homo sapiens)
PRMT5 [nucleoplasm] (Homo sapiens)
PRMT5 methylates TP53 (Homo sapiens)
PRMT5 [nucleoplasm] (Homo sapiens)
p-S15,S20,Me-R333,Me2-R335,R337-TP53 Tetramer:p-S203,S221-TTC5:EP300:JMY:PRMT5 [nucleoplasm] (Homo sapiens)
PRMT5 [nucleoplasm] (Homo sapiens)
p-S15,S20-TP53 Tetramer:p-S203,S221-TTC5:EP300:JMY:PRMT5 [nucleoplasm] (Homo sapiens)
PRMT5 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14744 PRMT5
Gene Names
PRMT5, HRMT1L5, IBP72, JBP1, SKB1
Chain
initiator methionine:1, chain:1-637, chain:2-637
Reference Genes
BioGPS Gene:10419 PRMT5
COSMIC (genes):PRMT5 PRMT5
CTD Gene:10419 PRMT5
dbSNP Gene:10419 PRMT5
ENSEMBL:ENSG00000100462 PRMT5
ENSEMBL_homo_sapiens_GENE:ENSG00000100462 PRMT5
HGNC:10894 PRMT5
KEGG Gene (Homo sapiens):10419 PRMT5
Monarch:10419 PRMT5
NCBI Gene:10419 PRMT5
OMIM:604045 PRMT5
UCSC:O14744 PRMT5
Reference Transcript
RefSeq:NM_001039619.2 PRMT5
RefSeq:NM_001282956.1 PRMT5
RefSeq:NM_006109.4 PRMT5
RefSeq:NM_001282953.1 PRMT5
RefSeq:NM_001282955.1 PRMT5
Other Identifiers
0001570253
10419
11755951_s_at
12459
1564520_s_at
1564521_x_at
16790556
217786_at
3556925
3556926
3556927
3556928
3556929
3556931
3556934
3556935
3556937
3556938
3556939
3556940
3556941
3556942
3556943
3556945
3556946
3556948
3556950
3556952
3556953
3556954
3556955
3556956
3556957
3556958
3556959
3556960
4GQB
4X60
4X61
4X63
5525
56550_at
57340_s_at
5C9Z
5EMJ
5EMK
5EML
5EMM
5FA5
64708
6CKC
7977820
A_23_P76851
A_24_P298420
AAB66581
AAF04502
AAH25979
AB451246
AB451370
AF015913
AF015913_at
AF167572
AK075251
AK301812
AK302240
AL132780
BAG52095
BAG63261
BAG63592
BAG70060
BAG70184
BC005820
BC025979
C9JSX3
CAB012459
CAG33022
CCDS41922
CCDS61394
CCDS61395
CCDS61396
CCDS9579
CH471078
CR456741
EAW66218
EAW66219
EAW66220
EAW66221
ENSG00000100462
ENSP00000216350
ENSP00000319169
ENSP00000380582
ENSP00000380583
ENSP00000452555
ENST00000216350
ENST00000324366
ENST00000397440
ENST00000397441
ENST00000553897
EntrezGene:10419
G3V2F5
G3V2L6
G3V2X6
G3V3A3
G3V580
G3V5L5
G3V5T6
g5174682_3p_at
g5174682_3p_s_at
GE61958
GO:0000278
GO:0000387
GO:0000988
GO:0003674
GO:0003677
GO:0003714
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005737
GO:0005794
GO:0005829
GO:0006259
GO:0006325
GO:0006353
GO:0006397
GO:0006464
GO:0006479
GO:0007049
GO:0007088
GO:0007165
GO:0008150
GO:0008168
GO:0008283
GO:0008327
GO:0008469
GO:0009058
GO:0016274
GO:0016740
GO:0018216
GO:0019918
GO:0022607
GO:0022618
GO:0030154
GO:0032259
GO:0032922
GO:0032991
GO:0034641
GO:0034709
GO:0034969
GO:0035097
GO:0035243
GO:0035246
GO:0042118
GO:0042802
GO:0043021
GO:0043226
GO:0043985
GO:0044020
GO:0044030
GO:0044877
GO:0045596
GO:0046982
GO:0048511
GO:0048714
GO:0048856
GO:0051276
GO:0065003
GO:0070372
GO:0070888
GO:0090161
GO:0097421
GO:0140014
GO:1901796
GO:1903507
GO:1904992
H0YJ77
H0YJD3
H0YJX6
HGNC:10894
HPA005525
HPA064708
ILMN_1811955
ILMN_2403889
IPR007857
IPR025799
IPR029063
IPR035075
IPR035247
IPR035248
MIM:604045
NM_001039619
NM_001282953
NM_001282954
NM_001282955
NM_001282956
NM_006109
NP_001034708
NP_001269882
NP_001269883
NP_001269884
NP_001269885
NP_006100
PF05185
PF17285
PF17286
PH_hs_0017523
PRMT5
PRMT5-201
PRMT5-202
PRMT5-203
PRMT5-204
PRMT5-213
TC14000940.hg
uc001whl.3
uc001whm.2
uc001whn.3
uc010tng.3
uc010tnh.3
UPI000006F09F
UPI0000141374
UPI000015D937
UPI00017A82EE
UPI0001AE6957
XM_017020927
XR_001750113
XR_001750114
XR_429287
Participant Of
input
PRMT5 binds TTC5
PRMT5 binds WDR77
PRMT5 is tyrosine phosphorylated by JAK2 V617F
hasComponent
p-S15,S20,Me-R333,Me2-R335,R337-TP53 Tetramer:p-S203,S221-TTC5:EP300:JMY:PRMT5 [nucleoplasm]
p-S15,S20-TP53 Tetramer:p-S203,S221-TTC5:EP300:JMY:PRMT5 [nucleoplasm]
PRMT5:pT5-WDR77 [nucleoplasm]
PRMT5:WDR77 [nucleoplasm]
Other forms of this molecule
PRMT5 [cytosol]
p-Y297,304,307-PRMT5 [nucleoplasm]
Inferred To
Homologues of PRMT5 [nucleoplasm] (Mus musculus)
Homologues of PRMT5 [nucleoplasm] (Sus scrofa)
PRMT5 [nucleoplasm] (Arabidopsis thaliana)
PRMT5 [nucleoplasm] (Bos taurus)
PRMT5 [nucleoplasm] (Caenorhabditis elegans)
PRMT5 [nucleoplasm] (Canis familiaris)
PRMT5 [nucleoplasm] (Danio rerio)
PRMT5 [nucleoplasm] (Dictyostelium discoideum)
PRMT5 [nucleoplasm] (Drosophila melanogaster)
PRMT5 [nucleoplasm] (Mus musculus)
PRMT5 [nucleoplasm] (Oryza sativa)
PRMT5 [nucleoplasm] (Plasmodium falciparum)
PRMT5 [nucleoplasm] (Rattus norvegicus)
PRMT5 [nucleoplasm] (Saccharomyces cerevisiae)
PRMT5 [nucleoplasm] (Schizosaccharomyces pombe)
PRMT5 [nucleoplasm] (Sus scrofa)
PRMT5 [nucleoplasm] (Xenopus tropicalis)
Cross References
RefSeq
NP_001269882.1
,
NP_001269884.1
,
NP_001034708.1
,
NP_001269885.1
,
NP_006100.2
OpenTargets
ENSG00000100462
ZINC - Substances
ANM5_HUMAN
GeneCards
O14744
DOCK Blaster
5FA5
,
4X60
,
4GQB
,
4X63
,
5EML
,
4X61
,
5EMJ
,
5C9Z
,
5EMK
,
5EMM
ZINC target
O14744
PRO
O14744
BRENDA (Homo sapiens)
2.1.1.320
ZINC - Predictions - Purchasable
ANM5_HUMAN
HMDB Protein
HMDBP01721
PDB
5EML
,
5EMM
,
4X61
,
5EMJ
,
5C9Z
,
4X63
,
5EMK
,
4GQB
,
5FA5
,
6CKC
,
4X60
Interactors (37)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BQA1 WDR77
3
pT5-WDR77 [nucleoplasm]
(R-HSA-5205602)
WDR77 [cytosol]
(R-HSA-191823)
WDR77 [nucleoplasm]
(R-HSA-5205610)
0.96
17
UniProt:P54105 CLNS1A
1
CLNS1A [cytosol]
(R-HSA-191796)
0.777
8
UniProt:P62805 HIST1H4A
19
SUMO3-HIST1H4 [nucleoplasm]
(R-HSA-4570531)
HIST1H4A [extracellular region]
(R-HSA-977569)
SUMO1-HIST1H4 [nucleoplasm]
(R-HSA-4570518)
4xAcK-HIST1H4A [nucleoplasm]
(R-HSA-427390)
AcK5,12-HIST1H4A [nucleoplasm]
(R-HSA-212078)
AcK17-HIST1H4 [nucleoplasm]
(R-HSA-427469)
AcK13-HIST1H4 [nucleoplasm]
(R-HSA-4568744)
AcK6-HIST1H4 [nucleoplasm]
(R-HSA-4568748)
AcK17-HIST1H4 [nucleoplasm]
(R-HSA-4568749)
AcK9-HIST1H4 [nucleoplasm]
(R-HSA-4568758)
Me2aR4-HIST1H4 [nucleoplasm]
(R-HSA-5229015)
Me2sR4-HIST1H4 [nucleoplasm]
(R-HSA-4754243)
MeR4-HIST1H4 [nucleoplasm]
(R-HSA-4754240)
Me3K21-HIST1H4 [nucleoplasm]
(R-HSA-5651656)
MeK21-HIST1H4 [nucleoplasm]
(R-HSA-5423110)
AcK-HIST1H4 [nucleoplasm]
(R-HSA-3451124)
MeK-HIST1H4A [nucleoplasm]
(R-HSA-2172676)
HIST1H4 [nucleoplasm]
(R-HSA-181902)
Me2K21-HIST1H4 [nucleoplasm]
(R-HSA-5651652)
0.756
6
UniProt:O14744 PRMT5
3
p-Y297,304,307-PRMT5 [nucleoplasm]
(R-HSA-5211300)
PRMT5 [cytosol]
(R-HSA-191876)
PRMT5 [nucleoplasm]
(R-HSA-5205609)
0.693
3
UniProt:Q01094 E2F1
2
p-E2F1 [nucleoplasm]
(R-HSA-187911)
E2F1 [nucleoplasm]
(R-HSA-68639)
0.646
8
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.646
3
UniProt:Q86U06 RBM23
0.635
3
UniProt:Q91XC0 Ajuba
3
phospho-p-S-AJUBA [cytosol]
(R-MMU-2574841)
Ajuba [nucleoplasm]
(R-MMU-5687969)
AJUBA [cytosol]
(R-MMU-2564698)
0.623
4
UniProt:Q9NQ92 COPRS
1
COPRS [nucleoplasm]
(R-HSA-5212681)
0.616
6
UniProt:O75044 SRGAP2
1
SRGAP2 [cytosol]
(R-HSA-195131)
0.611
4
UniProt:Q9Y6K1 DNMT3A
2
DNMT3A [nucleoplasm]
(R-HSA-212287)
SUMO1-K-DNMT3A [nucleoplasm]
(R-HSA-4655415)
0.602
4
UniProt:Q9Y5B0 CTDP1
1
CTDP1 [nucleoplasm]
(R-HSA-113416)
0.591
3
UniProt:P24928 POLR2A
7
p-S5,S7-POLR2A [nucleoplasm]
(R-HSA-6810226)
p-S2,S7-POLR2A [nucleoplasm]
(R-HSA-6814543)
Ub,p-S2,S5-POLR2A [nucleoplasm]
(R-HSA-6781855)
p-3S-POLR2A [nucleoplasm]
(R-HSA-6797701)
p-S2,S5-POLR2A [nucleoplasm]
(R-HSA-113420)
p-S5-POLR2A [nucleoplasm]
(R-HSA-77100)
POLR2A [nucleoplasm]
(R-HSA-63502)
0.558
6
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:Q92731 ESR2
2
ESR2 [cytosol]
(R-HSA-9020970)
ESR2 [nucleoplasm]
(R-HSA-446165)
0.527
3
UniProt:Q86UQ8-1 NFE4
0.525
2
UniProt:P31269 HXA9
0.524
4
UniProt:Q9BX10 GTPBP2
2
GTPBP2 [platelet alpha granule lumen]
(R-HSA-8862960)
GTPBP2 [extracellular region]
(R-HSA-8863001)
0.508
2
UniProt:Q8WVJ2 NUDC2
0.508
2
UniProt:Q96RU7 TRIB3
2
TRIB3 [cytosol]
(R-HSA-162411)
TRIB3 [plasma membrane]
(R-HSA-199447)
0.508
2
UniProt:Q8TE85 GRHL3
0.508
2
UniProt:Q8N8U2 CDYL2
0.508
2
UniProt:Q9BRS2 RIOK1
2
RIOK1 [nucleoplasm]
(R-HSA-5226890)
RIOK1 [cytosol]
(R-HSA-6791525)
0.499
4
UniProt:P03418 NCAP
0.499
2
UniProt:Q9NX04 CA109
0.488
2
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.488
2
UniProt:O15197-2 EPHB6
0.488
2
UniProt:Q14241 ELOA
1
TCEB3 [nucleoplasm]
(R-HSA-112421)
0.488
2
UniProt:Q63ZY3 KANK2
0.488
2
UniProt:Q8TBB1 LNX1
1
LNX1 [cytosol]
(R-HSA-8851641)
0.488
2
UniProt:Q96E35 ZMY19
0.488
2
UniProt:Q08289 CACNB2
2
CACNB2 [plasma membrane]
(R-HSA-532200)
CACNB2 [cytosol]
(R-HSA-210496)
0.488
2
UniProt:Q96HA8 NTAQ1
0.488
2
UniProt:P38919 EIF4A3
2
EIF4A3 [nucleoplasm]
(R-HSA-8849149)
EIF4A3 [cytosol]
(R-HSA-927868)
0.488
2
UniProt:O95995 GAS8
1
GAS8 [cytosol]
(R-HSA-5633057)
0.488
2
UniProt:Q16637 SMN1
2
SMN1 [cytosol]
(R-HSA-191839)
SMN1 [nucleoplasm]
(R-HSA-191892)
0.462
2
UniProt:P12755 SKI
1
SKI [nucleoplasm]
(R-HSA-173473)
0.462
3
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