Reactome | PRMT5 [nucleoplasm]

PRMT5 [nucleoplasm]

Stable Identifier

R-HSA-5205609

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

JBP1

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O14744 PRMT5

Gene Names

PRMT5, HRMT1L5, IBP72, JBP1, SKB1

Chain

initiator methionine:1, chain:1-637, chain:2-637

Reference Genes

BioGPS Gene:10419 PRMT5

COSMIC (genes):PRMT5 PRMT5

CTD Gene:10419 PRMT5

dbSNP Gene:10419 PRMT5

ENSEMBL:ENSG00000100462 PRMT5

HGNC:10894 PRMT5

KEGG Gene (Homo sapiens):10419 PRMT5

Monarch:10419 PRMT5

NCBI Gene:10419 PRMT5

OMIM:604045 PRMT5

UCSC:O14744 PRMT5

Reference Transcript

Other Identifiers

0001570253

10419

11755951_s_at

1564520_s_at

1564521_x_at

16790556

217786_at

3556925

3556926

3556927

3556928

3556929

3556931

3556934

3556935

3556937

3556938

3556939

3556940

3556941

3556942

3556943

3556945

3556946

3556948

3556950

3556952

3556953

3556954

3556955

3556956

3556957

3556958

3556959

3556960

56550_at

57340_s_at

7977820

AF015913_at

A_23_P76851

A_24_P298420

GE61958

GO:0000278

GO:0000387

GO:0002039

GO:0003674

GO:0003677

GO:0003714

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005794

GO:0005829

GO:0006259

GO:0006325

GO:0006353

GO:0006355

GO:0006397

GO:0006464

GO:0006479

GO:0007049

GO:0007088

GO:0007165

GO:0008150

GO:0008168

GO:0008327

GO:0008469

GO:0009058

GO:0016274

GO:0016740

GO:0018216

GO:0019918

GO:0022607

GO:0022618

GO:0030154

GO:0032259

GO:0032922

GO:0032991

GO:0034641

GO:0034709

GO:0034969

GO:0035097

GO:0035243

GO:0035246

GO:0042118

GO:0042802

GO:0043021

GO:0043226

GO:0043985

GO:0044020

GO:0044030

GO:0044877

GO:0045596

GO:0046982

GO:0048511

GO:0048714

GO:0048856

GO:0051276

GO:0065003

GO:0070372

GO:0070888

GO:0090161

GO:0097421

GO:0140014

GO:1901796

GO:1903507

GO:1904992

ILMN_1811955

ILMN_2403889

PH_hs_0017523

TC14000940.hg

g5174682_3p_at

g5174682_3p_s_at

Participant Of

input

hasComponent

Other forms of this molecule

PRMT5 [cytosol]

p-Y297,304,307-PRMT5 [nucleoplasm]

Inferred To

csul [nucleoplasm] (Drosophila melanogaster)

hspa9 [nucleoplasm] (Xenopus tropicalis)

HSL7 [nucleoplasm] (Saccharomyces cerevisiae)

Prmt5 [nucleoplasm] (Mus musculus)

Prmt5 [nucleoplasm] (Rattus norvegicus)

prmt-5 [nucleoplasm] (Caenorhabditis elegans)

skb1 [nucleoplasm] (Schizosaccharomyces pombe)

PRMT5 [nucleoplasm] (Canis familiaris)

PRMT5 [nucleoplasm] (Plasmodium falciparum)

PRMT5 [nucleoplasm] (Sus scrofa)

prmt5 [nucleoplasm] (Danio rerio)

prmt5 [nucleoplasm] (Dictyostelium discoideum)

Cross References

RefSeq

NP_001269882.1, NP_001269885.1, NP_001034708.1, NP_006100.2, NP_001269884.1

OpenTargets

ENSG00000100462

IntEnz

2.1.1.320

HPA

ENSG00000100462-PRMT5

GeneCards

O14744

ZINC - Substances

ANM5_HUMAN

ZINC target

O14744

Ensembl

ENST00000397440, ENSP00000216350, ENSG00000100462, ENST00000397441, ENSP00000380583, ENST00000324366, ENSP00000380582, ENST00000553897, ENSP00000452555, ENST00000216350, ENSP00000319169

PRO

O14744

ZINC - Predictions - Purchasable

ANM5_HUMAN

HMDB Protein

HMDBP01721

PDB

6K1S, 5C9Z, 5EMJ, 5FA5, 4X63, 5EML, 6RLL, 5EMK, 4X61, 4GQB, 6CKC, 5EMM, 4X60, 6RLQ

Interactors (50)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BQA1 WDR77	3	WDR77 [nucleoplasm] (R-HSA-5205610) pT5-WDR77 [nucleoplasm] (R-HSA-5205602) WDR77 [cytosol] (R-HSA-191823)	0.96	17
UniProt:P54105 CLNS1A	1	CLNS1A [cytosol] (R-HSA-191796)	0.777	8
UniProt:P62805 H4C1	19	SUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) HIST1H4A [extracellular region] (R-HSA-977569) SUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK17-HIST1H4 [nucleoplasm] (R-HSA-4568749) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) MeK-HIST1H4A [nucleoplasm] (R-HSA-2172676) HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652)	0.756	6
UniProt:O14744 PRMT5	3	p-Y297,304,307-PRMT5 [nucleoplasm] (R-HSA-5211300) PRMT5 [cytosol] (R-HSA-191876) PRMT5 [nucleoplasm] (R-HSA-5205609)	0.693	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.666	4
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.646	3
UniProt:Q01094 E2F1	2	p-E2F1 [nucleoplasm] (R-HSA-187911) E2F1 [nucleoplasm] (R-HSA-68639)	0.646	8
UniProt:Q86U06 RBM23			0.635	3
UniProt:Q91XC0 Ajuba	3	phospho-Ajuba [cytosol] (R-MMU-2574841) Ajuba [nucleoplasm] (R-MMU-5687969) Ajuba [cytosol] (R-MMU-2564698)	0.623	4
UniProt:Q9NQ92 COPRS	1	COPRS [nucleoplasm] (R-HSA-5212681)	0.616	6
UniProt:O75044 SRGAP2	1	SRGAP2 [cytosol] (R-HSA-195131)	0.611	4
UniProt:Q9Y6K1 DNMT3A	2	DNMT3A [nucleoplasm] (R-HSA-212287) SUMO1-K-DNMT3A [nucleoplasm] (R-HSA-4655415)	0.602	4
UniProt:Q9Y5B0 CTDP1	1	CTDP1 [nucleoplasm] (R-HSA-113416)	0.591	3
UniProt:P24928 POLR2A	7	p-S5,S7-POLR2A [nucleoplasm] (R-HSA-6810226) p-S2,S7-POLR2A [nucleoplasm] (R-HSA-6814543) p-S5-POLR2A [nucleoplasm] (R-HSA-77100) Ub,p-S2,S5-POLR2A [nucleoplasm] (R-HSA-6781855) POLR2A [nucleoplasm] (R-HSA-63502) p-S2,S5-POLR2A [nucleoplasm] (R-HSA-113420) p-3S-POLR2A [nucleoplasm] (R-HSA-6797701)	0.558	6
UniProt:Q9NX04 CA109			0.556	3
UniProt:P78371 CCT2	3	CCT2 [extracellular region] (R-HSA-6806220) CCT2 [azurophil granule lumen] (R-HSA-6799356) CCT2 [cytosol] (R-HSA-390464)	0.556	3
UniProt:P38919 EIF4A3	2	EIF4A3 [nucleoplasm] (R-HSA-8849149) EIF4A3 [cytosol] (R-HSA-927868)	0.556	3
UniProt:O15197-2 EPHB6			0.556	3
UniProt:Q14241 ELOA	1	TCEB3 [nucleoplasm] (R-HSA-112421)	0.556	3
UniProt:P31930 UQCRC1	1	UQCRC1 [mitochondrial inner membrane] (R-HSA-164284)	0.556	3
UniProt:P40337-2 VHL			0.556	3
UniProt:Q96E35 ZMY19			0.556	3
UniProt:Q08289 CACNB2	2	CACNB2 [plasma membrane] (R-HSA-532200) CACNB2 [cytosol] (R-HSA-210496)	0.556	3
UniProt:Q96HA8 NTAQ1			0.556	3
UniProt:P06858 LPL	1	LPL [extracellular region] (R-HSA-174605)	0.556	3
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.556	3
UniProt:Q63ZY3 KANK2			0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:Q8WUW1 BRK1	1	BRK1 [cytosol] (R-HSA-1671645)	0.556	3
UniProt:P21964-2 COMT			0.556	3
UniProt:O95995 GAS8	1	GAS8 [cytosol] (R-HSA-5633057)	0.556	3
UniProt:Q08426 EHHADH	2	EHHADH [cytosol] (R-HSA-9033147) EHHADH [peroxisomal matrix] (R-HSA-400155)	0.556	3
UniProt:P01100 FOS	2	p-T325,T331,S362,S374-FOS [nucleoplasm] (R-HSA-450283) FOS [nucleoplasm] (R-HSA-450216)	0.556	3
UniProt:Q00613 HSF1	11	p-S303-HSF1 [cytosol] (R-HSA-4793927) p-S121-HSF1 [cytosol] (R-HSA-4793906) p-S307-HSF1 [cytosol] (R-HSA-4793929) p-S303,307-HSF1 [cytosol] (R-HSA-4793922) HSF1 [nucleoplasm] (R-HSA-5082385) hC36,103-HSF1 [cytosol] (R-HSA-4793916) p-S230-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082361) p-S326-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082355) Ac-K80-hC36,103-HSF1 [nucleoplasm] (R-HSA-5097238) HSF1 [cytosol] (R-HSA-3371452) hC36,103-HSF1 [nucleoplasm] (R-HSA-3371416)	0.556	3
UniProt:P01019 AGT	9	AGT(35-41) [cytosol] (R-HSA-8852195) AGT(36-41) [cytosol] (R-HSA-8852193) AGT(34-41) [extracellular region] (R-HSA-374187) AGT(34-43) [extracellular region] (R-HSA-2022346) AGT [extracellular region] (R-HSA-1998759) AGT(34-42) [extracellular region] (R-HSA-2022348) AGT(34-40) [extracellular region] (R-HSA-2022351) AGT(35-41) [extracellular region] (R-HSA-2022354) AGT(36-41) [extracellular region] (R-HSA-2022355)	0.556	3
UniProt:P03952 KLKB1	5	KLKB1(391-638) [plasma membrane] (R-HSA-158277) KLKB1(20-390) [plasma membrane] (R-HSA-158213) KLKB1(391-638) [extracellular region] (R-HSA-158181) KLKB1(20-390) [extracellular region] (R-HSA-158239) KLKB1(20-638) [plasma membrane] (R-HSA-158385)	0.556	3
UniProt:Q92731 ESR2	5	PalmS-ESR2 [plasma membrane] (R-HSA-9021059) PalmS-ESR2 [cytosol] (R-HSA-9020979) Me-PalmS-ESR2 [plasma membrane] (R-HSA-9637787) ESR2 [nucleoplasm] (R-HSA-446165) ESR2 [cytosol] (R-HSA-9020970)	0.527	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q86UQ8-1 NFE4			0.525	2
UniProt:P31269 HXA9			0.524	4
UniProt:Q8WVJ2 NUDC2			0.508	2
UniProt:Q9BX10 GTPBP2	2	GTPBP2 [platelet alpha granule lumen] (R-HSA-8862960) GTPBP2 [extracellular region] (R-HSA-8863001)	0.508	2
UniProt:Q8TE85 GRHL3			0.508	2
UniProt:Q8N8U2 CDYL2			0.508	2
UniProt:Q96RU7 TRIB3	3	TRIB3 [cytosol] (R-HSA-162411) TRIB3 [plasma membrane] (R-HSA-199447) TRIB3 [nucleoplasm] (R-HSA-9635877)	0.508	2
UniProt:P03418 NCAP			0.499	2
UniProt:Q9BRS2 RIOK1	2	RIOK1 [nucleoplasm] (R-HSA-5226890) RIOK1 [cytosol] (R-HSA-6791525)	0.499	4
UniProt:Q16526 CRY1	4	CRY1 [cytosol] (R-HSA-400247) Ub-p-S-CRY1 [nucleoplasm] (R-HSA-517931) p-S-CRY1 [nucleoplasm] (R-HSA-400340) p-S-CRY1 [cytosol] (R-HSA-400270)	0.499	3
UniProt:Q16637 SMN1	2	SMN1 [cytosol] (R-HSA-191839) SMN1 [nucleoplasm] (R-HSA-191892)	0.462	2
UniProt:P12755 SKI	1	SKI [nucleoplasm] (R-HSA-173473)	0.462	3

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