Reactome: A Curated Pathway Database

PRMT5

Stable Identifier
R-HSA-5205609
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
JBP1
Locations in the PathwayBrowser
External Reference Information
External Reference
UniProt:O14744 PRMT5
Gene Names
PRMT5, HRMT1L5, IBP72, JBP1, SKB1
Chain
initiator methionine:1, chain:1-637, chain:2-637
Reference Genes
COSMIC (genes):PRMT5 PRMT5, Monarch:10419 PRMT5, BioGPS Gene:10419 PRMT5, NCBI Gene:10419 PRMT5, dbSNP Gene:10419 PRMT5, CTD Gene:10419 PRMT5, HGNC:10894 PRMT5, OMIM:604045 PRMT5, ENSEMBL:ENSG00000100462 PRMT5, KEGG Gene (Homo sapiens):10419 PRMT5
Reference Transcript
Other Identifiers
 0001570253  10419  11755951_s_at  12459  1564520_s_at
 1564521_x_at  16790556  217786_at  3556925  3556926
 3556927  3556928  3556929  3556931  3556934
 3556935  3556937  3556938  3556939  3556940
 3556941  3556942  3556943  3556945  3556946
 3556948  3556950  3556952  3556953  3556954
 3556955  3556956  3556957  3556958  3556959
 3556960  4GQB  4X60  4X61  4X63
 5525  56550_at  57340_s_at  5C9Z  5EMJ
 5EMK  5EML  5EMM  5FA5  64708
 7977820  A_23_P76851  A_24_P298420  AAB66581  AAF04502
 AAH25979  AB451246  AB451370  AF015913  AF015913_at
 AF167572  AK075251  AK301812  AK302240  AL132780
 BAG52095  BAG63261  BAG63592  BAG70060  BAG70184
 BC005820  BC025979  CAB012459  CAG33022  CCDS41922
 CCDS61394  CCDS61395  CCDS61396  CCDS9579  CH471078
 CR456741  EAW66218  EAW66219  EAW66220  EAW66221
 ENSG00000100462  ENSP00000216350  ENSP00000319169  ENSP00000380582  ENSP00000380583
 ENSP00000452555  ENST00000216350  ENST00000324366  ENST00000397440  ENST00000397441
 ENST00000553897  EntrezGene:10419  g5174682_3p_at  g5174682_3p_s_at  GE61958
 GO:0000278  GO:0000387  GO:0000988  GO:0001046  GO:0003674
 GO:0003677  GO:0003714  GO:0005515  GO:0005575  GO:0005622
 GO:0005623  GO:0005634  GO:0005654  GO:0005737  GO:0005794
 GO:0005829  GO:0006259  GO:0006351  GO:0006353  GO:0006355
 GO:0006397  GO:0006464  GO:0006479  GO:0007049  GO:0007088
 GO:0007165  GO:0008150  GO:0008168  GO:0008283  GO:0008327
 GO:0008469  GO:0009058  GO:0016274  GO:0016569  GO:0016740
 GO:0018216  GO:0019918  GO:0022607  GO:0022618  GO:0030154
 GO:0032259  GO:0032403  GO:0032922  GO:0034641  GO:0034709
 GO:0035097  GO:0035243  GO:0035246  GO:0042118  GO:0043021
 GO:0043226  GO:0043234  GO:0043985  GO:0044020  GO:0044030
 GO:0045596  GO:0046982  GO:0048511  GO:0048714  GO:0048856
 GO:0051276  GO:0065003  GO:0070372  GO:0090161  GO:0097421
 GO:0140014  GO:1901796  GO:1903507  GO:1904992  HGNC:10894
 HPA005525  HPA064708  Hs.367854  ILMN_1811955  ILMN_2403889
 IPR007857  IPR025799  IPR029063  MIM:604045  NM_001039619
 NM_001282953  NM_001282954  NM_001282955  NM_001282956  NM_006109
 NP_001034708  NP_001269882  NP_001269883  NP_001269884  NP_001269885
 NP_006100  PF05185  PH_hs_0017523  PRMT5  PRMT5-201
 PRMT5-202  PRMT5-203  PRMT5-204  PRMT5-213  TC14000940.hg
 uc001whl.3  uc001whm.2  uc001whn.3  uc010tng.3  uc010tnh.3
 UPI000006F09F  UPI0000141374  UPI000015D937  UPI00017A82EE  UPI0001AE6957
 XM_017020927  XP_016876416  XR_001750113  XR_001750114  XR_429287
Participant Of
input
hasComponent
Other forms of this molecule
PRMT5 [cytosol] p-Y297,304,307-PRMT5 [nucleoplasm]
Inferred To
Cross References
RefSeq
NP_006100.2, NP_001034708.1, NP_001269882.1, NP_001269884.1, NP_001269885.1
UCSC human
O14744
GeneCards
O14744
ZINC - Substances
ANM5_HUMAN
DOCK Blaster
5EMM, 5C9Z, 4GQB, 4X60, 4X61, 4X63, 5EMK, 5FA5, 5EMJ, 5EML
ZINC target
O14744
PRO
O14744
ZINC - Predictions - Purchasable
ANM5_HUMAN
HMDB Protein
HMDBP01721
PDB
5EMM, 5FA5, 5C9Z, 5EMJ, 5EMK, 5EML, 4GQB, 4X60, 4X61, 4X63
Interactors
Confidence Score Interactor Accession Interactor Name Evidence (IntAct)
0.844 Q9BQA1 MEP50_HUMAN 11
0.777 P54105 ICLN_HUMAN 8
0.646 P63104 1433Z_HUMAN 3
0.646 Q01094 E2F1_HUMAN 8
0.635 Q86U06 RBM23_HUMAN 3
0.616 Q9NQ92 COPRS_HUMAN 6
0.611 O75044 SRGP2_HUMAN 4
0.591 Q9Y5B0 CTDP1_HUMAN 3
0.547 O14744 ANM5_HUMAN 2
0.527 P19320 VCAM1_HUMAN 4
0.524 P31269 HXA9_HUMAN 4
0.508 Q8WVJ2 NUDC2_HUMAN 2
0.508 Q8N8U2 CDYL2_HUMAN 2
0.508 Q96RU7 TRIB3_HUMAN 2
0.508 Q9BX10 GTPB2_HUMAN 2
0.508 Q8TE85 GRHL3_HUMAN 2
0.499 Q9BRS2 RIOK1_HUMAN 4
0.499 P03418 NCAP_HRSVA 2
0.488 Q16543 CDC37_HUMAN 2
0.488 Q14241 ELOA1_HUMAN 2
0.488 O15197-2 EPHB6 2
0.488 P38919 IF4A3_HUMAN 2
0.488 Q9NX04 CA109_HUMAN 2
0.488 Q8TBB1 LNX1_HUMAN 2
0.488 Q08289 CACB2_HUMAN 2
0.488 Q96E35 ZMY19_HUMAN 2
0.488 Q63ZY3 KANK2_HUMAN 2
0.488 Q96HA8 NTAQ1_HUMAN 2
0.488 O95995 GAS8_HUMAN 2
0.462 P12755 SKI_HUMAN 3
 
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