Mitophagy

Stable Identifier
R-HSA-5205647
Type
Pathway
Species
Homo sapiens
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Mitophagy is a specific form of autophagy where mitochondria are specifically targeted for degradation by autophagolysosomes.. In mammals there are a number of known mechanisms of mitophagy. One insures maternal inheritance of mitochondrial DNA through the elimination of sperm derived mitochondria. A second is elimination of functional mitochondria during erythrocyte maturation and eye lens maturation. It is established that the outer mitochondrial membrane receptor Nix (or Bnip3l) and autophagosome associated protein LC3 are important for mitochondrial degradation in erythrocytes. A third mechanism is driven by the Pink1 and Parkin proteins. Parkin is recruited to the mitochondria when the mitochondrial membrane potential is reduced due to uncoupling, thereby initiating mitophagy.

Literature References
PubMed ID Title Journal Year
21179058 Mechanisms of mitophagy

Youle, RJ, Narendra, DP

Nat. Rev. Mol. Cell Biol. 2011
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Orthologous Events
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