Pink1 recruits Parkin to the outer mitochondrial membrane.

Stable Identifier
R-HSA-5205652
Type
Reaction [binding]
Species
Homo sapiens
Compartment
mitochondrial outer membrane
ReviewStatus
5/5
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Pink1 recruits Parkin to the outer mitochondrial membrane.
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Parkin promotes the ubiquitination of outer mitochondrial membrane imbedded proteins including the mitofusin mitochondrial assembly regulatory factor (MARF), mitofusin 1, mitofusin 2 and voltage dependent anion selective channel protein 1 (vDAC1).
Literature References
PubMed ID Title Journal Year
20126261 PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

Tanaka, A, Jin, SM, Cookson, MR, Narendra, DP, Suen, DF, Shen, J, Youle, RJ, Gautier, CA

PLoS Biol. 2010
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Orthologous Events
Pink1 recruits Parkin to the outer mitochondrial membrane. (Bos taurus)
Pink1 recruits Parkin to the outer mitochondrial membrane. (Canis familiaris)
Pink1 recruits Parkin to the outer mitochondrial membrane. (Danio rerio)
Pink1 recruits Parkin to the outer mitochondrial membrane. (Drosophila melanogaster)
Pink1 recruits Parkin to the outer mitochondrial membrane. (Mus musculus)
Pink1 recruits Parkin to the outer mitochondrial membrane. (Rattus norvegicus)
Authored
Gillespie, ME  (2013-11-21)
Reviewed
Chauss, D  (2015-09-01)
Kantorow, M  (2015-09-01)
Created
Gillespie, ME  (2013-12-05)
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