PA63:ANTRX2 oligomer transports EF and LF (target cell endosome to cytosol)

Stable Identifier
R-HSA-5210943
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Bacillus anthracis
Compartment
endosome membrane, cytosol
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PA63:ANTRX2 oligomer transports EF and LF (target cell endosome to cytosol)
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Through the action of vacuolar ATPase the pH of the target cell early endosome is lowered. In this environment, PA63 (Anthrax protective antigen, large fragment) dissociates from its receptor and forms an oligomeric channel in the endosome membrane through which the anthrax EF (edema factor) and LF (lethal factor) pass (Milne et al. 1994). Entry of EF and LF into the target cell cytosol is thought to be mediated by back fusion of intraluminal vesicles with the late endosomal membrane and to be positively regulated by PDCD6IP / ALIX protein (Abrami et al. 2004).

Literature References
PubMed ID Title Journal Year
8051159 Anthrax protective antigen forms oligomers during intoxication of mammalian cells

Milne, JC, Furlong, D, Hanna, PC, Wall, JS, Collier, RJ

J. Biol. Chem. 1994
15337774 Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway

Abrami, L, Lindsay, M, Parton, RG, Leppla, SH, van der Goot, FG

J. Cell Biol. 2004
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein transmembrane transporter activity of EF:LF:(PA63:ANTXR2 oligomer) [endosome membrane]
Physical Entity
EF:LF:(PA63:ANTXR2 oligomer) [endosome membrane]
Activity
protein transmembrane transporter activity (0008320)
This event is regulated
Positively by
Disease
Name Identifier Synonyms
anthrax disease 7427
Authored
D'Eustachio, P  (2013-12-13)
Reviewed
Leppla, SH  (2014-05-19)
Liu, S  (2014-05-28)
Moayeri, M  (2014-05-28)
Turk, BE  (2014-05-23)
Created
D'Eustachio, P  (2013-12-07)