Anthrax cya catalyzes the conversion of ATP to cAMP

Stable Identifier
R-HSA-5211224
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Bacillus anthracis
Compartment
Synonyms
ATP => cAMP + PPi (EF)
ReviewStatus
5/5
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cya (EF, edema factor), transported to the cytosol of the target cell, catalyzes the synthesis of cAMP from ATP, in a reaction that requires target cell calmodulin (Leppla 1984; Labruyere et al. 1990).
Literature References
PubMed ID Title Journal Year
2114169 Characterization of ATP and calmodulin-binding properties of a truncated form of Bacillus anthracis adenylate cyclase

Laoide, B, Mock, M, Michelson, S, Bârzu, O, Labruyère, E, Gilles, AM, Ladant, D

Biochemistry 1990
6328915 Bacillus anthracis calmodulin-dependent adenylate cyclase: chemical and enzymatic properties and interactions with eucaryotic cells

Leppla, SH

Adv Cyclic Nucleotide Protein Phosphorylation Res 1984
Participants
Participates
Catalyst Activity

adenylate cyclase activity of cya [cytosol]

This event is regulated
Disease
Name Identifier Synonyms
anthrax disease DOID:7427
Cross References
Rhea
Authored
Reviewed
Created
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