SIRT1 deacetylates TAF1B in SL1 complex

Stable Identifier
R-HSA-5211239
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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SIRT1 deacetylates TAF1B in SL1 complex
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As inferred from mouse, SIRT1, an NAD+ dependent deacetylase, deacetylates the TAF1B (TAF(1)68) subunit of the SL1 complex. Deacetylation of TAF1B inhibits transcription of rRNA genes.

Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
NAD-dependent protein deacetylase activity of SIRT1 [nucleoplasm]
Physical Entity
SIRT1 [nucleoplasm]
Activity
NAD-dependent protein deacetylase activity (0034979)
Inferred From
Sirt1 deacetylates Taf1b in SL1 complex (Mus musculus)
Authored
May, B  (2013-11-15)
Reviewed
Voit, R  (2014-01-21)
Grummt, I  (2014-01-21)
Created
May, B  (2013-12-09)