MAP2K2(11-400) [cytosol]

Stable Identifier
R-HSA-5211337
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
MAP2K2 large LF fragment
MAP2K2(11-400) [cytosol] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
9563949 Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor

Klimpel, KR, Leppla, SH, Webb, CP, Paull, KD, Ahn, NG, Gordon, VM, Vande Woude, GF, Copeland, TD, Oskarsson, MK, Duesbery, NS, Fukasawa, K

Science 1998
9703991 Anthrax lethal factor cleaves the N-terminus of MAPKKs and induces tyrosine/threonine phosphorylation of MAPKs in cultured macrophages

Mock, M, Pellizzari, R, Napolitani, G, Montecucco, C, Recchi, C, Vitale, G

Biochem. Biophys. Res. Commun. 1998
External Reference Information
External Reference
Gene Names
MAP2K2, MEK2, MKK2, PRKMK2
Chain
chain:1-400
Reference Transcript
Other Identifiers
1131_at
11716318_x_at
202424_PM_at
202424_at
213490_PM_s_at
213490_s_at
3023305
3023308
3023309
3023310
3846639
3846640
3846643
3846645
3846646
3846650
3846652
3846653
3846654
3846659
3846660
3846663
3846664
3846665
3846666
5605
8032761
GE57609
GO:0000165
GO:0000166
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004708
GO:0004712
GO:0004713
GO:0005078
GO:0005515
GO:0005524
GO:0005576
GO:0005634
GO:0005737
GO:0005739
GO:0005768
GO:0005769
GO:0005770
GO:0005777
GO:0005778
GO:0005783
GO:0005794
GO:0005829
GO:0005856
GO:0005874
GO:0005886
GO:0005911
GO:0005925
GO:0006351
GO:0006355
GO:0006468
GO:0007507
GO:0009898
GO:0010628
GO:0014044
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0023052
GO:0030154
GO:0030165
GO:0030878
GO:0031410
GO:0032872
GO:0036211
GO:0036289
GO:0038133
GO:0042552
GO:0043226
GO:0043410
GO:0043539
GO:0045893
GO:0046872
GO:0048009
GO:0048471
GO:0048538
GO:0048679
GO:0048856
GO:0048870
GO:0050772
GO:0060090
GO:0060324
GO:0060425
GO:0060440
GO:0060502
GO:0070371
GO:0071902
GO:0090170
GO:0097110
GO:0098772
GO:0106310
GO:0140096
GO:2000147
GO:2000641
Hs.72241.1.S1_3p_a_at
ILMN_1657968
L11285_at
PH_hs_0029886
TC19001058.hg
g13489053_3p_at
g13489053_3p_x_at
Participates
Other forms of this molecule
Disease
Name Identifier Synonyms
anthrax disease DOID:7427
Cross References
RefSeq
ZINC - World Drugs
Guide to Pharmacology - Targets
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
PDB
ZINC - Investigational
GeneCards
Pharos - Targets
ZINC - Predictions - Purchasable
Orphanet
HMDB Protein
Interactors (37)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P10398 ARAF  4 0.91 10
 UniProt:P15056 BRAF  20 0.886 12
 UniProt:P04049 RAF1  20 0.85 7
 UniProt:Q8IVT5 KSR1  5 0.798 10
 UniProt:Q04917 YWHAH  1 0.725 5
 UniProt:P27348 YWHAQ  1 0.725 5
 UniProt:P31946 YWHAB  1 0.725 6
 UniProt:P61981 YWHAG  1 0.671 5
 UniProt:P68366 TUBA4A  9 0.643 4
 UniProt:Q6VAB6 KSR2  1 0.643 9
 UniProt:P11142 HSPA8  10 0.643 5
 UniProt:Q02750 MAP2K1  20 0.643 5
 UniProt:Q96II5 Q96II5      0.601 4
 UniProt:P61978-2 HNRNPK      0.556 3
 UniProt:O95273 CCDB1      0.556 3
 UniProt:P00540 MOS      0.556 3
 UniProt:P05067 APP  20 0.556 3
 UniProt:Q92905 COPS5  2 0.553 2
 UniProt:Q12959 DLG1  4 0.543 10
 UniProt:P32970 CD70  1 0.527 2
 UniProt:Q58FG1 HS904      0.527 3
 UniProt:Q58FG0 HS905      0.527 3
 UniProt:Q58FF6 H90B4      0.527 3
 UniProt:P04439 HLA-A  9 0.527 2
 UniProt:hspa1a_hspa1b_human-1 EBI-11820565      0.527 3
 UniProt:Q16543 CDC37  1 0.527 3
 UniProt:O95816 BAG2  1 0.527 3
 UniProt:Q9BQE3 TUBA1C  9 0.527 3
 UniProt:P63104 YWHAZ  2 0.527 4
 UniProt:P62258 YWHAE  1 0.527 3
 UniProt:P07437 TUBB  3 0.527 3
 UniProt:P05120 SERPINB2  2 0.527 3
 UniProt:P07900 HSP90AA1  8 0.527 3
 UniProt:P08238 HSP90AB1  6 0.527 3
 UniProt:Q61097  5 0.508 2
 UniProt:P06929 VE6      0.488 2
 UniProt:Q9NQZ2 UTP3  1 0.483 2
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