Anthrax lef cleaves target cell MAP2K2 (MEK2)

Stable Identifier
R-HSA-5211356
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Bacillus anthracis
Compartment
cytosol
ReviewStatus
5/5
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Anthrax lef cleaves target cell MAP2K2 (MEK2)
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lef (Anthrax LF, lethal factor) a zinc metalloprotease (Klimpel et al, 1994) in the target cell cytosol, cleaves MAP2K2 (MEK2, mitogen activated protein kinase kinase 2). While the kinase domain of MAP2K2 is unaffected, an aminoterminal docking domain is disrupted by the cleavage (Duesbery et al. 1998; Vitale et al. 1998).

Literature References
PubMed ID Title Journal Year
9563949 Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor

Klimpel, KR, Leppla, SH, Webb, CP, Paull, KD, Ahn, NG, Gordon, VM, Vande Woude, GF, Copeland, TD, Oskarsson, MK, Duesbery, NS, Fukasawa, K

Science 1998
9703991 Anthrax lethal factor cleaves the N-terminus of MAPKKs and induces tyrosine/threonine phosphorylation of MAPKs in cultured macrophages

Mock, M, Pellizzari, R, Napolitani, G, Montecucco, C, Recchi, C, Vitale, G

Biochem. Biophys. Res. Commun. 1998
7854123 Anthrax toxin lethal factor contains a zinc metalloprotease consensus sequence which is required for lethal toxin activity

Klimpel, KR, Leppla, SH, Arora, N

Mol. Microbiol. 1994
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Output
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Catalyst Activity

metallopeptidase activity of lef [cytosol]

Physical Entity
lef [cytosol] (Bacillus anthracis)
Activity
metallopeptidase activity (GO:0008237)
Disease
Name Identifier Synonyms
anthrax disease DOID:7427
Authored
D'Eustachio, P  (2013-12-13)
Reviewed
Leppla, SH  (2014-05-19)
Moayeri, M  (2014-05-28)
Turk, BE  (2014-05-23)
Liu, S  (2014-05-28)
Created
D'Eustachio, P  (2013-12-10)
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