Reactome | MAP2K7(?-419) [cytosol]

MAP2K7(?-419) [cytosol]

Stable Identifier

R-HSA-5211401

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

MAP2K7 large LF fragment

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Literature References

PubMed ID	Title	Journal	Year
11104681	Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor Mock, M, Napolitani, G, Montecucco, C, Bernardi, L, Vitale, G	Biochem. J.	2000

External Reference Information

External Reference

UniProt:O14733 MAP2K7

Gene Names

MAP2K7, JNKK2, MEK7, MKK7, PRKMK7, SKK4

Chain

initiator methionine:, chain:2-419

Reference Genes

BioGPS Gene:5609 MAP2K7

COSMIC (genes):MAP2K7 MAP2K7

CTD Gene:5609 MAP2K7

dbSNP Gene:5609 MAP2K7

ENSEMBL:ENSG00000076984 MAP2K7

ENSEMBL_homo_sapiens_GENE:ENSG00000076984.18 MAP2K7

HGNC:6847 MAP2K7

KEGG Gene (Homo sapiens):5609 MAP2K7

Monarch:5609 MAP2K7

NCBI Gene:5609 MAP2K7

OMIM:603014 MAP2K7

UCSC:O14733 MAP2K7

Reference Transcript

Other Identifiers

11723595_s_at

11723596_a_at

11723597_at

11723598_x_at

11752702_a_at

16857799

209951_PM_s_at

209951_s_at

209952_PM_s_at

209952_s_at

226023_PM_at

226023_at

226053_PM_at

226053_at

3819264

3819265

3819266

3819274

3819275

3819277

3819279

3819281

3819283

3819285

3819286

3819287

3819288

3819289

3819290

3819291

3819292

3819293

3819294

3819295

3819296

3819297

41444_at

5609

59996_at

8025351

A_23_P78628

A_33_P3236651

GE785894

GO:0000166

GO:0000287

GO:0002376

GO:0003824

GO:0004672

GO:0004674

GO:0004707

GO:0004708

GO:0004713

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006468

GO:0006915

GO:0006970

GO:0007165

GO:0007254

GO:0008545

GO:0009408

GO:0009411

GO:0009611

GO:0012501

GO:0016301

GO:0016310

GO:0016740

GO:0019899

GO:0019901

GO:0019903

GO:0023052

GO:0032200

GO:0032212

GO:0034612

GO:0036211

GO:0038095

GO:0043226

GO:0043507

GO:0045893

GO:0046330

GO:0046872

GO:0051403

GO:0051716

GO:0051973

GO:0070374

GO:0071222

GO:0071347

GO:0090398

GO:0098772

GO:0106310

GO:0140096

GO:0140677

GO:1904355

GO:2000671

HMNXSV003016511

HMNXSV003058459

Hs.110299.0.A1_3p_a_at

Hs.296234.0.A1_3p_at

Hs.296234.0.A2_3p_at

ILMN_1781104

PH_hs_0006079

TC19000140.hg

g2811125_3p_a_at

Participates

as an output of

Anthrax lef cleaves target cell MAP2K7 (MEK7) (Homo sapiens)

Other forms of this molecule

MAP2K7(2-?) [cytosol]

MAP2K7 [cytosol]

p-S271,T275-MAP2K7 [cytosol]

Disease

Name	Identifier	Synonyms
anthrax disease	DOID:7427

Cross References

RefSeq

NP_001284484.1, NP_001284485.1, NP_660186.1

ZINC - World Drugs

MP2K7_HUMAN

Guide to Pharmacology - Targets

2068

OpenTargets

ENSG00000076984

ZINC - FDA approved

MP2K7_HUMAN

ZINC - Substances

MP2K7_HUMAN

ZINC - Biogenic

MP2K7_HUMAN

ZINC target

O14733

PRO

O14733

PDB

6YG6, 5B2M, 6YG7, 5Z1D, 6QFL, 6YG1, 5Z1E, 6YG0, 7OVJ, 6YFZ, 6YZ4, 7OVI, 6IB0, 7CBX, 6YG2, 6QFR, 6QFT, 6YG3, 3WZU, 5Y8U, 7OVL, 5Y90, 7OVK, 6IB2, 4UX9, 6QG4, 6QG7, 6YG4, 5B2K, 7OVN, 6QHO, 6QHR, 2DYL, 6YG5, 7OVM, 5B2L

ZINC - Investigational

MP2K7_HUMAN

IntEnz

2.7.12.2

HPA

ENSG00000076984-MAP2K7

GeneCards

O14733

Ensembl

ENST00000397981, ENST00000397983, ENSG00000076984, ENSP00000381068, ENSP00000381070, ENSP00000381066, ENST00000397979

Pharos - Targets

O14733

ZINC - Predictions - Purchasable

MP2K7_HUMAN

HMDB Protein

HMDBP08761

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43318 MAP3K7	10	PolyUb-MAP3K7 [cytosol] (R-HSA-6782968) MAP3K7 [plasma membrane] (R-HSA-9012677) K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol] (R-HSA-5607649) K63polyUb-34,158-TAK1 [cytosol] (R-HSA-5607643) p-MAP3K7 [cytosol] (R-HSA-168163) p-T187-MAP3K7 [cytosol] (R-HSA-206014) MAP3K7 [endosome membrane] (R-HSA-450315) p-T184,T187-MAP3K7 [endosome membrane] (R-HSA-450332) MAP3K7 [cytosol] (R-HSA-168156) p-T184,T187-MAP3K7 [cytosol] (R-HSA-202527)	0.674	3
IntAct:EBI-9998887 (DTP3)-TYR,ARG,PHE			0.672	7
UniProt:O75293 GA45B			0.645	8
UniProt:Q9UQF2 JIP1			0.623	5
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.564	2
UniProt:P45983 MAPK8	3	MAPK8 [cytosol] (R-HSA-168141) p-T,Y-MAPK8 [cytosol] (R-HSA-194371) p-T,Y-MAPK8 [nucleoplasm] (R-HSA-216349)	0.483	4
UniProt:P27986 PIK3R1	16	p-Y-PIK3R1 [cytosol] (R-HSA-9680647) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.462	3

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