Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
RNF31 [cytosol]
Stable Identifier
R-HSA-5212660
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
HOIL-1-interacting protein, ZIBRA, E3 ubiquitin-protein ligase RNF31, HOIP
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Death Receptor Signalling (Homo sapiens)
TNF signaling (Homo sapiens)
Regulation of TNFR1 signaling (Homo sapiens)
LUBAC comlex binds OTULIN (Homo sapiens)
LUBAC [cytosol] (Homo sapiens)
RNF31 [cytosol] (Homo sapiens)
LUBAC:OTULIN [cytosol] (Homo sapiens)
LUBAC [cytosol] (Homo sapiens)
RNF31 [cytosol] (Homo sapiens)
TNFR1-induced NFkappaB signaling pathway (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
LUBAC [cytosol] (Homo sapiens)
RNF31 [cytosol] (Homo sapiens)
TNFalpha:TNF-R1:TRADD:K63polyUb-RIP1:BIRC2/3:IKKA:IKKB:NEMO [plasma membrane] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
LUBAC [cytosol] (Homo sapiens)
RNF31 [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Homo sapiens)
LUBAC [cytosol] (Homo sapiens)
RNF31 [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
LUBAC [cytosol] (Homo sapiens)
RNF31 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96EP0 RNF31
Gene Names
RNF31, ZIBRA
Chain
chain:1-1072
Reference Genes
BioGPS Gene:55072 RNF31
COSMIC (genes):RNF31 RNF31
CTD Gene:55072 RNF31
dbSNP Gene:55072 RNF31
ENSEMBL:ENSG00000092098 RNF31
ENSEMBL:ENSG00000285152 RNF31
HGNC:16031 RNF31
KEGG Gene (Homo sapiens):55072 RNF31
Monarch:55072 RNF31
NCBI Gene:55072 RNF31
OMIM:612487 RNF31
UCSC:Q96EP0 RNF31
Reference Transcript
RefSeq:NM_001310332.1 RNF31
RefSeq:NM_017999.4 RNF31
Other Identifiers
0002650440
11717173_a_at
16782640
220788_s_at
3529650
3529651
3529652
3529653
3529654
3529655
3529656
3529658
3529660
3529661
3529662
3529663
3529664
3529665
3529667
3529668
3529669
3529671
3529672
3529673
3529674
3529675
3529676
3529678
3529679
3529680
3529681
3529682
3529684
3529685
3529691
3529693
3529694
3529695
3529696
3529697
55072
57838_at
57839_g_at
7973584
81057_at
A_23_P99632
GE55666
GO:0000209
GO:0002376
GO:0003674
GO:0004842
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005829
GO:0005886
GO:0006464
GO:0006605
GO:0006810
GO:0007005
GO:0007165
GO:0007249
GO:0008150
GO:0009058
GO:0009898
GO:0010803
GO:0015031
GO:0016740
GO:0019899
GO:0023035
GO:0031625
GO:0032182
GO:0032991
GO:0034641
GO:0035631
GO:0042802
GO:0043123
GO:0043130
GO:0043167
GO:0046872
GO:0050852
GO:0051092
GO:0071797
GO:0097039
GO:1903955
ILMN_1758831
PH_hs_0029932
g8922234_3p_a_at
g8922234_3p_x_at
Participant Of
hasComponent
LUBAC [cytosol]
Inferred To
RNF31 [cytosol] (Bos taurus)
RNF31 [cytosol] (Canis familiaris)
RNF31 [cytosol] (Sus scrofa)
rnf31 [cytosol] (Xenopus tropicalis)
Rnf31 [cytosol] (Mus musculus)
Rnf31 [cytosol] (Rattus norvegicus)
LOC100334178 [cytosol] (Danio rerio)
Cross References
RefSeq
NP_060469.4
,
NP_001297261.1
OpenTargets
ENSG00000092098
HPA
ENSG00000092098-RNF31
GeneCards
Q96EP0
Ensembl
ENSP00000453574
,
ENST00000647495
,
ENSP00000315112
,
ENSP00000496609
,
ENSG00000285152
,
ENST00000324103
,
ENSP00000494011
,
ENST00000642631
,
ENST00000559275
,
ENSG00000092098
PRO
Q96EP0
Orphanet
23269
PDB
4P0B
,
4DBG
,
6KC6
,
4LJP
,
6SC8
,
6SC9
,
4LJO
,
5X0W
,
4OWF
,
4P0A
,
6SC5
,
2CT7
,
5EDV
,
6KC5
,
4P09
,
4JUY
,
6SC6
,
4LJQ
,
6SC7
,
5LJN
,
4OYK
,
6GZY
,
4OYJ
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9H0F6 SHARPIN
1
SHARPIN [cytosol]
(R-HSA-5212666)
0.953
32
UniProt:Q9Y6K9 IKBKG
12
IKBKG [nucleoplasm]
(R-HSA-4755413)
SUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wro*447 [cytosol]
(R-HSA-5262978)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
K63polyUb-NEMO [cytosol]
(R-HSA-202530)
IKBKG [cytosol]
(R-HSA-168108)
0.773
10
UniProt:P01375 TNF
5
TNF(1-34) [plasma membrane]
(R-HSA-8863367)
TNF(52-76) [extracellular region]
(R-HSA-8863375)
TNF(1-76) [plasma membrane]
(R-HSA-8863120)
TNF(77-233) [extracellular region]
(R-HSA-976821)
TNF(1-233) [plasma membrane]
(R-HSA-66220)
0.643
3
UniProt:P54252 ATXN3
2
ATXN3 [cytosol]
(R-HSA-5625607)
ATXN3 [nucleoplasm]
(R-HSA-6783285)
0.556
3
UniProt:Q13490 BIRC2
5
K48pUb-BIRC2 [cytosol]
(R-HSA-5675479)
K63polyUb-BIRC2 [cytosol]
(R-HSA-5668512)
BIRC2(1-372) [cytosol]
(R-HSA-202913)
BIRC2(373-618) [cytosol]
(R-HSA-202931)
BIRC2 [cytosol]
(R-HSA-50847)
0.527
3
UniProt:P21580 TNFAIP3
1
TNFAIP3 [cytosol]
(R-HSA-688989)
0.527
2
UniProt:P84022 SMAD3
21
p-S423,S425-SMAD3 D258N [cytosol]
(R-HSA-3315470)
Ub-SMAD3 [cytosol]
(R-HSA-6782830)
p-S423,S425-SMAD3 R268C [cytosol]
(R-HSA-3315075)
p-S423,S425-SMAD3 R268H [cytosol]
(R-HSA-3315080)
SMAD3 Q316* [cytosol]
(R-HSA-9668765)
SMAD3 Y384* [cytosol]
(R-HSA-9668782)
SMAD3 W326* [cytosol]
(R-HSA-9668766)
SMAD3 E246* [cytosol]
(R-HSA-9668776)
SMAD3 Q358* [cytosol]
(R-HSA-9668772)
SMAD3 Q322* [cytosol]
(R-HSA-9668773)
SMAD3 S425F [cytosol]
(R-HSA-8944158)
SMAD3 E383* [cytosol]
(R-HSA-9668775)
SMAD3 R368* [cytosol]
(R-HSA-9668768)
SMAD3 Y298* [cytosol]
(R-HSA-9668769)
SMAD3 S425C [cytosol]
(R-HSA-3308499)
2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2187326)
p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2176471)
SMAD3 [nucleoplasm]
(R-HSA-206150)
SMAD3 [cytosol]
(R-HSA-170855)
p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-177104)
p-S423,S425-SMAD3 [cytosol]
(R-HSA-171184)
0.508
2
© 2021
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text