Reactome | RNF31 [cytosol]

RNF31 [cytosol]

Stable Identifier

R-HSA-5212660

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

HOIL-1-interacting protein, ZIBRA, E3 ubiquitin-protein ligase RNF31, HOIP

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q96EP0 RNF31

Gene Names

RNF31, ZIBRA

Chain

chain:1-1072

Reference Genes

COSMIC (genes):RNF31 RNF31

ENSEMBL:ENSG00000092098 RNF31

HGNC:16031 RNF31

UCSC:Q96EP0 RNF31

Participates

as a component of

LUBAC [cytosol] (Homo sapiens)

Inferred To

Ghost homologue of RNF31 [cytosol] (Danio rerio)

RNF31 [cytosol] (Bos taurus)

RNF31 [cytosol] (Canis familiaris)

RNF31 [cytosol] (Sus scrofa)

Rnf31 [cytosol] (Mus musculus)

Rnf31 [cytosol] (Rattus norvegicus)

Cross References

ENSEMBL

ENST00000642631, ENST00000324103, ENSP00000494011, ENSP00000315112, ENST00000647495, ENSG00000285152, ENSP00000496609, ENSP00000453574, ENST00000559275, ENSG00000092098

OpenTargets

ENSG00000092098

HPA

ENSG00000092098-RNF31

PRO

Q96EP0

Pharos - Targets

Q96EP0

Orphanet

RNF31

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H0F6 SHARPIN	1	SHARPIN [cytosol] (R-HSA-5212666)	0.958	36
UniProt:Q9Y6K9 IKBKG	12	IKBKG [cytosol] (R-HSA-168108) Ub-285-IKBKG [cytosol] (R-HSA-741397) K63polyUb-IKBKG [cytosol] (R-HSA-202530) IKBKG [nucleoplasm] (R-HSA-4755413) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG D406V [cytosol] (R-HSA-5262943)	0.773	10
UniProt:P01375 TNF	5	TNF(1-233) [plasma membrane] (R-HSA-66220) TNF(77-233) [extracellular region] (R-HSA-976821) TNF(1-76) [plasma membrane] (R-HSA-8863120) TNF(1-34) [plasma membrane] (R-HSA-8863367) TNF(52-76) [extracellular region] (R-HSA-8863375)	0.725	10
UniProt:Q13490 BIRC2	5	BIRC2 [cytosol] (R-HSA-50847) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2(373-618) [cytosol] (R-HSA-202931) BIRC2(1-372) [cytosol] (R-HSA-202913) K63polyUb-BIRC2 [cytosol] (R-HSA-5668512)	0.669	8
UniProt:P62837 UBE2D2	4	Ub-C85-UBE2D2 [cytosol] (R-HSA-8864214) UBE2D2 [cytosol] (R-HSA-934628) UBE2D2 [nucleoplasm] (R-HSA-8852067) Ub-C85-UBE2D2 [nucleoplasm] (R-HSA-8864153)	0.618	3
UniProt:P54252 ATXN3	2	ATXN3 [nucleoplasm] (R-HSA-6783285) ATXN3 [cytosol] (R-HSA-5625607)	0.556	3
UniProt:Q9UIM3 FKBPL	1	FKBPL [cytosol] (R-HSA-8852374)	0.527	2
UniProt:P36941 LTBR	1	LTBR [plasma membrane] (R-HSA-5668750)	0.527	2
UniProt:P32455 GBP1	6	GBP1 [cytosol] (R-HSA-1031698) S-farn-C589-GBP1 [cytosol] (R-HSA-9947912) S-farn-C589, p-S156, T590-GBP1 [cytosol] (R-HSA-9954274) GBP1(1-192) [cytosol] (R-HSA-9956711) GBP1(193-592) [cytosol] (R-HSA-9956716) K48polyUb-GBP1 [cytosol] (R-HSA-9955186)	0.527	2
UniProt:P21580 TNFAIP3	1	TNFAIP3 [cytosol] (R-HSA-688989)	0.527	2
UniProt:P84022 SMAD3	20	p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-177104) p-S423,S425-SMAD3 [cytosol] (R-HSA-171184) SMAD3 [cytosol] (R-HSA-170855) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471) Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-9773841) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) SMAD3 [nucleoplasm] (R-HSA-206150) p-S208-SMAD3 [cytosol] (R-HSA-9731114) SMAD3 S425C [cytosol] (R-HSA-3308499) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 Q316* [cytosol] (R-HSA-9668765) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080)	0.508	2

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