Reactome | RNF31 [cytosol]

RNF31 [cytosol]

Stable Identifier

R-HSA-5212660

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

HOIL-1-interacting protein, ZIBRA, E3 ubiquitin-protein ligase RNF31, HOIP

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q96EP0 RNF31

Gene Names

RNF31, ZIBRA

Chain

chain:1-1072

Reference Genes

BioGPS Gene:55072 RNF31

COSMIC (genes):RNF31 RNF31

CTD Gene:55072 RNF31

dbSNP Gene:55072 RNF31

ENSEMBL:ENSG00000092098 RNF31

ENSEMBL:ENSG00000285152 RNF31

HGNC:16031 RNF31

KEGG Gene (Homo sapiens):55072 RNF31

Monarch:55072 RNF31

NCBI Gene:55072 RNF31

OMIM:612487 RNF31

UCSC:Q96EP0 RNF31

Reference Transcript

Other Identifiers

0002650440

11717173_a_at

16782640

220788_PM_s_at

220788_s_at

3529650

3529651

3529652

3529653

3529654

3529655

3529656

3529658

3529660

3529661

3529662

3529663

3529664

3529665

3529667

3529668

3529669

3529671

3529672

3529673

3529674

3529675

3529676

3529678

3529679

3529680

3529681

3529682

3529684

3529685

3529691

3529693

3529694

3529695

3529696

3529697

55072

57838_at

57839_g_at

7973584

81057_at

A_23_P99632

GE55666

GO:0000209

GO:0002376

GO:0003674

GO:0004842

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005829

GO:0005886

GO:0006464

GO:0006605

GO:0006810

GO:0006914

GO:0006950

GO:0007005

GO:0007165

GO:0008150

GO:0009056

GO:0009058

GO:0009898

GO:0015031

GO:0016740

GO:0019899

GO:0023035

GO:0031625

GO:0032182

GO:0032991

GO:0034641

GO:0035631

GO:0036435

GO:0042742

GO:0042802

GO:0043123

GO:0043130

GO:0043167

GO:0046872

GO:0050852

GO:0051092

GO:0061630

GO:0070530

GO:0071797

GO:0097039

GO:1903955

GO:1904417

GO:1990450

ILMN_1758831

PH_hs_0029932

g8922234_3p_a_at

g8922234_3p_x_at

Participates

as a component of

LUBAC [cytosol] (Homo sapiens)

Inferred To

IRF9 [cytosol] (Canis familiaris)

RNF31 [cytosol] (Bos taurus)

RNF31 [cytosol] (Sus scrofa)

Rnf31 [cytosol] (Mus musculus)

Rnf31 [cytosol] (Rattus norvegicus)

LOC100334178 [cytosol] (Danio rerio)

Cross References

RefSeq

NP_060469.4, NP_001297261.1

OpenTargets

ENSG00000092098

IntEnz

2.3.2.31

GeneCards

Q96EP0

HPA

ENSG00000092098-RNF31

Ensembl

ENST00000647495, ENSP00000453574, ENSP00000315112, ENSG00000092098, ENST00000642631, ENST00000324103, ENST00000559275, ENSP00000494011, ENSG00000285152, ENSP00000496609

PRO

Q96EP0

Pharos - Targets

Q96EP0

Orphanet

23269

PDB

4LJQ, 4DBG, 4OYK, 4LJP, 6KC5, 4P0A, 6SC5, 6SC9, 6SC6, 5X0W, 6KC6, 4P0B, 4OWF, 5EDV, 5LJN, 4JUY, 4P09, 6SC7, 6GZY, 2CT7, 4LJO, 6SC8, 4OYJ

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H0F6 SHARPIN	1	SHARPIN [cytosol] (R-HSA-5212666)	0.953	32
UniProt:Q9Y6K9 IKBKG	12	monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG [nucleoplasm] (R-HSA-4755413) IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wro447 [cytosol] (R-HSA-5262978) K63polyUb-NEMO [cytosol] (R-HSA-202530) Ub-285-IKBKG [cytosol] (R-HSA-741397) IKBKG [cytosol] (R-HSA-168108)	0.773	10
UniProt:P01375 TNF	5	TNF(52-76) [extracellular region] (R-HSA-8863375) TNF(1-34) [plasma membrane] (R-HSA-8863367) TNF(1-76) [plasma membrane] (R-HSA-8863120) TNF(77-233) [extracellular region] (R-HSA-976821) TNF(1-233) [plasma membrane] (R-HSA-66220)	0.643	3
UniProt:P54252 ATXN3	2	ATXN3 [nucleoplasm] (R-HSA-6783285) ATXN3 [cytosol] (R-HSA-5625607)	0.556	3
UniProt:Q13490 BIRC2	5	K63polyUb-BIRC2 [cytosol] (R-HSA-5668512) BIRC2(1-372) [cytosol] (R-HSA-202913) BIRC2(373-618) [cytosol] (R-HSA-202931) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2 [cytosol] (R-HSA-50847)	0.527	3
UniProt:P21580 TNFAIP3	1	TNFAIP3 [cytosol] (R-HSA-688989)	0.527	2
UniProt:P84022 SMAD3	20	Ub-SMAD3 [cytosol] (R-HSA-6782830) p-S423,S425-SMAD3 D258N [cytosol] (R-HSA-3315470) p-S423,S425-SMAD3 R268C [cytosol] (R-HSA-3315075) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080) SMAD3 Q316* [cytosol] (R-HSA-9668765) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 S425C [cytosol] (R-HSA-3308499) p-S208-SMAD3 [cytosol] (R-HSA-9731114) SMAD3 [nucleoplasm] (R-HSA-206150) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-9773841) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471)	0.508	2

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