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RNF31 [cytosol]
Stable Identifier
R-HSA-5212660
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
HOIL-1-interacting protein, ZIBRA, E3 ubiquitin-protein ligase RNF31, HOIP
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Death Receptor Signalling (Homo sapiens)
TNF signaling (Homo sapiens)
Regulation of TNFR1 signaling (Homo sapiens)
LUBAC comlex binds OTULIN (Homo sapiens)
LUBAC [cytosol] (Homo sapiens)
RNF31 [cytosol] (Homo sapiens)
LUBAC:OTULIN [cytosol] (Homo sapiens)
LUBAC [cytosol] (Homo sapiens)
RNF31 [cytosol] (Homo sapiens)
TNFR1-induced NFkappaB signaling pathway (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
LUBAC [cytosol] (Homo sapiens)
RNF31 [cytosol] (Homo sapiens)
TNFalpha:TNF-R1:TRADD:K63polyUb-RIP1:BIRC2/3:IKKA:IKKB:NEMO [plasma membrane] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
LUBAC [cytosol] (Homo sapiens)
RNF31 [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Homo sapiens)
LUBAC [cytosol] (Homo sapiens)
RNF31 [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
LUBAC [cytosol] (Homo sapiens)
RNF31 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96EP0 RNF31
Gene Names
RNF31, ZIBRA
Chain
chain:1-1072
Reference Genes
BioGPS Gene:55072 RNF31
COSMIC (genes):RNF31 RNF31
CTD Gene:55072 RNF31
dbSNP Gene:55072 RNF31
ENSEMBL:ENSG00000092098 RNF31
ENSEMBL:ENSG00000285152 RNF31
HGNC:16031 RNF31
KEGG Gene (Homo sapiens):55072 RNF31
Monarch:55072 RNF31
NCBI Gene:55072 RNF31
OMIM:612487 RNF31
UCSC:Q96EP0 RNF31
Reference Transcript
RefSeq:NM_017999.4 RNF31
RefSeq:NM_001310332.1 RNF31
Other Identifiers
0002650440
11717173_a_at
16782640
220788_s_at
2CT7
3529650
3529651
3529652
3529653
3529654
3529655
3529656
3529658
3529660
3529661
3529662
3529663
3529664
3529665
3529667
3529668
3529669
3529671
3529672
3529673
3529674
3529675
3529676
3529678
3529679
3529680
3529681
3529682
3529684
3529685
3529691
3529693
3529694
3529695
3529696
3529697
48745
4DBG
4JUY
4LJO
4LJP
4LJQ
4OWF
4OYJ
4OYK
4P09
4P0A
4P0B
55072
57838_at
57839_g_at
5EDV
5LJN
5X0W
6GZY
7973584
81057_at
9063
A0A494C1G4
A_23_P99632
AAH09821
AAH12077
AAH17376
AAP12522
AB265810
AK000973
AK027154
AK055542
AK074144
AK291247
AL136295
AY256461
BAA91450
BAB15675
BAB70948
BAB84970
BAF35583
BAF83936
BC009821
BC012077
BC017376
CAB009063
CCDS41931
CCDS81792
CH471078
EAW66098
ENSG00000092098
ENSG00000285152
ENSP00000315112
ENSP00000453574
ENSP00000494011
ENSP00000496609
ENST00000324103
ENST00000324103.10
ENST00000559275
ENST00000559275.5
ENST00000642631
ENST00000647495
EntrezGene:55072
EntrezGene:RNF31
g8922234_3p_a_at
g8922234_3p_x_at
GE55666
GO:0000209
GO:0002376
GO:0003674
GO:0004842
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005737
GO:0005829
GO:0005886
GO:0006464
GO:0006605
GO:0006810
GO:0007005
GO:0007165
GO:0007249
GO:0008150
GO:0009058
GO:0009898
GO:0010803
GO:0015031
GO:0016740
GO:0019899
GO:0023035
GO:0031625
GO:0032182
GO:0032991
GO:0034641
GO:0035631
GO:0043123
GO:0043130
GO:0043167
GO:0046872
GO:0050852
GO:0051092
GO:0071797
GO:0097039
GO:1903955
H0YM13
H0YM57
H0YMG8
H0YMK6
H0YNC1
H0YNJ0
H0YNK5
HGNC:16031
HPA048745
ILMN_1758831
IPR001876
IPR002867
IPR013083
IPR015940
IPR017907
IPR018997
IPR026254
IPR032065
IPR036339
IPR036443
IPR040641
IPR041031
LRG_1315
LRG_1315t1
MIM:612487
NM_001310332
NM_017999
NP_001297261
NP_060469
PF01485
PF09409
PF16678
PF18091
PF18486
PH_hs_0029932
RNF31
RNF31-201
RNF31-211
RNF31-228
RNF31-250
SM00547
SM00647
UPI0000072F93
UPI000051AE9C
Participant Of
hasComponent
LUBAC [cytosol]
Inferred To
RNF31 [cytosol] (Bos taurus)
RNF31 [cytosol] (Canis familiaris)
RNF31 [cytosol] (Danio rerio)
RNF31 [cytosol] (Mus musculus)
RNF31 [cytosol] (Rattus norvegicus)
RNF31 [cytosol] (Sus scrofa)
RNF31 [cytosol] (Xenopus tropicalis)
Cross References
RefSeq
NP_060469.4
,
NP_001297261.1
OpenTargets
ENSG00000092098
GeneCards
Q96EP0
PRO
Q96EP0
Orphanet
23269
PDB
4LJQ
,
4P09
,
4P0B
,
2CT7
,
4OYJ
,
4LJP
,
4P0A
,
4DBG
,
6GZY
,
4OWF
,
5LJN
,
5EDV
,
4LJO
,
5X0W
,
4JUY
,
4OYK
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9H0F6 SHARPIN
1
SHARPIN [cytosol]
(R-HSA-5212666)
0.953
32
UniProt:Q9Y6K9 IKBKG
12
IKBKG [nucleoplasm]
(R-HSA-4755413)
SUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wro*447 [cytosol]
(R-HSA-5262978)
IKBKG [cytosol]
(R-HSA-168108)
K63polyUb-NEMO [cytosol]
(R-HSA-202530)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
0.773
10
UniProt:P01375 TNF
5
TNF(1-34) [plasma membrane]
(R-HSA-8863367)
TNF(52-76) [extracellular region]
(R-HSA-8863375)
TNF(1-76) [plasma membrane]
(R-HSA-8863120)
TNF(77-233) [extracellular region]
(R-HSA-976821)
TNF(1-233) [plasma membrane]
(R-HSA-66220)
0.643
3
UniProt:Q13490 BIRC2
5
K48pUb-BIRC2 [cytosol]
(R-HSA-5675479)
K63polyUb-BIRC2 [cytosol]
(R-HSA-5668512)
BIRC2(1-372) [cytosol]
(R-HSA-202913)
BIRC2 [cytosol]
(R-HSA-50847)
BIRC2(373-618) [cytosol]
(R-HSA-202931)
0.527
3
UniProt:P21580 TNFAIP3
1
TNFAIP3 [cytosol]
(R-HSA-688989)
0.527
2
UniProt:P84022 SMAD3
12
p-S423,S425-SMAD3 D258N [cytosol]
(R-HSA-3315470)
Ub-SMAD3 [cytosol]
(R-HSA-6782830)
p-S423,S425-SMAD3 R268C [cytosol]
(R-HSA-3315075)
p-S423,S425-SMAD3 R268H [cytosol]
(R-HSA-3315080)
SMAD3 S425F [cytosol]
(R-HSA-8944158)
p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-177104)
p-S423,S425-SMAD3 [cytosol]
(R-HSA-171184)
SMAD3 [cytosol]
(R-HSA-170855)
p-T179,S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2176471)
SMAD3 [nucleoplasm]
(R-HSA-206150)
2xADPRib-p-S423,S425-SMAD3 [nucleoplasm]
(R-HSA-2187326)
SMAD3 S425C [cytosol]
(R-HSA-3308499)
0.508
2
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