Reactome | SHARPIN [cytosol]

SHARPIN [cytosol]

Stable Identifier

R-HSA-5212666

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Shank-associated RH domain-interacting protein, SIPL1, hSIPL1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9H0F6 SHARPIN

Gene Names

SHARPIN, SIPL1, PSEC0216

Chain

chain:1-387

Reference Genes

BioGPS Gene:81858 SHARPIN

COSMIC (genes):SHARPIN SHARPIN

CTD Gene:81858 SHARPIN

dbSNP Gene:81858 SHARPIN

ENSEMBL:ENSG00000179526 SHARPIN

HGNC:25321 SHARPIN

KEGG:hsa:81858 SHARPIN

Monarch:81858 SHARPIN

NCBI Gene:81858 SHARPIN

OMIM:611885 SHARPIN

UCSC:Q9H0F6 SHARPIN

Reference Transcript

Other Identifiers

11724263_a_at

11744686_a_at

17082487

220973_PM_s_at

220973_s_at

3158115

3158116

3158117

3158118

3158119

3158120

3158121

3158122

3158123

3158124

3158125

3158126

3158128

3158129

3158130

3158131

3158132

3158134

3158135

3158136

3158137

3158138

3158139

3158140

3158141

3158142

3158145

3158146

44103_at

64307_s_at

72049_at

8153652

81858

A_23_P94942

A_24_P255798

A_33_P3213551

A_33_P3380567

GE83212

GO:0003824

GO:0004842

GO:0005515

GO:0005737

GO:0005829

GO:0007005

GO:0008544

GO:0010803

GO:0014069

GO:0016567

GO:0016740

GO:0030163

GO:0030262

GO:0030425

GO:0030674

GO:0031424

GO:0031593

GO:0042742

GO:0042802

GO:0043123

GO:0043130

GO:0043161

GO:0043226

GO:0044877

GO:0045202

GO:0046872

GO:0048856

GO:0050728

GO:0060090

GO:0071797

GO:0097039

GO:0098542

GO:0098978

GO:0140096

GO:2000348

HMNXSV003012451

ILMN_1794780

PH_hs_0028139

PH_hs_0039581

TC08001742.hg

TC08002572.hg

g13569949_3p_s_at

Participates

as a component of

as an input of

SHARPIN binds SHANK proteins (Homo sapiens)

Inferred To

Ghost homologue of SHARPIN [cytosol] (Bos taurus)

Ghost homologue of SHARPIN [cytosol] (Canis familiaris)

Ghost homologue of SHARPIN [cytosol] (Gallus gallus)

Ghost homologue of SHARPIN [cytosol] (Mus musculus)

Ghost homologue of SHARPIN [cytosol] (Rattus norvegicus)

Ghost homologue of SHARPIN [cytosol] (Sus scrofa)

Cross References

ENSEMBL

ENSP00000352551, ENSG00000179526, ENSP00000381698, ENST00000398712, ENST00000359551

OpenTargets

ENSG00000179526

GeneCards

SHARPIN

HPA

ENSG00000179526-SHARPIN

PRO

Q9H0F6

Pharos - Targets

Q9H0F6

PDB

8K6P, 4EMO, 5X0W

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96EP0 RNF31	1	RNF31 [cytosol] (R-HSA-5212660)	0.956	34
UniProt:Q9BYM8 RBCK1	1	RBCK1 [cytosol] (R-HSA-976018)	0.868	28
UniProt:Q9Y6K9 IKBKG	12	IKBKG [cytosol] (R-HSA-168108) Ub-285-IKBKG [cytosol] (R-HSA-741397) K63polyUb-IKBKG [cytosol] (R-HSA-202530) IKBKG [nucleoplasm] (R-HSA-4755413) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG D406V [cytosol] (R-HSA-5262943)	0.818	14
IntAct:EBI-4399559 UBIQ			0.737	6
UniProt:P01375 TNF	5	TNF(1-233) [plasma membrane] (R-HSA-66220) TNF(77-233) [extracellular region] (R-HSA-976821) TNF(1-76) [plasma membrane] (R-HSA-8863120) TNF(1-34) [plasma membrane] (R-HSA-8863367) TNF(52-76) [extracellular region] (R-HSA-8863375)	0.725	4
UniProt:P17301 ITGA2	1	ITGA2 [plasma membrane] (R-HSA-57562)	0.664	5
UniProt:P08648 ITGA5	3	ITGA5 [plasma membrane] (R-HSA-9857636) p-S-ITGA5 [plasma membrane] (R-HSA-9857662) ITGA5(42-894) [plasma membrane] (R-HSA-202735)	0.602	4
UniProt:P21580 TNFAIP3	1	TNFAIP3 [cytosol] (R-HSA-688989)	0.597	3
UniProt:P07098 LIPF	1	LIPF [extracellular region] (R-HSA-6789323)	0.527	2
UniProt:P36941 LTBR	1	LTBR [plasma membrane] (R-HSA-5668750)	0.527	2

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