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SHARPIN [cytosol]
Stable Identifier
R-HSA-5212666
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Shank-associated RH domain-interacting protein, SIPL1, hSIPL1
Locations in the PathwayBrowser
Expand all
Neuronal System (Homo sapiens)
Protein-protein interactions at synapses (Homo sapiens)
Neurexins and neuroligins (Homo sapiens)
SHARPIN binds SHANK proteins (Homo sapiens)
SHARPIN [cytosol] (Homo sapiens)
SHARPIN:SHANK1,2,3 [cytosol] (Homo sapiens)
SHARPIN [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signalling (Homo sapiens)
TNF signaling (Homo sapiens)
Regulation of TNFR1 signaling (Homo sapiens)
LUBAC comlex binds OTULIN (Homo sapiens)
LUBAC [cytosol] (Homo sapiens)
SHARPIN [cytosol] (Homo sapiens)
LUBAC:OTULIN [cytosol] (Homo sapiens)
LUBAC [cytosol] (Homo sapiens)
SHARPIN [cytosol] (Homo sapiens)
TNFR1-induced NFkappaB signaling pathway (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:K63polyUb-RIPK1:BIRC2,3:LUBAC recruits IKKA:IKBKB:IKBKG (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
LUBAC [cytosol] (Homo sapiens)
SHARPIN [cytosol] (Homo sapiens)
TNFalpha:TNF-R1:TRADD:K63polyUb-RIP1:BIRC2/3:IKKA:IKKB:NEMO [plasma membrane] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
LUBAC [cytosol] (Homo sapiens)
SHARPIN [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:RIPK1 binds LUBAC (Homo sapiens)
LUBAC [cytosol] (Homo sapiens)
SHARPIN [cytosol] (Homo sapiens)
TNF:TNFR1:TRADD:TRAF2:BIRC2/3:K63polyUB-RIP1:LUBAC [plasma membrane] (Homo sapiens)
LUBAC [cytosol] (Homo sapiens)
SHARPIN [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H0F6 SHARPIN
Gene Names
SHARPIN, SIPL1, PSEC0216
Chain
chain:1-387
Reference Genes
BioGPS Gene:81858 SHARPIN
COSMIC (genes):SHARPIN SHARPIN
CTD Gene:81858 SHARPIN
dbSNP Gene:81858 SHARPIN
ENSEMBL:ENSG00000179526 SHARPIN
HGNC:25321 SHARPIN
KEGG Gene (Homo sapiens):81858 SHARPIN
Monarch:81858 SHARPIN
NCBI Gene:81858 SHARPIN
OMIM:611885 SHARPIN
UCSC:Q9H0F6 SHARPIN
Reference Transcript
RefSeq:XM_017013888.1 SHARPIN
RefSeq:NM_030974.3 SHARPIN
Other Identifiers
0002940577
11724263_a_at
11744686_a_at
17082487
220973_PM_s_at
220973_s_at
3158115
3158116
3158118
3158119
3158121
3158123
3158124
3158125
3158126
3158128
3158129
3158130
3158131
3158136
3158137
3158138
3158139
3158140
3158141
3158142
44103_at
64307_s_at
8153652
A_23_P94942
A_24_P255798
A_33_P3213551
A_33_P3380567
GE83212
GO:0000151
GO:0002376
GO:0003674
GO:0004842
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005829
GO:0006464
GO:0006950
GO:0007005
GO:0007165
GO:0007420
GO:0008150
GO:0008219
GO:0008544
GO:0009056
GO:0010803
GO:0014069
GO:0030054
GO:0030154
GO:0030262
GO:0030425
GO:0031424
GO:0031593
GO:0032182
GO:0032991
GO:0042742
GO:0042802
GO:0043123
GO:0043130
GO:0043161
GO:0043167
GO:0043226
GO:0044877
GO:0045202
GO:0046872
GO:0048856
GO:0050728
GO:0071797
GO:0097039
GO:2000348
HMNXSV003012451
ILMN_1794780
ILMN_1804169
PH_hs_0028139
TC08001742.hg
TC08002572.hg
g13569949_3p_s_at
Participates
as a component of
LUBAC [cytosol] (Homo sapiens)
SHARPIN:SHANK1,2,3 [cytosol] (Homo sapiens)
as an input of
SHARPIN binds SHANK proteins (Homo sapiens)
Inferred To
Sharpin [cytosol]
(Mus musculus)
Sharpin [cytosol]
(Rattus norvegicus)
SHARPIN [cytosol]
(Bos taurus)
SHARPIN [cytosol]
(Canis familiaris)
SHARPIN [cytosol]
(Sus scrofa)
rbck1 [cytosol]
(Danio rerio)
Cross References
RefSeq
XP_016869377.1
,
NP_112236.3
OpenTargets
ENSG00000179526
GeneCards
Q9H0F6
HPA
ENSG00000179526-SHARPIN
Ensembl
ENSP00000352551
,
ENSP00000381698
,
ENST00000359551
,
ENST00000398712
,
ENSG00000179526
PRO
Q9H0F6
Pharos - Targets
Q9H0F6
Orphanet
24897
PDB
5X0W
,
4EMO
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96EP0 RNF31
1
RNF31 [cytosol]
(R-HSA-5212660)
0.953
32
UniProt:Q9BYM8 RBCK1
1
RBCK1 [cytosol]
(R-HSA-976018)
0.829
26
UniProt:Q9Y6K9 IKBKG
12
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG [nucleoplasm]
(R-HSA-4755413)
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wro*447 [cytosol]
(R-HSA-5262978)
K63polyUb-NEMO [cytosol]
(R-HSA-202530)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
IKBKG [cytosol]
(R-HSA-168108)
0.818
14
IntAct:EBI-4399559 UBIQ
0.737
6
UniProt:P01375 TNF
5
TNF(52-76) [extracellular region]
(R-HSA-8863375)
TNF(1-34) [plasma membrane]
(R-HSA-8863367)
TNF(1-76) [plasma membrane]
(R-HSA-8863120)
TNF(77-233) [extracellular region]
(R-HSA-976821)
TNF(1-233) [plasma membrane]
(R-HSA-66220)
0.725
4
UniProt:P17301 ITGA2
1
ITGA2 [plasma membrane]
(R-HSA-57562)
0.664
5
UniProt:P08648 ITGA5
1
ITGA5(42-894) [plasma membrane]
(R-HSA-202735)
0.602
4
UniProt:P21580 TNFAIP3
1
TNFAIP3 [cytosol]
(R-HSA-688989)
0.597
3
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