'p-Y297,304,307-PRMT5 [nucleoplasm]' negatively regulates 'PRMT5 binds WDR77'

Stable Identifier
R-HSA-5212683
Type
NegativeRegulation
Locations in the PathwayBrowser
Summation

JAK2 mutation V617F casues JAK2 to be constitutively activated. One outcome is increased tyrosine phosphorylation of PRMT5. This phosphorylation inhibits the binding of PRMT5 to WDR77, which is an enhancer of PRMT5 methyltransferase activity.

Regulation participants
Regulation type
NegativeRegulation
Regulated entity