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LCN2 [extracellular region]
Stable Identifier
R-HSA-5215934
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Neutrophil gelatinase-associated lipocalin, NGAL_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
Expression of STAT3-upregulated extracellular proteins (Homo sapiens)
STAT3-upregulated extracellular proteins [extracellular region] (Homo sapiens)
LCN2 [extracellular region] (Homo sapiens)
Innate Immune System (Homo sapiens)
Antimicrobial peptides (Homo sapiens)
Metal sequestration by antimicrobial proteins (Homo sapiens)
LCN2:2,5DHBA binds Fe3+ (Homo sapiens)
LCN2:2,5DHBA [extracellular region] (Homo sapiens)
LCN2 [extracellular region] (Homo sapiens)
LCN2:2,5DHBA:Fe3+ [extracellular region] (Homo sapiens)
LCN2:2,5DHBA [extracellular region] (Homo sapiens)
LCN2 [extracellular region] (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of specific granule lumen proteins (Homo sapiens)
Specific granule lumen proteins [extracellular region] (Homo sapiens)
LCN2 [extracellular region] (Homo sapiens)
Transport of small molecules (Homo sapiens)
Iron uptake and transport (Homo sapiens)
Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA (Homo sapiens)
SLC22A17:LCN2:2,5DHBA [plasma membrane] (Homo sapiens)
LCN2:2,5DHBA [extracellular region] (Homo sapiens)
LCN2 [extracellular region] (Homo sapiens)
SLC22A17:LCN2:2,5DHBA:Fe3+ [plasma membrane] (Homo sapiens)
LCN2:2,5DHBA:Fe3+ [extracellular region] (Homo sapiens)
LCN2:2,5DHBA [extracellular region] (Homo sapiens)
LCN2 [extracellular region] (Homo sapiens)
LCN2:2,5DHBA binds Fe3+ (Homo sapiens)
LCN2:2,5DHBA [extracellular region] (Homo sapiens)
LCN2 [extracellular region] (Homo sapiens)
LCN2:2,5DHBA:Fe3+ [extracellular region] (Homo sapiens)
LCN2:2,5DHBA [extracellular region] (Homo sapiens)
LCN2 [extracellular region] (Homo sapiens)
SLC22A17 binds LCN2:2,5DHBA:Fe3+ (Homo sapiens)
LCN2:2,5DHBA:Fe3+ [extracellular region] (Homo sapiens)
LCN2:2,5DHBA [extracellular region] (Homo sapiens)
LCN2 [extracellular region] (Homo sapiens)
SLC22A17:LCN2:2,5DHBA:Fe3+ [plasma membrane] (Homo sapiens)
LCN2:2,5DHBA:Fe3+ [extracellular region] (Homo sapiens)
LCN2:2,5DHBA [extracellular region] (Homo sapiens)
LCN2 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P80188 LCN2
Gene Names
LCN2, HNL, NGAL
Chain
signal peptide:1-20, chain:21-198
Reference Genes
BioGPS Gene:3934 LCN2
COSMIC (genes):LCN2 LCN2
CTD Gene:3934 LCN2
dbSNP Gene:3934 LCN2
ENSEMBL:ENSG00000148346 LCN2
ENSEMBL_homo_sapiens_GENE:ENSG00000148346.12 LCN2
HGNC:6526 LCN2
KEGG Gene (Homo sapiens):3934 LCN2
Monarch:3934 LCN2
NCBI Gene:3934 LCN2
OMIM:600181 LCN2
UCSC:P80188 LCN2
Reference Transcript
RefSeq:NM_005564.4 LCN2
Other Identifiers
11757634_a_at
17089525
212531_PM_at
212531_at
3190192
3190193
3190194
3190195
3190196
3190198
3190199
3190202
3190204
3190205
3190209
32821_at
3934
8158167
A_14_P100877
A_23_P169437
GE81528
GE88852
GO:0002376
GO:0005506
GO:0005515
GO:0005576
GO:0005615
GO:0006811
GO:0006915
GO:0012501
GO:0015891
GO:0031410
GO:0034755
GO:0035580
GO:0036094
GO:0042742
GO:0042802
GO:0043226
GO:0045087
GO:0055085
GO:0060205
GO:0070062
GO:0098542
GO:0120162
GO:0140313
GO:0140315
GO:1903981
HMNXSV003047065
Hs.204238.0.S1_3p_at
ILMN_1692223
PH_hs_0011986
S75256_s_at
TC09000677.hg
Participates
as a member of
STAT3-upregulated extracellular proteins [extracellular region] (Homo sapiens)
Specific granule lumen proteins [extracellular region] (Homo sapiens)
as a component of
LCN2:2,5DHBA [extracellular region] (Homo sapiens)
Other forms of this molecule
LCN2 [specific granule lumen]
Inferred To
LOC555483 [extracellular region]
(Danio rerio)
ptgds [extracellular region]
(Danio rerio)
ptgds [extracellular region]
(Xenopus tropicalis)
cb193 [extracellular region]
(Danio rerio)
Dmel\CG44014 [extracellular region]
(Drosophila melanogaster)
LCN2 [extracellular region]
(Bos taurus)
LCN2 [extracellular region]
(Canis familiaris)
LCN2 [extracellular region]
(Danio rerio)
LCN2 [extracellular region]
(Gallus gallus)
LCN2 [extracellular region]
(Mus musculus)
LCN2 [extracellular region]
(Rattus norvegicus)
LCN2 [extracellular region]
(Sus scrofa)
Homologues of LCN2 [extracellular region]
(Danio rerio)
zgc:153919 [extracellular region]
(Danio rerio)
Cross References
RefSeq
NP_005555.2
OpenTargets
ENSG00000148346
GeneCards
P80188
HPA
ENSG00000148346-LCN2
Ensembl
ENSP00000277480
,
ENSP00000362108
,
ENSG00000148346
,
ENST00000277480
,
ENST00000373017
PRO
P80188
Pharos - Targets
P80188
PDB
3PED
,
3DSZ
,
6SUA
,
6QMU
,
3U0D
,
4IAW
,
1X89
,
5MHH
,
6O5D
,
3HWG
,
6Z2C
,
4IAX
,
3TF6
,
1QQS
,
4ZHF
,
3I0A
,
3T1D
,
5N48
,
4ZHG
,
1X71
,
4MVK
,
4QAE
,
4ZFX
,
3FW5
,
6GQZ
,
1DFV
,
1X8U
,
5KID
,
3TZS
,
3PEC
,
4GH7
,
3HWD
,
1L6M
,
3K3L
,
3CBC
,
3HWE
,
5NKN
,
3HWF
,
4K19
,
6S8V
,
1NGL
,
5KHP
,
3DTQ
,
4ZHC
,
3FW4
,
4MVI
,
4ZHD
,
6Z6Z
,
5JR8
,
5N47
,
4MVL
,
4ZHH
,
3CMP
,
5KIC
,
6GR0
,
3BY0
Interactors (19)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q969M7 UBE2F
3
G76-NEDD8-C116-AcM-UBE2F [cytosol]
(R-HSA-8951758)
AcM-UBE2F [cytosol]
(R-HSA-8951623)
UBE2F [cytosol]
(R-HSA-947635)
0.556
3
UniProt:P54646 PRKAA2
4
PRKAA2 [cytosol]
(R-HSA-200405)
p-T172-PRKAA2 [cytosol]
(R-HSA-200417)
p-T172-PRKAA2 [nucleoplasm]
(R-HSA-164171)
PRKAA2 [nucleoplasm]
(R-HSA-163682)
0.556
3
UniProt:Q08426 EHHADH
2
EHHADH [peroxisomal matrix]
(R-HSA-400155)
EHHADH [cytosol]
(R-HSA-9033147)
0.556
3
UniProt:Q12837 POU4F2
1
POU4F2 [nucleoplasm]
(R-HSA-6804414)
0.556
3
UniProt:O43715 TRIAP1
1
TRIAP1 [mitochondrial intermembrane space]
(R-HSA-1307778)
0.556
3
UniProt:Q6ISS4 LAIR2
1
LAIR2 [extracellular region]
(R-HSA-5696342)
0.556
3
UniProt:Q96LC9 BMF
3
BMF [plasma membrane]
(R-HSA-140209)
p-BMF(1-89) [cytosol]
(R-HSA-140529)
p-BMF [mitochondrial outer membrane]
(R-HSA-3145026)
0.556
3
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.556
3
UniProt:O14595 CTDSP2
1
CTDSP2 [nucleoplasm]
(R-HSA-535488)
0.556
3
UniProt:O96006 ZBED1
1
ZBED1 [nucleoplasm]
(R-HSA-8956376)
0.556
3
UniProt:Q13526 PIN1
2
PIN1 [cytosol]
(R-HSA-9626823)
PIN1 [nucleoplasm]
(R-HSA-936016)
0.556
3
UniProt:Q99757 TXN2
2
2xHC-TXN2 [mitochondrial matrix]
(R-HSA-3323059)
TXN2 [mitochondrial matrix]
(R-HSA-3323048)
0.556
3
UniProt:Q9H0D6 XRN2
2
XRN2 [nucleoplasm]
(R-HSA-6791205)
XRN2 [cytosol]
(R-HSA-391297)
0.556
3
UniProt:Q9Y6Y9 LY96
3
LY96 [extracellular region]
(R-HSA-9707658)
LY96 [endosome membrane]
(R-HSA-2201307)
2xN4GlycoAsn-LY96 [plasma membrane]
(R-HSA-166047)
0.556
3
UniProt:Q96FA3 PELI1
2
PELI1 [cytosol]
(R-HSA-450696)
p-PELI1 [cytosol]
(R-HSA-450815)
0.556
3
UniProt:P24863 CCNC
1
CCNC [nucleoplasm]
(R-HSA-212418)
0.556
3
UniProt:P07237 P4HB
3
P4HB [endoplasmic reticulum lumen]
(R-HSA-174692)
HC53,56-P4HB [endoplasmic reticulum lumen]
(R-HSA-3341287)
p-P4HB [endoplasmic reticulum lumen]
(R-HSA-8956902)
0.556
3
UniProt:Q969S2 NEIL2
1
NEIL2 [nucleoplasm]
(R-HSA-5649650)
0.556
3
UniProt:Q969H8 C19orf10
1
C19orf10 [endoplasmic reticulum lumen]
(R-HSA-535584)
0.556
3
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