Reactome | AHCYL1 [endoplasmic reticulum membrane]

AHCYL1 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-5215973

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Putative adenosylhomocysteinase 2, SAHH2_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O43865 AHCYL1

Gene Names

AHCYL1, DCAL, IRBIT, XPVKONA

Chain

initiator methionine:, chain:2-530

Reference Genes

BioGPS Gene:10768 AHCYL1

COSMIC (genes):AHCYL1 AHCYL1

CTD Gene:10768 AHCYL1

dbSNP Gene:10768 AHCYL1

ENSEMBL:ENSG00000168710 AHCYL1

ENSEMBL_homo_sapiens_GENE:ENSG00000168710.18 AHCYL1

HGNC:344 AHCYL1

KEGG Gene (Homo sapiens):10768 AHCYL1

Monarch:10768 AHCYL1

NCBI Gene:10768 AHCYL1

OMIM:607826 AHCYL1

UCSC:O43865 AHCYL1

Reference Transcript

Other Identifiers

10768

11743426_s_at

11743427_at

11745746_a_at

11745747_x_at

11747331_a_at

11755901_x_at

16668439

200848_PM_at

200848_at

200849_PM_s_at

200849_s_at

200850_PM_s_at

200850_s_at

2351122

2351123

2351124

2351125

2351137

2351141

2351142

2351144

2351145

2351146

2351147

2351149

2351150

2351152

2351154

2351156

2351157

2351160

2351163

2351165

2351167

2351168

2351169

2351170

34727_at

34728_g_at

34792_at

41302_at

7903803

A_14_P100333

A_23_P368126

A_24_P11307

GE56213

GO:0003723

GO:0003824

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005783

GO:0005789

GO:0005829

GO:0005886

GO:0006611

GO:0006730

GO:0006790

GO:0006886

GO:0006913

GO:0006915

GO:0010765

GO:0012501

GO:0016020

GO:0016071

GO:0016324

GO:0016787

GO:0023052

GO:0030234

GO:0031440

GO:0032412

GO:0033353

GO:0038166

GO:0042045

GO:0042802

GO:0043226

GO:0043231

GO:0044070

GO:0044233

GO:0051592

GO:0055085

GO:0070062

GO:0098772

GO:1990456

HMNXSV003013425

Hs.4113.0.S2_3p_at

Hs.4113.0.S3_3p_a_at

ILMN_1770412

PH_hs_0000454

TC01000956.hg

g5729723_3p_a_at

Participates

as a component of

AHCYL1:NAD+ [endoplasmic reticulum membrane] (Homo sapiens)

Inferred To

Homologues of AHCYL1 [endoplasmic reticulum membrane] (Drosophila melanogaster)

AHCYL1 [endoplasmic reticulum membrane] (Bos taurus)

AHCYL1 [endoplasmic reticulum membrane] (Canis familiaris)

AHCYL1 [endoplasmic reticulum membrane] (Danio rerio)

AHCYL1 [endoplasmic reticulum membrane] (Drosophila melanogaster)

AHCYL1 [endoplasmic reticulum membrane] (Gallus gallus)

AHCYL1 [endoplasmic reticulum membrane] (Mus musculus)

AHCYL1 [endoplasmic reticulum membrane] (Plasmodium falciparum)

AHCYL1 [endoplasmic reticulum membrane] (Rattus norvegicus)

AHCYL1 [endoplasmic reticulum membrane] (Sus scrofa)

Cross References

RefSeq

NP_006612.2, NP_001229602.1, NP_001229604.1, NP_001229603.1, NP_001229605.1

OpenTargets

ENSG00000168710

GeneCards

O43865

HPA

ENSG00000168710-AHCYL1

Ensembl

ENST00000369799, ENSG00000168710, ENSP00000377238, ENST00000359172, ENST00000393614, ENSP00000352092, ENSP00000358814

PRO

O43865

Pharos - Targets

O43865

HMDB Protein

HMDBP00663

PDB

3MTG

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P55040 GEM	1	GEM [plasma membrane] (R-HSA-9769962)	0.718	8
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.59	3
UniProt:P04608 tat	1	Tat (P04608) [nucleoplasm] (R-HIV-175856)	0.558	5
UniProt:O60437 PPL	2	PPL [cytosol] (R-HSA-6810850) PPL [cornified envelope] (R-HSA-8847709)	0.556	3
UniProt:P55957 BID	4	MYS-BID(62-195) [mitochondrial outer membrane] (R-HSA-114266) MYS-BID(62-195) [cytosol] (R-HSA-141373) BID(1-195) [cytosol] (R-HSA-50825) BID(62-195) [cytosol] (R-HSA-139953)	0.556	3
UniProt:Q8N2W9 PIAS4	2	PIAS4 [nucleoplasm] (R-HSA-2993789) monoSUMO1-K35-PIAS4 [nucleoplasm] (R-HSA-3968415)	0.556	3
UniProt:Q9BZF9 UACA	1	UACA [cytosol] (R-HSA-6804636)	0.556	3
UniProt:P49674 CSNK1E	2	CSNK1E [nucleoplasm] (R-HSA-421306) CSNK1E [cytosol] (R-HSA-205877)	0.527	2
UniProt:P23526 AHCY	3	AHCY Y143C [cytosol] (R-HSA-5579098) AHCY W112* [cytosol] (R-HSA-5579042) AHCY [cytosol] (R-HSA-174373)	0.527	2
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.527	3
UniProt:Q14562 DHX8	1	DHX8 [nucleoplasm] (R-HSA-5688092)	0.527	3
UniProt:P31152 MAPK4	4	MAPK4 [nucleoplasm] (R-HSA-5686975) MAPK4 [cytosol] (R-HSA-5686973) p-S186 MAPK4 [cytosol] (R-HSA-5687023) p-S186 MAPK4 [nucleoplasm] (R-HSA-5687022)	0.527	3
UniProt:Q9UG63 ABCF2	1	ABCF2 [plasma membrane] (R-HSA-5215945)	0.527	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.519	7
UniProt:P27824 CANX	2	CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum lumen] (R-HSA-195906)	0.483	2