Reactome | ATP5S [mitochondrial inner membrane]

ATP5S [mitochondrial inner membrane]

Stable Identifier

R-HSA-5215992

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

ATP synthase subunit s, mitochondrial, ATP5S_HUMAN

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- Aerobic respiration and respiratory electron transport (Homo sapiens)
  - Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Homo sapiens)
    - Formation of ATP by chemiosmotic coupling (Homo sapiens)
      - ADP and Pi bind to ATPase (Homo sapiens)
        
        ATPase:ADP:Pi [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATP5S tetramer [mitochondrial inner membrane] (Homo sapiens)
        
        ATP5S [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATP5S tetramer [mitochondrial inner membrane] (Homo sapiens)
        
        ATP5S [mitochondrial inner membrane] (Homo sapiens)
      - ATPase synthesizes ATP (Homo sapiens)
        
        ATPase:ADP:Pi [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATP5S tetramer [mitochondrial inner membrane] (Homo sapiens)
        
        ATP5S [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase:ATP [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATP5S tetramer [mitochondrial inner membrane] (Homo sapiens)
        
        ATP5S [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATP5S tetramer [mitochondrial inner membrane] (Homo sapiens)
        
        ATP5S [mitochondrial inner membrane] (Homo sapiens)
      - Enzyme-bound ATP is released (Homo sapiens)
        
        ATPase:ATP [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATP5S tetramer [mitochondrial inner membrane] (Homo sapiens)
        
        ATP5S [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATP5S tetramer [mitochondrial inner membrane] (Homo sapiens)
        
        ATP5S [mitochondrial inner membrane] (Homo sapiens)

Organelle biogenesis and maintenance (Homo sapiens)

- Mitochondrial biogenesis (Homo sapiens)
  - Cristae formation (Homo sapiens)
    - F1Fo ATP synthase dimerizes (Homo sapiens)
      - F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATP5S tetramer [mitochondrial inner membrane] (Homo sapiens)
        
        ATP5S [mitochondrial inner membrane] (Homo sapiens)
      - F1Fo ATP synthase dimer [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATP5S tetramer [mitochondrial inner membrane] (Homo sapiens)
        
        ATP5S [mitochondrial inner membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q99766 DMAC2L

Gene Names

DMAC2L, ATP5S, ATPW

Chain

transit peptide:1-25, chain:26-200

Reference Genes

BioGPS Gene:27109 DMAC2L

COSMIC (genes):DMAC2L DMAC2L

CTD Gene:27109 DMAC2L

dbSNP Gene:27109 DMAC2L

ENSEMBL:ENSG00000125375 ATP5S

ENSEMBL_homo_sapiens_GENE:ENSG00000125375.18 DMAC2L

HGNC:18799 DMAC2L

KEGG Gene (Homo sapiens):27109 DMAC2L

Monarch:27109 DMAC2L

NCBI Gene:27109 DMAC2L

OMIM:618579 DMAC2L

UCSC:Q99766 DMAC2L

Reference Transcript

Other Identifiers

11728435_a_at

11753485_a_at

1554177_3p_a_at

1554177_PM_a_at

1554177_a_at

206992_PM_s_at

206992_s_at

213995_PM_at

213995_at

239859_PM_x_at

27109

3535126

3535127

3535128

3535135

3535137

3535142

3535145

3535146

40025_at

40026_g_at

40027_at

57916_s_at

7974257

A_33_P3279798

GE82031

GO:0005215

GO:0005737

GO:0005739

GO:0005743

GO:0006754

GO:0006811

GO:0015078

GO:0016020

GO:0043226

GO:0045263

GO:0046872

GO:0055085

GO:0055086

GO:1901135

GO:1902600

HMNXSV003035993

HMNXSV003056250

Hs.56155.1.S1_3p_at

ILMN_1679188

ILMN_1700625

ILMN_2299843

TC14001680.hg

U79253_at

g7661835_3p_a_at

Participates

as a component of

ATP5S tetramer [mitochondrial inner membrane] (Homo sapiens)

Inferred To

ATP5S [mitochondrial inner membrane] (Bos taurus)

ATP5S [mitochondrial inner membrane] (Gallus gallus)

ATP5S [mitochondrial inner membrane] (Mus musculus)

ATP5S [mitochondrial inner membrane] (Rattus norvegicus)

Dmel\CG14316 [mitochondrial inner membrane] (Drosophila melanogaster)

atp5s [mitochondrial inner membrane] (Danio rerio)

DMAC2L [mitochondrial inner membrane] (Canis familiaris)

DMAC2L [mitochondrial inner membrane] (Sus scrofa)

RAD7 [mitochondrial inner membrane] (Saccharomyces cerevisiae)

Ghost homologue of ATP5S [mitochondrial inner membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001003805.1, NP_056499.2, NP_001003803.1, XP_011534958.1

OpenTargets

ENSG00000125375

HPA

ENSG00000125375-DMAC2L

GeneCards

Q99766

Ensembl

ENSP00000245448, ENST00000554204, ENSP00000451583, ENST00000245448, ENSG00000125375

PRO

Q99766

Pharos - Targets

Q99766