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GPIHBP1 [plasma membrane]
Stable Identifier
R-HSA-5216067
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1, HDBP1_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of fat-soluble vitamins (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
LPL hydrolyses TGs from mature CMs (Homo sapiens)
GPIHBP1:HSPG:LPL dimer [plasma membrane] (Homo sapiens)
GPIHBP1 [plasma membrane] (Homo sapiens)
Sensory Perception (Homo sapiens)
Visual phototransduction (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
LPL hydrolyses TGs from mature CMs (Homo sapiens)
GPIHBP1:HSPG:LPL dimer [plasma membrane] (Homo sapiens)
GPIHBP1 [plasma membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
Plasma lipoprotein assembly, remodeling, and clearance (Homo sapiens)
Plasma lipoprotein remodeling (Homo sapiens)
Assembly of active LPL and LIPC lipase complexes (Homo sapiens)
GPIHBP1 binds HSPG:LPL dimer (Homo sapiens)
GPIHBP1 [plasma membrane] (Homo sapiens)
GPIHBP1:HSPG:LPL dimer [plasma membrane] (Homo sapiens)
GPIHBP1 [plasma membrane] (Homo sapiens)
PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Homo sapiens)
GPIHBP1 [plasma membrane] (Homo sapiens)
GPIHBP1:HSPG:LPL dimer [plasma membrane] (Homo sapiens)
GPIHBP1 [plasma membrane] (Homo sapiens)
PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Homo sapiens)
GPIHBP1 [plasma membrane] (Homo sapiens)
GPIHBP1:HSPG:LPL dimer [plasma membrane] (Homo sapiens)
GPIHBP1 [plasma membrane] (Homo sapiens)
Chylomicron remodeling (Homo sapiens)
chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols (Homo sapiens)
GPIHBP1:HSPG:LPL dimer [plasma membrane] (Homo sapiens)
GPIHBP1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8IV16 GPIHBP1
Gene Names
GPIHBP1, HBP1
Chain
signal peptide:1-20, chain:21-151, propeptide:152-184
Reference Genes
BioGPS Gene:338328 GPIHBP1
COSMIC (genes):GPIHBP1 GPIHBP1
CTD Gene:338328 GPIHBP1
dbSNP Gene:338328 GPIHBP1
ENSEMBL:ENSG00000277494 GPIHBP1
ENSEMBL_homo_sapiens_GENE:ENSG00000277494.2 GPIHBP1
HGNC:24945 GPIHBP1
KEGG Gene (Homo sapiens):338328 GPIHBP1
Monarch:338328 GPIHBP1
NCBI Gene:338328 GPIHBP1
OMIM:612757 GPIHBP1
UCSC:Q8IV16 GPIHBP1
Reference Transcript
RefSeq:NM_001301772.1 GPIHBP1
RefSeq:NM_178172.5 GPIHBP1
Other Identifiers
11725876_at
17073290
238062_PM_at
238062_at
3119435
3119437
3119439
3119440
3119441
3119442
3119443
338328
50768_at
8148591
A_23_P72697
GE88778
GO:0005215
GO:0005515
GO:0005576
GO:0005886
GO:0006629
GO:0006886
GO:0008289
GO:0009897
GO:0016020
GO:0016192
GO:0016323
GO:0016324
GO:0017038
GO:0019433
GO:0030550
GO:0034394
GO:0035473
GO:0035478
GO:0042632
GO:0045056
GO:0050821
GO:0051006
GO:0060230
GO:0070328
GO:0071503
GO:0071813
GO:0090321
GO:0098552
GO:0098772
GO:0140318
GO:1902494
HMNXSV003000136
Hs.11112.0.A1_3p_at
ILMN_1726210
ILMN_1734076
ILMN_2307150
PH_hs_0019842
TC08000816.hg
TC08002148.hg
Participates
as an output of
PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Homo sapiens)
PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Homo sapiens)
as an input of
GPIHBP1 binds HSPG:LPL dimer (Homo sapiens)
as a component of
GPIHBP1:HSPG:LPL dimer [plasma membrane] (Homo sapiens)
Other forms of this molecule
cleaved GPI-GPIHBP1 [extracellular region]
GPI-GPIHBP1 [plasma membrane]
Inferred To
GPIHBP1 [plasma membrane]
(Bos taurus)
GPIHBP1 [plasma membrane]
(Canis familiaris)
GPIHBP1 [plasma membrane]
(Gallus gallus)
GPIHBP1 [plasma membrane]
(Sus scrofa)
Homologues of GPIHBP1 [plasma membrane]
(Gallus gallus)
Gpihbp1 [plasma membrane]
(Mus musculus)
Gpihbp1 [plasma membrane]
(Rattus norvegicus)
BP1009 [plasma membrane]
(Drosophila melanogaster)
LOC101747868 [plasma membrane]
(Gallus gallus)
Cross References
RefSeq
NP_001288701.1
,
NP_835466.2
OpenTargets
ENSG00000277494
GeneCards
Q8IV16
HPA
ENSG00000277494-GPIHBP1
Ensembl
ENSG00000277494
,
ENST00000622500
,
ENSP00000480053
PRO
Q8IV16
Pharos - Targets
Q8IV16
Orphanet
18433
PDB
6OAZ
,
6OB0
,
6E7K
,
6OAU
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P06858 LPL
1
LPL [extracellular region]
(R-HSA-174605)
0.744
7
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
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