Reactome | LIN7B [plasma membrane]

LIN7B [plasma membrane]

Stable Identifier

R-HSA-5216107

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Protein lin-7 homolog B, LIN7B_HUMAN

Locations in the PathwayBrowser for interactor UniProt:O14936 CASK

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase Effectors (Homo sapiens)
      - RHO GTPases Activate Rhotekin and Rhophilins (Homo sapiens)
        
        RHOA:GTP:RTKN binds LIN7B (Homo sapiens)
        
        LIN7B [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9HAP6 LIN7B

Gene Names

LIN7B, MALS2, VELI2, UNQ3116/PRO10200

Chain

chain:1-207

Reference Genes

BioGPS Gene:64130 LIN7B

COSMIC (genes):LIN7B LIN7B

CTD Gene:64130 LIN7B

dbSNP Gene:64130 LIN7B

ENSEMBL:ENSG00000104863 LIN7B

HGNC:17788 LIN7B

KEGG:hsa:64130 LIN7B

Monarch:64130 LIN7B

NCBI Gene:64130 LIN7B

OMIM:612331 LIN7B

UCSC:Q9HAP6 LIN7B

Reference Transcript

Other Identifiers

11734594_a_at

16863992

219760_PM_at

219760_at

241957_PM_x_at

241957_x_at

3838239

3838240

3838241

3838242

3838243

3838244

3838245

3838246

3838247

3838249

3838250

3838251

3838252

3838253

3838255

64130

69031_at

69033_g_at

76367_at

8030212

A_14_P131888

A_23_P164912

GE62060

GO:0005515

GO:0005886

GO:0005911

GO:0005923

GO:0006887

GO:0007163

GO:0007269

GO:0015031

GO:0016192

GO:0016323

GO:0019901

GO:0019904

GO:0030165

GO:0043226

GO:0045199

GO:0045202

GO:0045211

GO:0097016

GO:0097025

GO:0098793

GO:0098839

GO:0099092

GO:1903361

HMNXSV003010794

Hs.194118.0.A1_3p_at

ILMN_1663444

PH_hs_0023116

TC19000725.hg

TC19000726.hg

g11545919_3p_at

Participates

as a component of

RHOA:GTP:RTKN:LIN7B [plasma membrane] (Homo sapiens)

as an input of

RHOA:GTP:RTKN binds LIN7B (Homo sapiens)

as a member of

LIN7A,B,C [plasma membrane] (Homo sapiens)

Other forms of this molecule

LIN7B [transport vesicle membrane]

Inferred To

LIN7B [plasma membrane] (Bos taurus)

LIN7B [plasma membrane] (Canis familiaris)

LIN7B [plasma membrane] (Sus scrofa)

veli [plasma membrane] (Drosophila melanogaster)

Lin7b [plasma membrane] (Mus musculus)

Lin7b [plasma membrane] (Rattus norvegicus)

lin-7 [plasma membrane] (Caenorhabditis elegans)

lin7b [plasma membrane] (Danio rerio)

lin7b [plasma membrane] (Xenopus tropicalis)

Cross References

ENSEMBL

ENSP00000375737, ENSG00000104863, ENST00000221459, ENSP00000221459, ENST00000391864

OpenTargets

ENSG00000104863

GeneCards

LIN7B

HPA

ENSG00000104863-LIN7B

PRO

Q9HAP6

Pharos - Targets

Q9HAP6

HMDB Protein

HMDBP07776

PDB

2DKR

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5T2T1 MPP7	1	MPP7 [plasma membrane] (R-HSA-9714466)	0.666	5
UniProt:Q9NZW5 PALS2			0.666	7
UniProt:Q13368 MPP3			0.666	9
UniProt:Q8N3R9 MPP5	2	MPP5 [plasma membrane] (R-HSA-419969) MPP5 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-9689606)	0.666	5
UniProt:P20618 PSMB1	7	PSMB1 [cytosol] (R-HSA-68738) PSMB1 [nucleoplasm] (R-HSA-174347) pro-PSMB1 [cytosol] (R-HSA-9908139) PSMB1(1-28) [cytosol] (R-HSA-9908143) PSMB1 [ficolin-1-rich granule lumen] (R-HSA-6803340) PSMB1 [extracellular region] (R-HSA-6806477) PSMB1 [secretory granule lumen] (R-HSA-6803287)	0.556	3
UniProt:Q8WVT3 TRAPPC12	1	TRAPPC12 [cytosol] (R-HSA-5683753)	0.556	3
UniProt:O14936-4 CASK			0.556	3
UniProt:Q9H0I2 ENKD1			0.556	3
UniProt:Q9BXY0 MAK16			0.556	3
UniProt:Q14168-4 MPP2			0.556	3
UniProt:Q96HA8 NTAQ1			0.556	3
UniProt:Q8N8B7-2 TCEANC			0.556	3
UniProt:Q9NUP9 LIN7C	2	LIN7C [plasma membrane] (R-HSA-5216165) LIN7C [transport vesicle membrane] (R-HSA-9610411)	0.527	2
UniProt:O14936 CASK	1	CASK [cytosol] (R-HSA-373631)	0.527	3
UniProt:P48050 KCNJ4	1	KCNJ4 [plasma membrane] (R-HSA-975336)	0.508	3

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