Reactome | SEC22A [endoplasmic reticulum membrane]

SEC22A [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-5216111

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Vesicle-trafficking protein SEC22a, SC22A_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPII-mediated vesicle transport (Homo sapiens)
        
        SEC31:SEC13 and v-SNARE recruitment (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        ER-to-ERGIC v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC22A [endoplasmic reticulum membrane] (Homo sapiens)
        
        ER-to-ERGIC v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC22A [endoplasmic reticulum membrane] (Homo sapiens)
        
        Vesicle budding (Homo sapiens)
        
        COPII cargo:receptors:SAR1B:GTP:SEC23:SEC24:SEC16A:SEC16B:TFG hexamer:SEC13:SEC31:SEC23IP:v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        ER-to-ERGIC v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)
        
        SEC22A [endoplasmic reticulum membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96IW7 SEC22A

Gene Names

SEC22A, SEC22L2

Chain

initiator methionine:, chain:2-307

Reference Genes

BioGPS Gene:26984 SEC22A

COSMIC (genes):SEC22A SEC22A

CTD Gene:26984 SEC22A

dbSNP Gene:26984 SEC22A

ENSEMBL:ENSG00000121542 SEC22A

HGNC:20260 SEC22A

KEGG:hsa:26984 SEC22A

Monarch:26984 SEC22A

NCBI Gene:26984 SEC22A

OMIM:612442 SEC22A

UCSC:Q96IW7 SEC22A

Reference Transcript

Other Identifiers

11720987_at

11720988_at

16944763

218703_PM_at

218703_at

238078_PM_at

238078_at

2639310

2639311

2639312

2639314

2639317

2639318

2639325

2639326

2639327

2639328

2639329

2639330

2639340

2639341

2639342

2639343

2639348

2639352

2639353

2639354

2639355

2639356

2639357

2639358

2639359

2639360

2639362

26984

46901_at

48596_at

8082153

A_14_P117180

A_23_P259874

A_32_P233019

GE79743

GO:0005484

GO:0005515

GO:0005737

GO:0005783

GO:0005789

GO:0005794

GO:0006888

GO:0006890

GO:0015031

GO:0016020

GO:0016192

GO:0031410

GO:0033116

GO:0042470

GO:0043226

GO:0043231

GO:0060090

GO:0061024

GO:0061025

HMNXSV003014068

Hs.53126.0.A1_3p_at

ILMN_1775036

PH_hs_0025151

TC03003364.hg

g6912647_3p_at

Participates

as a candidate of

ER-to-ERGIC v-SNARES [endoplasmic reticulum membrane] (Homo sapiens)

Other forms of this molecule

SEC22A [ER to Golgi transport vesicle membrane]

SEC22A [endoplasmic reticulum-Golgi intermediate compartment membrane]

Inferred To

Sec22a [endoplasmic reticulum membrane] (Mus musculus)

Sec22a [endoplasmic reticulum membrane] (Rattus norvegicus)

sec22a [endoplasmic reticulum membrane] (Xenopus tropicalis)

SEC22A [endoplasmic reticulum membrane] (Bos taurus)

SEC22A [endoplasmic reticulum membrane] (Canis familiaris)

SEC22A [endoplasmic reticulum membrane] (Gallus gallus)

SEC22A [endoplasmic reticulum membrane] (Sus scrofa)

Cross References

OpenTargets

ENSG00000121542

ENSEMBL

ENST00000492595, ENSG00000121542, ENSP00000417972, ENSP00000310521, ENST00000309934

HPA

ENSG00000121542-SEC22A

GeneCards

SEC22A

PRO

Q96IW7

Pharos - Targets

Q96IW7

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92838 EDA	1	EDA [plasma membrane] (R-HSA-5667156)	0.781	7
UniProt:P11686 SFTPC	9	pro-SFTPC P115L [endoplasmic reticulum membrane] (R-HSA-5688352) pro-SFTPC P30L [endoplasmic reticulum membrane] (R-HSA-5688365) pro-SFTPC [endoplasmic reticulum membrane] (R-HSA-5683842) pro-SFTPC [multivesicular body lumen] (R-HSA-5685298) SFTPC [extracellular region] (R-HSA-5683685) SFTPC [clathrin-coated endocytic vesicle] (R-HSA-5686342) SFTPC [lamellar body] (R-HSA-5683717) SFTPC(24-58) [multivesicular body lumen] (R-HSA-5685899) SFTPC(59-197) [multivesicular body lumen] (R-HSA-5685871)	0.718	6
UniProt:Q12846 STX4	4	STX4 [plasma membrane] (R-HSA-181519) STX4 [phagocytic vesicle membrane] (R-HSA-2029044) STX4 [cytosol] (R-HSA-114505) p-STX4 [cytosol] (R-HSA-114681)	0.718	6
UniProt:Q96A56 TP53INP1	1	TP53INP1 [nucleoplasm] (R-HSA-3215226)	0.556	3
UniProt:Q9NX18 SDHAF2	1	SDHAF2 [mitochondrial matrix] (R-HSA-9854689)	0.556	3
UniProt:Q9UP52 TFR2	1	TFR2 [plasma membrane] (R-HSA-5691118)	0.556	3
UniProt:Q9GZU1 MCOLN1	2	MCOLN1 [plasma membrane] (R-HSA-3211764) MCOLN1 [endosome membrane] (R-HSA-917803)	0.556	3
UniProt:P63252 KCNJ2	1	KCNJ2 [plasma membrane] (R-HSA-975378)	0.556	3
UniProt:P35232 PHB	2	PHB [cytosol] (R-HSA-5672944) PHB [mitochondrial inner membrane] (R-HSA-8953720)	0.556	3
UniProt:O60883 GPR37L1	1	GPR37L1 [plasma membrane] (R-HSA-5336178)	0.556	3
UniProt:P43657 LPAR6	1	LPAR6 [plasma membrane] (R-HSA-417913)	0.556	3
UniProt:Q16623 STX1A	5	STX1A [plasma membrane] (R-HSA-449128) STX1A(?-288) [plasma membrane] (R-HSA-5246518) STX1A(1-?) [cytosol] (R-HSA-3065964) STX1A [cytosol] (R-HSA-9609866) STX1A [endoplasmic reticulum membrane] (R-HSA-9609878)	0.556	3
UniProt:Q96BA8 CREB3L1	7	CREB3L1 [Golgi membrane] (R-HSA-8874155) CREB3L1(427-519) [Golgi membrane] (R-HSA-8874139) CREB3L1(1-426) [Golgi membrane] (R-HSA-8874153) CREB3L1 [endoplasmic reticulum membrane] (R-HSA-8874157) CREB3L1(1-375) [cytosol] (R-HSA-8874215) CREB3L1(376-426) [Golgi membrane] (R-HSA-8874213) CREB3L1(1-375) [nucleoplasm] (R-HSA-8874222)	0.556	3
UniProt:Q8TDQ0 HAVCR2	1	HAVCR2 [plasma membrane] (R-HSA-5340408)	0.556	3
UniProt:P50876 RNF144A	1	RNF144A [endosome membrane] (R-HSA-8938771)	0.556	3
UniProt:Q9BRI3 SLC30A2	2	SLC30A2 [endosome membrane] (R-HSA-435363) SLC30A2 [synaptic vesicle membrane] (R-HSA-4084714)	0.556	3
UniProt:Q8IUN9 CLEC10A	1	CLEC10A [plasma membrane] (R-HSA-1472863)	0.556	3
UniProt:Q05329 GAD2	2	PXLP-K396-GAD2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888582) PXLP-K396-GAD2 [plasma membrane] (R-HSA-936509)	0.556	3
UniProt:P21217 FUT3	1	FUT3 [Golgi membrane] (R-HSA-5693934)	0.556	3
UniProt:Q9NR28 DIABLO	2	DIABLO [cytosol] (R-HSA-114298) DIABLO [mitochondrial intermembrane space] (R-HSA-64637)	0.556	3
UniProt:Q6PIZ9 TRAT1	1	p-Y63,Y79,Y110-TRAT1 [plasma membrane] (R-HSA-202201)	0.556	3
UniProt:P17643 TYRP1	1	TYRP1 [melanosome membrane] (R-HSA-8878574)	0.556	3
UniProt:P32942 ICAM3	1	ICAM3 [plasma membrane] (R-HSA-197682)	0.556	3
UniProt:Q8NBQ5 HSD17B11	1	HSD17B11 [cytosol] (R-HSA-5693370)	0.556	3

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