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ARL2 [cytosol]
Stable Identifier
R-HSA-5216230
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
ADP-ribosylation factor-like protein 2, ARL2_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Protein folding (Homo sapiens)
Post-chaperonin tubulin folding pathway (Homo sapiens)
Beta-tubulin:GTP + Cofactor D -> Beta-tubulin:GTP: Cofactor D (Homo sapiens)
ARL2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS processing (Homo sapiens)
ARL2:GTP bind PDE6D on KRAS4B (Homo sapiens)
ARL2:GTP [cytosol] (Homo sapiens)
ARL2 [cytosol] (Homo sapiens)
S-Farn-Me KRAS4B:CALM1:4xCa2+:PDE6D:ARL2:GTP [cytosol] (Homo sapiens)
ARL2:GTP [cytosol] (Homo sapiens)
ARL2 [cytosol] (Homo sapiens)
KRAS4B recycles to the plasma membrane (Homo sapiens)
ARL2:GTP [cytosol] (Homo sapiens)
ARL2 [cytosol] (Homo sapiens)
S-Farn-Me KRAS4B:CALM1:4xCa2+:PDE6D:ARL2:GTP [cytosol] (Homo sapiens)
ARL2:GTP [cytosol] (Homo sapiens)
ARL2 [cytosol] (Homo sapiens)
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of vitamins, nucleosides, and related molecules (Homo sapiens)
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane (Homo sapiens)
ARL2:GTP binds ARL2BP (Homo sapiens)
ARL2:GTP [cytosol] (Homo sapiens)
ARL2 [cytosol] (Homo sapiens)
ARL2:GTP:ARL2BP [cytosol] (Homo sapiens)
ARL2:GTP [cytosol] (Homo sapiens)
ARL2 [cytosol] (Homo sapiens)
ARL2:GTP:ARL2BP translocates from cytosol to the mitochondrial matrix (Homo sapiens)
ARL2:GTP:ARL2BP [cytosol] (Homo sapiens)
ARL2:GTP [cytosol] (Homo sapiens)
ARL2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P36404 ARL2
Gene Names
ARL2
Chain
initiator methionine:, chain:2-184
Reference Genes
BioGPS Gene:402 ARL2
COSMIC (genes):ARL2 ARL2
CTD Gene:402 ARL2
dbSNP Gene:402 ARL2
ENSEMBL:ENSG00000213465 ARL2
ENSEMBL_homo_sapiens_GENE:ENSG00000213465.8 ARL2
HGNC:693 ARL2
KEGG Gene (Homo sapiens):402 ARL2
Monarch:402 ARL2
NCBI Gene:402 ARL2
OMIM:601175 ARL2
UCSC:P36404 ARL2
Reference Transcript
RefSeq:NM_001199745.1 ARL2
RefSeq:NM_001667.3 ARL2
Other Identifiers
11718129_x_at
11753624_a_at
202564_PM_x_at
202564_x_at
31893_at
3334784
3334785
3334789
3334790
3334792
3334793
3334794
3334795
3334796
402
7941104
A_23_P98252
GE57629
GO:0000166
GO:0003824
GO:0003924
GO:0005515
GO:0005525
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005739
GO:0005758
GO:0005759
GO:0005794
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0005925
GO:0005975
GO:0006091
GO:0006110
GO:0006457
GO:0007010
GO:0007049
GO:0007098
GO:0007155
GO:0010811
GO:0015630
GO:0016328
GO:0016787
GO:0019003
GO:0031113
GO:0031116
GO:0034260
GO:0034330
GO:0043226
GO:0051457
GO:0055086
GO:0065003
GO:0070830
GO:1901135
GO:1903715
HMNXSV003032149
ILMN_1787879
TC11003457.hg
g4502228_3p_at
g4502228_3p_x_at
Participates
as a component of
ARL2:GTP [cytosol] (Homo sapiens)
This entity regulates
Negatively
Beta-tubulin:GTP + Cofactor D -> Beta-tubulin:GTP: Cofactor D
(Homo sapiens)
Other forms of this molecule
ARL2 [mitochondrial matrix]
Inferred To
Ghost homologue of ARL2 [cytosol]
(Gallus gallus)
arl2 [cytosol]
(Danio rerio)
arl2 [cytosol]
(Xenopus tropicalis)
ARL2 [cytosol]
(Bos taurus)
ARL2 [cytosol]
(Caenorhabditis elegans)
ARL2 [cytosol]
(Canis familiaris)
ARL2 [cytosol]
(Dictyostelium discoideum)
ARL2 [cytosol]
(Drosophila melanogaster)
ARL2 [cytosol]
(Mus musculus)
ARL2 [cytosol]
(Plasmodium falciparum)
ARL2 [cytosol]
(Rattus norvegicus)
ARL2 [cytosol]
(Saccharomyces cerevisiae)
ARL2 [cytosol]
(Schizosaccharomyces pombe)
ARL2 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_001658.2
,
NP_001186674.1
OpenTargets
ENSG00000213465
HPA
ENSG00000213465-ARL2
GeneCards
P36404
Ensembl
ENSP00000436021
,
ENSP00000432971
,
ENST00000533729
,
ENSP00000246747
,
ENSG00000213465
,
ENST00000529384
,
ENST00000246747
PRO
P36404
Pharos - Targets
P36404
PDB
3DOE
,
3DOF
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y2Y0 ARL2BP
2
ARL2BP [cytosol]
(R-HSA-5215982)
ARL2BP [mitochondrial matrix]
(R-HSA-5250220)
0.966
27
UniProt:O43924 PDE6D
2
PDE6D [cilium]
(R-HSA-5624884)
PDE6D [cytosol]
(R-HSA-2565921)
0.955
19
UniProt:Q13432 U119A
0.884
12
UniProt:Q9BTW9 TBCD
1
TBCD [cytosol]
(R-HSA-379540)
0.688
4
UniProt:Q9BZK7 TBL1XR1
1
TBL1XR1 [nucleoplasm]
(R-HSA-351643)
0.666
4
UniProt:Q969G2 LHX4
1
LHX4 [nucleoplasm]
(R-HSA-9010585)
0.556
3
UniProt:Q13885 TUBB2A
6
TUBB2A folding intermediate [cytosol]
(R-HSA-392802)
TUBB2A unfolded [cytosol]
(R-HSA-392776)
Polyglycyl-TUBB2A [cytosol]
(R-HSA-8867466)
Polyglutamyl-TUBB2A [cytosol]
(R-HSA-8867392)
TUBB2A [axonemal microtubule]
(R-HSA-5610431)
TUBB2A [cytosol]
(R-HSA-191699)
0.527
4
UniProt:P09923 ALPI
3
cleaved GPI-ALPI [extracellular region]
(R-HSA-8943401)
GPI-ALPI [plasma membrane]
(R-HSA-8940717)
ALPI [plasma membrane]
(R-HSA-8878783)
0.527
2
UniProt:Q9BVA1 TUBB2B
6
TUBB2B folding intermediate [cytosol]
(R-HSA-392796)
TUBB2B unfolded [cytosol]
(R-HSA-392768)
Polyglycyl-TUBB2B [cytosol]
(R-HSA-8867393)
Polyglutamyl-TUBB2B [cytosol]
(R-HSA-8867426)
TUBB2B [axonemal microtubule]
(R-HSA-5610432)
TUBB2B [cytosol]
(R-HSA-191705)
0.527
3
UniProt:P07437 TUBB
3
TUBB [cytosol]
(R-HSA-9020816)
TUBB [azurophil granule lumen]
(R-HSA-6799370)
TUBB [extracellular region]
(R-HSA-380317)
0.527
3
UniProt:P21589 NT5E
1
NT5E [plasma membrane]
(R-HSA-49191)
0.527
2
UniProt:Q68D85 NCR3LG1
1
NCR3LG1 [plasma membrane]
(R-HSA-5683240)
0.527
2
UniProt:P68371 TUBB4B
8
TUBB4B [cytosol]
(R-HSA-191702)
TUBB4B [azurophil granule lumen]
(R-HSA-6799347)
TUBB4B [extracellular region]
(R-HSA-6806178)
TUBB4B [axonemal microtubule]
(R-HSA-5610441)
Polyglutamyl-TUBB4B [cytosol]
(R-HSA-8867427)
Polyglycyl-TUBB4B [cytosol]
(R-HSA-8867452)
TUBB4B unfolded [cytosol]
(R-HSA-392779)
TUBB4B folding intermediate [cytosol]
(R-HSA-392788)
0.527
4
UniProt:Q96G28 CFA36
0.527
3
UniProt:P04350 TUBB4A
6
TUBB4A [cytosol]
(R-HSA-190588)
TUBB4A [axonemal microtubule]
(R-HSA-5610435)
Polyglutamyl-TUBB4A [cytosol]
(R-HSA-8867425)
Polyglycyl-TUBB4A [cytosol]
(R-HSA-8867397)
TUBB4A unfolded [cytosol]
(R-HSA-392778)
TUBB4A folding intermediate [cytosol]
(R-HSA-392789)
0.527
3
UniProt:P36405 ARL3
1
ARL3 [cilium]
(R-HSA-5618182)
0.508
2
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