Reactome | p-Y31,Y118-PXN [cytosol]

p-Y31,Y118-PXN [cytosol]

Stable Identifier

R-HSA-5218693

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-Y31,Y118-Paxillin

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by PTK6 (Homo sapiens)
    - PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Homo sapiens)
      - Activation of RAC1 by the PXN:CRK complex (Homo sapiens)
        
        p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        p-Y31,Y118-PXN [cytosol] (Homo sapiens)
      - PTK6 phosphorylates PXN (Homo sapiens)
        
        p-Y31,Y118-PXN [cytosol] (Homo sapiens)
      - Phosphorylated PXN recruits the CRK complex (Homo sapiens)
        
        p-Y31,Y118-PXN [cytosol] (Homo sapiens)
        
        p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        p-Y31,Y118-PXN [cytosol] (Homo sapiens)
- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by VEGF (Homo sapiens)
    - VEGFA-VEGFR2 Pathway (Homo sapiens)
      - CRK binds BCAR1 and or PXN (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        p-Y31,Y118-PXN [cytosol] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        p-Y31,Y118-PXN [cytosol] (Homo sapiens)
      - DOCK180:ELMO binds CRK (Homo sapiens)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        p-Y31,Y118-PXN [cytosol] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        p-Y31,Y118-PXN [cytosol] (Homo sapiens)
      - DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Homo sapiens)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        p-Y31,Y118-PXN [cytosol] (Homo sapiens)
      - PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        p-Y31,Y118-PXN [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P49023 PXN

Gene Names

PXN

Chain

initiator methionine:, chain:1-591

Reference Genes

BioGPS Gene:5829 PXN

COSMIC (genes):PXN PXN

CTD Gene:5829 PXN

dbSNP Gene:5829 PXN

ENSEMBL:ENSG00000089159 PXN

HGNC:9718 PXN

KEGG Gene (Homo sapiens):5829 PXN

Monarch:5829 PXN

NCBI Gene:5829 PXN

OMIM:602505 PXN

UCSC:P49023 PXN

Reference Transcript

Other Identifiers

11717617_a_at

11717618_s_at

11736017_s_at

11736018_x_at

11748796_a_at

11749054_x_at

11752827_a_at

11752828_x_at

16771242

201087_at

211823_s_at

3474373

3474374

3474375

3474376

3474377

3474378

3474379

3474380

3474384

3474385

3474386

3474387

3474388

3474390

3474402

3474403

3474404

3474405

3474406

3474407

3474416

3474417

38644_at

5829

7967002

A_24_P184555

A_33_P3380098

GE58953

GO:0000902

GO:0001725

GO:0003674

GO:0003712

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005829

GO:0005856

GO:0005875

GO:0005886

GO:0005911

GO:0005925

GO:0005938

GO:0006936

GO:0006950

GO:0007010

GO:0007155

GO:0007160

GO:0007165

GO:0007172

GO:0007179

GO:0008013

GO:0008092

GO:0008150

GO:0009058

GO:0017166

GO:0019899

GO:0019903

GO:0022607

GO:0030027

GO:0030054

GO:0030154

GO:0032991

GO:0034446

GO:0034614

GO:0034641

GO:0038191

GO:0040011

GO:0043167

GO:0043226

GO:0043542

GO:0046872

GO:0048010

GO:0048856

GO:0048870

GO:0051496

GO:0060396

GO:0065003

HMNXSV003050935

TC12002037.hg

U14588_at

g1912054_3p_a_at

g4506344_3p_at

Participates

as a component of

as an output of

PTK6 phosphorylates PXN (Homo sapiens)

as an input of

Phosphorylated PXN recruits the CRK complex (Homo sapiens)

Other forms of this molecule

p-Y-PXN [plasma membrane]

PXN [plasma membrane]

PXN [cytosol]

Inferred To

phospho-pxl-1 [cytosol] (Caenorhabditis elegans)

phospho-PXL1 [cytosol] (Saccharomyces cerevisiae)

phospho-pxn [cytosol] (Xenopus tropicalis)

phospho-Pxn [cytosol] (Mus musculus)

phospho-Pxn [cytosol] (Rattus norvegicus)

phospho-TGFB1I1 [cytosol] (Gallus gallus)

phospho-pxnb [cytosol] (Danio rerio)

phospho-limB [cytosol] (Dictyostelium discoideum)

phospho-Pax [cytosol] (Drosophila melanogaster)

phospho-p-Y31,Y118-PXN [cytosol] (Schizosaccharomyces pombe)

phospho-PXN [cytosol] (Bos taurus)

phospho-PXN [cytosol] (Canis familiaris)

phospho-PXN [cytosol] (Sus scrofa)

Modified Residues

Name

O4'-phospho-L-tyrosine at 31

Coordinate

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 118

Coordinate

118

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_002850.2, NP_079433.3, NP_001230685.1, XP_016875232.1, NP_001074324.1

OpenTargets

ENSG00000089159

HPA

ENSG00000089159-PXN

GeneCards

P49023

Ensembl

ENSP00000267257, ENSP00000228307, ENST00000458477, ENSG00000089159, ENST00000267257, ENSP00000391283, ENSP00000395536, ENST00000424649, ENST00000228307

PRO

P49023

Pharos - Targets

P49023

GlyGen

P49023

PDB

6U4N, 2K2R, 3U3F, 5UWH, 1OW8, 4XH2, 4XGZ, 2VZI, 1OW7, 3RQF, 3RQE, 6U4M, 1KL0, 1KKY, 2VZD, 3GM1, 3RQG, 4R32, 1OW6, 6PW8, 3PY7, 4EDN, 2VZG, 6IUI, 2O9V

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q05397 PTK2	11	pY-PTK2 [cytosol] (R-HSA-9632393) PTK2(773-1052) [cytosol] (R-HSA-202829) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) p-6Y-PTK2 [cytosol] (R-HSA-354128) p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613) p-5Y-PTK2 [cytosol] (R-HSA-5218711) p-Y397-PTK2 [cytosol] (R-HSA-354068) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) PTK2(1-772) [cytosol] (R-HSA-202827) PTK2 [cytosol] (R-HSA-201621) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006)	0.91	17
UniProt:P06931 VE6			0.744	4
UniProt:Q14161 GIT2	1	GIT2 [cytosol] (R-HSA-446034)	0.688	4
UniProt:P13612 ITGA4	1	ITGA4 [plasma membrane] (R-HSA-198007)	0.688	4
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.669	4
UniProt:P41240 CSK	2	CSK [plasma membrane] (R-HSA-180499) CSK [cytosol] (R-HSA-203776)	0.623	4
UniProt:Q62417-2 SORBS1			0.61	8
UniProt:Q06124 PTPN11	4	PTPN11 [nucleoplasm] (R-HSA-8937745) p-Y546-PTPN11 [cytosol] (R-HSA-1369081) PTPN11 [cytosol] (R-HSA-162563) p-Y546,Y584-PTPN11 [cytosol] (R-HSA-162573)	0.604	3
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) CTNNB1 S45F [cytosol] (R-HSA-4791268) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45P [cytosol] (R-HSA-4791272) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619)	0.602	4
UniProt:Q99942 RNF5	1	RNF5 [endoplasmic reticulum membrane] (R-HSA-975990)	0.591	6
UniProt:Q9Y2X7 GIT1	2	GIT1 [cytosol] (R-HSA-430326) p-Y383-GIT1 [cytosol] (R-HSA-3928463)	0.564	3
UniProt:P13569 CFTR	17	CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR [plasma membrane] (R-HSA-383188) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR [endosome membrane] (R-HSA-6782965) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) CFTR N1303K [plasma membrane] (R-HSA-5678983) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) ub-CFTR F508del [cytosol] (R-HSA-8866838) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	9
UniProt:P05556-1 ITGB1			0.524	2
UniProt:Q09463	2	rnf-5 [endoplasmic reticulum membrane] (R-CEL-975990) rnf-5 [endoplasmic reticulum membrane] (R-CEL-8861819)	0.524	2
UniProt:Q13480 GAB1	4	p-Y-GAB1 [cytosol] (R-HSA-8855306) p-Y627,Y659-GAB1 [cytosol] (R-HSA-180496) GAB1 [cytosol] (R-HSA-179795) p-5Y-GAB1 [cytosol] (R-HSA-180344)	0.499	2
UniProt:P02751 FN1	10	FN1(32-2386) [platelet alpha granule lumen] (R-HSA-114620) FN1(32-271) [extracellular region] (R-HSA-3787935) FN1(32-2386) [extracellular region] (R-HSA-54851) FN1(32-1201)-p-7Y ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713462) p-FN1 [endoplasmic reticulum lumen] (R-HSA-8956937) FN1(32-1201)-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713459) FN1(272-2386) [extracellular region] (R-HSA-3788024) FN1(?-2386) [extracellular region] (R-HSA-2533841) FN1 [endoplasmic reticulum lumen] (R-HSA-8956708) FN1(32-?) [extracellular region] (R-HSA-2533850)	0.491	2
UniProt:O13016 PTN1			0.489	2
UniProt:P34152 Ptk2	13	Ptk2 [cytosol] (R-MMU-202827) Ptk2 [cytosol] (R-MMU-202829) phospho-Ptk2 [cytosol] (R-MMU-9632393) phospho-Ptk2 [cytosol] (R-MMU-5229006) phospho-Ptk2 [cytosol] (R-MMU-354128) phospho-Ptk2 [cytosol] (R-MMU-5218711) Fak1 [cytosol] (R-MMU-3928448) Ptk2 [cytosol] (R-MMU-201621) phospho-Ptk2 [cytosol] (R-MMU-5218694) p-Y428-FAK1 [cytosol] (R-MMU-3928397) phospho-Ptk2 [cytosol] (R-MMU-354068) phospho-Ptk2 [cytosol] (R-MMU-8874613) phospho-Ptk2 [cytosol] (R-MMU-8874600)	0.463	2
UniProt:P16671 CD36	5	4xPalmC-CD36 [specific granule membrane] (R-HSA-6806151) 4xPalmC-CD36 [endocytic vesicle membrane] (R-HSA-2239449) CD36 [platelet alpha granule membrane] (R-HSA-114687) CD36 [phagocytic vesicle] (R-HSA-1236835) 4xPalmC-CD36 [plasma membrane] (R-HSA-51645)	0.462	2

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