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p-Y31,Y118-PXN [cytosol]
Stable Identifier
R-HSA-5218693
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-Y31,Y118-Paxillin
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PTK6 (Homo sapiens)
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Homo sapiens)
Activation of RAC1 by the PXN:CRK complex (Homo sapiens)
p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
p-Y31,Y118-PXN [cytosol] (Homo sapiens)
PTK6 phosphorylates PXN (Homo sapiens)
p-Y31,Y118-PXN [cytosol] (Homo sapiens)
Phosphorylated PXN recruits the CRK complex (Homo sapiens)
p-Y31,Y118-PXN [cytosol] (Homo sapiens)
p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
p-Y31,Y118-PXN [cytosol] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
CRK binds BCAR1 and or PXN (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
p-Y31,Y118-PXN [cytosol] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
p-Y31,Y118-PXN [cytosol] (Homo sapiens)
DOCK180:ELMO binds CRK (Homo sapiens)
CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
p-Y31,Y118-PXN [cytosol] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
p-Y31,Y118-PXN [cytosol] (Homo sapiens)
DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Homo sapiens)
CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
p-Y31,Y118-PXN [cytosol] (Homo sapiens)
PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
p-Y31,Y118-PXN [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49023 PXN
Gene Names
PXN
Chain
initiator methionine:, chain:1-591
Reference Genes
BioGPS Gene:5829 PXN
COSMIC (genes):PXN PXN
CTD Gene:5829 PXN
dbSNP Gene:5829 PXN
ENSEMBL:ENSG00000089159 PXN
HGNC:9718 PXN
KEGG Gene (Homo sapiens):5829 PXN
Monarch:5829 PXN
NCBI Gene:5829 PXN
OMIM:602505 PXN
UCSC:P49023 PXN
Reference Transcript
RefSeq:NM_001243756.1 PXN
RefSeq:XM_017019743.1 PXN
RefSeq:NM_002859.3 PXN
RefSeq:NM_025157.4 PXN
RefSeq:NM_001080855.2 PXN
Other Identifiers
11717617_a_at
11717618_s_at
11736017_s_at
11736018_x_at
11748796_a_at
11749054_x_at
11752827_a_at
11752828_x_at
16771242
201087_at
211823_s_at
3474373
3474374
3474375
3474376
3474377
3474378
3474379
3474380
3474384
3474385
3474386
3474387
3474388
3474390
3474402
3474403
3474404
3474405
3474406
3474407
3474416
3474417
38644_at
5829
7967002
A_24_P184555
A_33_P3380098
GE58953
GO:0000902
GO:0001725
GO:0003674
GO:0003712
GO:0005178
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005829
GO:0005856
GO:0005875
GO:0005886
GO:0005911
GO:0005925
GO:0005938
GO:0006936
GO:0006950
GO:0007010
GO:0007155
GO:0007165
GO:0007172
GO:0007179
GO:0008013
GO:0008092
GO:0008150
GO:0009058
GO:0017166
GO:0019899
GO:0019901
GO:0019903
GO:0022607
GO:0030027
GO:0030054
GO:0030154
GO:0031625
GO:0032991
GO:0034446
GO:0034614
GO:0034641
GO:0038191
GO:0040011
GO:0043167
GO:0043226
GO:0043542
GO:0044877
GO:0046872
GO:0048010
GO:0048856
GO:0048870
GO:0051496
GO:0060396
GO:0065003
GO:1901652
GO:1903506
TC12002037.hg
U14588_at
g1912054_3p_a_at
g4506344_3p_at
Participant Of
hasComponent
p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol]
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane]
output
PTK6 phosphorylates PXN
input
Phosphorylated PXN recruits the CRK complex
Other forms of this molecule
p-Y-PXN [plasma membrane]
PXN [plasma membrane]
PXN [cytosol]
Inferred To
phospho-pxl-1 [cytosol] (Caenorhabditis elegans)
phospho-PXL1 [cytosol] (Saccharomyces cerevisiae)
phospho-pxn [cytosol] (Xenopus tropicalis)
phospho-Pxn [cytosol] (Mus musculus)
phospho-Pxn [cytosol] (Rattus norvegicus)
Ghost homologue of p-Y31,Y118-PXN [cytosol] (Gallus gallus)
phospho-limB [cytosol] (Dictyostelium discoideum)
phospho-Pax [cytosol] (Drosophila melanogaster)
phospho-pxna [cytosol] (Danio rerio)
phospho-p-Y31,Y118-PXN [cytosol] (Schizosaccharomyces pombe)
phospho-PXN [cytosol] (Bos taurus)
phospho-PXN [cytosol] (Canis familiaris)
phospho-PXN [cytosol] (Sus scrofa)
Modified Residues
Name
O4'-phospho-L-tyrosine at 31
Coordinate
31
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 118
Coordinate
118
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
XP_016875232.1
,
NP_001074324.1
,
NP_002850.2
,
NP_001230685.1
,
NP_079433.3
OpenTargets
ENSG00000089159
GeneCards
P49023
HPA
ENSG00000089159-PXN
Ensembl
ENST00000458477
,
ENSP00000228307
,
ENSP00000267257
,
ENSP00000391283
,
ENST00000267257
,
ENSG00000089159
,
ENSP00000395536
,
ENST00000228307
,
ENST00000424649
PRO
P49023
PDB
1OW8
,
3GM1
,
2K2R
,
5UWH
,
2VZD
,
3U3F
,
1OW7
,
3RQG
,
6IUI
,
4R32
,
4XGZ
,
4XH2
,
3RQF
,
1OW6
,
2VZI
,
6U4N
,
6U4M
,
1KL0
,
3RQE
,
2O9V
,
4EDN
,
2VZG
,
1KKY
,
3PY7
Interactors (19)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q05397 PTK2
11
p-Y194,Y397,Y576,Y577-PTK2 [cytosol]
(R-HSA-8874613)
pY-PTK2 [cytosol]
(R-HSA-9632393)
p-Y194,Y397-PTK2 [cytosol]
(R-HSA-8874600)
PTK2(773-1052) [cytosol]
(R-HSA-202829)
PTK2(1-772) [cytosol]
(R-HSA-202827)
p-5Y-PTK2 [cytosol]
(R-HSA-5218711)
p-5Y,S732-PTK2 [cytosol]
(R-HSA-5229006)
p-6Y,S732-PTK2 [cytosol]
(R-HSA-5218694)
PTK2 [cytosol]
(R-HSA-201621)
p-Y397-PTK2 [cytosol]
(R-HSA-354068)
p-6Y-PTK2 [cytosol]
(R-HSA-354128)
0.91
17
UniProt:P06931 VE6
0.744
4
UniProt:Q14161 GIT2
0.688
4
UniProt:P13612 ITGA4
1
ITGA4 [plasma membrane]
(R-HSA-198007)
0.688
4
UniProt:Q13418 ILK
1
ILK [cytosol]
(R-HSA-432864)
0.669
4
UniProt:Q06124 PTPN11
4
PTPN11 [nucleoplasm]
(R-HSA-8937745)
p-Y546-PTPN11 [cytosol]
(R-HSA-1369081)
PTPN11 [cytosol]
(R-HSA-162563)
p-Y546,Y584-PTPN11 [cytosol]
(R-HSA-162573)
0.641
3
UniProt:P41240 CSK
2
CSK [cytosol]
(R-HSA-203776)
CSK [plasma membrane]
(R-HSA-180499)
0.623
4
UniProt:Q62417-2 SORBS1
0.61
8
UniProt:P35222 CTNNB1
33
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
Ub-K,p-Y-CTNNB1 [cytosol]
(R-HSA-8877006)
p-Y-CTNNB1 [cytosol]
(R-HSA-8876940)
p-S552-CTNNB1 [nucleoplasm]
(R-HSA-3134926)
p-S552-CTNNB1 [cytosol]
(R-HSA-3134933)
CTNNB1(116-376) [cytosol]
(R-HSA-202950)
CTNNB1(1-115) [cytosol]
(R-HSA-202930)
CTNNB1 [plasma membrane]
(R-HSA-9038440)
p-S45 CTNNB1 [cytosol]
(R-HSA-8942363)
p-T41,S45 CTNNB1 [cytosol]
(R-HSA-8942367)
p-S37,T41,S45, CTNNB1 [cytosol]
(R-HSA-8942369)
p-S33,S37,T41,S45 CTNNB1 [cytosol]
(R-HSA-8942374)
CTNNB1 [cytosol]
(R-HSA-448839)
CTNNB1 [nucleoplasm]
(R-HSA-3451168)
0.602
4
UniProt:Q99942 RNF5
1
RNF5 [endoplasmic reticulum membrane]
(R-HSA-975990)
0.591
6
UniProt:P27986 PIK3R1
15
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [plasma membrane]
(R-HSA-198365)
PIK3R1 [cytosol]
(R-HSA-74789)
0.589
2
UniProt:Q9Y2X7 GIT1
2
GIT1 [cytosol]
(R-HSA-430326)
p-Y383-GIT1 [cytosol]
(R-HSA-3928463)
0.564
3
UniProt:P05556-1 ITGB1
0.524
2
UniProt:Q09463
2
rnf-5 [endoplasmic reticulum membrane]
(R-CEL-975990)
rnf-5 [endoplasmic reticulum membrane]
(R-CEL-8861819)
0.524
2
UniProt:Q13480 GAB1
4
p-5Y-GAB1 [cytosol]
(R-HSA-180344)
GAB1 [cytosol]
(R-HSA-179795)
p-Y627,Y659-GAB1 [cytosol]
(R-HSA-180496)
p-Y-GAB1 [cytosol]
(R-HSA-8855306)
0.499
2
UniProt:P02751 FN1
8
FN1(32-271) [extracellular region]
(R-HSA-3787935)
FN1(32-2386) [platelet alpha granule lumen]
(R-HSA-114620)
FN1(272-2386) [extracellular region]
(R-HSA-3788024)
FN1(32-?) [extracellular region]
(R-HSA-2533850)
FN1(?-2386) [extracellular region]
(R-HSA-2533841)
p-FN1 [endoplasmic reticulum lumen]
(R-HSA-8956937)
FN1 [endoplasmic reticulum lumen]
(R-HSA-8956708)
FN1(32-2386) [extracellular region]
(R-HSA-54851)
0.491
2
UniProt:O13016 PTN1
0.489
2
UniProt:P34152 Ptk2
13
phospho-Ptk2 [cytosol]
(R-MMU-8874613)
phospho-Ptk2 [cytosol]
(R-MMU-9632393)
phospho-Ptk2 [cytosol]
(R-MMU-354128)
phospho-Ptk2 [cytosol]
(R-MMU-354068)
Ptk2 [cytosol]
(R-MMU-201621)
phospho-Ptk2 [cytosol]
(R-MMU-5218694)
phospho-Ptk2 [cytosol]
(R-MMU-5229006)
phospho-Ptk2 [cytosol]
(R-MMU-5218711)
Fak1 [cytosol]
(R-MMU-3928448)
p-Y428-FAK1 [cytosol]
(R-MMU-3928397)
Ptk2 [cytosol]
(R-MMU-202827)
Ptk2 [cytosol]
(R-MMU-202829)
phospho-Ptk2 [cytosol]
(R-MMU-8874600)
0.463
2
UniProt:P16671 CD36
5
CD36 [platelet alpha granule membrane]
(R-HSA-114687)
4xPalmC-CD36 [endocytic vesicle membrane]
(R-HSA-2239449)
4xPalmC-CD36 [specific granule membrane]
(R-HSA-6806151)
CD36 [phagocytic vesicle]
(R-HSA-1236835)
4xPalmC-CD36 [plasma membrane]
(R-HSA-51645)
0.462
2
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