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p-Y31,Y118-PXN
Stable Identifier
R-HSA-5218693
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-Y31,Y118-Paxillin
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PTK6 (Homo sapiens)
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Homo sapiens)
Activation of RAC1 by the PXN:CRK complex (Homo sapiens)
p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
p-Y31,Y118-PXN [cytosol] (Homo sapiens)
PTK6 phosphorylates PXN (Homo sapiens)
p-Y31,Y118-PXN [cytosol] (Homo sapiens)
Phosphorylated PXN recruits the CRK complex (Homo sapiens)
p-Y31,Y118-PXN [cytosol] (Homo sapiens)
p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
p-Y31,Y118-PXN [cytosol] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
CRK binds BCAR1 and or PXN (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
p-Y31,Y118-PXN [cytosol] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
p-Y31,Y118-PXN [cytosol] (Homo sapiens)
DOCK180:ELMO binds CRK (Homo sapiens)
CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
p-Y31,Y118-PXN [cytosol] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
p-Y31,Y118-PXN [cytosol] (Homo sapiens)
DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Homo sapiens)
CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
p-Y31,Y118-PXN [cytosol] (Homo sapiens)
PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Homo sapiens)
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
p-Y31,Y118-PXN [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49023 PXN
Gene Names
PXN
Chain
chain:1-591
Reference Genes
BioGPS Gene:5829 PXN
COSMIC (genes):PXN PXN
CTD Gene:5829 PXN
dbSNP Gene:5829 PXN
ENSEMBL:ENSG00000089159 PXN
ENSEMBL:ENSG00000089159 PXN
HGNC:9718 PXN
KEGG Gene (Homo sapiens):hsa:5829 PXN
Monarch:5829 PXN
NCBI Gene:5829 PXN
OMIM:602505 PXN
UCSC:P49023 PXN
Reference Transcript
RefSeq:NM_001243756.1 PXN
RefSeq:NM_001080855.2 PXN
RefSeq:NM_002859.3 PXN
RefSeq:NM_025157.4 PXN
RefSeq:XM_017019743.1 PXN
Other Identifiers
11717617_a_at
11717618_s_at
11736017_s_at
11736018_x_at
11748796_a_at
11749054_x_at
11752827_a_at
11752828_x_at
16771242
1KKY
1KL0
1OW6
1OW7
1OW8
201087_at
211823_s_at
2K2R
2O9V
2VZD
2VZG
2VZI
3474373
3474374
3474375
3474376
3474377
3474378
3474379
3474380
3474384
3474385
3474386
3474387
3474388
3474390
3474402
3474403
3474404
3474405
3474406
3474407
3474416
3474417
3841
3GM1
3PY7
3RQE
3RQF
3RQG
3U3F
4EDN
4R32
4XGZ
4XH2
51309
5829
5UWH
7967002
A0A140VJQ8
A_24_P184555
A_33_P3380098
AAC05175
AAC50104
AAD00648
AAI36788
AAI36795
AAI44411
AC004263
AEE61045
AK314204
BAA18997
BAA18998
BAG36880
BC136787
BC136794
BC144410
BX648777
CAB003841
CAI46024
CCDS44996
CCDS44997
CCDS44998
CCDS58281
CH471054
D86862
D86863
EAW98179
ENSG00000089159
ENSP00000228307
ENSP00000267257
ENSP00000391283
ENSP00000395536
ENST00000228307
ENST00000267257
ENST00000424649
ENST00000458477
EntrezGene:5829
g1912054_3p_a_at
g4506344_3p_at
GE58953
GO:0001725
GO:0003674
GO:0005178
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005737
GO:0005829
GO:0005856
GO:0005875
GO:0005886
GO:0005925
GO:0005938
GO:0006461
GO:0006936
GO:0006950
GO:0007010
GO:0007155
GO:0007160
GO:0007165
GO:0007172
GO:0007173
GO:0007179
GO:0008013
GO:0008092
GO:0008150
GO:0017166
GO:0019899
GO:0019901
GO:0022607
GO:0030027
GO:0030054
GO:0031625
GO:0034614
GO:0038191
GO:0040011
GO:0043167
GO:0043226
GO:0043234
GO:0043542
GO:0046872
GO:0048010
GO:0048870
GO:0051496
GO:0060396
GO:0065003
GO:1901652
HGNC:9718
HM005447
HPA051309
IPR001781
IPR001904
IPR017305
MIM:602505
NM_001080855
NM_001243756
NM_002859
NM_025157
NP_001074324
NP_001230685
NP_002850
NP_079433
PF00412
PF03535
PR00832
PXN
PXN-201
PXN-202
PXN-204
PXN-206
SM00132
TC12002037.hg
U14588
U14588_at
U87941
U87942
U87943
U87944
U87945
U87946
uc001txt.4
uc001txv.3
uc001txx.4
uc001txy.4
UPI000013C8CD
UPI00001FBC71
UPI0000E00CD4
UPI0001711D29
XM_017019735
XM_017019739
XM_017019742
XM_017019743
XP_016875224
XP_016875228
XP_016875231
XP_016875232
Participant Of
input
Phosphorylated PXN recruits the CRK complex
output
PTK6 phosphorylates PXN
hasComponent
p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol]
VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane]
Other forms of this molecule
PXN [plasma membrane]
p-Y-PXN [plasma membrane]
PXN [cytosol]
Inferred To
Homologues of p-Y31,Y118-PXN [cytosol] (Danio rerio)
Homologues of p-Y31,Y118-PXN [cytosol] (Drosophila melanogaster)
Homologues of p-Y31,Y118-PXN [cytosol] (Gallus gallus)
Homologues of p-Y31,Y118-PXN [cytosol] (Xenopus tropicalis)
phospho-p-Y31,Y118-PXN [cytosol] (Bos taurus)
phospho-p-Y31,Y118-PXN [cytosol] (Caenorhabditis elegans)
phospho-p-Y31,Y118-PXN [cytosol] (Canis familiaris)
phospho-p-Y31,Y118-PXN [cytosol] (Danio rerio)
phospho-p-Y31,Y118-PXN [cytosol] (Dictyostelium discoideum)
phospho-p-Y31,Y118-PXN [cytosol] (Drosophila melanogaster)
phospho-p-Y31,Y118-PXN [cytosol] (Gallus gallus)
phospho-p-Y31,Y118-PXN [cytosol] (Mus musculus)
phospho-p-Y31,Y118-PXN [cytosol] (Rattus norvegicus)
phospho-p-Y31,Y118-PXN [cytosol] (Sus scrofa)
phospho-p-Y31,Y118-PXN [cytosol] (Taeniopygia guttata)
phospho-p-Y31,Y118-PXN [cytosol] (Xenopus tropicalis)
Modified Residues
Name
O4'-phospho-L-tyrosine at 31
Coordinate
31
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 118
Coordinate
118
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_001074324.1
,
NP_002850.2
,
XP_016875232.1
,
NP_079433.3
,
NP_001230685.1
GeneCards
P49023
DOCK Blaster
2VZD
,
2VZI
,
5UWH
,
3RQF
,
3RQE
,
3PY7
,
4XGZ
,
2VZG
,
4EDN
,
3GM1
,
4R32
,
3RQG
,
4XH2
,
2O9V
,
3U3F
,
1OW6
,
1OW7
,
1OW8
PRO
P49023
PDB
1OW6
,
2K2R
,
4EDN
,
2VZI
,
3PY7
,
5UWH
,
1OW7
,
3RQE
,
3RQG
,
2O9V
,
2VZD
,
4R32
,
3U3F
,
1KKY
,
1KL0
,
3GM1
,
1OW8
,
4XH2
,
4XGZ
,
2VZG
,
3RQF
Interactors (18)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q05397 PTK2
10
p-Y194,Y397-PTK2 [cytosol]
(R-HSA-8874600)
p-Y194,Y397,Y576,Y577-PTK2 [cytosol]
(R-HSA-8874613)
PTK2(773-1052) [cytosol]
(R-HSA-202829)
PTK2(1-772) [cytosol]
(R-HSA-202827)
p-5Y-PTK2 [cytosol]
(R-HSA-5218711)
p-5Y,S732-PTK2 [cytosol]
(R-HSA-5229006)
p-6Y,S732-PTK2 [cytosol]
(R-HSA-5218694)
PTK2 [cytosol]
(R-HSA-201621)
p-Y397-PTK2 [cytosol]
(R-HSA-354068)
p-6Y-PTK2 [cytosol]
(R-HSA-354128)
0.878
15
UniProt:P06931 VE6
0.744
4
UniProt:P13612 ITGA4
1
ITGA4 [plasma membrane]
(R-HSA-198007)
0.688
4
UniProt:Q06124 PTPN11
4
PTPN11 [nucleoplasm]
(R-HSA-8937745)
p-Y546-PTPN11 [cytosol]
(R-HSA-1369081)
PTPN11 [cytosol]
(R-HSA-162563)
p-Y546,Y584-PTPN11 [cytosol]
(R-HSA-162573)
0.641
3
UniProt:Q62417-2 SORBS1
0.61
8
UniProt:P35222 CTNNB1
24
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
Ub-K,p-Y-CTNNB1 [cytosol]
(R-HSA-8877006)
p-Y-CTNNB1 [cytosol]
(R-HSA-8876940)
p-S552-CTNNB1 [nucleoplasm]
(R-HSA-3134926)
p-S552-CTNNB1 [cytosol]
(R-HSA-3134933)
CTNNB1(116-376) [cytosol]
(R-HSA-202950)
CTNNB1(1-115) [cytosol]
(R-HSA-202930)
CTNNB1 [plasma membrane]
(R-HSA-9038440)
p-S45 CTNNB1 [cytosol]
(R-HSA-8942363)
p-T41,S45 CTNNB1 [cytosol]
(R-HSA-8942367)
p-S37,T41,S45, CTNNB1 [cytosol]
(R-HSA-8942369)
p-S33,S37,T41,S45 CTNNB1 [cytosol]
(R-HSA-8942374)
CTNNB1 [cytosol]
(R-HSA-448839)
CTNNB1 [nucleoplasm]
(R-HSA-3451168)
0.602
4
UniProt:Q99942 RNF5
1
RNF5 [endoplasmic reticulum membrane]
(R-HSA-975990)
0.591
6
UniProt:Q14161 GIT2
0.589
2
UniProt:P27986 PIK3R1
15
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [cytosol]
(R-HSA-74789)
PIK3R1 [plasma membrane]
(R-HSA-198365)
0.589
2
UniProt:Q13418 ILK
1
ILK [cytosol]
(R-HSA-432864)
0.564
2
UniProt:P05556-1 ITGB1
0.524
2
UniProt:Q09463
1
RNF5 [endoplasmic reticulum membrane]
(R-CEL-975990)
0.524
2
UniProt:P41240 CSK
2
CSK [cytosol]
(R-HSA-203776)
CSK [plasma membrane]
(R-HSA-180499)
0.499
2
UniProt:Q13480 GAB1
3
p-5Y-GAB1 [cytosol]
(R-HSA-180344)
p-Y627,Y659-GAB1 [cytosol]
(R-HSA-180496)
GAB1 [cytosol]
(R-HSA-179795)
0.499
2
UniProt:P02751 FN1
8
FN1(32-271) [extracellular region]
(R-HSA-3787935)
FN1(32-2386) [platelet alpha granule lumen]
(R-HSA-114620)
FN1(272-2386) [extracellular region]
(R-HSA-3788024)
FN1(32-?) [extracellular region]
(R-HSA-2533850)
FN1(?-2386) [extracellular region]
(R-HSA-2533841)
p-FN1 [endoplasmic reticulum lumen]
(R-HSA-8956937)
FN1 [endoplasmic reticulum lumen]
(R-HSA-8956708)
FN1(32-2386) [extracellular region]
(R-HSA-54851)
0.491
2
UniProt:O13016 PTN1
0.489
2
UniProt:P34152 Ptk2
12
phospho-p-Y397-PTK2 [cytosol]
(R-MMU-354068)
phospho-p-6Y-PTK2 [cytosol]
(R-MMU-354128)
PTK2 [cytosol]
(R-MMU-201621)
phospho-p-6Y,S732-PTK2 [cytosol]
(R-MMU-5218694)
phospho-p-5Y,S732-PTK2 [cytosol]
(R-MMU-5229006)
phospho-p-5Y-PTK2 [cytosol]
(R-MMU-5218711)
Fak1 [cytosol]
(R-MMU-3928448)
p-Y428-FAK1 [cytosol]
(R-MMU-3928397)
PTK2(1-772) [cytosol]
(R-MMU-202827)
PTK2(773-1052) [cytosol]
(R-MMU-202829)
phospho-p-Y194,Y397-PTK2 [cytosol]
(R-MMU-8874600)
phospho-p-Y194,Y397,Y576,Y577-PTK2 [cytosol]
(R-MMU-8874613)
0.463
2
UniProt:P16671 CD36
5
CD36 [phagocytic vesicle]
(R-HSA-1236835)
4xPalmC-CD36 [endocytic vesicle membrane]
(R-HSA-2239449)
CD36 [platelet alpha granule membrane]
(R-HSA-114687)
4xPalmC-CD36 [specific granule membrane]
(R-HSA-6806151)
4xPalmC-CD36 [plasma membrane]
(R-HSA-51645)
0.462
2
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