Reactome: A Curated Pathway Database

p-Y31,Y118-PXN

Stable Identifier
R-HSA-5218693
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-Y31,Y118-Paxillin
Locations in the PathwayBrowser
External Reference Information
External Reference
UniProt:P49023 PXN
Gene Names
PXN
Chain
chain:1-591
Reference Genes
BioGPS Gene:5829 PXN, CTD Gene:5829 PXN, Monarch:5829 PXN, dbSNP Gene:5829 PXN, OMIM:602505 PXN, NCBI Gene:5829 PXN, KEGG Gene (Homo sapiens):5829 PXN, COSMIC (genes):PXN PXN, HGNC:9718 PXN, ENSEMBL:ENSG00000089159 PXN
Reference Transcript
Other Identifiers
 11717617_a_at  11717618_s_at  11736017_s_at  11736018_x_at  11748796_a_at
 11749054_x_at  11752827_a_at  11752828_x_at  16771242  1KKY
 1KL0  1OW6  1OW7  1OW8  201087_at
 211823_s_at  2K2R  2O9V  2VZD  2VZG
 2VZI  3474373  3474374  3474375  3474376
 3474377  3474378  3474379  3474380  3474384
 3474385  3474386  3474387  3474388  3474390
 3474402  3474403  3474404  3474405  3474406
 3474407  3474416  3474417  3841  3GM1
 3PY7  3RQE  3RQF  3RQG  3U3F
 4EDN  4R32  4XGZ  4XH2  51309
 5829  5UWH  7967002  A0A140VJQ8  A_24_P184555
 A_33_P3380098  AAC05175  AAC50104  AAD00648  AAI36788
 AAI36795  AAI44411  AC004263  AEE61045  AK314204
 BAA18997  BAA18998  BAG36880  BC136787  BC136794
 BC144410  BX648777  CAB003841  CAI46024  CCDS44996
 CCDS44997  CCDS44998  CCDS58281  CH471054  D86862
 D86863  EAW98179  ENSG00000089159  ENSP00000228307  ENSP00000267257
 ENSP00000391283  ENSP00000395536  ENST00000228307  ENST00000267257  ENST00000424649
 ENST00000458477  EntrezGene:5829  g1912054_3p_a_at  g4506344_3p_at  GE58953
 GO:0001725  GO:0003674  GO:0005178  GO:0005515  GO:0005575
 GO:0005622  GO:0005623  GO:0005737  GO:0005829  GO:0005856
 GO:0005875  GO:0005886  GO:0005925  GO:0005938  GO:0006461
 GO:0006936  GO:0006950  GO:0007155  GO:0007160  GO:0007165
 GO:0007172  GO:0007173  GO:0007179  GO:0008013  GO:0008092
 GO:0008150  GO:0008270  GO:0017166  GO:0019899  GO:0019901
 GO:0022607  GO:0030027  GO:0030054  GO:0031625  GO:0032403
 GO:0034614  GO:0043167  GO:0043226  GO:0043234  GO:0046872
 GO:0048010  GO:0060396  GO:0065003  GO:1901652  HGNC:9718
 HM005447  HPA051309  Hs.446336  IPR001781  IPR001904
 MIM:602505  NM_001080855  NM_001243756  NM_002859  NM_025157
 NP_001074324  NP_001230685  NP_002850  NP_079433  PF00412
 PF03535  PR00832  PXN  PXN-201  PXN-202
 PXN-204  PXN-206  SM00132  TC12002037.hg  U14588
 U14588_at  U87941  U87942  U87943  U87944
 U87945  U87946  uc001txt.4  uc001txv.3  uc001txx.4
 uc001txy.4  UPI000013C8CD  UPI00001FBC71  UPI0000E00CD4  UPI0001711D29
 XM_017019743  XP_016875232
Participant Of
input
hasComponent
output
Other forms of this molecule
PXN [plasma membrane] PXN [cytosol]
Inferred To
Modified Residues
Name Coordinate Modification PsiMod
O4'-phospho-L-tyrosine at 118 118
O4'-phospho-L-tyrosine [MOD:00048] A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
O4'-phospho-L-tyrosine at 31 31
O4'-phospho-L-tyrosine [MOD:00048] A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_001074324.1, NP_001230685.1, NP_079433.3, NP_002850.2, XP_016875232.1
UCSC human
P49023
GeneCards
P49023
DOCK Blaster
3GM1, 2O9V, 4EDN, 3RQG, 2VZD, 4XH2, 1OW8, 5UWH, 1OW7, 4XGZ, 1OW6, 4R32, 2VZG, 3PY7, 2VZI, 3RQE, 3RQF, 3U3F
PRO
P49023
PDB
4EDN, 4R32, 2O9V, 2VZD, 4XH2, 1KKY, 1OW8, 3U3F, 3RQG, 2K2R, 5UWH, 3PY7, 3RQF, 3RQE, 1OW7, 1OW6, 4XGZ, 2VZI, 2VZG, 3GM1, 1KL0
Interactors
Confidence Score Interactor Accession Interactor Name Evidence (IntAct)
0.878 Q05397 FAK1_HUMAN 15
0.641 Q06124 PTN11_HUMAN 3
0.61 Q62417-2 SORBS1 8
0.602 P35222 CTNB1_HUMAN 4
0.591 Q99942 RNF5_HUMAN 6
0.589 P27986 P85A_HUMAN 2
0.589 Q14161 GIT2_HUMAN 2
0.589 P06931 VE6_BPV1 2
0.576 P13612 ITA4_HUMAN 3
0.564 Q13418 ILK_HUMAN 2
0.524 P05556-1 ITGB1 2
0.524 Q09463 RNF5_CAEEL 2
0.499 Q13480 GAB1_HUMAN 2
0.499 P41240 CSK_HUMAN 2
0.491 P02751 FINC_HUMAN 2
0.489 O13016 PTN1_CHICK 2
0.463 P34152 FAK1_MOUSE 2
 
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