Reactome | p-Y31,Y118-PXN [cytosol]

p-Y31,Y118-PXN [cytosol]

Stable Identifier

R-HSA-5218693

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-Y31,Y118-Paxillin

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by PTK6 (Homo sapiens)
    - PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Homo sapiens)
      - Activation of RAC1 by the PXN:CRK complex (Homo sapiens)
        
        p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        p-Y31,Y118-PXN [cytosol] (Homo sapiens)
      - PTK6 phosphorylates PXN (Homo sapiens)
        
        p-Y31,Y118-PXN [cytosol] (Homo sapiens)
      - Phosphorylated PXN recruits the CRK complex (Homo sapiens)
        
        p-Y31,Y118-PXN [cytosol] (Homo sapiens)
        
        p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        p-Y31,Y118-PXN [cytosol] (Homo sapiens)
- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by VEGF (Homo sapiens)
    - VEGFA-VEGFR2 Pathway (Homo sapiens)
      - CRK binds BCAR1 and or PXN (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        p-Y31,Y118-PXN [cytosol] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        p-Y31,Y118-PXN [cytosol] (Homo sapiens)
      - DOCK180:ELMO binds CRK (Homo sapiens)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        p-Y31,Y118-PXN [cytosol] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        p-Y31,Y118-PXN [cytosol] (Homo sapiens)
      - DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Homo sapiens)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        p-Y31,Y118-PXN [cytosol] (Homo sapiens)
      - PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        p-Y31,Y118-PXN [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P49023 PXN

Gene Names

PXN

Chain

initiator methionine:, chain:1-591

Reference Genes

BioGPS Gene:5829 PXN

COSMIC (genes):PXN PXN

CTD Gene:5829 PXN

dbSNP Gene:5829 PXN

ENSEMBL:ENSG00000089159.17 PXN

HGNC:9718 PXN

KEGG Gene (Homo sapiens):5829 PXN

Monarch:5829 PXN

NCBI Gene:5829 PXN

OMIM:602505 PXN

UCSC:P49023 PXN

Reference Transcript

Other Identifiers

11717617_a_at

11717618_s_at

11736017_s_at

11736018_x_at

11748796_a_at

11749054_x_at

11752827_a_at

11752828_x_at

16771242

201087_PM_at

201087_at

211823_PM_s_at

211823_s_at

3474373

3474374

3474375

3474376

3474377

3474378

3474379

3474380

3474384

3474385

3474386

3474387

3474388

3474390

3474402

3474403

3474404

3474405

3474406

3474407

3474416

3474417

38644_at

5829

7967002

A_24_P184555

A_33_P3380098

GE58953

GO:0001725

GO:0003712

GO:0005515

GO:0005737

GO:0005829

GO:0005856

GO:0005875

GO:0005886

GO:0005911

GO:0005925

GO:0005938

GO:0006351

GO:0007010

GO:0007155

GO:0007160

GO:0007165

GO:0007172

GO:0007179

GO:0008013

GO:0008092

GO:0016477

GO:0017166

GO:0019903

GO:0023052

GO:0030027

GO:0030154

GO:0034446

GO:0034614

GO:0038191

GO:0043226

GO:0043542

GO:0046872

GO:0048856

GO:0048870

GO:0051496

GO:0060396

GO:0065003

GO:0070161

GO:0140110

HMNXSV003050935

TC12002037.hg

U14588_at

g1912054_3p_a_at

g4506344_3p_at

Participates

as a component of

as an output of

PTK6 phosphorylates PXN (Homo sapiens)

as an input of

Phosphorylated PXN recruits the CRK complex (Homo sapiens)

Other forms of this molecule

p-Y-PXN [plasma membrane]

PXN [plasma membrane]

PXN [cytosol]

Inferred To

phospho-paxB [cytosol] (Dictyostelium discoideum)

phospho-pxl-1 [cytosol] (Caenorhabditis elegans)

phospho-pxn [cytosol] (Xenopus tropicalis)

phospho-Pxn [cytosol] (Mus musculus)

phospho-Pxn [cytosol] (Rattus norvegicus)

Homologues of p-Y31,Y118-PXN [cytosol] (Dictyostelium discoideum)

phospho-limB [cytosol] (Dictyostelium discoideum)

phospho-Pax [cytosol] (Drosophila melanogaster)

phospho-p-Y31,Y118-PXN [cytosol] (Canis familiaris)

phospho-p-Y31,Y118-PXN [cytosol] (Danio rerio)

phospho-p-Y31,Y118-PXN [cytosol] (Gallus gallus)

phospho-p-Y31,Y118-PXN [cytosol] (Sus scrofa)

phospho-limA [cytosol] (Dictyostelium discoideum)

phospho-PXN [cytosol] (Bos taurus)

Modified Residues

Name

O4'-phospho-L-tyrosine at 31

Coordinate

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 118

Coordinate

118

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_002850.2, NP_001230685.1, XP_016875232.1, NP_001074324.1, NP_079433.3

OpenTargets

ENSG00000089159

GeneCards

P49023

HPA

ENSG00000089159-PXN

Ensembl

ENST00000267257, ENSG00000089159, ENSP00000267257, ENSP00000391283, ENST00000458477, ENST00000424649, ENST00000228307, ENSP00000228307, ENSP00000395536

PRO

P49023

Pharos - Targets

P49023

PDB

2VZG, 3PY7, 4EDN, 3RQE, 3RQF, 1OW6, 6PW8, 2VZI, 4XGZ, 3RQG, 1OW7, 6IUI, 4XH2, 3U3F, 1OW8, 3GM1, 4R32, 6U4M, 2K2R, 5UWH, 6U4N, 2O9V, 2VZD

Interactors (21)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q05397 PTK2	11	p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) PTK2(773-1052) [cytosol] (R-HSA-202829) PTK2(1-772) [cytosol] (R-HSA-202827) pY-PTK2 [cytosol] (R-HSA-9632393) p-5Y-PTK2 [cytosol] (R-HSA-5218711) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) PTK2 [cytosol] (R-HSA-201621) p-Y397-PTK2 [cytosol] (R-HSA-354068) p-6Y-PTK2 [cytosol] (R-HSA-354128)	0.937	18
UniProt:P06931 VE6			0.744	4
UniProt:Q14161 GIT2	1	GIT2 [cytosol] (R-HSA-446034)	0.688	4
UniProt:P13612 ITGA4	1	ITGA4 [plasma membrane] (R-HSA-198007)	0.688	4
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.669	4
UniProt:P41240 CSK	2	CSK [plasma membrane] (R-HSA-180499) CSK [cytosol] (R-HSA-203776)	0.623	4
UniProt:Q62417-2 SORBS1			0.61	8
UniProt:Q06124 PTPN11	4	p-Y542-PTPN11 [cytosol] (R-HSA-1369081) PTPN11 [nucleoplasm] (R-HSA-8937745) PTPN11 [cytosol] (R-HSA-162563) p-Y542,Y580-PTPN11 [cytosol] (R-HSA-162573)	0.604	3
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.602	4
UniProt:Q99942 RNF5	1	RNF5 [endoplasmic reticulum membrane] (R-HSA-975990)	0.591	6
UniProt:Q05209 PTPN12	2	PTPN12 [cytosol] (R-HSA-432933) PTPN12 [nucleoplasm] (R-HSA-9008905)	0.571	2
UniProt:Q9Y2X7 GIT1	2	p-Y383-GIT1 [cytosol] (R-HSA-3928463) GIT1 [cytosol] (R-HSA-430326)	0.564	3
UniProt:Q14289 PTK2B	3	p-Y-PTK2B [cytosol] (R-HSA-508515) PTK2B [cytosol] (R-HSA-390932) PTK2B [cytosol] (R-HSA-5218721)	0.527	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	9
UniProt:P05556-1 ITGB1			0.524	2
UniProt:Q09463	2	rnf-5 [endoplasmic reticulum membrane] (R-CEL-8861819) rnf-5 [endoplasmic reticulum membrane] (R-CEL-975990)	0.524	2
UniProt:Q13480 GAB1	4	GAB1 [cytosol] (R-HSA-179795) p-5Y-GAB1 [cytosol] (R-HSA-180344) p-Y627,Y659-GAB1 [cytosol] (R-HSA-180496) p-Y-GAB1 [cytosol] (R-HSA-8855306)	0.499	2
UniProt:P02751 FN1	10	FN1(32-2386) [platelet alpha granule lumen] (R-HSA-114620) FN1(32-271) [extracellular region] (R-HSA-3787935) FN1(272-2386) [extracellular region] (R-HSA-3788024) FN1(32-?) [extracellular region] (R-HSA-2533850) FN1(?-2386) [extracellular region] (R-HSA-2533841) FN1(32-1201)-p-7Y-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713462) FN1(32-1201)-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713459) p-FN1 [endoplasmic reticulum lumen] (R-HSA-8956937) FN1 [endoplasmic reticulum lumen] (R-HSA-8956708) FN1(32-2386) [extracellular region] (R-HSA-54851)	0.491	2
UniProt:O13016 PTN1			0.489	2
UniProt:P34152 Ptk2	13	phospho-p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-MMU-8874613) phospho-p-6Y-PTK2 [cytosol] (R-MMU-354128) phospho-p-Y397-PTK2 [cytosol] (R-MMU-354068) PTK2 [cytosol] (R-MMU-201621) phospho-p-6Y,S732-PTK2 [cytosol] (R-MMU-5218694) phospho-p-5Y,S732-PTK2 [cytosol] (R-MMU-5229006) phospho-p-5Y-PTK2 [cytosol] (R-MMU-5218711) Fak1 [cytosol] (R-MMU-3928448) p-Y428-FAK1 [cytosol] (R-MMU-3928397) phospho-pY-PTK2 [cytosol] (R-MMU-9632393) PTK2(1-772) [cytosol] (R-MMU-202827) PTK2(773-1052) [cytosol] (R-MMU-202829) phospho-p-Y194,Y397-PTK2 [cytosol] (R-MMU-8874600)	0.463	2
UniProt:P16671 CD36	5	CD36 [platelet alpha granule membrane] (R-HSA-114687) 4xPalmC-CD36 [endocytic vesicle membrane] (R-HSA-2239449) 4xPalmC-CD36 [specific granule membrane] (R-HSA-6806151) CD36 [phagocytic vesicle] (R-HSA-1236835) 4xPalmC-CD36 [plasma membrane] (R-HSA-51645)	0.462	2

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