Reactome | p-Y31,Y118-PXN [cytosol]

p-Y31,Y118-PXN [cytosol]

Stable Identifier

R-HSA-5218693

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-Y31,Y118-Paxillin

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by PTK6 (Homo sapiens)
    - PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Homo sapiens)
      - Activation of RAC1 by the PXN:CRK complex (Homo sapiens)
        
        p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        p-Y31,Y118-PXN [cytosol] (Homo sapiens)
      - PTK6 phosphorylates PXN (Homo sapiens)
        
        p-Y31,Y118-PXN [cytosol] (Homo sapiens)
      - Phosphorylated PXN recruits the CRK complex (Homo sapiens)
        
        p-Y31,Y118-PXN [cytosol] (Homo sapiens)
        
        p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        p-Y31,Y118-PXN [cytosol] (Homo sapiens)
- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by VEGF (Homo sapiens)
    - VEGFA-VEGFR2 Pathway (Homo sapiens)
      - CRK binds BCAR1 and or PXN (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        p-Y31,Y118-PXN [cytosol] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        p-Y31,Y118-PXN [cytosol] (Homo sapiens)
      - DOCK180:ELMO binds CRK (Homo sapiens)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        p-Y31,Y118-PXN [cytosol] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        p-Y31,Y118-PXN [cytosol] (Homo sapiens)
      - DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Homo sapiens)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        p-Y31,Y118-PXN [cytosol] (Homo sapiens)
      - PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        p-Y31,Y118-PXN [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P49023 PXN

Gene Names

PXN

Chain

chain:1-591

Reference Genes

BioGPS Gene:5829 PXN

COSMIC (genes):PXN PXN

CTD Gene:5829 PXN

dbSNP Gene:5829 PXN

ENSEMBL:ENSG00000089159 PXN

HGNC:9718 PXN

KEGG Gene (Homo sapiens):5829 PXN

Monarch:5829 PXN

NCBI Gene:5829 PXN

OMIM:602505 PXN

UCSC:P49023 PXN

Reference Transcript

Other Identifiers

11717617_a_at

11717618_s_at

11736017_s_at

11736018_x_at

11748796_a_at

11749054_x_at

11752827_a_at

11752828_x_at

16771242

1KKY

1KL0

1OW6

1OW7

1OW8

201087_at

211823_s_at

2K2R

2O9V

2VZD

2VZG

2VZI

3474373

3474374

3474375

3474376

3474377

3474378

3474379

3474380

3474384

3474385

3474386

3474387

3474388

3474390

3474402

3474403

3474404

3474405

3474406

3474407

3474416

3474417

3841

38644_at

3GM1

3PY7

3RQE

3RQF

3RQG

3U3F

4EDN

4R32

4XGZ

4XH2

51309

5829

5UWH

7967002

A0A140VJQ8

A0A1B0GTU4

A0A1B0GU60

A0A1B0GV30

A_24_P184555

A_33_P3380098

AAC05175

AAC50104

AAD00648

AAI36788

AAI36795

AAI44411

AC004263

AEE61045

AK314204

BAA18997

BAA18998

BAG36880

BC136787

BC136794

BC144410

BX648777

CAB003841

CAI46024

CCDS44996

CCDS44997

CCDS44998

CCDS58281

CH471054

D86862

D86863

EAW98179

ENSG00000089159

ENSP00000228307

ENSP00000267257

ENSP00000391283

ENSP00000395536

ENST00000228307

ENST00000228307.11

ENST00000267257

ENST00000267257.11

ENST00000424649

ENST00000424649.6

ENST00000458477

ENST00000458477.6

EntrezGene:5829

EntrezGene:PXN

F5GZ78

F5H836

F8VZ39

F8W0G0

F8W0K8

F8W1E0

g1912054_3p_a_at

g4506344_3p_at

GE58953

GO:0000902

GO:0001725

GO:0003674

GO:0003712

GO:0005178

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005829

GO:0005856

GO:0005875

GO:0005886

GO:0005912

GO:0005925

GO:0005938

GO:0006936

GO:0006950

GO:0007010

GO:0007155

GO:0007165

GO:0007172

GO:0007179

GO:0008013

GO:0008092

GO:0008150

GO:0009058

GO:0017166

GO:0019899

GO:0019901

GO:0019903

GO:0022607

GO:0030027

GO:0030054

GO:0030154

GO:0031625

GO:0032991

GO:0034446

GO:0034614

GO:0034641

GO:0038191

GO:0040011

GO:0043167

GO:0043226

GO:0043542

GO:0044877

GO:0046872

GO:0048010

GO:0048856

GO:0048870

GO:0051496

GO:0060396

GO:0065003

GO:1901652

GO:1903506

HGNC:9718

HM005447

HPA051309

IPR001781

IPR017305

MIM:602505

NM_001080855

NM_001243756

NM_002859

NM_025157

NP_001074324

NP_001230685

NP_002850

NP_079433

PF00412

PF03535

PR00832

PXN

PXN-201

PXN-202

PXN-204

PXN-206

SM00132

TC12002037.hg

U14588

U14588_at

U87941

U87942

U87943

U87944

U87945

U87946

UPI000013C8CD

UPI00001FBC71

UPI0000E00CD4

UPI0001711D29

XM_017019735

XM_017019739

XM_017019742

XM_017019743

XP_016875224

XP_016875228

XP_016875231

XP_016875232

Participant Of

hasComponent

output

PTK6 phosphorylates PXN

input

Phosphorylated PXN recruits the CRK complex

Other forms of this molecule

p-Y-PXN [plasma membrane]

PXN [plasma membrane]

PXN [cytosol]

Inferred To

Ghost homologue of p-Y31,Y118-PXN [cytosol] (Gallus gallus)

Homologues of p-Y31,Y118-PXN [cytosol] (Dictyostelium discoideum)

Homologues of p-Y31,Y118-PXN [cytosol] (Drosophila melanogaster)

phospho-p-Y31,Y118-PXN [cytosol] (Bos taurus)

phospho-p-Y31,Y118-PXN [cytosol] (Caenorhabditis elegans)

phospho-p-Y31,Y118-PXN [cytosol] (Canis familiaris)

phospho-p-Y31,Y118-PXN [cytosol] (Danio rerio)

phospho-p-Y31,Y118-PXN [cytosol] (Dictyostelium discoideum)

phospho-p-Y31,Y118-PXN [cytosol] (Drosophila melanogaster)

phospho-p-Y31,Y118-PXN [cytosol] (Mus musculus)

phospho-p-Y31,Y118-PXN [cytosol] (Rattus norvegicus)

phospho-p-Y31,Y118-PXN [cytosol] (Saccharomyces cerevisiae)

phospho-p-Y31,Y118-PXN [cytosol] (Schizosaccharomyces pombe)

phospho-p-Y31,Y118-PXN [cytosol] (Sus scrofa)

phospho-p-Y31,Y118-PXN [cytosol] (Xenopus tropicalis)

Modified Residues

Name

O4'-phospho-L-tyrosine at 31

Coordinate

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 118

Coordinate

118

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_016875232.1, NP_001230685.1, NP_002850.2, NP_079433.3, NP_001074324.1

OpenTargets

ENSG00000089159

GeneCards

P49023

PRO

P49023

PDB

1OW8, 2K2R, 5UWH, 2O9V, 4EDN, 1KKY, 3RQF, 4R32, 3RQE, 2VZD, 3U3F, 1KL0, 3RQG, 1OW6, 1OW7, 3PY7, 2VZI, 4XH2, 2VZG, 3GM1, 4XGZ

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q05397 PTK2	11	p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613) pY-PTK2 [cytosol] (R-HSA-9632393) p-5Y-PTK2 [cytosol] (R-HSA-5218711) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) PTK2(773-1052) [cytosol] (R-HSA-202829) PTK2(1-772) [cytosol] (R-HSA-202827) PTK2 [cytosol] (R-HSA-201621) p-Y397-PTK2 [cytosol] (R-HSA-354068) p-6Y-PTK2 [cytosol] (R-HSA-354128)	0.878	15
UniProt:P06931 VE6			0.744	4
UniProt:P13612 ITGA4	1	ITGA4 [plasma membrane] (R-HSA-198007)	0.688	4
UniProt:Q06124 PTPN11	4	PTPN11 [nucleoplasm] (R-HSA-8937745) p-Y546-PTPN11 [cytosol] (R-HSA-1369081) PTPN11 [cytosol] (R-HSA-162563) p-Y546,Y584-PTPN11 [cytosol] (R-HSA-162573)	0.641	3
UniProt:Q62417-2 SORBS1			0.61	8
UniProt:P35222 CTNNB1	24	CTNNB1 S45P [cytosol] (R-HSA-4791272) CTNNB1 S45F [cytosol] (R-HSA-4791268) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612) Ub-K,p-Y-CTNNB1 [cytosol] (R-HSA-8877006) p-Y-CTNNB1 [cytosol] (R-HSA-8876940) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) CTNNB1 [plasma membrane] (R-HSA-9038440) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1 [nucleoplasm] (R-HSA-3451168)	0.602	4
UniProt:Q99942 RNF5	1	RNF5 [endoplasmic reticulum membrane] (R-HSA-975990)	0.591	6
UniProt:Q14161 GIT2			0.589	2
UniProt:P27986 PIK3R1	15	PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.589	2
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.564	2
UniProt:P05556-1 ITGB1			0.524	2
UniProt:Q09463	2	RNF5 [endoplasmic reticulum membrane] (R-CEL-975990) RNF185 [endoplasmic reticulum membrane] (R-CEL-8861819)	0.524	2
UniProt:P41240 CSK	2	CSK [cytosol] (R-HSA-203776) CSK [plasma membrane] (R-HSA-180499)	0.499	2
UniProt:Q13480 GAB1	4	p-Y627,Y659-GAB1 [cytosol] (R-HSA-180496) p-Y-GAB1 [cytosol] (R-HSA-8855306) p-5Y-GAB1 [cytosol] (R-HSA-180344) GAB1 [cytosol] (R-HSA-179795)	0.499	2
UniProt:P02751 FN1	8	FN1(32-271) [extracellular region] (R-HSA-3787935) FN1(32-2386) [platelet alpha granule lumen] (R-HSA-114620) FN1(272-2386) [extracellular region] (R-HSA-3788024) FN1(32-?) [extracellular region] (R-HSA-2533850) FN1(?-2386) [extracellular region] (R-HSA-2533841) p-FN1 [endoplasmic reticulum lumen] (R-HSA-8956937) FN1 [endoplasmic reticulum lumen] (R-HSA-8956708) FN1(32-2386) [extracellular region] (R-HSA-54851)	0.491	2
UniProt:O13016 PTN1			0.489	2
UniProt:P34152 Ptk2	13	phospho-p-Y397-PTK2 [cytosol] (R-MMU-354068) phospho-p-6Y-PTK2 [cytosol] (R-MMU-354128) PTK2 [cytosol] (R-MMU-201621) PTK2(1-772) [cytosol] (R-MMU-202827) PTK2(773-1052) [cytosol] (R-MMU-202829) phospho-p-6Y,S732-PTK2 [cytosol] (R-MMU-5218694) phospho-p-5Y,S732-PTK2 [cytosol] (R-MMU-5229006) phospho-p-5Y-PTK2 [cytosol] (R-MMU-5218711) Fak1 [cytosol] (R-MMU-3928448) p-Y428-FAK1 [cytosol] (R-MMU-3928397) phospho-pY-PTK2 [cytosol] (R-MMU-9632393) phospho-p-Y194,Y397-PTK2 [cytosol] (R-MMU-8874600) phospho-p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-MMU-8874613)	0.463	2
UniProt:P16671 CD36	5	CD36 [platelet alpha granule membrane] (R-HSA-114687) 4xPalmC-CD36 [endocytic vesicle membrane] (R-HSA-2239449) CD36 [phagocytic vesicle] (R-HSA-1236835) 4xPalmC-CD36 [plasma membrane] (R-HSA-51645) 4xPalmC-CD36 [specific granule membrane] (R-HSA-6806151)	0.462	2