Reactome | p-Y31,Y118-PXN [cytosol]

p-Y31,Y118-PXN [cytosol]

Stable Identifier

R-HSA-5218693

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-Y31,Y118-Paxillin

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by PTK6 (Homo sapiens)
    - PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Homo sapiens)
      - Activation of RAC1 by the PXN:CRK complex (Homo sapiens)
        
        p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        p-Y31,Y118-PXN [cytosol] (Homo sapiens)
      - PTK6 phosphorylates PXN (Homo sapiens)
        
        p-Y31,Y118-PXN [cytosol] (Homo sapiens)
      - Phosphorylated PXN recruits the CRK complex (Homo sapiens)
        
        p-Y31,Y118-PXN [cytosol] (Homo sapiens)
        
        p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        p-Y31,Y118-PXN [cytosol] (Homo sapiens)
- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by VEGF (Homo sapiens)
    - VEGFA-VEGFR2 Pathway (Homo sapiens)
      - CRK binds BCAR1 and or PXN (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        p-Y31,Y118-PXN [cytosol] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        p-Y31,Y118-PXN [cytosol] (Homo sapiens)
      - DOCK180:ELMO binds CRK (Homo sapiens)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        p-Y31,Y118-PXN [cytosol] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1/p-Y31,Y118-PAX:CRK [plasma membrane] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        p-Y31,Y118-PXN [cytosol] (Homo sapiens)
      - DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Homo sapiens)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        p-Y31,Y118-PXN [cytosol] (Homo sapiens)
      - PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118 (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        p-Y31,Y118-PXN [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P49023 PXN

Gene Names

PXN

Chain

initiator methionine:, chain:1-591

Reference Genes

BioGPS Gene:5829 PXN

COSMIC (genes):PXN PXN

CTD Gene:5829 PXN

dbSNP Gene:5829 PXN

ENSEMBL:ENSG00000089159 PXN

HGNC:9718 PXN

KEGG:hsa:5829 PXN

Monarch:5829 PXN

NCBI Gene:5829 PXN

OMIM:602505 PXN

UCSC:P49023 PXN

Reference Transcript

Participates

as a component of

as an output of

PTK6 phosphorylates PXN (Homo sapiens)

as an input of

Phosphorylated PXN recruits the CRK complex (Homo sapiens)

Other forms of this molecule

PXN [cytosol]

PXN [plasma membrane]

p-Y-PXN [plasma membrane]

Inferred To

phospho-Pxn [cytosol] (Mus musculus)

phospho-Pxn [cytosol] (Rattus norvegicus)

Ghost homologue of p-Y31,Y118-PXN [cytosol] (Caenorhabditis elegans)

Ghost homologue of p-Y31,Y118-PXN [cytosol] (Xenopus tropicalis)

phospho-limB [cytosol] (Dictyostelium discoideum)

phospho-Pax [cytosol] (Drosophila melanogaster)

phospho-pxna [cytosol] (Danio rerio)

phospho-p-Y31,Y118-PXN [cytosol] (Gallus gallus)

phospho-PXN [cytosol] (Bos taurus)

phospho-PXN [cytosol] (Canis familiaris)

phospho-PXN [cytosol] (Sus scrofa)

Modified Residues

Name

O4'-phospho-L-tyrosine at 31

Coordinate

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 118

Coordinate

118

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_016875232.1, NP_001074324.1, NP_079433.3, NP_002850.2, NP_001230685.1

OpenTargets

ENSG00000089159

ENSEMBL

ENSP00000391283, ENST00000424649, ENSP00000267257, ENST00000267257, ENSP00000228307, ENSP00000395536, ENSG00000089159, ENST00000228307, ENST00000458477

GeneCards

PXN

HPA

ENSG00000089159-PXN

PRO

P49023

Pharos - Targets

P49023

GlyGen

P49023

PDB

6IUI, 4R32, 2VZD, 4EDN, 4XH2, 6U4M, 6U4N, 3RQE, 3U3F, 2VZG, 6PW8, 3RQG, 4XGZ, 1OW8, 1OW7, 1OW6, 3RQF, 2VZI, 5UWH, 2O9V, 3PY7, 2K2R, 3GM1, 7QB0

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q05397 PTK2	11	p-6Y-PTK2 [cytosol] (R-HSA-354128) p-Y397-PTK2 [cytosol] (R-HSA-354068) PTK2 [cytosol] (R-HSA-201621) PTK2(1-772) [cytosol] (R-HSA-202827) PTK2(773-1052) [cytosol] (R-HSA-202829) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-5Y-PTK2 [cytosol] (R-HSA-5218711) pY-PTK2 [cytosol] (R-HSA-9632393) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613)	0.942	19
UniProt:Q05209 PTPN12	2	PTPN12 [cytosol] (R-HSA-432933) PTPN12 [nucleoplasm] (R-HSA-9008905)	0.762	4
UniProt:P06931 VE6			0.744	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.706	12
UniProt:Q14161 GIT2	1	GIT2 [cytosol] (R-HSA-446034)	0.688	4
UniProt:P13612 ITGA4	1	ITGA4 [plasma membrane] (R-HSA-198007)	0.688	5
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.669	4
UniProt:P41240 CSK	2	CSK [cytosol] (R-HSA-203776) CSK [plasma membrane] (R-HSA-180499)	0.623	4
UniProt:Q62417-2 SORBS1			0.61	8
UniProt:Q06124 PTPN11	4	p-Y542,Y580-PTPN11 [cytosol] (R-HSA-162573) PTPN11 [cytosol] (R-HSA-162563) PTPN11 [nucleoplasm] (R-HSA-8937745) p-Y542-PTPN11 [cytosol] (R-HSA-1369081)	0.604	3
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-Y-CTNNB1 [cytosol] (R-HSA-8876940)	0.602	4
UniProt:Q99942 RNF5	1	RNF5 [endoplasmic reticulum membrane] (R-HSA-975990)	0.591	6
UniProt:Q9Y2X7 GIT1	2	GIT1 [cytosol] (R-HSA-430326) p-Y383-GIT1 [cytosol] (R-HSA-3928463)	0.564	3
UniProt:Q14289 PTK2B	3	PTK2B [cytosol] (R-HSA-5218721) PTK2B [cytosol] (R-HSA-390932) p-Y-PTK2B [cytosol] (R-HSA-508515)	0.527	2
UniProt:Q14155 ARHGEF7	1	ARHGEF7 [cytosol] (R-HSA-430346)	0.527	3
UniProt:P12931 SRC	6	MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-SRC [plasma membrane] (R-HSA-8876922) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [cytosol] (R-HSA-8964276) p-Y419-SRC [nucleoplasm] (R-HSA-8937690)	0.527	2
UniProt:P63167 DYNLL1	6	DYNLL1 [cytosol] (R-HSA-387105) DYNLL1 [plasma membrane] (R-HSA-54017) DYNLL1 [tertiary granule membrane] (R-HSA-6801482) DYNLL1 [ficolin-1-rich granule membrane] (R-HSA-6801518) DYNLL1 [cilium] (R-HSA-5624863) DYNLL1 [ciliary tip] (R-HSA-5625335)	0.527	2
UniProt:Q96B26 EXOSC8	3	EXOSC8 [nucleolus] (R-HSA-9935805) EXOSC8 [nucleoplasm] (R-HSA-6791571) EXOSC8 [cytosol] (R-HSA-429912)	0.527	2
UniProt:Q96FJ2 DYNLL2	4	DYNLL2 [cytosol] (R-HSA-2029024) DYNLL2 [plasma membrane] (R-HSA-140527) DYNLL2 [cilium] (R-HSA-5624865) DYNLL2 [ciliary tip] (R-HSA-5625337)	0.527	2
UniProt:Q09463	2	rnf-5 [endoplasmic reticulum membrane] (R-CEL-8861819) rnf-5 [endoplasmic reticulum membrane] (R-CEL-975990)	0.524	2
UniProt:Q13480 GAB1	4	GAB1 [cytosol] (R-HSA-179795) p-5Y-GAB1 [cytosol] (R-HSA-180344) p-Y627,Y659-GAB1 [cytosol] (R-HSA-180496) p-Y-GAB1 [cytosol] (R-HSA-8855306)	0.499	2
UniProt:P02751 FN1	10	FN1(32-2477) [extracellular region] (R-HSA-54851) FN1(32-2477) [platelet alpha granule lumen] (R-HSA-114620) FN1 [endoplasmic reticulum lumen] (R-HSA-8956708) p-FN1 [endoplasmic reticulum lumen] (R-HSA-8956937) FN1(32-1201)-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713459) FN1(32-1201)-p-7Y-ALK(1022-1620) fusion [plasma membrane] (R-HSA-9713462) FN1(?-2386) [extracellular region] (R-HSA-2533841) FN1(32-?) [extracellular region] (R-HSA-2533850) FN1(272-2386) [extracellular region] (R-HSA-3788024) FN1(32-271) [extracellular region] (R-HSA-3787935)	0.491	2
UniProt:O13016 PTN1			0.489	2
UniProt:P34152 Ptk2	13	phospho-p-6Y-PTK2 [cytosol] (R-MMU-354128) phospho-p-Y397-PTK2 [cytosol] (R-MMU-354068) PTK2 [cytosol] (R-MMU-201621) PTK2(1-772) [cytosol] (R-MMU-202827) PTK2(773-1052) [cytosol] (R-MMU-202829) phospho-p-6Y,S732-PTK2 [cytosol] (R-MMU-5218694) phospho-p-5Y,S732-PTK2 [cytosol] (R-MMU-5229006) phospho-p-5Y-PTK2 [cytosol] (R-MMU-5218711) Fak1 [cytosol] (R-MMU-3928448) p-Y428-FAK1 [cytosol] (R-MMU-3928397) phospho-pY-PTK2 [cytosol] (R-MMU-9632393) phospho-p-Y194,Y397-PTK2 [cytosol] (R-MMU-8874600) phospho-p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-MMU-8874613)	0.463	2
UniProt:P16671 CD36	5	4xPalmC-CD36 [plasma membrane] (R-HSA-51645) 4xPalmC-CD36 [specific granule membrane] (R-HSA-6806151) CD36 [phagocytic vesicle] (R-HSA-1236835) 4xPalmC-CD36 [endocytic vesicle membrane] (R-HSA-2239449) CD36 [platelet alpha granule membrane] (R-HSA-114687)	0.462	2

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