Reactome | p-Y130,S141,T402-PAK2 [cytosol]

p-Y130,S141,T402-PAK2 [cytosol]

Stable Identifier

R-HSA-5218705

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by VEGF (Homo sapiens)
    - VEGFA-VEGFR2 Pathway (Homo sapiens)
      - FYN phosphorylates PAK2 (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP [plasma membrane] (Homo sapiens)
        
        p-3Y-PAK2 dimer:CDC42:GTP [plasma membrane] (Homo sapiens)
        
        p-3Y-PAK2 dimer [cytosol] (Homo sapiens)
        
        p-Y130,S141,T402-PAK2 [cytosol] (Homo sapiens)
      - p38 MAPK activation by VEGFR (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP [plasma membrane] (Homo sapiens)
        
        p-3Y-PAK2 dimer:CDC42:GTP [plasma membrane] (Homo sapiens)
        
        p-3Y-PAK2 dimer [cytosol] (Homo sapiens)
        
        p-Y130,S141,T402-PAK2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13177 PAK2

Gene Names

PAK2

Chain

initiator methionine:1, chain:2-524, chain:2-212, chain:213-524

Reference Genes

BioGPS Gene:5062 PAK2

CTD Gene:5062 PAK2

dbSNP Gene:5062 PAK2

ENSEMBL:ENSG00000180370 PAK2

ENSEMBL_homo_sapiens_GENE:ENSG00000180370 PAK2

HGNC:8591 PAK2

KEGG Gene (Homo sapiens):5062 PAK2

Monarch:5062 PAK2

NCBI Gene:5062 PAK2

OMIM:605022 PAK2

UCSC:Q13177 PAK2

Reference Transcript

Other Identifiers

0003830148

04150+2.7.11.1

04151+2.7.11.1

04714+2.7.11.1

04926+2.7.11.1

05163+2.7.11.1

05165+2.7.11.1

05170+2.7.11.1

11739268_s_at

11739269_s_at

11739270_at

11739271_s_at

11739272_x_at

11739273_at

11739274_s_at

11739275_x_at

1245_i_at

1559052_s_at

1560_g_at

16950017

208875_s_at

208876_s_at

208877_3p_at

208877_at

208878_s_at

2659578

2659584

2659585

2659586

2659587

2659588

2659589

2659591

2659593

2659594

2659597

2659600

2659601

2659602

2659603

2659604

2659605

2659606

2659607

2659608

2659609

2659610

2659611

2659612

2659613

2659614

34329_at

3612676

3612683

3612686

3612689

3612690

3612691

3612693

3PCS

5062

55663_at

7794

8084963

A_14_P125078

A_23_P327307

A_32_P104075

A_33_P3220833

AAA65442

AAA75468

AAH69613

BC069613

CAB007794

CCDS3321

ENSG00000180370

ENSP00000314067

ENST00000327134

ENST00000327134.7

EntrezGene:5062

g5138913_3p_a_at

GE59022

GO:0000166

GO:0002223

GO:0002376

GO:0003674

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005575

GO:0005634

GO:0005737

GO:0005829

GO:0005886

GO:0006464

GO:0006468

GO:0006469

GO:0006915

GO:0006950

GO:0007165

GO:0008150

GO:0008152

GO:0008219

GO:0014069

GO:0016020

GO:0016032

GO:0016301

GO:0016310

GO:0016477

GO:0016740

GO:0018105

GO:0019899

GO:0019901

GO:0023014

GO:0030234

GO:0030296

GO:0031098

GO:0031267

GO:0031295

GO:0032147

GO:0035722

GO:0038095

GO:0040008

GO:0040011

GO:0042802

GO:0042981

GO:0043066

GO:0043167

GO:0043226

GO:0043408

GO:0044403

GO:0045296

GO:0046777

GO:0048010

GO:0048365

GO:0048471

GO:0048856

GO:0048870

GO:0050690

GO:0050731

GO:0050852

GO:0060996

GO:0061098

GO:0071407

GO:0098978

GO:2001238

GO:2001271

HGNC:8591

Hs.284275.0.S1_3p_a_at

Hs.284275.0.S2_3p_a_at

Hs.284275.0.S4_3p_at

Hs.284275.0.S4_3p_s_at

Hs.284275.0.S4_3p_x_at

Hs.56974.0.A1_3p_s_at

Hs2.56974.1.S1_3p_s_at

ILMN_1676385

ILMN_1712687

ILMN_1743106

IPR000095

IPR000719

IPR008271

IPR011009

IPR017441

IPR033923

IPR035064

IPR035065

IPR036936

MIM:605022

NM_002577

NP_002568

PAK2

PAK2-201

PF00069

PF00786

PH_hs_0014731

SM00220

SM00285

TC03001100.hg

U24153

U25975

U25975_at

UPI0000141B02

XM_011512870

XM_017006501

XP_011511172

XP_016861990

Participant Of

hasComponent

p-3Y-PAK2 dimer [cytosol]

Other forms of this molecule

p-S141,T402-PAK2 [cytosol]

PAK2 [cytosol]

p-5S-PAK2 [cytosol]

PAK2(213-524) [cytosol]

p-5S-PAK2(2-212) [cytosol]

p-T402-PAK2(213-524) [cytosol]

p-T402-PAK2(213-524) [nucleoplasm]

K48polyUb-p-T402-PAK-2p43 [cytosol]

p-S141,T402-PAK2 [plasma membrane]

PAK2(1-524) [plasma membrane]

Inferred To

phospho-p-Y130,S141,T402-PAK2 [cytosol] (Bos taurus)

phospho-p-Y130,S141,T402-PAK2 [cytosol] (Canis familiaris)

phospho-p-Y130,S141,T402-PAK2 [cytosol] (Danio rerio)

phospho-p-Y130,S141,T402-PAK2 [cytosol] (Mus musculus)

phospho-p-Y130,S141,T402-PAK2 [cytosol] (Rattus norvegicus)

phospho-p-Y130,S141,T402-PAK2 [cytosol] (Sus scrofa)

phospho-p-Y130,S141,T402-PAK2 [cytosol] (Xenopus tropicalis)

Modified Residues

Name

O-phospho-L-serine at 141

Coordinate

141

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 402

Coordinate

402

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O4'-phospho-L-tyrosine at 130

Coordinate

130

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_002568.2, XP_016861990.1, XP_011511172.1

ZINC - World Drugs

PAK2_HUMAN

OpenTargets

ENSG00000180370

ZINC - FDA approved

PAK2_HUMAN

ZINC - Substances

PAK2_HUMAN

GeneCards

Q13177

ZINC target

Q13177

PRO

Q13177

ZINC - Predictions - Purchasable

PAK2_HUMAN

PDB

3PCS

HMDB Protein

HMDBP01457

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P60953 CDC42	3	CDC42 [cytosol] (R-HSA-442630) CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086) CDC42 [plasma membrane] (R-HSA-449545)	0.821	7
UniProt:P63000 RAC1	6	RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.78	4
UniProt:O60504 SORBS3	1	SORBS3 [cytosol] (R-HSA-445805)	0.775	6
UniProt:Q9H4E5 RHOJ	2	RHOJ [plasma membrane] (R-HSA-3006725) RHOJ [cytosol] (R-HSA-3006722)	0.696	5
UniProt:Q14155 ARHGEF7	1	ARHGEF7 [cytosol] (R-HSA-430346)	0.688	4
UniProt:Q15052 ARHGEF6	1	ARHGEF6 [cytosol] (R-HSA-195017)	0.683	4
UniProt:Q9Y2X7 GIT1	2	GIT1 [cytosol] (R-HSA-430326) p-Y383-GIT1 [cytosol] (R-HSA-3928463)	0.669	3
UniProt:O55043 Arhgef7	3	Arhgef7 [cytosol] (R-RNO-442693) p-S516-Arhgef7 [cytosol] (R-RNO-9619782) ARHGEF7 [cytosol] (R-RNO-430346)	0.655	8
UniProt:P55210 CASP7	5	CASP7(207-303) [nucleoplasm] (R-HSA-351924) CASP7(24-198) [nucleoplasm] (R-HSA-351927) CASP7(24-198) [cytosol] (R-HSA-141641) CASP7(207-303) [cytosol] (R-HSA-141642) CASP7(2-303) [cytosol] (R-HSA-57029)	0.619	6
UniProt:Q13177 PAK2	11	PAK2 [cytosol] (R-HSA-211604) p-S141,T402-PAK2 [cytosol] (R-HSA-399824) p-Y130,S141,T402-PAK2 [cytosol] (R-HSA-5218705) p-5S-PAK2 [cytosol] (R-HSA-211609) PAK2(213-524) [cytosol] (R-HSA-211653) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709) K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873) p-S141,T402-PAK2 [plasma membrane] (R-HSA-5096524) PAK2(1-524) [plasma membrane] (R-HSA-164946)	0.602	3
UniProt:Q14161 GIT2			0.564	2
UniProt:P53667 LIMK1	3	p-T508-LIMK1 [cytosol] (R-HSA-399816) LIMK1 [cytosol] (R-HSA-397785) p-S,T508-LIMK1 [cytosol] (R-HSA-419610)	0.558	2
UniProt:P04049 RAF1	10	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) RAF1 [cytosol] (R-HSA-167205) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S259,S621-RAF1 [cytosol] (R-HSA-109786) hyperphosphorylated RAF1 [plasma membrane] (R-HSA-5675193) p-S621-RAF1 [plasma membrane] (R-HSA-206222) p-Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5675420) p-S621-RAF1 [cytosol] (R-HSA-206028) p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5672665) p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (R-HSA-5672664)	0.558	2
UniProt:Q5PP90 Q5PP90			0.558	2
UniProt:P08631 HCK	1	HCK [cytosol] (R-HSA-167708)	0.524	2
UniProt:P16333 NCK1	2	NCK1 [cytosol] (R-HSA-197954) NCK1 [plasma membrane] (R-HSA-202992)	0.524	2
UniProt:Q8TEJ3 SH3R3			0.524	2
UniProt:P12931 SRC	6	p-Y416-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [nucleoplasm] (R-HSA-8937690) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.524	2
UniProt:O94875 SRBS2			0.524	2
UniProt:Q9BX66 SORBS1	1	SORBS1 [cytosol] (R-HSA-445795)	0.524	2
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.524	2
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.488	2
UniProt:Q9NYB9-2 ABI2			0.488	2