Reactome | p-Y130,S141,T402-PAK2 [cytosol]

p-Y130,S141,T402-PAK2 [cytosol]

Stable Identifier

R-HSA-5218705

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by VEGF (Homo sapiens)
    - VEGFA-VEGFR2 Pathway (Homo sapiens)
      - FYN phosphorylates PAK2 (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP [plasma membrane] (Homo sapiens)
        
        p-3Y-PAK2 dimer:CDC42:GTP [plasma membrane] (Homo sapiens)
        
        p-3Y-PAK2 dimer [cytosol] (Homo sapiens)
        
        p-Y130,S141,T402-PAK2 [cytosol] (Homo sapiens)
      - p38 MAPK activation by VEGFR (Homo sapiens)
        
        VEGFA:p-6Y-VEGFR2:NCK:p-S21,Y420-FYN:p-3Y-PAK2:CDC42:GTP [plasma membrane] (Homo sapiens)
        
        p-3Y-PAK2 dimer:CDC42:GTP [plasma membrane] (Homo sapiens)
        
        p-3Y-PAK2 dimer [cytosol] (Homo sapiens)
        
        p-Y130,S141,T402-PAK2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13177 PAK2

Gene Names

PAK2

Chain

initiator methionine:1, chain:2-524, chain:2-212, chain:213-524

Reference Genes

BioGPS Gene:5062 PAK2

CTD Gene:5062 PAK2

dbSNP Gene:5062 PAK2

ENSEMBL:ENSG00000180370 PAK2

HGNC:8591 PAK2

KEGG Gene (Homo sapiens):5062 PAK2

Monarch:5062 PAK2

NCBI Gene:5062 PAK2

OMIM:605022 PAK2

UCSC:Q13177 PAK2

Reference Transcript

Other Identifiers

0003830148

11739268_s_at

11739269_s_at

11739270_at

11739271_s_at

11739272_x_at

11739273_at

11739274_s_at

11739275_x_at

1245_i_at

1559052_s_at

1560_g_at

16950017

208875_s_at

208876_s_at

208877_3p_at

208877_at

208878_s_at

2659578

2659584

2659585

2659586

2659587

2659588

2659589

2659591

2659593

2659594

2659597

2659600

2659601

2659602

2659603

2659604

2659605

2659606

2659607

2659608

2659609

2659610

2659611

2659612

2659613

2659614

2659630

34329_at

3612676

3612683

3612686

3612689

3612690

3612691

3612693

5062

55663_at

8084963

A_14_P125078

A_23_P327307

A_32_P104075

A_33_P3220833

GE59022

GO:0000166

GO:0000278

GO:0002223

GO:0002376

GO:0003674

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0005886

GO:0005911

GO:0006464

GO:0006468

GO:0006469

GO:0006915

GO:0006950

GO:0007010

GO:0007049

GO:0007155

GO:0007165

GO:0007346

GO:0008150

GO:0008152

GO:0008219

GO:0014069

GO:0016020

GO:0016032

GO:0016301

GO:0016310

GO:0016740

GO:0018105

GO:0019899

GO:0019901

GO:0022607

GO:0023014

GO:0030154

GO:0030234

GO:0030296

GO:0031098

GO:0031267

GO:0031295

GO:0032147

GO:0034330

GO:0034333

GO:0035722

GO:0038095

GO:0040007

GO:0040008

GO:0042802

GO:0042981

GO:0043066

GO:0043167

GO:0043226

GO:0044403

GO:0045296

GO:0046777

GO:0048010

GO:0048365

GO:0048471

GO:0048856

GO:0050690

GO:0050731

GO:0050852

GO:0051493

GO:0051497

GO:0060996

GO:0061098

GO:0070830

GO:0071407

GO:0098978

GO:0150105

GO:2001238

GO:2001271

Hs.284275.0.S1_3p_a_at

Hs.284275.0.S2_3p_a_at

Hs.284275.0.S4_3p_at

Hs.284275.0.S4_3p_s_at

Hs.284275.0.S4_3p_x_at

Hs.56974.0.A1_3p_s_at

Hs2.56974.1.S1_3p_s_at

ILMN_1676385

ILMN_1712687

ILMN_1743106

PH_hs_0014731

TC03001100.hg

U25975_at

g5138913_3p_a_at

Participant Of

hasComponent

p-3Y-PAK2 dimer [cytosol]

Other forms of this molecule

PAK2(1-524) [plasma membrane]

p-S141,T402-PAK2 [plasma membrane]

K48polyUb-p-T402-PAK-2p43 [cytosol]

p-S141,T402-PAK2 [cytosol]

PAK2 [cytosol]

p-5S-PAK2 [cytosol]

PAK2(213-524) [cytosol]

p-5S-PAK2(2-212) [cytosol]

p-T402-PAK2(213-524) [cytosol]

p-T402-PAK2(213-524) [nucleoplasm]

Inferred To

phospho-p-Y130,S141,T402-PAK2 [cytosol] (Bos taurus)

phospho-PAK2 [cytosol] (Canis familiaris)

phospho-PAK2 [cytosol] (Gallus gallus)

phospho-PAK2 [cytosol] (Sus scrofa)

phospho-pak2 [cytosol] (Xenopus tropicalis)

phospho-pak2a [cytosol] (Danio rerio)

phospho-Pak2 [cytosol] (Mus musculus)

phospho-Pak2 [cytosol] (Rattus norvegicus)

Modified Residues

Name

O-phospho-L-serine at 141

Coordinate

141

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 402

Coordinate

402

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O4'-phospho-L-tyrosine at 130

Coordinate

130

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_016861990.1, XP_011511172.1, NP_002568.2

ZINC - World Drugs

PAK2_HUMAN

OpenTargets

ENSG00000180370

ZINC - FDA approved

PAK2_HUMAN

ZINC - Substances

PAK2_HUMAN

ZINC target

Q13177

ZINC - Biogenic

PAK2_HUMAN

PRO

Q13177

PDB

3PCS

ZINC - Investigational

PAK2_HUMAN

GeneCards

Q13177

HPA

ENSG00000180370-PAK2

Ensembl

ENSG00000180370, ENST00000327134, ENSP00000314067

ZINC - Predictions - Purchasable

PAK2_HUMAN

HMDB Protein

HMDBP01457

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P60953 CDC42	3	CDC42 [cytosol] (R-HSA-442630) CDC42 [endoplasmic reticulum membrane] (R-HSA-5672086) CDC42 [plasma membrane] (R-HSA-449545)	0.834	8
UniProt:P63000 RAC1	6	RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.78	4
UniProt:O60504 SORBS3	1	SORBS3 [cytosol] (R-HSA-445805)	0.775	6
UniProt:Q9H4E5 RHOJ	2	RHOJ [plasma membrane] (R-HSA-3006725) RHOJ [cytosol] (R-HSA-3006722)	0.718	6
UniProt:Q15052 ARHGEF6	1	ARHGEF6 [cytosol] (R-HSA-195017)	0.709	5
UniProt:P16333 NCK1	2	NCK1 [cytosol] (R-HSA-197954) NCK1 [plasma membrane] (R-HSA-202992)	0.709	5
UniProt:Q14155 ARHGEF7	1	ARHGEF7 [cytosol] (R-HSA-430346)	0.688	4
UniProt:Q9Y2X7 GIT1	2	GIT1 [cytosol] (R-HSA-430326) p-Y383-GIT1 [cytosol] (R-HSA-3928463)	0.669	3
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.666	8
UniProt:O55043 Arhgef7	3	Arhgef7 [cytosol] (R-RNO-442693) p-S516-Arhgef7 [cytosol] (R-RNO-9619782) Arhgef7 [cytosol] (R-RNO-430346)	0.655	8
UniProt:P55210 CASP7	5	CASP7(207-303) [nucleoplasm] (R-HSA-351924) CASP7(24-198) [nucleoplasm] (R-HSA-351927) CASP7(2-303) [cytosol] (R-HSA-57029) CASP7(24-198) [cytosol] (R-HSA-141641) CASP7(207-303) [cytosol] (R-HSA-141642)	0.619	6
UniProt:Q13177 PAK2	11	p-S141,T402-PAK2 [plasma membrane] (R-HSA-5096524) PAK2(1-524) [plasma membrane] (R-HSA-164946) K48polyUb-p-T402-PAK-2p43 [cytosol] (R-HSA-3095873) p-Y130,S141,T402-PAK2 [cytosol] (R-HSA-5218705) p-S141,T402-PAK2 [cytosol] (R-HSA-399824) PAK2 [cytosol] (R-HSA-211604) p-5S-PAK2 [cytosol] (R-HSA-211609) PAK2(213-524) [cytosol] (R-HSA-211653) p-5S-PAK2(2-212) [cytosol] (R-HSA-211588) p-T402-PAK2(213-524) [cytosol] (R-HSA-211654) p-T402-PAK2(213-524) [nucleoplasm] (R-HSA-211709)	0.602	3
UniProt:Q14161 GIT2			0.564	2
UniProt:Q5PP90 Q5PP90			0.558	2
UniProt:P04049 RAF1	54	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) RAF1 [cytosol] (R-HSA-167205) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098) p-S621-RAF1 G361A [cytosol] (R-HSA-9656092) p-S621-RAF1 G370R [cytosol] (R-HSA-9656094) p-S621-RAF1 D486G [cytosol] (R-HSA-9656085) p-S621-RAF1 T491R [cytosol] (R-HSA-9656145) p-S338,Y341,T492,S494,S621 RAF1 D486N [cytosol] (R-HSA-9656026) p-S338,Y341,T492,S494,S621 RAF1 S427G [cytosol] (R-HSA-9656070) p-S338,Y341,T492,S494,S621 RAF1 L613V [cytosol] (R-HSA-9656035) p-S338,Y341,S494,S621-RAF1 T491I [cytosol] (R-HSA-9656019) p-S338,Y341,T492,S494,S621 RAF1 G361A [cytosol] (R-HSA-9656029) p-S338,Y341,T492,S494,S621 RAF1 G370R [cytosol] (R-HSA-9656031) p-S338,Y341,T492,S494,S621 RAF1 D486G [cytosol] (R-HSA-9656023) p-S338,Y341,S494,S621 RAF1 T491R [cytosol] (R-HSA-9656017) p-S338,Y341,T492,S494,S621 RAF1 S259F [cytosol] (R-HSA-9656062) p-S338,Y341,T492,S494,S621 RAF1 P261A [cytosol] (R-HSA-9656041) p-S338,Y341,T492,S494,S621 RAF1 S257L [cytosol] (R-HSA-9656058) p-S338,Y341,T492,S494,S621 RAF1 P261L [cytosol] (R-HSA-9656043) p-S338,Y341,T492,S494,S621 RAF1 P261T [cytosol] (R-HSA-9656053) p-S338,Y341,T492,S494,S621 RAF1 N262K [cytosol] (R-HSA-9656037) p-S338,Y341,T492,S494,S621 RAF1 P261S [cytosol] (R-HSA-9656050) p-S338,Y341,T492,S494,S621 RAF1 S259T [cytosol] (R-HSA-9656067) p-S338,Y341,T492,S494,S621 RAF1 T260R [cytosol] (R-HSA-9656077) p-S338,Y341,T492,S494,S621 RAF1 P261R [cytosol] (R-HSA-9656047) p-S338,Y341,T492,S494,S621 RAF1 R256S [cytosol] (R-HSA-9656056) p-S338,Y341,T492,S494,S621 RAF1 T260I [cytosol] (R-HSA-9656074) p-S338,Y341,T492,S494,S621 RAF1 V263A [cytosol] (R-HSA-9656080) p-S338,Y341,T492,S494,S621 RAF1 S259P [cytosol] (R-HSA-9656065) hyperphosphorylated RAF1 [plasma membrane] (R-HSA-5675193) p-S621-RAF1 [plasma membrane] (R-HSA-206222) p-Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5675420) p-S259,S621-RAF1 [cytosol] (R-HSA-109786) p-S621-RAF1 [cytosol] (R-HSA-206028) p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5672665) p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (R-HSA-5672664)	0.558	2
UniProt:P53667 LIMK1	3	p-T508-LIMK1 [cytosol] (R-HSA-399816) LIMK1 [cytosol] (R-HSA-397785) p-S,T508-LIMK1 [cytosol] (R-HSA-419610)	0.558	2
UniProt:Q9NYB9-2 ABI2			0.556	3
UniProt:Q9NVF7 FBX28			0.527	3
UniProt:Q13153 PAK1	6	p-S144-PAK1 [cytosol] (R-HSA-451339) Active PAK1 [cytosol] (R-HSA-8964622) PAK1 [plasma membrane] (R-HSA-3928409) p-S144,T423-PAK1 [plasma membrane] (R-HSA-3928472) PAK1 [cytosol] (R-HSA-162629) p-S144,T423-PAK1 [cytosol] (R-HSA-399819)	0.527	3
UniProt:O94875 SRBS2			0.524	2
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.524	2
UniProt:P08631 HCK	1	HCK [cytosol] (R-HSA-167708)	0.524	2
UniProt:Q8TEJ3 SH3R3			0.524	2
UniProt:P12931 SRC	6	p-Y416-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [nucleoplasm] (R-HSA-8937690) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.524	2
UniProt:Q9BX66 SORBS1	1	SORBS1 [cytosol] (R-HSA-445795)	0.524	2

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