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p-S225-SPHK1 [cytosol]
Stable Identifier
R-HSA-5218716
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
PKR-mediated signaling (Homo sapiens)
PKR forms a dimer (Homo sapiens)
EIF2AK2:p-SPHK1 [cytosol] (Homo sapiens)
p-S225-SPHK1 [cytosol] (Homo sapiens)
SPHK1 binds PKR (Homo sapiens)
EIF2AK2:p-SPHK1 [cytosol] (Homo sapiens)
p-S225-SPHK1 [cytosol] (Homo sapiens)
p-S225-SPHK1 [cytosol] (Homo sapiens)
p-S225-SPHK1 localizes to cytosol (Homo sapiens)
p-S225-SPHK1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
VEGFR2 mediated cell proliferation (Homo sapiens)
PKC phosphorylates sphingosine kinase 1 (Homo sapiens)
p-S225-SPHK1 [cytosol] (Homo sapiens)
p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate (Homo sapiens)
p-S225-SPHK1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NYA1 SPHK1
Gene Names
SPHK1, SK1, SPHK, SPK
Chain
chain:1-384
Reference Genes
BioGPS Gene:8877 SPHK1
COSMIC (genes):SPHK1 SPHK1
CTD Gene:8877 SPHK1
dbSNP Gene:8877 SPHK1
ENSEMBL:ENSG00000176170 SPHK1
HGNC:11240 SPHK1
KEGG:hsa:8877 SPHK1
Monarch:8877 SPHK1
NCBI Gene:8877 SPHK1
OMIM:603730 SPHK1
UCSC:Q9NYA1 SPHK1
Reference Transcript
RefSeq:NM_001142601.1 SPHK1
RefSeq:XM_005257766.2 SPHK1
RefSeq:NM_001142602.1 SPHK1
RefSeq:NM_182965.2 SPHK1
RefSeq:NM_021972.3 SPHK1
Participates
as an input of
SPHK1 binds PKR (Homo sapiens)
as an output of
p-S225-SPHK1 localizes to cytosol (Homo sapiens)
PKC phosphorylates sphingosine kinase 1 (Homo sapiens)
as a component of
EIF2AK2:p-SPHK1 [cytosol] (Homo sapiens)
Other forms of this molecule
SPHK1 [cytosol]
p-S225-SPHK1 [nucleoplasm]
SPHK1 [nucleoplasm]
Inferred To
phospho-Sk1 [cytosol]
(Drosophila melanogaster)
phospho-SPHK1 [cytosol]
(Bos taurus)
phospho-SPHK1 [cytosol]
(Canis familiaris)
phospho-SPHK1 [cytosol]
(Gallus gallus)
phospho-SPHK1 [cytosol]
(Sus scrofa)
phospho-p-S225-SPHK1 [cytosol]
(Caenorhabditis elegans)
phospho-p-S225-SPHK1 [cytosol]
(Dictyostelium discoideum)
phospho-p-S225-SPHK1 [cytosol]
(Mus musculus)
phospho-p-S225-SPHK1 [cytosol]
(Rattus norvegicus)
phospho-p-S225-SPHK1 [cytosol]
(Saccharomyces cerevisiae)
phospho-p-S225-SPHK1 [cytosol]
(Schizosaccharomyces pombe)
Modified Residues
Name
O-phospho-L-serine at 225
Coordinate
225
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
Guide to Pharmacology - Targets
2204
OpenTargets
ENSG00000176170
ENSEMBL
ENSP00000440970
,
ENST00000392496
,
ENST00000590959
,
ENSP00000468547
,
ENSG00000176170
,
ENST00000323374
,
ENST00000592299
,
ENSP00000465726
,
ENST00000545180
,
ENSP00000313681
,
ENSP00000376285
ZINC - Substances
SPHK1_HUMAN
ZINC target
Q9NYA1
ZINC - Biogenic
SPHK1_HUMAN
PRO
Q9NYA1
PDB
4V24
,
4L02
,
3VZB
,
3VZC
,
3VZD
ZINC - Investigational
SPHK1_HUMAN
ZINC - Metabolites
SPHK1_HUMAN
HPA
ENSG00000176170-SPHK1
GeneCards
SPHK1
Pharos - Targets
Q9NYA1
ZINC - Predictions - Purchasable
SPHK1_HUMAN
HMDB Protein
HMDBP01082
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q2M3C7 SPKAP
0.602
4
UniProt:P68104 EEF1A1
7
EEF1A1 [lysosomal membrane]
(R-HSA-9626022)
EEF1A1 [cytosol]
(R-HSA-156905)
EEF1A1 [ficolin-1-rich granule lumen]
(R-HSA-6801528)
EEF1A1 [extracellular region]
(R-HSA-6806456)
EEF1A1 [secretory granule lumen]
(R-HSA-6801479)
Me3K318-EEF1A1 [cytosol]
(R-HSA-8932419)
Me3K79-EEF1A1 [cytosol]
(R-HSA-8932212)
0.544
2
UniProt:Q14192 FHL2
1
FHL2 [nucleoplasm]
(R-HSA-561161)
0.543
7
UniProt:Q96PQ7 KLHL5
1
KLHL5 [cytosol]
(R-HSA-8863223)
0.482
2
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