Reactome | FYN autophosphorylates

FYN autophosphorylates

Stable Identifier

R-HSA-5218806

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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FYN recruited to VEGFR2 is activated; this is required for VEGF-induced actin remodelling and endothelial migration. Once Y531 in the negative regulatory site is dephosphorylated by a phosphatase, FYN undergoes autophosphorylation on Y420 (Yeo et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
20658524	Phosphorylation of Ser 21 in Fyn regulates its kinase activity, focal adhesion targeting, and is required for cell migration Cho, HS, Marcantonio, EE, Yeo, MG, Song, WK, Chun, JS, Oh, HJ	J. Cell. Physiol.	2011